Evaluating the pharmacological mechanism of Chinese Medicine Si-Wu-Tang through multi-level data integration

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Fang, Zhao ^a   Lu, Bingxin ^a   Liu, Mingyao ^a   Zhang, Meixia ^b   Yi, Zhenghui ^c   Wen, Chengping ^d   Shi, Tieliu ^a,e  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^e INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATOR OF 90 KDA HEAT SHOCK PROTEIN ATPASE HOMOLOG 1; CARNITINE TRANSPORTER 2; CASPASE 3; CHINESE DRUG; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE A; CYCLIN A2; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOCHROME P450 1A1; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; HEAT SHOCK PROTEIN 90; HEPARAN SULFATE GLUCOSAMINE 3 O SULFOTRANSFERASE 3A1; INITIATION FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN C FOS; PROTEIN CBFA2T1; PROTEIN SERINE THREONINE KINASE; SI WU TANG; SULFOTRANSFERASE; TELOMERASE; TELOMERASE PROTEIN COMPONENT 1; TRANSCRIPTION FACTOR AP 1; UBIQUITIN CARBOXYL TERMINAL HYDROLASE ISOZYME L1; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG; VASCULOTROPIN A;

AMENORRHEA; ARTICLE; BIOINFORMATICS; CHINESE MEDICINE; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; GYNECOLOGIC DISEASE; HUMAN; HUMAN CELL; MEDICINAL PLANT; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; OROBANCHACEAE; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RADIX ANGELICAE SINENSIS; RADIX PAEONIAE ALBA; RADIX REHMANNIAE PRAEPARATA; REHMANNIA; RHIZOMA LIGUSTICI CHUANXIONG; SIGNAL TRANSDUCTION;

AMENORRHEA; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; FEMALE; GENE REGULATORY NETWORKS; HUMANS; MCF-7 CELLS; MEDICINE, CHINESE TRADITIONAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN INTERACTION MAPS; TRANSCRIPTOME;

EID: 84892376708     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072334     Document Type: Article

References (48)

1. Zhao J, Jiang P, Zhang W (2010) Molecular networks for the study of TCM Pharmacology. Brief Bioinform 11: 417-430.
2. Li S, Zhang ZQ, Wu LJ, Zhang XG, Li YD, et al. (2007) Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network. IET Syst Biol 1: 51-60.
3. Chan E, Tan M, Xin J, Sudarsanam S, Johnson DE (2010) Interactions between traditional Chinese medicines and Western therapeutics. Curr Opin Drug Discov Devel 13: 50-65.
4. Cheung F (2011) TCM: Made in China. Nature 480: S82-S83.
5. Wang L, Zhou GB, Liu P, Song JH, Liang Y, et al. (2008) Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. PNAS 105: 4826-4831.
6. Wen Z, Wang Z, Wang S, Ravula R, Yang L, et al. (2011) Discovery of Molecular Mechanisms of Traditional Chinese Medicinal Formula Si-Wu-Tang Using Gene Expression Microarray and Connectivity Map. PLoS One 6: e18278.
7. Yan SK, Zhao J, Dou SS, Jiang P, Liu RH, et al. (2009) Methodology of Modernization Research in Traditional Chinese Medicine Based on Systems Biology and Network Biology. Chinese Journal of Natural Medicine 7: 2492259.
8. Tian P (2011) Convergence: Where West meets East. Nature 480: S84-S86.
9. Gao Y, Ma ZC, Liang QD, Tan HL, Liu M, et al. (2010) Combined Research of Si wu tang and Blood Deficiency. World Science And Technology 12: 211-216.
10. Wang L, Wang Z, Wo S, Lau CB, Chen X, et al. (2011) A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to Si Wu Tang, Int J Pharm 406: 99-105.
11. Yeh LL, Liu JY, Lin KS, Liu YS, Chiou JM, et al. (2007) A randomised placebo controlled trial of a traditional Chinese herbal formula in the treatment of primary dysmenorrhoea. PLoS One 2: e719.
12. Ohta H, Ni JW, Matsumoto K, Watanabe H, Shimizu M (1993) Peony and its major constituent, paeoniflorin, improve radial maze performance impaired by scopolamine in rats. Pharmacol Biochem Behav 45: 719-723.
13. Watanabe H (1998) Protective effect of a traditional medicine, shimotsu-to, on brain lesion in rats. J Toxicol Sci 23: 234-236.
14. Wang ZJ, Wo SK, Wang L, Lau CB, Lee VH, et al. (2009) Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry. J Pharm Biomed Anal 50: 232-244.
15. Zhang H, Shen P, Cheng Y (2004) Identification and determination of the major constituents in traditional Chinese medicine Si-Wu-Tang by HPLC coupled with DAD and ESI-MS. J Pharm Biomed Anal 34: 705-713.
16. Dai Y, But PP, Chan YP, Matsuda H, Kubo M (2002) Antipruritic and Antiinflammatory Effects of Aqueous Extract from Si-Wu-Tang. Biol Pharm Bull 25: 1175-1178.
17. Liang QD, Gao Y, Tan HL, Guo P, Li YF, et al. (2006) Effects of four Si-Wu-Tang's constituents and their combination on irradiated mice. Biol Pharm Bull 29: 1378-1382.
18. Greenbaum D, Colangelo C, Williams K, Gerstein M (2003) Comparing protein abundance and mRNA expression levels on a genomic scale. Genome Biology 4: 117.
19. Gygi SP, Rochon Y, Franza BR, Aebersold R (1999) Correlation between Protein and mRNA Abundance in Yeast. Mol Cell Biol 19: 1720-1730.
20. Xue RC, Fang Z, Zhang MX, Yi ZH, Shi TL (2013) TCMID: Traditional Chinese Medicine integrative database for herb molecular mechanism analysis. Nucleic Acids Res 41: D1055-D1059.
21. Seal RL, Gordon SM, Lush MJ, Wright MW, Bruford EA (2011) genenames. org: the GNC resources in 2011. Nucleic Acids Res 39: D514-D519.
22. Bindea G, Mlecnik B, Hackl H, Charoentong P, Tosolini M, et al. (2009) ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics 25: 1091-1093.
23. Keshava Prasad TS, Goel R, Kandasamy K, Keerthikumar S, Kumar S, et al. (2009) Human Protein Reference Database-2009 update. Nucleic Acids Res 37: D767-D772.
24. Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, et al. (2011) The STRING database in 2011: functional interaction networks of roteins, globally integrated and scored. Nucleic Acids Res 39: D561-D568.
25. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, et al. (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13: 2498-2504.
26. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, et al. (2008) DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res 36: D901-D906.
27. Hinke V, Seck T, Clanget C, Scheidt-Nave C, Ziegler R, et al. (2001) Association of transforming growth factor-β1 (TGFβ1) T29→C gene polymorphism with bone mineral density (BMD), changes in BMD, and serum concentrations of TGF-β1 in a population-based sample of postmenopausal German women. Calcif. Tissue Int 69: 315-320.
28. Yamada Y, Miyauchi A, Goto J, Takagi Y, Okuizumi H, et al. (1998) Association of a polymorphism of the transforming growth factor-β1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J Bone Miner Res 13: 1569-1576.
29. Os I, Djurovic S, Seljeflot I, Berg K (2002) Transforming growth factor (TGF)-β1 inversely related to vascular cell adhesion molecule-1 in postmenopausal women with coronary artery disease. A possible mechanism for the putative cardioprotective role of TGF-β1? Journal of Internal Medicine 251: 223-227.
30. Chen ZW, Xu HY, Ma WC, Wang LH (2010) Study of Siwu Tang formula granule on the expression of TGF-B1 and Smads in bone marrow depressed mice. China Occupational Medicine 37: 279-281.
31. Singh A, Bodas M, Wakabayashi N, Bunz F, Biswal S (2010) Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. Antioxid Redox Signal 13: 1627-1637.
32. Gao Y, Ma ZC, Tan HL, Tong Li, Dai WQ, et al. (2003) Effects of Si-Wu-Tang and it s extracts on medullary hematopoiesis in mice of blood deficiency induced by 60Coc irradiation. Tianjin Journal of Traditional Chinese Medicine 20: 47-51.
33. 34 Antigen Expression in one Marrow of Mice with Blood Deficiency. Traditional Chinese Drug Research & Clinical Pharmacology 13: 11-13.
34. Ma ZC, Gao Y, Tang HL, Wang SQ (2003) The Effects of Si-Wu-Tang on Serum Protein of Blood Deficient Mice Induced by Radiation. China Journal of Chinese Materia Medica 28: 1050-1053.
35. Zhang T, Tan YY, Pan YS (2000) Effects of Siwu Decotion on RBC Immunoadhesive Function and Stem Cell Multiplication. Journal of Beijing University of TCM 23: 36-38.
36. Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, et al. (2002) DREAM is a critical transcriptional repressor for pain modulation. Cell 108: 31-43.
37. Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (1999) DREAM is a Ca2+-regulated transcriptional repressor. Nature 398: 80-84.
38. Li Y, Zhang Y, Han JS, Wang Y (2008) Distinct Responses of DREAM to Electroacupuncture Stimulation with Different Frequencies During Physiological and Inflammatory Conditions in Rats. Neurochem Res 33: 2070-2077.
39. Naranjo JR, Mellström B, Achaval M, Sassone-Corsi P (1991) Molecular pathways of pain: Fos/Jun-mediated activation of a noncanonical AP-1 site in the prodynorphin gene. Neuron 6: 607-617.
40. Liu L, Duan JA, Liu P, Zhu M, Su SL, et al. (2012) Study on compare Taohong Siwu Decoction,Taoren-Honghua pair and Siwu Decoction. Pharmacology and Clinics of Chinese Materia Medica 28: 2-6.
41. Liu L, Ma H, Tang Y, Chen W, Lu Y, et al. (2012) Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells. Bioorg Med Chem Lett 22: 154-163.
42. Zhang CB, Lu Y, Duan JA, Su SL, Tang YP, et al. (2007) Study on Siwu Decoction and its serial decoctionsin dysmenorrhea model mice. Pharmaceutical and Clinical Research 15: 459-461.
43. Hua YQ, Duan JA, Su SL, Lu Yin, Wang QJ, et al. (2008) Bioactivity evaluation of Siwu Decoction and its derived formulaes in the treatment of primary dysmenorrhea (I). Journal of China Pharmaceutical University 39: 72-76.
44. Debnath B, Al-Mawsawi LQ, Neamati N (2010) Are we living in the end of the blockbuster drug era? Drug News Perspect 23: 670-684.
45. Narvekar N, Critchley HO, Cheng L, Baird DT (2006) Mifepristone-induced amenorrhoea is associated with an increase in microvessel density and glucocorticoid receptor and a decrease in stromal vascular endothelial growth factor. Hum Reprod 21: 2312-2318.
46. Li G, Miao R, Zhao H (2012) Progression and prospects of translational medicine in China. Science China Life Sciences 55: 1022-1025.
47. Leng F (2012) Progression and prospects of translational medicine in China. Science China Life Sciences 55: 1022-1025.
48. Zhang B, Wang X, Li S (2013) An Integrative Platform of TCM Network Pharmacology and Its Application on a Herbal Formula, Qing-Luo-Yin. Evid Based Complement Alternat. doi: 10.1155/2013/456747.