LC-MS/MS method for the determination of agomelatine in human plasma and its application to a pharmacokinetic study

Biomedical Chromatography

Volumn 28, Issue 2, 2014, Pages 218-222

  Wang, Xiaolin ^a   Zhang, Dan ^a   Liu, Man ^a   Zhao, Hongna ^a   Du, Aihua ^a   Meng, Lingjie ^a   Liu, Huichen ^a  

^a AEROSPACE CENTER HOSPITAL   (China)

Author keywords

Agomelatine; LC MS MS; Pharmacokinetics; Plasma

Indexed keywords

ELECTROSPRAY IONIZATION; EXTRACTION; PLASMA (HUMAN);

AGOMELATINE; ANALYTES; HUMAN PLASMAS; ISOCRATIC MOBILE PHASE; ITS APPLICATIONS; LC-MS-MS; LC.MS/MS; LIQUID-LIQUID EXTRACTION; PHARMACOKINETIC STUDIES; SIMPLE LIQUIDS;

PHARMACOKINETICS;

AGOMELATINE; AMMONIUM ACETATE; DIAZEPAM; METHANOL;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CHINESE; DILUTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG STABILITY; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PLASMA; SINGLE DRUG DOSE; STANDARD; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

AGOMELATINE; LC-MS/MS; PHARMACOKINETICS; PLASMA;

ACETAMIDES; AREA UNDER CURVE; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; LIQUID-LIQUID EXTRACTION; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84892367021     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3008     Document Type: Article

References (7)

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