Exhaled breath condensate in intubated neonates- a window into the lung's glutathione status

Respiratory Research

Volumn 15, Issue 1, 2014, Pages

  Rosso, Maria I ^a   Roark, Susan ^b   Taylor, Esther ^b   Ping, XiaoDu ^a   Ward, Janine M ^a   Roche, Katherine ^b   McCracken, Courtney ^a   Brown, Lou Ann S ^a,c   Gauthier, Theresa W ^a,c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

^c Center for Developmental Lung Biology   (United States)

Author keywords

Exhaled breath condensate; Glutathione; Prematurity; Tracheal aspirate

Indexed keywords

GLUTATHIONE; GLUTATHIONE DISULFIDE; UREA;

ARTICLE; ARTIFICIAL VENTILATION; BIRTH WEIGHT; CLINICAL ARTICLE; COLORIMETRY; EXHALED BREATH CONDENSATE; EXPIRED AIR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOFLUORESCENCE; INTUBATION; LUNG ALVEOLUS MACROPHAGE; MEASUREMENT; NEWBORN; NEWBORN ASSESSMENT; NEWBORN MONITORING; TRACHEAL ASPIRATION PROCEDURE; UREA NITROGEN BLOOD LEVEL; BREATH ANALYSIS; CHEMISTRY; ENDOTRACHEAL INTUBATION; EXHALATION; LUNG; METABOLISM; METHODOLOGY; PHYSIOLOGY; PILOT STUDY;

BREATH TESTS; EXHALATION; GLUTATHIONE; HUMANS; INFANT, NEWBORN; INTUBATION, INTRATRACHEAL; LUNG; PILOT PROJECTS;

EID: 84892143233     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-15-1     Document Type: Article

References (40)

1. Jobe AH. The new bronchopulmonary dysplasia. Curr Opin Pediatr 2011, 23(2):167-172. 10.1097/MOP.0b013e3283423e6b, 3265791, 21169836.
2. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, Hale EC, Newman NS, Schibler K, Carlo WA, et al. Neonatal outcomes of extremely preterm infants from the NICHD neonatal research network. Pediatrics 2010, 126(3):443-456. 10.1542/peds.2009-2959, 2982806, 20732945.
3. Viscardi RM. Perinatal inflammation and lung injury. Semin Fetal Neonatal Med 2012, 17(1):30-35. 10.1016/j.siny.2011.08.002, 3228907, 21855435.
4. Bustani P, Kotecha S. Role of cytokines in hyperoxia mediated inflammation in the developing lung. Front Biosci 2003, 8:s694-704. 10.2741/1113, 12700133.
5. Jobe AH, Ikegami M. Prevention of bronchopulmonary dysplasia. Curr Opin Pediatr 2001, 13(2):124-129. 10.1097/00008480-200104000-00006, 11317052.
6. Davis JM, Auten RL. Maturation of the antioxidant system and the effects on preterm birth. Semin Fetal Neonatal Med 2010, 15(4):191-195. 10.1016/j.siny.2010.04.001, 20452845.
7. Jain A, Mehta T, Auld PA, Rodrigues J, Ward RF, Schwartz MK, Martensson J. Glutathione metabolism in newborns: evidence for glutathione deficiency in plasma, bronchoalveolar lavage fluid, and lymphocytes in prematures. Pediatr Pulmonol 1995, 20(3):160-166. 10.1002/ppul.1950200306, 8545167.
8. Grigg J, Barber A, Silverman M. Bronchoalveolar lavage fluid glutathione in intubated premature infants. Arch Dis Child 1993, 69(1 Spec No):49-51. 10.1136/adc.69.1_Spec_No.49, 1029398, 8346954.
9. Gauthier TW, Ping XD, Harris FL, Wong M, Elbahesh H, Brown LA. Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability. Pediatr Res 2005, 57(1):76-81. 10.1203/01.PDR.0000149108.44152.D3, 15531743.
10. Harwood DT, Darlow BA, Cheah FC, McNeill N, Graham P, Winterbourn CC. Biomarkers of neutrophil-mediated glutathione and protein oxidation in tracheal aspirates from preterm infants: association with bacterial infection. Pediatr Res 2011, 69(1):28-33. 10.1203/PDR.0b013e3181ff2378, 20924318.
11. Schneibel KR, Fitzpatrick AM, Ping XD, Brown LA, Gauthier TW. Inflammatory mediator patterns in tracheal aspirate and their association with bronchopulmonary dysplasia in very low birth weight neonates. J Perinatol 2013, 35(5):383-387.
12. Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, Becher G, van Beurden WJ, Corradi M, Dekhuijzen R, et al. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005, 26(3):523-548. 10.1183/09031936.05.00029705, 16135737.
13. Ahmadzai H, Huang S, Hettiarachchi R, Lin JL, Thomas PS, Zhang Q. Exhaled breath condensate: a comprehensive update. Clin Chem Lab Med 2013, 51(7):1343-1361.
14. Rosias P. Methodological aspects of exhaled breath condensate collection and analysis. J Breath Res 2012, 6(2):027102. 10.1088/1752-7155/6/2/027102, 22522968.
15. Hunt J. Exhaled breath condensate pH: reflecting acidification of the airway at all levels. Am J Respir Crit Care Med 2006, 173(4):366-367. 10.1164/rccm.2512001, 16467175.
16. Greenwald R, Fitzpatrick AM, Gaston B, Marozkina NV, Erzurum S, Teague WG. Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma. PLoS ONE 2010, 5(7):e11919. 10.1371/journal.pone.0011919, 2912922, 20689836.
17. Liang Y, Yeligar SM, Brown LA. Exhaled breath condensate: a promising source for biomarkers of lung disease. Scientific World J 2012, 2012:217518.
18. Fitzpatrick AM, Teague WG, Holguin F, Yeh M, Brown LA. Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress. J Allergy Clin Immunol 2009, 123(1):146-152. e148, 10.1016/j.jaci.2008.10.047, 2649685, 19130935.
19. Yeh MY, Burnham EL, Moss M, Brown LA. Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics. Respir Med 2008, 102(2):248-255. 10.1016/j.rmed.2007.09.005, 2238178, 17977706.
20. Forman HJ, Skelton DC. Protection of alveolar macrophages from hyperoxia by gamma-glutamyl transpeptidase. Am J Physiol 1990, 259(2 Pt 1):L102-107.
21. Yeh MY, Burnham EL, Moss M, Brown LA. Chronic alcoholism alters systemic and pulmonary glutathione redox status. Am J Respir Crit Care Med 2007, 176(3):270-276. 10.1164/rccm.200611-1722OC, 1994217, 17507544.
22. Fitzpatrick AM, Teague WG, Burwell L, Brown MS, Brown LA. Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma. Pediatr Res 2011, 69(2):154-159. 10.1203/PDR.0b013e3182026370, 3066054, 20975618.
23. Gauthier TW, Kable JA, Burwell L, Coles CD, Brown LA. Maternal alcohol use during pregnancy causes systemic oxidation of the glutathione redox system. Alcohol Clin Exp Res 2010, 34(1):123-130. 10.1111/j.1530-0277.2009.01072.x, 2851176, 19860801.
24. Komatsu H, Hoshino A, Funayama M, Kawahara K, Obata F. Oxidative modulation of the glutathione-redox couple enhances lipopolysaccharide-induced interleukin 12 P40 production by a mouse macrophage cell line, J774A.1. Free Radic Res 2003, 37(3):293-299. 10.1080/1071576021000046613, 12688424.
25. Gauthier TW, Ping XD, Gabelaia L, Brown LA. Delayed neonatal lung macrophage differentiation in a mouse model of in utero ethanol exposure. Am J Physiol Lung Cell Mol Physiol 2010, 299(1):L8-16. 10.1152/ajplung.90609.2008, 2904088, 20382747.
26. Rahman I, Biswas SK. Non-invasive biomarkers of oxidative stress: reproducibility and methodological issues. Redox Rep 2004, 9(3):125-143. 10.1179/135100004225005219, 15327743.
27. Vogelberg C, Wurfel C, Knoetzsch A, Kahlert A, Range U, Leupold W. Exhaled breath condensate pH in infants and children with acute and recurrent wheezy bronchitis. Pediatr Pulmonol 2007, 42(12):1166-1172. 10.1002/ppul.20712, 17960820.
28. Moeller A, Franklin P, Hall GL, Horak F, Wildhaber JH, Stick SM. Measuring exhaled breath condensates in infants. Pediatr Pulmonol 2006, 41(2):184-187. 10.1002/ppul.20362, 16372354.
29. Walsh BK, Mackey DJ, Pajewski T, Yu Y, Gaston BM, Hunt JF. Exhaled-breath condensate pH can be safely and continuously monitored in mechanically ventilated patients. Respir Care 2006, 51(10):1125-1131.
30. Cheah FC, Darlow BA, Winterbourn CC. Problems associated with collecting breath condensate for the measurement of exhaled hydrogen peroxide from neonates on respiratory support. Biol Neonate 2003, 84(4):338-341. 10.1159/000073644, 14593246.
31. Jackson AS, Sandrini A, Campbell C, Chow S, Thomas PS, Yates DH. Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage. Am J Respir Crit Care Med 2007, 175(3):222-227. 10.1164/rccm.200601-107OC, 17110649.
32. Folesani G, Corradi M, Goldoni M, Manini P, Acampa O, Andreoli R, Bertorelli G, David S, Franchini I. Urea in exhaled breath condensate of uraemics and patients with chronic airway diseases. Acta Biomed 2008, 79(1):79-86.
33. Knobloch H, Becher G, Decker M, Reinhold P. Evaluation of H2O2 and pH in exhaled breath condensate samples: methodical and physiological aspects. Biomarkers 2008, 13(3):319-341. 10.1080/13547500701831440, 18415804.
34. Czebe K, Barta I, Antus B, Valyon M, Horvath I, Kullmann T. Influence of condensing equipment and temperature on exhaled breath condensate pH, total protein and leukotriene concentrations. Respir Med 2008, 102(5):720-725. 10.1016/j.rmed.2007.12.013, 18249106.
35. Esther CR, Boysen G, Olsen BM, Collins LB, Ghio AJ, Swenberg JW, Boucher RC. Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis. Am J Physiol Lung Cell Mol Physiol 2009, 296(6):L987-993. 10.1152/ajplung.90512.2008, 2692804, 19304910.
36. Effros RM. Exhaled breath condensate: delusion or dilution?. Chest 2010, 138(3):471-472. 10.1378/chest.10-0821, 20822983.
37. Kazani S, Israel E. Exhaled breath condensates in asthma: diagnostic and therapeutic implications. J Breath Res 2010, 4(4):047001. 10.1088/1752-7155/4/4/047001, 21383487.
38. Welty SE. Is there a role for antioxidant therapy in bronchopulmonary dysplasia?. J Nutr 2001, 131(3):947S-950S.
39. Jones DP. Redefining oxidative stress. Antioxid Redox Signal 2006, 8(9-10):1865-1879.
40. Wright CJ, Kirpalani H. Targeting inflammation to prevent bronchopulmonary dysplasia: can new insights be translated into therapies?. Pediatrics 2011, 128(1):111-126. 10.1542/peds.2010-3875, 3124103, 21646264.