Treatment of KPC-2 Enterobacter cloacae empyema with cefepime and levofloxacin

Diagnostic Microbiology and Infectious Disease

Volumn 78, Issue 2, 2014, Pages 199-200

  Cardile, Anthony P ^a   Briggs, Heather ^b   Burguete, S Rodrigo ^b   Herrera, Monica ^c   Wickes, Brian L ^c   Jorgensen, James H ^b,c  

^a BROOKE ARMY MEDICAL CENTER   (United States)

^b University of Texas Health Science Center   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Carbapenemase; Empyema; Enterobacter cloacae; KPC

Indexed keywords

AMIKACIN; AMPICILLIN; CARBAPENEMASE; CEFAZOLIN; CEFEPIME; CEFTRIAXONE; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; ERTAPENEM; IMIPENEM; KLEBSIELLA PNEUMONIAE CARBAPENEMASE 2; LEVOFLOXACIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; RNA 16S; SULTAMICILLIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ACUTE KIDNEY FAILURE; ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; BRONCHOSCOPY; CASE REPORT; CHEST TUBE; COMPUTER ASSISTED TOMOGRAPHY; CONTINUOUS INFUSION; COUGHING; DRUG MEGADOSE; DRUG WITHDRAWAL; DYSPNEA; EMPYEMA; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE INFECTION; HUMAN; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLEURA EFFUSION; PRIORITY JOURNAL; RNA SEQUENCE;

CARBAPENEMASE; EMPYEMA; ENTEROBACTER CLOACAE; KPC;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CEPHALOSPORINS; DRUG THERAPY, COMBINATION; EMPYEMA; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE INFECTIONS; HUMANS; LEVOFLOXACIN; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84892479419     PISSN: 07328893     EISSN: 18790070     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2013.10.012     Document Type: Article

References (19)

1. Anderson K.F., Lonsway D.R., Rasheed J.K., Biddle J., Jensen B., McDougal L.K., et al. Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae. J Clin Microbiol 2007, 45(8):2723-2725.
2. Bennett J.W., Herrera M.L., Lewis J.S., Wickes B.W., Jorgensen J.H. KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient. Antimicrob Agents Chemother 2009, 53(1):292-294.
3. Bulik C.C., Nicolau D.P. Double-carbapenem therapy for carbapenemase-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 2011, 55(6):3002-3004.
4. Centers for Disease Control, Prevention (CDC) Vital signs: carbapenem-resistant Enterobacteriaceae. MMWR Morb Mortal Wkly Rep 2013, 62(9):165-170.
5. Gonçalves-Pereira J., Póvoa P. Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams. Crit Care 2011, 15(5):R206.
6. Hirsch E.B., Guo B., Chang K.T., Cao H., Ledesma K.R., Singh M., et al. Assessment of antimicrobial combinations for Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. J Infect Dis 2013, 207(5):786-793.
7. Jernigan M.G., Press E.G., Nguyen M.H., Clancy C.J., Shields R.K. The combination of doripenem and colistin is bactericidal and synergistic against colistin-resistant, carbapenemase-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 2012, 56(6):3395-3398.
8. Kontopidou F., Giamarellou H., Katerelos P., Maragos A., Kioumis I., Trikka-Graphakos E., et al. Infections caused by carbapenem-resistant Klebsiella pneumoniae among patients in intensive care units in Greece: a multi-centre study on clinical outcome and therapeutic options. Clin Microbiol Infect 2013, The group for the study of KPC-producing Klebsiella pneumoniae infections in intensive care units, [Epub ahead of print]. http://dx.doi.org/10.1111/1469-0691.12341.
9. Lee G.C., Burgess D.S. Polymyxins and doripenem combination against KPC-producing Klebsiella pneumoniae. J Clin Med Res 2013, 5(2):97-100.
10. Lee G.C., Burgess D.S. Treatment of Klebsiella pneumoniae carbapenemase (KPC) infections: a review of published case series and case reports. Ann Clin Microbiol Antimicrob 2012, 11:32.
11. Maviglia R., Nestorini R., Pennisi M. Role of old antibiotics in multidrug resistant bacterial infections. Curr Drug Targets 2009, 10(9):895-905.
12. Queenan A.M., Bush K. Carbapenemases: the versatile beta-lactamases. Clin Microbiol Rev 2007, 20(3):440-458.
13. Qureshi Z.A., Paterson D.L., Potoski B.A., Kilayko M.C., Sandovsky G., Sordillo E., et al. Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens. Antimicrob Agents Chemother 2012, 56(4):2108-2113.
14. Pankey G.A., Ashcraft D.S. Detection of synergy using the combination of polymyxin B with either meropenem or rifampin against carbapenemase-producing Klebsiella pneumoniae. Diagn Microbiol Infect Dis 2011, 70(4):561-564.
15. Rodvold K.A., George J.M., Yoo L. Penetration of anti-infective agents into pulmonary epithelial lining fluid: focus on antibacterial agents. Clin Pharmacokinet 2011, 50(10):637-664.
16. Sbrana F., Malacarne P., Viaggi B., Costanzo S., Leonetti P., Leonildi A., et al. Carbapenem-sparing antibiotic regimens for infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae in intensive care unit. Clin Infect Dis 2013, 56(5):697-700.
17. Tascini C., Tagliaferri E., Giani T., Leonildi A., Flammini S., Casini B., et al. Synergistic activity of colistin plus rifampin against colistin-resistant KPC-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 2013, 57(8):3990-3993.
18. Tumbarello M., Viale P., Viscoli C., Trecarichi E.M., Tumietto F., Marchese A., et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin Infect Dis 2012, 55(7):943-950.
19. Watanabe K., Kodama Y., Harayama S. Design and evaluation of PCR primers to amplify bacterial 16S ribosomal DNA fragments used for community fingerprinting. J Microbiol Methods 2001, 44(3):253-262.