Myocardial infarction and ischemic heart disease in overweight and obesity with and without metabolic Syndrome

JAMA Internal Medicine

Volumn 174, Issue 1, 2014, Pages 15-22

  Thomsen, Mette ^a,b   Nordestgaard, Børge G ^a,b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ANTIHYPERTENSIVE THERAPY; ARTICLE; BODY MASS; BODY WEIGHT; CARDIOMETABOLIC RISK; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DENMARK; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; PRIORITY JOURNAL; SMOKING; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WEIGHT REDUCTION;

ADULT; AGED; BODY MASS INDEX; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DENMARK; FEMALE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; OBESITY; OVERWEIGHT; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84892396800     PISSN: 21686106     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamainternmed.2013.10522     Document Type: Article

References (27)

1. Manson JE, Colditz GA, Stampfer M.J., et al A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med. 1990;322(13):882-889.
2. Whitlock G, Lewington S, Sherliker P., et al.; Prospective Studies Collaboration. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373(9669):1083- 1096.
3. Nordestgaard BG, PalmerTM, Benn M, et al. The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach. PLoSMed. 2012;9(5):e1001212.
4. Alberti KG, Eckel RH, Grundy SM, et al.; International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640-1645.
5. Lakka HM, Laaksonen DE, Lakka T.A., et al The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288(21):2709-2716.
6. Malik S, Wong ND, Franklin S.S., et al Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation. 2004;110(10):1245-1250.
7. Sundström J., Risérus U, Byberg L., Zethelius B, Lithell H, Lind L. Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. BMJ. 2006;332(7546): 878-882.
8. Stefan N, Kantartzis K, Machann J., et al Identification and characterization of metabolically benign obesity in humans. Arch Intern Med. 2008;168(15):1609-1616.
9. Wildman RP, Muntner P, Reynolds K., et al The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med. 2008;168(15):1617-1624.
10. Arnlöv J., Ingelsson E, Sundström J, Lind L. Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men. Circulation. 2010;121(2):230-236.
11. Kip KE, Marroquin OC, Kelley D.E., et al Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women: a report from the Women's Ischemia Syndrome Evaluation (WISE) study. Circulation. 2004;109(6):706-713.
12. Meigs JB, Wilson PW, Fox C.S., et al Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab. 2006;91(8):2906-2912.
13. Nordestgaard BG, Benn M, Schnohr P., Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298(3):299-308.
14. Frikke-Schmidt R., Nordestgaard BG, Stene M.C., et al Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. JAMA. 2008;299(21):2524-2532.
15. Zacho J, Tybjaerg-Hansen A, Jensen J.S., Grande P., Sillesen H, Nordestgaard BG Genetically elevated C-reactive protein and ischemic vascular disease. N Engl J Med. 2008;359(18):1897-1908.
16. * Trial). Am J Cardiol. 2003;92(2):152-160.
17. Harrell FE J.r., Califf RM, Pryor D.B., Lee KL, Rosati RA Evaluating the yield of medical tests. JAMA. 1982;247(18):2543-2546.
18. Lin DY, Fleming TR, De Gruttola V. Estimating the proportion of treatment effect explained by a surrogate marker. Stat Med. 1997;16(13):1515-1527.
19. Cameron AJ, Boyko EJ, Sicree R.A., et al Central obesity as a precursor to the metabolic syndrome in the AusDiab study and Mauritius. Obesity (Silver Spring). 2008;16(12):2707-2716.
20. Chang Y, Ryu S, Suh B.S., Yun KE, Kim CW, Cho SI Impact of BMI on the incidence of metabolic abnormalities in metabolically healthy men. Int J Obes (Lond). 2012;36(9):1187-1194.
21. Chuang SY, Chou P, Hsu P.F., et al Presence and progression of abdominal obesity are predictors of future high blood pressure and hypertension. Am J Hypertens. 2006;19(8):788-795.
22. Hillier TA, Fagot-Campagna A, Eschwège E, Vol S., Cailleau M, Balkau B; D.E.S.I.R. Study group. Weight change and changes in the metabolic syndrome as the French population moves towards overweight: the D.E.S.I.R. cohort. Int J Epidemiol. 2006;35(1):190-196.
23. Shen BJ, Todaro JF, Niaura R, et al Are metabolic risk factors one unified syndrome? modeling the structure of the metabolic syndrome X. Am J Epidemiol. 2003;157(8):701-711.
24. Timpson NJ, Harbord R, Davey Smith G, Zacho J, Tybjaerg-Hansen A, Nordestgaard BG Does greater adiposity increase blood pressure and hypertension risk? Mendelian randomization using the FTO/MC4R genotype. Hypertension. 2009;54(1):84-90.
25. St-Pierre A.C., Cantin B, Mauriège P, et al Insulin resistance syndrome, body mass index and the risk of ischemic heart disease. CMAJ. 2005;172(10): 1301-1305.
26. Freiberg JJ, Tybjaerg-Hansen A, Jensen J.S., Nordestgaard BG Nonfasting triglycerides and risk of ischemic stroke in the general population. JAMA. 2008;300(18):2142-2152.
27. Lin HJ, Lee BC, Ho Y.L., et al Postprandial glucose improves the risk prediction of cardiovascular death beyond the metabolic syndrome in the nondiabetic population. Diabetes Care. 2009;32(9):1721-1726.