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Clinical and Vaccine Immunology
Volumn 21, Issue 1, 2014, Pages 29-38
Dengue virus subverts the interferon induction pathway via NS2B/3 protease-IκB kinase ε interaction
Author keywords

[No Author keywords available]
Indexed keywords

I KAPPA B KINASE EPSILON; INTERFERON; INTERFERON REGULATORY FACTOR 3; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; RETINOIC ACID INDUCIBLE GENE I LIKE RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; UNCLASSIFIED DRUG;
EID: 84892164414     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00500-13     Document Type: Article
Times cited : (65)
References (50)
  • 1
    • 77950551422 scopus 로고    scopus 로고
    • WHO and TDR World Health Organization and the Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland
    • WHO and TDR. 2009. Dengue: guidelines for diagnosis, treatment, prevention and control: new edition. World Health Organization and the Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland.
    • (2009) Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition
  • 2
    • 0036468861 scopus 로고    scopus 로고
    • Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century
    • Gubler DJ. 2002. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 10: 100-103. http://dx.doi.org/10.1016/S0966-842X(01)02288-0.
    • (2002) Trends Microbiol. , vol.10 , pp. 100-103
    • Gubler, D.J.1
  • 4
    • 0025864149 scopus 로고
    • Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins
    • Falgout B, Pethel M, Zhang YM, Lai CJ. 1991. Both nonstructural proteins NS2B and NS3 are required for the proteolytic processing of dengue virus nonstructural proteins. J. Virol. 65: 2467-2475.
    • (1991) J. Virol. , vol.65 , pp. 2467-2475
    • Falgout, B.1    Pethel, M.2    Zhang, Y.M.3    Lai, C.J.4
  • 6
    • 33748051738 scopus 로고    scopus 로고
    • IRFs: Master regulators of signalling by toll-like receptors and cytosolic pattern-recognition receptors
    • Honda K, Taniguchi T. 2006. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6: 644-658. http://dx.doi.org/10.1038/nri1900.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 644-658
    • Honda, K.1    Taniguchi, T.2
  • 7
    • 33744539798 scopus 로고    scopus 로고
    • Toll-like receptors and RNA helicases: Two parallel waystotrigger antiviral responses
    • Meylan E, Tschopp J. 2006. Toll-like receptors and RNA helicases: two parallel waystotrigger antiviral responses. Mol. Cell 22: 561-569. http://dx.doi.org/10.1016/j.molcel.2006.05.012.
    • (2006) Mol. Cell , vol.22 , pp. 561-569
    • Meylan, E.1    Tschopp, J.2
  • 8
    • 34548126512 scopus 로고    scopus 로고
    • RIG-I family RNA helicases: Cytoplasmic sensor for antiviral innate immunity
    • Yoneyama M, Fujita T. 2007. RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity. Cytokine Growth Factor Rev. 18: 545-551. http://dx.doi.org/10.1016/j.cytogfr.2007.06.023.
    • (2007) Cytokine Growth Factor Rev. , vol.18 , pp. 545-551
    • Yoneyama, M.1    Fujita, T.2
  • 9
    • 66149083542 scopus 로고    scopus 로고
    • Differential modification of interferon regulatory factor 3 following virus particle entry
    • Noyce RS, Collins SE, Mossman KL. 2009. Differential modification of interferon regulatory factor 3 following virus particle entry. J. Virol. 83: 4013-4022. http://dx.doi.org/10.1128/JVI.02069-08.
    • (2009) J. Virol. , vol.83 , pp. 4013-4022
    • Noyce, R.S.1    Collins, S.E.2    Mossman, K.L.3
  • 10
    • 66649109939 scopus 로고    scopus 로고
    • ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
    • Sun W, Li Y, Chen L, Chen H, You F, Zhou X, Zhou Y, Zhai Z, Chen D, Jiang Z. 2009. ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. U. S. A. 106: 8653-8658. http://dx.doi.org/10.1073/pnas.0900850106.
    • (2009) Proc. Natl. Acad. Sci. U. S. A , vol.106 , pp. 8653-8658
    • Sun, W.1    Li, Y.2    Chen, L.3    Chen, H.4    You, F.5    Zhou, X.6    Zhou, Y.7    Zhai, Z.8    Chen, D.9    Jiang, Z.10
  • 11
    • 84856501373 scopus 로고    scopus 로고
    • Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling
    • Sun L, Xing Y, Chen X, Zheng Y, Yang Y, Nichols DB, Clementz MA, Banach BS, Li K, Baker SC, Chen Z. 2012. Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling. PLoS One 7:e30802. http://dx.doi.org/10.1371/journal.pone.0030802.
    • (2012) PLoS One , vol.7
    • Sun, L.1    Xing, Y.2    Chen, X.3    Zheng, Y.4    Yang, Y.5    Nichols, D.B.6    Clementz, M.A.7    Banach, B.S.8    Li, K.9    Baker, S.C.10    Chen, Z.11
  • 12
    • 6344278510 scopus 로고    scopus 로고
    • The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation
    • Donelan NR, Dauber B, Wang X, Basler CF, Wolff T, García-Sastre A. 2004. The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation. J. Virol. 78: 11574-11582. http://dx.doi.org/10.1128/JVI.78.21.11574-11582.2004.
    • (2004) J. Virol. , vol.78 , pp. 11574-11582
    • Donelan, N.R.1    Dauber, B.2    Wang, X.3    Basler, C.F.4    Wolff, T.5    García-Sastre, A.6
  • 13
    • 0033870894 scopus 로고    scopus 로고
    • Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein
    • Talon J, Horvath CM, Polley R, Basler CF, Muster T, Palese P, García-Sastre A. 2000. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J. Virol. 74: 7989-7996. http://dx.doi.org/10.1128/JVI.74.17.7989-7996.2000.
    • (2000) J. Virol. , vol.74 , pp. 7989-7996
    • Talon, J.1    Horvath, C.M.2    Polley, R.3    Basler, C.F.4    Muster, T.5    Palese, P.6    García-Sastre, A.7
  • 15
    • 18144378011 scopus 로고    scopus 로고
    • Nuclear localization of the nipah virus W protein allows for inhibition of both virus- and toll-like receptor 3-triggered signaling pathways
    • Shaw ML, Cardenas WB, Zamarin D, Palese P, Basler CF. 2005. Nuclear localization of the Nipah virus W protein allows for inhibition of both virus- and Toll-like receptor 3-triggered signaling pathways. J. Virol. 79: 6078-6088. http://dx.doi.org/10.1128/JVI.79.10.6078-6088.2005.
    • (2005) J. Virol. , vol.79 , pp. 6078-6088
    • Shaw, M.L.1    Cardenas, W.B.2    Zamarin, D.3    Palese, P.4    Basler, C.F.5
  • 16
    • 34548126511 scopus 로고    scopus 로고
    • Innate immune evasion by hepatitis C virus and west nile virus
    • Keller BC, Johnson CL, Erickson AK, Gale M, Jr. 2007. Innate immune evasion by hepatitis C virus and West Nile virus. Cytokine Growth Factor Rev. 18: 535-544. http://dx.doi.org/10.1016/j.cytogfr.2007.06.006.
    • (2007) Cytokine Growth Factor Rev. , vol.18 , pp. 535-544
    • Keller, B.C.1    Johnson, C.L.2    Erickson, A.K.3    Gale Jr., M.4
  • 17
    • 20444409731 scopus 로고    scopus 로고
    • Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating tyk2-STAT signaling in the human dendritic cell
    • Ho LJ, Hung LF, Weng CY, Wu WL, Chou P, Lin YL, Chang DM, Tai TY, Lai JH. 2005. Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell. J. Immunol. 174: 8163-8172.
    • (2005) J. Immunol. , vol.174 , pp. 8163-8172
    • Ho, L.J.1    Hung, L.F.2    Weng, C.Y.3    Wu, W.L.4    Chou, P.5    Lin, Y.L.6    Chang, D.M.7    Tai, T.Y.8    Lai, J.H.9
  • 18
    • 80053437858 scopus 로고    scopus 로고
    • Janus kinase/signal transducer and activator of transcription 3 signaling pathway is crucial in chemokine production from hepatocytes infected by dengue virus
    • Tsai YT, Chen YH, Chang DM, Chen PC, Lai JH. 2011. Janus kinase/signal transducer and activator of transcription 3 signaling pathway is crucial in chemokine production from hepatocytes infected by dengue virus. Exp. Biol. Med. (Maywood) 236: 1156-1165. http://dx.doi.org/10.1258/ebm.2011.011060.
    • (2011) Exp. Biol. Med. (Maywood) , vol.236 , pp. 1156-1165
    • Tsai, Y.T.1    Chen, Y.H.2    Chang, D.M.3    Chen, P.C.4    Lai, J.H.5
  • 19
    • 74049129541 scopus 로고    scopus 로고
    • Subversion of interferon by dengue virus
    • Muñoz-Jordán JL. 2010. Subversion of interferon by dengue virus. Curr. Top. Microbiol. Immunol. 338: 35-44. http://dx.doi.org/10.1007/978- 3-642-02215-9-3.
    • (2010) Curr. Top. Microbiol. Immunol. , vol.338 , pp. 35-44
    • Muñoz-Jordán, J.L.1
  • 20
    • 79952086084 scopus 로고    scopus 로고
    • How flaviviruses activate and suppress the interferon response
    • Muñoz-Jordán JL, Fredericksen BL. 2010. How flaviviruses activate and suppress the interferon response. Viruses 2: 676-691. http://dx.doi.org/10.3390/v2020676.
    • (2010) Viruses , vol.2 , pp. 676-691
    • Muñoz-Jordán, J.L.1    Fredericksen, B.L.2
  • 22
    • 66149146738 scopus 로고    scopus 로고
    • NS5 of dengue virus mediates STAT2 binding and degradation
    • Ashour J, Laurent-Rolle M, Shi PY, García-Sastre A. 2009. NS5 of dengue virus mediates STAT2 binding and degradation. J. Virol. 83: 5408-5418. http://dx.doi.org/10.1128/JVI.02188-08.
    • (2009) J. Virol. , vol.83 , pp. 5408-5418
    • Ashour, J.1    Laurent-Rolle, M.2    Shi, P.Y.3    García-Sastre, A.4
  • 23
    • 33746028777 scopus 로고    scopus 로고
    • Intracellular pattern recognition receptors in the host response
    • Meylan E, Tschopp J, Karin M. 2006. Intracellular pattern recognition receptors in the host response. Nature 442: 39-44. http://dx.doi.org/10.1038/ nature04946.
    • (2006) Nature , vol.442 , pp. 39-44
    • Meylan, E.1    Tschopp, J.2    Karin, M.3
  • 25
    • 70349807812 scopus 로고    scopus 로고
    • The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection
    • Papon L, Oteiza A, Imaizumi T, Kato H, Brocchi E, Lawson TG, Akira S, Mechti N. 2009. The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection. Virology 393: 311-318. http://dx.doi.org/10.1016/j.virol.2009.08.009.
    • (2009) Virology , vol.393 , pp. 311-318
    • Papon, L.1    Oteiza, A.2    Imaizumi, T.3    Kato, H.4    Brocchi, E.5    Lawson, T.G.6    Akira, S.7    Mechti, N.8
  • 27
    • 0027499688 scopus 로고
    • Deletion analysis of dengue virus type 4 nonstructural protein NS2B: Identification of a domain required for NS2B-NS3 protease activity
    • Falgout B, Miller RH, Lai CJ. 1993. Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity. J. Virol. 67: 2034-2042.
    • (1993) J. Virol. , vol.67 , pp. 2034-2042
    • Falgout, B.1    Miller, R.H.2    Lai, C.J.3
  • 28
    • 0345832301 scopus 로고    scopus 로고
    • ClusPro: An automated docking and discrimination method for the prediction of protein complexes
    • Comeau SR, Gatchell DW, Vajda S, Camacho CJ. 2004. ClusPro: an automated docking and discrimination method for the prediction of protein complexes. Bioinformatics 20: 45-50. http://dx.doi.org/10.1093/bioinformatics/btg371.
    • (2004) Bioinformatics , vol.20 , pp. 45-50
    • Comeau, S.R.1    Gatchell, D.W.2    Vajda, S.3    Camacho, C.J.4
  • 29
    • 43049094372 scopus 로고    scopus 로고
    • Contribution of ser386 and ser396 to activation of interferon regulatory factor 3
    • Chen W, Srinath H, Lam SS, Schiffer CA, Royer WE, Jr, Lin K. 2008. Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3. J. Mol. Biol. 379: 251-260. http://dx.doi.org/10.1016/j.jmb.2008.03.050.
    • (2008) J. Mol. Biol. , vol.379 , pp. 251-260
    • Chen, W.1    Srinath, H.2    Lam, S.S.3    Schiffer, C.A.4    Royer Jr., W.E.5    Lin, K.6
  • 30
    • 1642297150 scopus 로고    scopus 로고
    • Identification of ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation
    • Mori M, Yoneyama M, Ito T, Takahashi K, Inagaki F, Fujita T. 2004. Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation. J. Biol. Chem. 279: 9698-9702. http://dx.doi.org/10.1074/jbc.M310616200.
    • (2004) J. Biol. Chem. , vol.279 , pp. 9698-9702
    • Mori, M.1    Yoneyama, M.2    Ito, T.3    Takahashi, K.4    Inagaki, F.5    Fujita, T.6
  • 31
    • 46949097299 scopus 로고    scopus 로고
    • Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
    • Kato H, Takeuchi O, Mikamo-Satoh E, Hirai R, Kawai T, Matsushita K, Hiiragi A, Dermody TS, Fujita T, Akira S. 2008. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J. Exp. Med. 205: 1601-1610. http://dx.doi.org/10.1084/jem.20080091.
    • (2008) J. Exp. Med. , vol.205 , pp. 1601-1610
    • Kato, H.1    Takeuchi, O.2    Mikamo-Satoh, E.3    Hirai, R.4    Kawai, T.5    Matsushita, K.6    Hiiragi, A.7    Dermody, T.S.8    Fujita, T.9    Akira, S.10
  • 33
    • 77956859036 scopus 로고    scopus 로고
    • Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex
    • Rodriguez-Madoz JR, Belicha-Villanueva A, Bernal-Rubio D, Ashour J, Ayllon J, Fernandez-Sesma A. 2010. Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex. J. Virol. 84: 9760-9774. http://dx.doi.org/10.1128/JVI. 01051-10.
    • (2010) J. Virol. , vol.84 , pp. 9760-9774
    • Rodriguez-Madoz, J.R.1    Belicha-Villanueva, A.2    Bernal-Rubio, D.3    Ashour, J.4    Ayllon, J.5    Fernandez-Sesma, A.6
  • 34
    • 0036004555 scopus 로고    scopus 로고
    • In vitro determination of dengue virus type 2 NS2B-NS3 protease activity with fluorescent peptide substrates
    • Khumthong R, Angsuthanasombat C, Panyim S, Katzenmeier G. 2002. In vitro determination of dengue virus type 2 NS2B-NS3 protease activity with fluorescent peptide substrates. J. Biochem. Mol. Biol. 35: 206-212. http://dx.doi.org/10. 5483/BMBRep.2002.35.2.206.
    • (2002) J. Biochem. Mol. Biol. , vol.35 , pp. 206-212
    • Khumthong, R.1    Angsuthanasombat, C.2    Panyim, S.3    Katzenmeier, G.4
  • 35
    • 18744403660 scopus 로고    scopus 로고
    • Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions
    • Yang H, Lin CH, Ma G, Orr M, Baffi MO, Wathelet MG. 2002. Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions. Eur. J. Biochem. 269: 6142-6151. http://dx.doi.org/10.1046/j.1432-1033.2002.03330.x.
    • (2002) Eur. J. Biochem. , vol.269 , pp. 6142-6151
    • Yang, H.1    Lin, C.H.2    Ma, G.3    Orr, M.4    Baffi, M.O.5    Wathelet, M.G.6
  • 36
    • 0033485542 scopus 로고    scopus 로고
    • NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase
    • Pomerantz JL, Baltimore D. 1999. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 18: 6694-6704. http://dx.doi.org/10.1093/emboj/18.23.6694.
    • (1999) EMBO J. , vol.18 , pp. 6694-6704
    • Pomerantz, J.L.1    Baltimore, D.2
  • 37
    • 4544222882 scopus 로고    scopus 로고
    • Activation of TBK1 and IKKepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity
    • ten Oever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, Hemmi H, Yamamoto M, Akira S, Yeh WC, Lin R, Hiscott J. 2004. Activation of TBK1 and IKKepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J. Virol. 78: 10636-10649. http://dx.doi.org/10.1128/JVI.78.19.10636-10649.2004.
    • (2004) J. Virol. , vol.78 , pp. 10636-10649
    • Ten Oever, B.R.1    Sharma, S.2    Zou, W.3    Sun, Q.4    Grandvaux, N.5    Julkunen, I.6    Hemmi, H.7    Yamamoto, M.8    Akira, S.9    Yeh, W.C.10    Lin, R.11    Hiscott, J.12
  • 40
    • 70349432365 scopus 로고    scopus 로고
    • Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation
    • Mazzon M, Jones M, Davidson A, Chain B, Jacobs M. 2009. Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation. J. Infect. Dis. 200: 1261-1270. http://dx.doi.org/10.1086/605847.
    • (2009) J. Infect. Dis. , vol.200 , pp. 1261-1270
    • Mazzon, M.1    Jones, M.2    Davidson, A.3    Chain, B.4    Jacobs, M.5
  • 41
    • 84864036246 scopus 로고    scopus 로고
    • Dengue virus targets the adaptor protein MITA to subvert host innate immunity
    • Yu CY, Chang TH, Liang JJ, Chiang RL, Lee YL, Liao CL, Lin YL. 2012. Dengue virus targets the adaptor protein MITA to subvert host innate immunity. PLoS Pathog. 8:e1002780. http://dx.doi.org/10.1371/journal.ppat.1002780.
    • (2012) PLoS Pathog. , vol.8
    • Yu, C.Y.1    Chang, T.H.2    Liang, J.J.3    Chiang, R.L.4    Lee, Y.L.5    Liao, C.L.6    Lin, Y.L.7
  • 42
    • 34547930163 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch
    • Panne D, McWhirter SM, Maniatis T, Harrison SC. 2007. Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch. J. Biol. Chem. 282: 22816-22822. http://dx.doi.org/10.1074/jbc.M703019200.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22816-22822
    • Panne, D.1    McWhirter, S.M.2    Maniatis, T.3    Harrison, S.C.4
  • 43
    • 77950824984 scopus 로고    scopus 로고
    • Dengue virus inhibits the production of type I interferon in primary human dendritic cells
    • Rodriguez-Madoz JR, Bernal-Rubio D, Kaminski D, Boyd K, Fernandez-Sesma A. 2010. Dengue virus inhibits the production of type I interferon in primary human dendritic cells. J. Virol. 84: 4845-4850. http://dx.doi.org/10.1128/JVI. 02514-09.
    • (2010) J. Virol. , vol.84 , pp. 4845-4850
    • Rodriguez-Madoz, J.R.1    Bernal-Rubio, D.2    Kaminski, D.3    Boyd, K.4    Fernandez-Sesma, A.5
  • 45
    • 79851492362 scopus 로고    scopus 로고
    • RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection
    • Nasirudeen AM, Wong HH, Thien P, Xu S, Lam KP, Liu DX. 2011. RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection. PLoS Negl. Trop. Dis. 5:e926. http://dx.doi.org/10.1371/journal.pntd. 0000926.
    • (2011) PLoS Negl. Trop. Dis. , vol.5
    • Nasirudeen, A.M.1    Wong, H.H.2    Thien, P.3    Xu, S.4    Lam, K.P.5    Liu, D.X.6
  • 46
    • 77749295592 scopus 로고    scopus 로고
    • Mechanisms of immune evasion induced by a complex of dengue virus and preexisting enhancing antibodies
    • Ubol S, Phuklia W, Kalayanarooj S, Modhiran N. 2010. Mechanisms of immune evasion induced by a complex of dengue virus and preexisting enhancing antibodies. J. Infect. Dis. 201: 923-935. http://dx.doi.org/10.1086/651018.
    • (2010) J. Infect. Dis. , vol.201 , pp. 923-935
    • Ubol, S.1    Phuklia, W.2    Kalayanarooj, S.3    Modhiran, N.4
  • 47
    • 84869208689 scopus 로고    scopus 로고
    • Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKepsilon and TBK1 functions
    • Kaukinen P, Sillanpää M, Nousiainen L, Melen K, Julkunen I. 2013. Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKepsilon and TBK1 functions. J. Med. Virol. 85: 71-82. http://dx.doi.org/10.1002/jmv.23442.
    • (2013) J. Med. Virol. , vol.85 , pp. 71-82
    • Kaukinen, P.1    Sillanpää, M.2    Nousiainen, L.3    Melen, K.4    Julkunen, I.5
  • 49
    • 84857937262 scopus 로고    scopus 로고
    • STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
    • Tanaka Y, Chen ZJ. 2012. STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci. Signal. 5:ra20. http://dx.doi.org/10. 1126/scisignal.2002521.
    • (2012) Sci. Signal , vol.5
    • Tanaka, Y.1    Chen, Z.J.2
  • 50
    • 84871218439 scopus 로고    scopus 로고
    • STING and the innate immune response to nucleic acids in the cytosol
    • BurdetteDL, Vance RE. 2013. STING and the innate immune response to nucleic acids in the cytosol. Nat. Immunol. 14: 19-26. http://dx.doi.org/10. 1038/ni.2491.
    • (2013) Nat. Immunol. , vol.14 , pp. 19-26
    • Burdette, D.L.1    Vance, R.E.2

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