Facilitates Chromatin Transcription Complex Is an "Accelerator" of Tumor Transformation and Potential Marker and Target of Aggressive Cancers

Cell Reports

Volumn 4, Issue 1, 2013, Pages 159-173

  Garcia, Henry ^a   Miecznikowski, Jeffrey C ^b   Safina, Alfiya ^a   Commane, Mairead ^a   Ruusulehto, Anja ^c   Kilpinen, Sami ^c   Leach, Robert W ^b   Attwood, Kristopher ^a   Li, Yan ^a   Degan, Seamus ^a   Omilian, Angela R ^a   Guryanova, Olga ^d   Papantonopoulou, Olympia ^a   Wang, Jianmin ^a   Buck, Michael ^e   Liu, Song ^a   Morrison, Carl ^a   Gurova, Katerina V ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c MediSapiens Ltd   (Finland)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; FACILITATE CHROMATIN TRANSCRIPTION COMPLEX PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CELLULAR STRESS RESPONSE; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CLINICAL FEATURE; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE MARKER; DNA SEQUENCE; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALIGNANT NEOPLASTIC DISEASE; MALIGNANT TRANSFORMATION; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE ANALYSIS; SURVIVAL RATE;

ANIMALS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HIGH MOBILITY GROUP PROTEINS; HUMANS; MCF-7 CELLS; MICE; MICE, INBRED C57BL; MICE, SCID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ELONGATION FACTORS;

MAMMALIA;

EID: 84892445850     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.06.013     Document Type: Article

References (39)

1. Belotserkovskaya R., Oh S., Bondarenko V.A., Orphanides G., Studitsky V.M., Reinberg D. FACT facilitates transcription-dependent nucleosome alteration. Science 2003, 301:1090-1093.
2. Birch J.L., Tan B.C., Panov K.I., Panova T.B., Andersen J.S., Owen-Hughes T.A., Russell J., Lee S.C., Zomerdijk J.C. FACT facilitates chromatin transcription by RNA polymerases I and III. EMBO J. 2009, 28:854-865.
3. Brenner A.J., Stampfer M.R., Aldaz C.M. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation. Oncogene 1998, 17:199-205.
4. Bunker C.A., Kingston R.E. Identification of a cDNA for SSRP1, an HMG-box protein, by interaction with the c-Myc oncoprotein in a novel bacterial expression screen. Nucleic Acids Res. 1995, 23:269-276.
5. Duroux M., Houben A., Růzicka K., Friml J., Grasser K.D. The chromatin remodelling complex FACT associates with actively transcribed regions of the Arabidopsis genome. Plant J. 2004, 40:660-671.
6. Feng X., Grossman R., Stein L. PeakRanger: a cloud-enabled peak caller for ChIP-seq data. BMC Bioinformatics 2011, 12:139.
7. Formosa T. The role of FACT in making and breaking nucleosomes. Biochim. Biophys. Acta 2012, 1819:247-255.
8. Garbe J.C., Bhattacharya S., Merchant B., Bassett E., Swisshelm K., Feiler H.S., Wyrobek A.J., Stampfer M.R. Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res. 2009, 69:7557-7568.
9. Garcia H., Fleyshman D., Kolesnikova K., Safina A., Commane M., Paszkiewicz G., Omelian A., Morrison C., Gurova K. Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells. Oncotarget 2011, 2:783-796.
10. Gasparian A.V., Burkhart C.A., Purmal A.A., Brodsky L., Pal M., Saranadasa M., Bosykh D.A., Commane M., Guryanova O.A., Pal S., et al. Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci. Transl. Med. 2011, 3. 95ra74.
11. Gudkov A.V., Gurova K.V., Komarova E.A. Inflammation and p53: a tale of two stresses. Genes Cancer 2011, 2:503-516.
12. Gurova K.V., Hill J.E., Razorenova O.V., Chumakov P.M., Gudkov A.V. p53 pathway in renal cell carcinoma is repressed by a dominant mechanism. Cancer Res. 2004, 64:1951-1958.
13. Gurova K.V., Hill J.E., Guo C., Prokvolit A., Burdelya L.G., Samoylova E., Khodyakova A.V., Ganapathi R., Ganapathi M., Tararova N.D., et al. Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proc. Natl. Acad. Sci. USA 2005, 102:17448-17453.
14. Heo K., Kim H., Choi S.H., Choi J., Kim K., Gu J., Lieber M.R., Yang A.S., An W. FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol. Cell 2008, 30:86-97.
15. Hudson M.E., Pozdnyakova I., Haines K., Mor G., Snyder M. Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays. Proc. Natl. Acad. Sci. USA 2007, 104:17494-17499.
16. Ikeda Y., Kinoshita Y., Susaki D., Ikeda Y., Iwano M., Takayama S., Higashiyama T., Kakutani T., Kinoshita T. HMG domain containing SSRP1 is required for DNA demethylation and genomic imprinting in Arabidopsis. Dev. Cell 2011, 21:589-596.
17. Keller D.M., Zeng X., Wang Y., Zhang Q.H., Kapoor M., Shu H., Goodman R., Lozano G., Zhao Y., Lu H. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol. Cell 2001, 7:283-292.
18. Kihara T., Kano F., Murata M. Modulation of SRF-dependent gene expression by association of SPT16 with MKL1. Exp. Cell Res. 2008, 314:629-637.
19. Koman I.E., Commane M., Paszkiewicz G., Hoonjan B., Pal S., Safina A., Toshkov I., Purmal A.A., Wang D., Liu S., et al. Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice. Cancer Prev. Res. (Phila.) 2012, 5:1025-1035.
20. Kumari A., Mazina O.M., Shinde U., Mazin A.V., Lu H. A role for SSRP1 in recombination-mediated DNA damage response. J.Cell. Biochem. 2009, 108:508-518.
21. Li Y., Keller D.M., Scott J.D., Lu H. CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity. J.Biol. Chem. 2005, 280:11869-11875.
22. Lolas I.B., Himanen K., Grønlund J.T., Lynggaard C., Houben A., Melzer M., Van Lijsebettens M., Grasser K.D. The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2. Plant J. 2010, 61:686-697.
23. Pardo M., Lang B., Yu L., Prosser H., Bradley A., Babu M.M., Choudhary J. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell 2010, 6:382-395.
24. Peto R., Peto J. Asymptotically efficient rank invariant test procedures. J.R. Stat. Soc. Ser. A 1972, 135:185-207.
25. Reinberg D., Sims R.J. de FACTo nucleosome dynamics. J.Biol. Chem. 2006, 281:23297-23301.
26. R Team (2012). The R Project for Statistical Computing. http://www.r-project.org/.
27. Safina A., Garcia H., Commane M., Guryanova O., Degan S., Kolesnikova K., Gurova K.V. Complex mutual regulation of facilitates chromatin transcription (FACT) subunits on mRNA and protein levels in human cells. Cell Cycle 2013, Published online June 28, 2013.
28. Saunders A., Werner J., Andrulis E.D., Nakayama T., Hirose S., Reinberg D., Lis J.T. Tracking FACT and the RNA polymerase II elongation complex through chromatin invivo. Science 2003, 301:1094-1096.
29. Singer R.A., Johnston G.C. The FACT chromatin modulator: genetic and structure/function relationships. Biochem. Cell Biol. 2004, 82:419-427.
30. Spencer J.A., Baron M.H., Olson E.N. Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1. J.Biol. Chem. 1999, 274:15686-15693.
31. Stampfer M.R., Bartley J.C. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene. Proc. Natl. Acad. Sci. USA 1985, 82:2394-2398.
32. Stampfer M.R., Garbe J., Nijjar T., Wigington D., Swisshelm K., Yaswen P. Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines. Oncogene 2003, 22:5238-5251.
33. Tan B.C., Chien C.T., Hirose S., Lee S.C. Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication. EMBO J. 2006, 25:3975-3985.
34. Tan B.C., Liu H., Lin C.L., Lee S.C. Functional cooperation between FACT and MCM is coordinated with cell cycle and differential complex formation. J.Biomed. Sci. 2010, 17:11.
35. van den Berg D.L., Snoek T., Mullin N.P., Yates A., Bezstarosti K., Demmers J., Chambers I., Poot R.A. An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 2010, 6:369-381.
36. Yang N., Morrison C.D., Liu P., Miecznikowski J., Bshara W., Han S., Zhu Q., Omilian A.R., Li X., Zhang J. TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin. Cell Cycle 2012, 11:2922-2930.
37. Zeng S.X., Li Y., Jin Y., Zhang Q., Keller D.M., McQuaw C.M., Barklis E., Stone S., Hoatlin M., Zhao Y., Lu H. Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis. Mol. Cell. Biol. 2010, 30:935-947.
38. Zhang Y., Liu T., Meyer C.A., Eeckhoute J., Johnson D.S., Bernstein B.E., Nusbaum C., Myers R.M., Brown M., Li W., Liu X.S. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008, 9:R137.
39. Zhou Y., Wang T.S. A coordinated temporal interplay of nucleosome reorganization factor, sister chromatin cohesion factor, and DNA polymerase alpha facilitates DNA replication. Mol. Cell. Biol. 2004, 24:9568-9579.