Effect of relative humidity on the aerosolization and total inflammatory potential of fungal particles from dust-inoculated gypsum boards

Indoor Air

Volumn 24, Issue 1, 2014, Pages 16-28

  Frankel, M ^a,b   Hansen, E W ^b   Madsen, A M ^a  

^a NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Aerosolization; Fungal microparticles; Gypsum boards; Inflammatory potential; Microbial particles; Relative humidity

Indexed keywords

AEROSOLS; DUST; GYPSUM;

AEROSOLIZATION; CULTURABLE; FUNGAL MICROPARTICLE; GLUCANS; GYPSUM BOARD; HIGHER RELATIVE HUMIDITY; INFLAMMATORY POTENTIAL; LOW RELATIVE HUMIDITIES; MICRO PARTICLES; MICROBIAL PARTICLE;

FUNGI;

FUNGI; PENICILLIUM;

BETA GLUCAN;

AEROSOL; ARTICLE; BUILDING MATERIAL; DENMARK; FUNGAL MICROPARTICLES; FUNGUS; GROWTH, DEVELOPMENT AND AGING; GYPSUM BOARDS; HL 60 CELL LINE; HUMAN; HUMIDITY; IMMUNOLOGY; INDOOR AIR POLLUTION; INFLAMMATORY POTENTIAL; MICROBIAL PARTICLES; MICROBIOLOGY; PARTICULATE MATTER; SEASON;

AEROSOLIZATION; FUNGAL MICROPARTICLES; GYPSUM BOARDS; INFLAMMATORY POTENTIAL; MICROBIAL PARTICLES; RELATIVE HUMIDITY;

AIR MICROBIOLOGY; AIR POLLUTION, INDOOR; BETA-GLUCANS; CONSTRUCTION MATERIALS; DENMARK; FUNGI; HL-60 CELLS; HUMANS; HUMIDITY; PARTICULATE MATTER; SEASONS;

EID: 84892369139     PISSN: 09056947     EISSN: 16000668     Source Type: Journal    
DOI: 10.1111/ina.12055     Document Type: Article

References (58)

1. Acuña-Argüelles, M., Gutiérrez-Rojas, M., Viniegra-González, G. and Favela-Torres, E. (1994) Effect of water activity on exo-pectinase production by Aspergillus niger CH4 on solid state fermentation, Biotechnol. Lett., 16, 23-28.
2. Allermann, L., Meyer, H.W., Poulsen, O.M., Nielsen, J.B. and Gyntelberg, F. (2003) Inflammatory potential of dust from schools and building related symptoms, Occup. Environ. Med., 60, E5.
3. Bornehag, C.G., Blomquist, G., Gyntelberg, F., Jarvholm, B., Malmberg, P., Nordvall, L., Nielsen, A., Pershagen, G. and Sundell, J. (2001) Dampness in buildings and health. Nordic interdisciplinary review of the scientific evidence on associations between exposure to "dampness" in buildings and health effects (NORDDAMP), Indoor Air, 11, 72-86.
4. CEN Standard EN 481 (1993) Workplace atmospheres. Size fraction definitions for measurement of airborne particles, London, British Standards Institution (BSI) Publishers.
5. Chew, G.L., Douwes, J., Doekes, G., Higgins, K.M., van, S.R., Spithoven, J. and Brunekreef, B. (2001) Fungal extracellular polysaccharides, beta (1->3)-glucans and culturable fungi in repeated sampling of house dust, Indoor Air, 11, 171-178.
6. Comerio, R., Fernandez Pinto, V. and Vaamonde, G. (1998) Influence of water activity on Penicillium citrinum growth and kinetics of citrinin accumulation in wheat, Int. J. Food Microbiol., 42, 219-223.
7. Crous, P.W., Verkley, G.J.M., Groenewald, J.Z. and Samson, R.A. (2009) Fungal Biodiversity, Utrecht, CBS-KNAW Fungal Biodiversity Centre, pp. 1-269.
8. Dales, R.E., Burnett, R. and Zwanenburg, H. (1991) Adverse health effects among adults exposed to home dampness and molds, Am. Rev. Respir. Dis., 143, 505-509.
9. Domsch, K.H., Gams, W. and Anderson, T.H. (1993) Penicillium. In: Compendium of soil fungi, Anonymous (ed.), Eching, Germany, IHW-Verlag, 540-611.
10. Eduard, W. (2009) Fungal spores: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting, Crit. Rev. Toxicol., 39, 799-864.
11. Frankel, M., Beko, G., Timm, M., Gustavsen, S., Hansen, E.W. and Madsen, A.M. (2012a) Seasonal variation of indoor microbial exposures and their relations to temperature, relative humidity and air exchange rates, Appl. Environ. Microbiol. 78, 8289-8297.
12. Frankel, M., Timm, M., Hansen, E.W. and Madsen, A.M. (2012b) Comparison of sampling methods for the assessment of indoor microbial exposure, Indoor Air, 22, 405-414.
13. Górny, R.L., Reponen, T., Grinshpun, S.A. and Willeke, K. (2001) Source strength of fungal spore aerosolization from mouldy building material, Atmos. Environ., 35, 4853-4862.
14. Górny, R.L., Reponen, T., Willeke, K., Schmechel, D., Robine, E., Boissier, M. and Grinshpun, S.A. (2002) Fungal fragments as indoor air biocontaminants, Appl. Environ. Microbiol., 68, 3522-3531.
15. Gravesen, S., Frisvad, J.C. and Samson, R.A. (1994) Microfungi, Denmark, Special-Trykkeriet, Ed. 1 pp. 7-168.
16. Green, B.J., Mitakakis, T.Z. and Tovey, E.R. (2003) Allergen detection from 11 fungal species before and after germination, J. Allergy Clin. Immunol., 111, 285-289.
17. Gussman, R.A. and Kenny, L.C. (2000) Design and calibration of a cyclone for PM-1 ambient air sampling., Aerosol Sci., 31, 194-195.
18. Herbarth, O., Schlink, U., Muller, A. and Richter, M. (2003) Spatiotemporal distribution of airborne mould spores in apartments, Mycol. Res., 107, 1361-1371.
19. Heyder, J., Gebhart, J., Rudolf, G., Schiller, C.F. and Stahlhofen, W. (1986) Deposition of particles in the human respiratory tract in the size range 0.005-15 μm, Aerosol Sci., 17, 811-825.
20. Hinds, W.C. (1999) Respiratory Deposition. In: Anonymous (ed.) Aerosol technology: Properties, behavior, and measurement of airborne particles, New York, NY, Wiley-Interscience, 233-259.
21. Hofmann, W. (2011) Modelling inhaled particle deposition in the human lung-A review, J. Aerosol sci., 42, 693-724.
22. Kildesø, J., Würtz, H., Nielsen, K.F., Kruse, P., Wilkins, K., Thrane, U., Gravesen, S., Nielsen, P.A. and Schneider, T. (2003) Determination of fungal spore release from wet building materials, Indoor Air, 13, 148-155.
23. Lebron, F., Vassallo, R., Puri, V. and Limper, A.H. (2003) Pneumocystis carinii cell wall beta-glucans initiate macrophage inflammatory responses through NF-kappaB activation, J. Biol. Chem., 278, 25001-25008.
24. Levy, J.I., Hammitt, J.K. and Spengler, J.D. (2000) Estimating the mortality impacts of particulate matter: what can be learned from between-study variability, Environ. Health Perspect., 108, 109-117.
25. Madelin, T.M. and Johnson, H.E. (1992) Fungal and actinomycete spore aerosols measured at different humidities with an aerodynamic particle sizer, J. Appl. Bacteriol., 72, 400-409.
26. Madsen, A.M. (2012) Effects of air flow and changing humidity on the aerosolisation of respirable fungal fragments and conidia of Botrytis cinerea, Appl. Environ. Microbiol., 78, 3999-4007.
27. Madsen, A.M., Wilkins, C.K. and Poulsen, O.M. (2005) Micro-Particles from fungi. In Johanning, E. (ed.), Bioaerosols, fungi, bacteria, mycotoxins and human health: patho-physiology, clinical effects, exposure assessment, prevention and control in indoor environments and work. Fungal research group foundation, Inc., Albany, NY, 276-291.
28. Madsen, A.M., Kruse, P. and Schneider, T. (2006) Characterization of microbial particle release from biomass and building material surfaces for inhalation exposure risk assessment, Ann. Occup. Hyg., 50, 175-187.
29. Madsen, A.M., Schlunssen, V., Olsen, T., Sigsgaard, T. and Avci, H. (2009) Airborne fungal and bacterial components in PM1 dust from biofuel plants, Ann. Occup. Hyg., 53, 749-757.
30. Madsen, A.M., Frederiksen, M.W., Allermann, L. and Pejtersen, J.H. (2011) (1-3)-beta-D-glucan in different background environments and seasons, Aerobiologia, 27, 173-187.
31. Meklin, T., Potus, T., Pekkanen, J., Hyvärinen, A., Hirvonen, M.R. and Nevalainen, A. (2005) Effects of moisture-damage repairs on microbial exposure and symptoms in schoolchildren, Indoor Air, 15(Suppl 10), 40-47.
32. Mendell, M.J., Mirer, A.G., Cheung, K., Tong, M. and Douwes, J. (2011) Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence, Environ. Health Perspect., 119, 748-756.
33. Nevalainen, A., Pasanen, A.P., Niininen, M., Reponen, T., Kalliokoski, P. and Jantunen, M. (1991) The Indoor Air Quality in Finnish Homes with Mold Problems, Environ. Int., 17, 299-302.
34. Pardo, E., Marin, S., Sanchis, V. and Ramos, A.J. (2004) Prediction of fungal growth and ochratoxin A production by Aspergillus ochraceus on irradiated barley grain as influenced by temperature and water activity, Int. J. Food Microbiol., 95, 79-88.
35. Pasanen, A.L., Kalliokoski, P. and Pasanen, P. (1991a) Laboratory studies on the relationship between fungal growth and atmospheric temperature and humidity, Environ. Int., 17, 225-228.
36. Pasanen, A.L., Pasanen, P., Jantunen, M.J. and Kalliokoski, P. (1991b) Significance of air humidity and air velocity for fungal spore release into the air, Atmos. Environ., 25A, 459-462.
37. Pasanen, A.L., Juutinen, T., Jantunen, M.J. and Kalliokoski, P. (1992) Occurrence and moisture requirements of microbial growth in building materials, Int. Biodeterior. Biodegrad., 30, 273-283.
38. Peat, J.K., Dickerson, J. and Li, J. (1998) Effects of damp and mould in the home on respiratory health: a review of the literature, Allergy, 53, 120-128.
39. Pegg, D.E. (1976) Long-term preservation of cells and tissues: a review, J. Clin. Pathol., 29, 271-285.
40. Pirhonen, I., Nevalainen, A., Husman, T. and Pekkanen, J. (1996) Home dampness, moulds and their influence on respiratory infections and symptoms in adults in Finland, Eur. Respir. J., 9, 2618-2622.
41. Purokivi, M.K., Hirvonen, M.R., Randell, J.T., Roponen, M.H., Meklin, T.M., Nevalainen, A.L., Husman, T.M. and Tukiainen, H.O. (2001) Changes in pro-inflammatory cytokines in association with exposure to moisture-damaged building microbes, Eur. Respir. J., 18, 951-958.
42. Ren, P., Jankun, T.M. and Leaderer, B.P. (1999) Comparisons of seasonal fungal prevalence in indoor and outdoor air and in house dusts of dwellings in one Northeast American county, J. Expo. Anal. Environ. Epidemiol., 9, 560-568.
43. Reponen, T., Singh, U., Schaffer, C., Vesper, S., Johansson, E., Adhikari, A., Grinshpun, S.A., Indugula, R., Ryan, P., Levin, L. and LeMasters, G. (2010) Visually observed mold and moldy odor versus quantitatively measured microbial exposure in homes, Sci. Total Environ., 408, 5565-5574.
44. Rylander, R. (1999) Indoor air-related effects and airborne (1 -> 3)-beta-D-glucan, Environ. Health Perspect., 107(Suppl 3), 501-503.
45. Schwartz, J. and Neas, L.M. (2000) Fine particles are more strongly associated than coarse particles with acute respiratory health effects in schoolchildren, Epidemiology, 11, 6-10.
46. Seo, S.C., Reponen, T., Levin, L., Borchelt, T. and Grinshpun, S.A. (2008) Aerosolization of particulate (1->3)-beta-D-glucan from moldy materials, Appl. Environ. Microbiol., 74, 585-593.
47. Shelton, B.G., Kirkland, K.H., Flanders, W.D. and Morris, G.K. (2002) Profiles of airborne fungi in buildings and outdoor environments in the United States, Appl. Environ. Microbiol., 68, 1743-1753.
48. Singh, K., Frisvad, J.C., Thrane, U. and Mathur, S.B. (1991) An illustrated manual on identification of some seed-borne Aspergilli, Fusaria, Penicillia and their mycotoxins, Denmark, AiO Tryk as, ed. 1 pp. 5-133.
49. Singh, U., Levin, L., Grinshpun, S.A., Schaffer, C., Adhikari, A. and Reponen, T. (2011) Influence of home characteristics on airborne and dustborne endotoxin and beta-D-glucan, J. Environ. Monit., 13, 3246-3253.
50. Strachan, D.P., Flannigan, B., McCabe, E.M. and McGarry, F. (1990) Quantification of airborne moulds in the homes of children with and without wheeze, Thorax, 45, 382-387.
51. Timm, M., Hansen, E.W., Moesby, L. and Christensen, J.D. (2006) Utilization of the human cell line HL-60 for chemiluminescence based detection of microorganisms and related substances, Eur. J. Pharm. Sci., 27, 252-258.
52. Timm, M., Madsen, A.M., Hansen, J.V., Moesby, L. and Hansen, E.W. (2009) Assessment of the total inflammatory potential of bioaerosols by using a granulocyte assay, Appl. Environ. Microbiol., 75, 7655-7662.
53. Trail, F. (2007) Fungal cannons: explosive spore discharge in the Ascomycota, FEMS Microbiol. Lett., 276, 12-18.
54. Verhoeff, A.P. and Burge, H.A. (1997) Health risk assessment of fungi in home environments, Ann. Allergy Asthma Immunol., 78, 544-554.
55. Wexler, A. and Hasegawa, S. (1954) Relative humidity-temperature relationships of some saturated salt solutions in the temperature range 0-50 C, J. Res. Natl. Bur. Stand., 53, 19-26.
56. Wu, P.C., Su, H.J. and Ho, H.M. (2000) A comparison of sampling media for environmental viable fungi collected in a hospital environment, Environ. Res., 82, 253-257.
57. Zhang, K. and Petty, H.R. (1994) Influence of polysaccharides on neutrophil function: specific antagonists suggest a model for cooperative saccharide-associated inhibition of immune complex-triggered superoxide production, J. Cell. Biochem., 56, 225-235.
58. Zoberi, M.H. (1961) Take-Off of Mould Spores in Relation to Wind Speed and Humidity, Ann. Bot., 25, 53-64.