Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone

Clinical Pharmacology in Drug Development

Volumn 3, Issue 1, 2014, Pages 13-17

  Langsjoen, Peter H ^a   Langsjoen, Alena M ^a  

^a Coenzyme Q10 Laboratory Inc ^*  (United States)

Author keywords

Coenzyme Q10; Plasma level; Supplementation; Ubiquinol; Ubiquinone

Indexed keywords

ALPHA TOCOPHEROL; CHOLESTEROL; EXCIPIENT; KANEKAQ10; KANEKAQH; QUINONE DERIVATIVE; UBIDECARENONE; UBIQUINOL; UBIQUINONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG STRUCTURE; ENZYME BLOOD LEVEL; EVENING DOSAGE; HUMAN; HUMAN EXPERIMENT; MIDDLE AGED; NORMAL HUMAN; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 84892469655     PISSN: 2160763X     EISSN: 21607648     Source Type: Journal    
DOI: 10.1002/cpdd.73     Document Type: Article

References (36)

1. Mitchell P. Possible molecular mechanism of the protonmotive function of cytochrome systems. J Theor Biol. 1976; 62(2):327-367.
2. Mitchell P. The classical mobile carrier function of lipophilic quinones in the osmochemistry of electron-driven proton translocation. In: Lenaz G, Barnabei O, Rabbi A, Battino M, eds. Highlights in Ubiquinone Research. London: Taylor and Francis; 1990: 77-82.
3. Lenaz G. The role of mobility of redox components in the inner mitochondrial membrane. J Membr Biol. 1988; 104(3):193-209.
4. Lenaz G, Fato R, Castelluccio C, et al. Coenzyme Q saturation kinetics of mitochondrial enzymes: Theory, experimental aspects and biomedical implications. In: Folkers K, Yamagami T, Littarru GP, eds. Biomedical and Clinical Aspects of Coenzyme Q. Vol. 6. Amsterdam: Elsevier; 1991: 11-18.
5. Ozawa T. Formation of oxygen radicals in the electron transfer chain and antioxidant properties of coenzyme Q. In: Lenaz G ed. Coenzyme Q. Biochemistry, Bioenergetics and Clinical Applications of Ubiquinone. Chichester: John Wiley & Sons; 1985: 441-456.
6. Beyer RF, Ernster L. The antioxidant role of coenzyme Q. In: Lenaz G, Barnabei O, Rabbi A, Battino M, eds. Highlights in Ubiquinone Research. London: Taylor and Francis; 1990: 191-213.
7. Ernster L, Forsmark-Andree P, Ubiquinol: An endogenous antioxidant in aerobic organisms. Clin Investig. 1993; 71(8 Suppl):S60-S65.
8. Yokoyama H, Lingle DM, Crestanello JA, et al. Coenzyme Q10 protects coronary endothelial function from ischemia reperfusion injury via an antioxidant effect. Surgery. 1996; 120(2):189-196.
9. Kalén A, Appelkvist EL, Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids. 1989; 24(7):579-584.
10. Söderberg M, Edlund C, Kristensson K, Dallner G. Lipid compositions of different regions of the human brain during aging. J Neurochem. 1990; 54(2):415-423.
11. Folkers K, Littarru GP, Ho L, Runge TM, Havanonda S, Cooley D. Evidence for a deficiency of coenzyme Q10 in human heart disease. Int Z Vitaminforsch. 1970; 40(3):380-390.
12. Folkers K, Vadhanavikit S. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci USA. 1985; 82(3):901-904.
13. Yamamura Y. Clinical status of coenzyme Q and prospects. In: Folkers K, Yamamura Y, eds. Biomedical, Clinical Aspects of Coenzyme Q. Amsterdam: Elsevier; 1977: 281-298.
14. Soja AM, Mortensen SA. Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol Aspects Med. 1997; 18(Suppl):S159-S168.
15. Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M. Study on safety and bioavailability of ubiquinol (Kaneka QH™) after single and 4 week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007; 47(1):19-28.
16. Miles MV, Patterson BJ, Chalfonte-Evans ML, et al. Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21. Pediatr Neurol. 2007; 37(6):398-403.
17. Teran E, Hernandez I, Nieto B, Tavara R, Ocampo JE, Calle A. Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. Int J Gynaecol Obstet. 2009; 105(1):43-45.
18. Johansen K, Theorell H, Karlsson J, Diamant B, Folkers K. Coenzyme Q10, alpha-tocopherol and free cholesterol in HDL and LDL fractions. Ann Med. 1991; 23(6):649-656.
19. Kaikkonen J, Tuomainen TP, Nyyssonen K, Salonen JT. Coenzyme Q10: Absorption, antioxidative properties, determinants, and plasma levels. Free Radic Res. 2002; 36(4):389-397.
20. Mabuchi H, Nohara A, Kobayashi J, et al. Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: A randomized double-blind study. Atherosclerosis. 2007; 195(2):e182-e189.
21. Žáková P, Kand'ár R, Škarydová L. Skalický J, Myjavec A, Vojtíšek P. Ubiquinol-10/lipids ratios in consecutive patients with different angiographic findings. Clin Chim Acta. 2007; 380(1-2):133-138.
22. Yamashita S, Yamamoto Y. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal Biochem. 1997; 250(1):66-73.
23. Hirayama A, Kubo H, Mita M, Shirota O, Yamamoto Y. High-sensitivity simultaneous analysis of ubiquinol-10 and ubiquinone-10 in human plasma. J Chromatogr Sci. 2008; 46(8):717-721.
24. Langsjoen PH, Langsjoen AM. Supplemental ubiquinol in patients with advanced congestive heart failure. Biofactors. 2008; 32(1-4):119-128.
25. Evans M, Baisley J, Barss S, Guthrie N. A randomized, double-blind trial on the bioavailability of two CoQ10 formulations. J Func Foods. 2009; 1:65-73.
26. Miles MV, Horn P, Miles L, Tang P, Steele P. Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res. 2002; 22:919-929.
27. Bhagavan HN, Chopra RJ. Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006; 40(5):445-453.
28. Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007; 7(Suppl):S78-S88.
29. Žmitek J, Žmitek K, Pravst I. Improving the bioavailability of coenzyme Q10. From theory to practice. Agro Food Ind Hi Tech. 2008; 19(4):8-10.
30. Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: Evidence of slowing of the functional decline. Arch Neurol. 2002; 59(10):1541-1550.
31. Langsjoen H, Langsjoen P, Langsjoen P, Willis R, Folkers K. Usefulness of coenzyme Q10 in clinical cardiology: A long-term study. Mol Aspects Med. 1994; 15(Suppl):S165-S175.
32. Wada H, Goto H, Hasegawa H, Yamamoto Y. Redox status of coenzyme Q10 is associated with chronological age. J Am Geriatr Soc. 2007; 55(7):1141-1142.
33. Sohmiya M, Tanaka M, Suzuki Y, Tanino Y, Okamoto K, Yamamoto Y. An increase of oxidized coenzyme Q10 occurs in the plasma of sporadic ALS patients. J Neurol Sci. 2005; 228(1):49-53.
34. Hasegawa G, Yamamoto Y, Zhi JG, et al. Daily profile of plasma %CoQ10 level, a biomarker of oxidative stress, in patients with diabetes manifesting postprandial hyperglycaemia. Acta Diabetol. 2005; 42(4):179-181.
35. Lim SC, Tan HH, Goh SK, et al. Oxidative burden in prediabetic and diabetic individuals: Evidence from plasma coenzyme Q(10). Diabet Med. 2006; 23(12):1344-1349.
36. Yamamoto Y, Yamashita S. Plasma ubiquinone to ubiquinol ratio in patients with hepatitis, cirrhosis, and hepatoma, and in patients treated with percutaneous transluminal coronary reperfusion. Biofactors. 1999; 9(2-4):241-246.