Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis in critically ill patients

Journal of International Medical Research

Volumn 42, Issue 1, 2014, Pages 93-110

  Nachtigall, Irit ^a   Tamarkin, Andrey ^a   Tafelski, Sascha ^a   Weimann, Andreas ^a   Rothbart, Andreas ^a   Heim, Susanne ^a   Wernecke, Klaus D ^a,b   Spies, Claudia ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b SOSTANA GMBH   (Germany)

Author keywords

Arg753Gln polymorphism; Asp299Gly polymorphism; septic shock; Toll like receptor 2; toll like receptor 4

Indexed keywords

ADULT; APACHE; ARTICLE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DIABETES MELLITUS; DISEASE SEVERITY; FEMALE; GENE; GENE FREQUENCY; GENOTYPE; HETEROZYGOTE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEPSIS; SEPTIC SHOCK; SINGLE NUCLEOTIDE POLYMORPHISM; TOLL LIKE RECEPTOR 2 GENE; TOLL LIKE RECEPTOR 4 GENE;

ARG753GLN POLYMORPHISM; ASP299GLY POLYMORPHISM; SEPTIC SHOCK; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

ADULT; AGED; BASE SEQUENCE; CRITICAL ILLNESS; DISEASE PROGRESSION; DNA PRIMERS; FEMALE; GENOTYPE; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEPSIS; SEVERITY OF ILLNESS INDEX; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84892457845     PISSN: 03000605     EISSN: 14732300     Source Type: Journal    
DOI: 10.1177/0300060513504358     Document Type: Article

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