Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters

Biochemical and Biophysical Research Communications

Volumn 443, Issue 2, 2014, Pages 505-510

  Kaneko, Masahiro ^a   Hakuno, Fumihiko ^a   Kamei, Hiroyasu ^a   Yamanaka, Daisuke ^a,b   Chida, Kazuhiro ^a   Minami, Shiro ^b   Coe, Imogen R ^c   Takahashi, Shin Ichiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c RYERSON UNIVERSITY   (Canada)

Author keywords

Estradiol; NBTI (S 4 nitrobenzyl 6 thioinosine); Nucleoside transporter; Steroid hormone

Indexed keywords

ESTRADIOL; HORMONE; NITROBENZYLTHIOINOSINE; NUCLEOSIDE; NUCLEOSIDE TRANSPORTER; PROGESTERONE; STEROID HORMONE; THYMIDINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING ASSAY; COMPETITIVE INHIBITION; CONTROLLED STUDY; ESTROGEN BINDING; HUMAN; HUMAN CELL; MAMMAL CELL; MYOBLAST; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOSIDE TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

MAMMALIA; RATTUS;

BOVINE SERUM ALBUMIN; BSA; CNT; CONCENTRATIVE NUCLEOSIDE TRANSPORTER; DMEM; DULBECCO'S MODIFIED EAGLE'S MEDIUM; E2; EDTA; ENT; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; ESTRADIOL; ETHYLENEDIAMINETETRAACETIC ACID; FBS; FETAL BOVINE SERUM; NBTI; NBTI (S-[4-NITROBENZYL]-6-THIOINOSINE); NT; NUCLEOSIDE TRANSPORTER; P4; PBS; PHOSPHATE BUFFERED SERINE; PROGESTERONE; S-[4-NITROBENZYL]-6-THIOINOSINE; STEROID HORMONE;

ANIMALS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; GONADAL STEROID HORMONES; HUMANS; MYOCYTES, CARDIAC; NEUROBLASTOMA; NUCLEOSIDE TRANSPORT PROTEINS; NUCLEOSIDES; PROGESTERONE; RATS;

EID: 84892441082     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.11.132     Document Type: Article

References (32)

1. J.R. Nofer Estrogens and atherosclerosis: insights from animal models and cell systems J. Mol. Endocrinol. 48 2012 R13 R29
2. B.J. Cheskis, J.G. Greger, S. Nagpal, and L.P. Freedman Signaling by estrogens J. Cell. Physiol. 213 2007 610 617
3. R.H. Straub The complex role of estrogens in inflammation Endocr. Rev. 28 2007 521 574
4. L. Prokai, and J.W. Simpkins Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds Pharmacol. Ther. 114 2007 1 12
5. F. Homo, F. Picard, S. Durant, D. Gagne, J. Simon, M. Dardenne, and D. Duval Glucocorticoid receptors and their functions in lymphocytes J. Steroid Biochem. 12 1980 433 443
6. D. Gagne, F. Homo, and D. Duval Steroid-induced inhibition of nucleoside uptake in isolated mouse thymocytes Biochim. Biophys. Acta 603 1980 27 35
7. M. Podgorska, K. Kocbuch, and T. Pawelczyk Recent advances in studies on biochemical and structural properties of equilibrative and concentrative nucleoside transporters Acta Biochim. Pol. 52 2005 749 758
8. A.E. King, M.A. Ackley, C.E. Cass, J.D. Young, and S.A. Baldwin Nucleoside transporters: from scavengers to novel therapeutic targets Trends Pharmacol. Sci. 27 2006 416 425
9. R.J. Paproski, S.Y. Yao, N. Favis, D. Evans, J.D. Young, C.E. Cass, and R.J. Zemp Human concentrative nucleoside transporter 3 transfection with ultrasound and microbubbles in nucleoside transport deficient HEK293 cells greatly increases gemcitabine uptake PLoS ONE 8 2013 e56423
10. A.K. Fotoohi, M. Lindqvist, C. Peterson, and F. Albertioni Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines Biochem. Biophys. Res. Commun. 343 2006 208 215
11. I. Hubeek, R.W. Stam, G.J. Peters, R. Broekhuizen, J.P. Meijerink, E.R. van Wering, B.E. Gibson, U. Creutzig, C.M. Zwaan, J. Cloos, D.J. Kuik, R. Pieters, and G.J. Kaspers The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia Br. J. Cancer 93 2005 1388 1394
12. M. Dixon The determination of enzyme inhibitor constants Biochem. J. 55 1953 170 171
13. G. Scatchard The attractions of proteins for small molecules and ions Ann. N. Y. Acad. Sci. 51 1949 660 672
14. G.P. Leung, C.M. Tse, and R.Y. Man Characterization of adenosine transport in H9c2 cardiomyoblasts Int. J. Cardiol. 116 2007 186 193
15. M.P. van den Berg, J.C. Verhoef, S.G. Romeijn, and F.W. Merkus Uptake of estradiol or progesterone into the CSF following intranasal and intravenous delivery in rats Eur. J. Pharm. Biopharm. 58 2004 131 135
16. B.J. Parker, and I.N. Bruce High dose methylprednisolone therapy for the treatment of severe systemic lupus erythematosus Lupus 16 2007 387 393
17. A. Sinha, and A. Bagga Pulse steroid therapy Indian J. Pediatr. 75 2008 1057 1066
18. T.M. LaVallee, X.H. Zhan, C.J. Herbstritt, E.C. Kough, S.J. Green, and V.S. Pribluda 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta Cancer Res. 62 2002 3691 3697
19. E. Motylewska, and G. Melen-Mucha Estrone and progesterone inhibit the growth of murine MC38 colon cancer line J. Steroid Biochem. Mol. Biol. 113 2009 75 79
20. F.H. Comhaire, and A. Vermeulen Testosterone concentration in the fluids of seminiferous tubules, the interstitium and the rete testis of the rat J. Endocrinol. 70 1976 229 235
21. J.R. Schreiber, K. Nakamura, and G.F. Erickson Progestins inhibit FSH-stimulated steroidogenesis in cultured rat granulosa cells Mol. Cell. Endocrinol. 19 1980 165 173
22. H. Mukai, T. Tsurugizawa, M. Ogiue-Ikeda, G. Murakami, Y. Hojo, H. Ishii, T. Kimoto, and S. Kawato Local neurosteroid production in the hippocampus: influence on synaptic plasticity of memory Neuroendocrinology 84 2006 255 263
23. K.G. Bhansali, and E.J. Eugere Quantitative determination of 17 beta-estradiol and progesterone in cellular fractions of term placentae of normal and hypertensive patients Res. Commun. Chem. Pathol. Pharmacol. 77 1992 161 169
24. C. Escudero, and L. Sobrevia A hypothesis for preeclampsia: adenosine and inducible nitric oxide synthase in human placental microvascular endothelium Placenta 29 2008 469 483
25. H.H. Kim, and J.K. Liao Translational therapeutics of dipyridamole Arterioscler. Thromb. Vasc. Biol. 28 2008 s39 s42
26. M. Huang, Y. Wang, S.B. Cogut, B.S. Mitchell, and L.M. Graves Inhibition of nucleoside transport by protein kinase inhibitors J. Pharmacol. Exp. Ther. 304 2003 753 760
27. E.J. Carrier, J.A. Auchampach, and C.J. Hillard Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression Proc. Natl. Acad. Sci. U.S.A. 103 2006 7895 7900
28. L.E. Nagy, I. Diamond, D.J. Casso, C. Franklin, and A.S. Gordon Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter J. Biol. Chem. 265 1990 1946 1951
29. W. Lin, and J.K. Buolamwini Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N, N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrative nucleoside transporter probe Bioconjug. Chem. 22 2011 1221 1227
30. Z. Naydenova, J.B. Rose, and I.R. Coe Inosine and equilibrative nucleoside transporter 2 contribute to hypoxic preconditioning in the murine cardiomyocyte HL-1 cell line Am. J. Physiol. Heart Circ. Physiol. 294 2008 H2687 H2692
31. J.C. Morote-Garcia, P. Rosenberger, N.M. Nivillac, I.R. Coe, and H.K. Eltzschig Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia Gastroenterology 136 2009 607 618
32. M. Loffler, J.C. Morote-Garcia, S.A. Eltzschig, I.R. Coe, and H.K. Eltzschig Physiological roles of vascular nucleoside transporters Arterioscler. Thromb. Vasc. Biol. 27 2007 1004 1013