Phototoxic effects of lysosome-associated genetically encoded photosensitizer killer red

Journal of Biomedical Optics

Volumn 19, Issue 7, 2014, Pages

  Serebrovskaya, Ekaterina O ^a   Ryumina, Alina P ^a   Boulina, Maria E ^a   Shirmanova, Marina V ^b   Zagaynova, Elena V ^b   Bogdanova, Ekaterina A ^a   Lukyanov, Sergey A ^a,b   Lukyanov, Konstantin A ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^b PRIVOLZHSKY RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

cell death; fluorescence microscopy; green fluorescent protein; photosensitizer; phototoxicity

Indexed keywords

CELL MORPHOLOGY; GREEN FLUORESCENT PROTEIN; LIGHT ILLUMINATION; LIGHT INTENSITY; MEMBRANE INTEGRITY; PHOTO-TOXICITY; RED FLUORESCENT PROTEINS; TIME-LAPSE MONITORING;

CELL CULTURE; CELL MEMBRANES; CELL PROLIFERATION; FLUORESCENCE MICROSCOPY; PHOTOSENSITIZERS;

CELL DEATH;

GREEN FLUORESCENT PROTEIN; GUANOSINE TRIPHOSPHATASE; KILLER RED PROTEIN, ANTHOMEDUSAE; PHOTOPROTEIN; PHOTOSENSITIZING AGENT; RAB PROTEIN; RAB7 PROTEIN; RED FLUORESCENT PROTEIN;

ANIMAL; APOPTOSIS; ARTICLE; CELL LINE; CELL MEMBRANE; CHEMISTRY; CYTOPLASM; EQUIPMENT; FIBROBLAST; HELA CELL LINE; HUMAN; LYSOSOME; METABOLISM; METHODOLOGY; NECROSIS; OXIDATIVE STRESS; PHOTOCHEMOTHERAPY; RAT;

ANIMALS; APOPTOSIS; CELL LINE; CELL MEMBRANE; CYTOPLASM; FIBROBLASTS; GREEN FLUORESCENT PROTEINS; GTP PHOSPHOHYDROLASES; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; LYSOSOMES; NECROSIS; OXIDATIVE STRESS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; RAB GTP-BINDING PROTEINS; RATS;

EID: 84892187718     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.19.7.071403     Document Type: Article

References (26)

1. A. P. Castano, T. N. Demidova, and M. R. Hamblin, "Mechanisms in photodynamic therapy: part one-photosensitizers, photochemistry and cellular localization," Photodiagn. Photodynam. Ther. 1(4), 279-293 (2004). (Pubitemid 40460316)
2. Z. Huang et al., "Photodynamic therapy for treatment of solid tumors-potential and technical challenges," Technol. Cancer Res. Treat. 7(4), 309-320 (2008).
3. D. Kessel et al., "The role of subcellular localization in initiation of apoptosis by photodynamic therapy," Photochem. Photobiol. 65(3), 422-426 (1997). (Pubitemid 27158974)
4. L. E. Broker, F. A. Kruyt, and G. Giaccone, "Cell death independent of caspases: a review," Clin. Cancer Res. 11(9), 3155-3162 (2005). (Pubitemid 40627860)
5. P. Benes, V. Vetvicka, and M. Fusek, "Cathepsin D-many functions of one aspartic protease," Crit. Rev. Oncol. Hematol. 68(1), 12-28 (2008).
6. M. E. Guicciardi, M. Leist, and G. J. Gores, "Lysosomes in cell death," Oncogene 23(16), 2881-2890 (2004). (Pubitemid 38638850)
7. P. Boya et al., "Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine, " Oncogene 22(25), 3927-3936 (2003). (Pubitemid 36819666)
8. W. Li et al., "Induction of cell death by the lysosomotropic detergent MSDH," FEBS Lett. 470(1), 35-39 (2000). (Pubitemid 30155619)
9. U. T. Brunk et al., "Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts," Free Radic. Biol. Med. 23(4), 616-626 (1997). (Pubitemid 27287345)
10. P. Boya et al., "Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion," J. Exp. Med. 197(10), 1323-1334 (2003). (Pubitemid 36617779)
11. M. E. Bulina et al., "A genetically encoded photosensitizer," Nat. Biotechnol. 24(1), 95-99 (2006). (Pubitemid 43083172)
12. R. B. Vegh et al., "Reactive oxygen species in photochemistry of the red fluorescent protein 'Killer Red'," Chem. Commun. Camb. 47(17), 4887-4889 (2011).
13. M. E. Bulina et al., "Chromophore-assisted light inactivation (CALI) using the phototoxic fluorescent protein KillerRed," Nat. Protoc. 1(2), 947-953 (2006).
14. O. Destaing et al., "Beta1A integrin is a master regulator of invadosome organization and function," Mol. Biol. Cell 21(23), 4108-4119 (2010).
15. S. Matsunaga et al., "RBMX: a regulator for maintenance and centromeric protection of sister chromatid cohesion," Cell Reports 1(4), 299-308 (2012).
16. F. Del, Bene et al., "Filtering of visual information in the tectum by an identified neural circuit," Science 330(6004), 669-673 (2010).
17. A. Lee et al., "The habenula prevents helpless behavior in larval zebrafish," Curr. Biol. 20(24), 2211-2216 (2010).
18. J. Kobayashi et al., "A method for selective ablation of neurons in C. elegans using the phototoxic fluorescent protein, KillerRed," Neurosci. Lett. 548, 261-264 (2013).
19. O. Ivashchenko et al., "Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk," Mol. Biol. Cell 22(9), 1440-1451 (2011).
20. T. Shibuya and Y. Tsujimoto, "Deleterious effects of mitochondrial ROS generated by KillerRed photodynamic action in human cell lines and C. elegans," J. Photochem. Photobiol. B 117, 1-12 (2012).
21. B. Wang et al., "Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells," Free Radic. Biol. Med. 65, 882-894 (2013).
22. E. O. Serebrovskaya et al., "Light-induced blockage of cell division with a chromatin-targeted phototoxic fluorescent protein," Biochem. J. 435(1), 65-71 (2011).
23. W. Waldeck et al., "Positioning effects of KillerRed inside of cells correlate with DNA strand breaks after activation with visible light," Int. J. Med. Sci. 8(2), 97-105 (2011).
24. J. S. Anant et al., "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex," Biochemistry 37(36), 12559-12568 (1998). (Pubitemid 28427540)
25. C. Bucci et al., "Rab7: a key to lysosome biogenesis," Mol. Biol. Cell 11 (2), 467-480 (2000). (Pubitemid 30112158)
26. B. S. Cummings, L. P. Wills, and R. G. Schnellmann, "Measurement of cell death in mammalian cells," Curr. Protoc. Pharmacol. 56, 12.8.1-12.8.24 (2012).