Upregulated acetylcholine synthesis during early differentiation in the embryonic stem cell line CGR8.

Neuroscience letters

Volumn 547, Issue , 2013, Pages 32-36

  Wessler, Ignaz ^a   Michel Schmidt, Rosmarie ^b   Schmidt, Harald ^b   Kaltwasser, Susanne ^b   Unger, Ronald ^b   Kirkpatrick, Charles James ^b  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CHOLINE ACETYLTRANSFERASE;

ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; EMBRYONIC STEM CELL; ENZYMOLOGY; METABOLISM; MOUSE; PHYSIOLOGY; PLURIPOTENT STEM CELL; UPREGULATION;

ACETYLCHOLINE; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CHOLINE O-ACETYLTRANSFERASE; EMBRYONIC STEM CELLS; MICE; PLURIPOTENT STEM CELLS; UP-REGULATION;

EID: 84892405826     PISSN: None     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.04.052     Document Type: Article

References (23)

1. T. Dobransky R.J. Rylett A model for dynamic regulation of choline acetyltransferase by phosphorylation J. Neurochem. 95 2005 305 313
2. S.A. Grando Biological functions of keratinocyte cholinergic receptors J. Invest. Dermatol. (Symp. Proc.) 2 1997 41 48
3. S.A. Grando M-R. Pittelkow K.U. Schallreuter Adrenergic and cholinergic control in the biology of epidermis: physiological and clinical significance J. Invest. Dermatol. 126 2006 1948 1965
4. T. Fujii Y. Takada-Takatori K. Kawashima Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity Life Sci. 80 2007 2320 2346
5. K. Kawashima T. Fujii Extraneuronal cholinergic system in lymphocytes Pharmacol. Ther. 86 2000 29 48
6. K. Kawashima T. Fujii The lymphocytic cholinergic system and its contribution to the regulation of immune activity Life Sci. 74 2003 675 696
7. M.H. Kim M.O. Kim J.S. Heo J.S. Kim H.J. Han Acetylcholine inhibits long-term hypoxia-induced apoptosis by suppressing the oxidative stress-mediated MAPKs activation as well as regulation of Bcl-2, c-IAPs, and caspase-3 in mouse embryonic stem cells Apoptosis 13 2008 295 304
8. H. Klapproth T. Reinheimer J. Metzen M. Munch F. Bittinger C.J. Kirkpatrick K.D. Höhle M. Schemann K. Racke I. Wessler Non-neuronal acetylcholine, a signalling molecule synthesized by surface cells of rat and man Naunyn Schmiedebergs Arch. Pharmacol. 355 1997 515 523
9. D. Landgraf M. Barth P.G. Layer L.E. Sperling Acetylcholine as a possible signalling molecule in embryonic stem cells: studies on survival, proliferation and death Chem. Biol. Interact. 187 2010 115 119
10. N. Liu M. Lu X. Tian Z. Han Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells J. Cell. Physiol. 211 2007 279 286
11. A. Matsuo J.P. Bellier T. Hisano Y. Aimi O. Yasuhara I. Tooyama N. Saito H. Kimura Rat choline acetyltransferase of the peripheral type differs from that of the common type in intracellular translocation Neurochem. Int. 46 2005 423 433
12. L.E. Paraoanu G. Steinert A. Koehler I. Wessler P.G. Layer Expression and possible functions of the cholinergic system in a murine embryonic stem cell line Life Sci. 80 2007 2375 2379
13. G.J. Prud’homme Cancer stem cells and novel targets for antitumor strategies Curr. Pharm. Des. 18 2012 2838 2849
14. J.P. Raufman K. Cheng N. Saxena A. Chahdi A. Belo S. Khurana G. Xie Muscarinic receptor agonists stimulate matrix metalloproteinase 1-dependent invasion of human colon cancer cells Biochem. Biophys. Res. Commun. 415 2011 319 324
15. J. Sainz F. Gracia-Alcalde A. Blanco A. Concha Genome-wide gene expression analysis in mouse embryonic stem cells Int. J. Dev. Biol. 55 2011 995 1006
16. H.M. Schuller Neurotransmitter receptor-mediated signaling pathways as modulators of carcinogenesis Prog. Exp. Tumor Res. 39 2007 45 63
17. P. Song H.S. Sekhon X.W. Fu M. Maier Y. Jia J. Duan B.J. Proskosil C. Gravett J. Lindstrom G.P. Mark S. Saha E.R. Spindel Activated cholinergic signalling provides a target in squamous cell lung carcinoma Cancer Res. 68 2008 4693 4700
18. J.M. Tournier P. Birembaut Nicotinic acetylcholine receptors and predisposition to lung cancer Curr. Opin. Oncol. 23 2011 83 87
19. F. Wang J. Wang D. Liu Y. Su Normalizing genes for real-time polymerase chain reaction in epithelial and nonepithelial cells of mouse small intestine Anal. Biochem. 399 2010 211 217
20. I. Wessler C.J. Kirkpatrick Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans Br. J. Pharmacol. 154 2008 1558 1571
21. I. Wessler R. Michel-Schmidt C. Brochhausen C.J. Kirkpatrick Subcellular distribution of choline acetyltransferase by immunogold electron microscopy in non-neuronal cells: placenta, airways and murine embryonic stem cells Life Sci. 91 2012 977 980
22. I. Wessler R. Michel-Schmidt E. Dohle C.J. Kirkpatrick Release of acetylcholine from murine embryonic stem cells: effect of nicotinic and muscarinic receptors and blockade of organic cation transporter Life Sci 91 2012 973 976
23. H. Zhang D. Guo L. Wang Y. Zhao Y. Cheng Z. Qiao Effect of nicotine on Oct-4 and Rex-1 expression of mouse embryonic stem cells Reprod. Toxicol. 19 2005 473 478