Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation

Cephalalgia

Volumn 34, Issue 2, 2014, Pages 136-147

  Ramachandran, Roshni ^a   Bhatt, Deepak Kumar ^a   Ploug, Kenneth Beri ^a   Hay Schmidt, Anders ^b   Jansen Olesen, Inger ^a   Gupta, Saurabh ^a   Olesen, Jes ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Glostrup Research Institute   (Denmark)

Author keywords

awake rat model; glyceryltrinitrate (GTN); L nitro arginine methyl ester (L NAME); migraine; neuronal activation; Nitric oxide (NO); nitric oxide synthase (NOS); olcegepant; sumatriptan; trigeminal vascular system

Indexed keywords

3 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 2 PHENYLPIPERIDINE; BETA ACTIN; CALCITONIN GENE RELATED PEPTIDE; N(G) NITROARGININE METHYL ESTER; NEUROKININ 1 RECEPTOR; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; OLCEGEPANT; PROTEIN C FOS; PROTEIN FOS;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE MEASUREMENT; DURA MATER; IMMUNOHISTOCHEMISTRY; MALE; MIGRAINE; NONHUMAN; PROTEIN EXPRESSION; RAT; SPINAL CORD DORSAL HORN; TRIGEMINAL NUCLEUS; UPREGULATION; WESTERN BLOTTING;

AWAKE RAT MODEL; GLYCERYLTRINITRATE (GTN); L-NITRO-ARGININE METHYL ESTER (L-NAME); MIGRAINE; NEURONAL ACTIVATION; NITRIC OXIDE (NO); NITRIC OXIDE SYNTHASE (NOS); OLCEGEPANT; SUMATRIPTAN; TRIGEMINAL VASCULAR SYSTEM;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; DIPEPTIDES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HUMANS; MALE; MIGRAINE DISORDERS; NEUROKININ-1 RECEPTOR ANTAGONISTS; NEURONS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE I; NITROGLYCERIN; PIPERIDINES; POSTERIOR HORN CELLS; PROTO-ONCOGENE PROTEINS C-FOS; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RECEPTORS, NEUROKININ-1; TRIGEMINAL NERVE; VASODILATOR AGENTS; WAKEFULNESS;

EID: 84892171973     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1177/0333102413502735     Document Type: Article

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