Challenges for transgenic resistance to control geminiviral diseases

Emerging Geminiviral Diseases and their Management

Volumn , Issue , 2011, Pages 1-35

  Ilyas, Muhammad ^a   Amin, Imran ^a   Mansoor, Shahid ^a   Briddon, Rob W ^a   Saeed, Muhammad ^a  

^a NATIONAL INSTITUTE FOR BIOTECHNOLOGY AND GENETIC ENGINEERING NIBGE   (Pakistan)

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EID: 84892023459     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (172)

1. Abel, P. P., Nelson, R. S., De, B., Hoffmann, N., Rogers, S. G., Fraley, R. T. & Beachy, R. N. (1986). Delay of disease development in transgenic plants that express the tobacco mosaic virus coat protein gene. Science 232, 738-743.
2. Abhary, M. K., Anfoka, G. H., Nakhla, M. K. & Maxwell, D. P. (2006). Post-transcriptional gene silencing in controlling viruses of the tomato yellow leaf curl virus complex. Archives of Virology 151, 2349-2363.
3. Akad, F., A., Eybishtz, D., Edelbaum, R., Gorovits, O., Dar-Issa, N. & H. Czosnek (2007). Making a friend from a foe: expressing a GroEL gene from the whitefly Bemisia tabaci in the phloem of tomato plants confers resistance to Tomato yellow leaf curl virus. Archives of Virology 152, 1323-1339.
4. Akad, F., Dotan, N. & Czosnek, H. (2004). Trapping of Tomato yellow leaf curl virus (TYLCV) and other plant viruses with a GroEL homologue from the whitefly Bemisia tabaci. Archives of Virology 149, 1481-1497.
5. Alves-Júnior, M., Alfenas-Zerbini, P., Andrade, E. C., Esposito, D. A., Silva, F. N., da Cruz, A. C. F., Ventrella, M. C., Otoni, W. C. & Zerbini, F. M. (2009). Synergism and negative interference during co-infection of tomato and Nicotiana benthamiana with two bipartite begomoviruses. Virology 387, 257-266.
6. Amrao, L., Amin, I., Shahid, S., Briddon, R.W. & Mansoor, S. (2010). Cotton leaf curl disease in resistant cotton is associated with a single begomovirus that lacks an intact transcriptional activator protein. Virus Research, in press.
7. Antignus, Y., Vunsh, R., Lachman, O., Pearlsman, M., Maslenin, L., Hananya, U. & Rosner, A. (2004). Truncated Rep gene originated from Tomato yellow leaf curl virus-Israel [Mild] confers strain-specific resistance in transgenic tomato. Annals of Applied Biology 144, 39-44.
8. Aragaõ, F. J. L., Ribeiro, S. G., Barros, L. M. G., Brasileiro, A. C. M., Maxwell, D. P., Rech, E. L. & Faria, J. C. (1998). Transgenic beans (Phaseolus vulgaris L.) engineered to express viral antisense RNAs show delayed and attenuated symptoms to bean golden mosaic geminivirus. Molecular Breeding 4, 491-499.
9. Arguello-Astorga, G., Lopez-Ochoa, L., Kong, L.-J., Orozco, B. M., Settlage, S. B. & Hanley-Bowdoin, L. (2004). A Novel motif in geminivirus replication proteins interacts with the plant retinoblastoma-related protein. Journal of Virology 78, 4817-4826.
10. Asad, S., Haris, W. A., Bashir, A., Zafar, Y., Malik, K. A., Malik, N. N. & Lichtenstein, C. P. (2003). Transgenic tobacco expressing geminiviral RNAs are resistant to the serious viral pathogen causing cotton leaf curl disease. Archives of Virology 148, 2341-2352.
11. Aufsatz, W., Mette, M. F., van der Winden, J., Matzke, A. J. & Matzke, M. (2002). RNAdirected DNA methylation in Arabidopsis. Proceedings of the National Academy of Sciences USA 99, 16499-16506.
12. Azzam, O., Diaz, O., Beaver, J. S., Gilbertson, R. L., Russell, D. R. & Maxwell, D. P. (1996). Transgenic beans with the bean golden mosaic geminivirus coat protein gene are susceptible to virus infection. Annual Report Bean Improvement Corporate 39, 276-277.
13. Bartel, D. P. (2004). MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116, 281-297.
14. Baulcombe, D. (2004). RNA silencing in plants. Nature 431, 356-363.
15. Bejarano, E. R. & Lichtenstein, C. P. (1994). Expression of TGMV antisense RNA in transgenic tobacco inhibits replication of BCTV but not ACMV geminiviruses. Plant Molecular Biology 24, 241-248.
16. Bendahmane, A., Kanyuka, K. & Baulcombe, D. C. (1999). The Rx gene from potato controls separate virus resistance and cell death responses. Plant Cell 11, 781-791.
17. Bendahmane, M. & Gronenborn, B. (1997). Engineering resistance against Tomato yellow leaf curl virus (TYLCV) using antisense RNA. Plant Molecular Biology 33, 351-357.
18. Bian, X.-Y., Rasheed, M. S., Seemanpillai, M. J. & Rezaian, M. A. (2006). Analysis of silencing escape of Tomato leaf curl virus: an evaluation of the role of DNA methylation. Molecular Plant-Microbe Interactions 19, 614-624.
19. Blevins, T., Rajeswaran, R., Shivaprasad, P. V., Beknazariants, D., Si-Ammour, A., Park, H. S., Vazquez, F., Robertson, D., Meins, F., Jr., Hohn, T. & Pooggin, M. M. (2006). Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing. Nucleic Acids Research 34, 6233-6246.
20. Bonfim, K., Faria, J. C., Nogueira, E. O., Mendes, E. A. & Aragao, F. J. (2007). RNAimediated resistance to Bean golden mosaic virus in genetically engineered common bean (Phaseolus vulgaris). Molecular Plant-Microbe Interactions 20, 717-26.
21. Borchert, G. M., Lanier, W. & Davidson, B. L. (2006). RNA polymerase III transcribes human microRNAs. Nature Structural & Molecular Biology 13, 1097-101.
22. Briddon, R. W. (1990). The molecular biology of geminivirus transmission by insects. Ph.D. Thesis, University of East Anglia, Norwich, UK.
23. Briddon, R. W., Bull, S. E., Amin, I., Mansoor, S., Bedford, I. D., Dhawan, P., Rishi, N., Siwatch, S. S., Abdel-Salam, A. M. & Markham, P. G. (2003). Diversity of DNA β; a satellite molecule associated with some monopartite begomoviruses. Virology 312, 106-121.
24. Briddon, R. W., Bull, S. E., Amin, I., Mansoor, S., Bedford, I. D., Rishi, N., S., S., Zafar, Y., Abdel-Salam, A. M. & Markham, P. G. (2004). Diversity of DNA 1: a satellite-like molecule associated with monopartite begomovirus-DNA β complexes. Virology 324, 462-474.
25. Briddon, R. W. & Markham, P. G. (2001). Cotton leaf curl virus disease. Virus Research 71, 151-159.
26. Briddon, R. W., Pinner, M. S., Stanley, J. & Markham, P. G. (1990). Geminivirus coat protein replacement alters insect specificity. Virology 177, 85-94.
27. Briddon, R. W. & Stanley, J. (2006). Sub-viral agents associated with plant-infecting singlestranded DNA viruses. Virology 344, 198-210.
28. Brunetti, A., Tavazza, M., Noris, E., Tavazza, R., Caciagli, P., Ancora, G., Crespi, S. & Accotto, G. P. (1997). High expression of truncated viral Rep protein confers resistance to Tomato yellow leaf curl virus in transgenic tomato plants. Molecular Plant-Microbe Interactions 10, 571-579.
29. Brunetti, A., Tavazza, R., Noris, E., Lucioli, A., Accotto, G. P. & Tavazza, M. (2001). Transgenically expressed T-Rep of Tomato yellow leaf curl Sardinia virus acts as a transdominant- negative mutant, inhibiting viral transcription and replication. Journal of Virology 75, 10573-10581.
30. Chanson, A. H., Becker, D. K., Harding, R. M. & Dale, J. L. (2007). Effect of Rep on recombinant protein production from a Tobacco yellow dwarf virus-based episomal expression vector, In: 5th International Geminivirus Symposium, 3rd International ssDNA Comparative Virology Workshop, Conference Proceedings, 2007, p. 82.
31. Chatterji, A., Beachy, R. N. & Fauquet, C. M. (2001). Expression of the oligomerization domain of the replication-associated protein (Rep) of Tomato leaf curl New Delhi virus interferes with DNA accumulation of heterologous geminiviruses. Journal of Biological Chemistry 276, 25631-25638.
32. Chellappan, P., Masona, M. V., Vanitharani, R., Taylor, N. J. & Fauquet, C. M. (2004). Broad spectrum resistance to ssDNA viruses associated with transgene-induced gene silencing in cassava. Plant Molecular Biology 56, 601-611.
33. Chilakamarthi, U., Mukherjee, S. K. & Deb, J. K. (2007). Intervention of geminiviral replication in yeast by ribozyme mediated downregulation of its Rep protein. FEBS Letters 581, 2675-2683.
34. Cohen, S. & Lapidot, M. (2007). Appearance and expansion of TYLCV: A historical point of view. In: H. Czosnek (Ed), Tomato yellow leaf curl virus disease, pp. 3-12. Springer.
35. Day, A. G., Bejarano, E. R., Buck, K. W., Burrell, M. & Lichtenstein, C. P. (1991). Expression of an antisense viral gene in transgenic tobacco confers resistance to the DNA virus Tomato golden mosaic virus. Proceedings of the National Academy of Sciences USA 88, 6721-6725.
36. Desbiez, C., David, C., Mettouchi, A., Laufs, J. & Groneborn, B. (1995). Rep protein of tomato yellow leaf curl geminivirus has an ATPase activity required for viral DNA replication. Proceeding of National Academy of Sciences U.S.A 92, 5640-5644.
37. Doherty, E. A. & Doudna, J. A. (2001). Ribozyme structures and mechanisms. Annual Review of Biophysics and Biomolecular Structure 30, 457-475.
38. Drake, J. W., Charlesworth, B., Charlesworth, D. & Crow, J. F. (1998). Rates of spontaneous mutation. Genetics 148, 1667-86.
39. Duan, C. G., Wang, C. H., Fang, R. X. & Guo, H. S. (2008). Artificial MicroRNAs highly accessible to targets confer efficient virus resistance in plants. Journal of Virology 82, 11084-11095.
40. Duan, Y.-P., Powell, C. A., Webb, S. E., Purcifull, D. E. & Hiebert, E. (1997). Geminivirus resistance in transgenic tobacco expressing mutated BC1 protein. Molecular Plant-Microbe Interactions 10, 617-623.
41. Duffy, S. & Holmes, E. C. (2008). Phylogenetic evidence for rapid rates of molecular evolution in the single-stranded DNA begomovirus Tomato yellow leaf curl virus. Journal of Virology 82, 957-65.
42. Durai, S., Mani, M., Kandavelou, K., Wu, J., Porteus, M. H. & Chandrasegaran, S. (2005). Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells. Nucleic Acids Research 33, 5978-5990.
43. Edelbaum, D., Gorovits, R., Sasaki, S., Ikegami, M. & Czosnek, H. (2009). Expressing a whitefly GroEL protein in Nicotiana benthamiana plants confers tolerance to Tomato yellow leaf curl virus and Cucumber mosaic virus, but not to Grapevine virus A or Tobacco mosaic virus. Archives of Virology 154, 399-407.
44. Farnham, G. & Baulcombe, D. C. (2006). Artificial evolution extends the spectrum of viruses that are targeted by a disease-resistance gene from potato. Proceedings of the National Academy of Sciences USA 103, 18828-18833.
45. Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E. & Mello, C. C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811.
46. Fojtova, M., Van Houdt, H., Depicker, A. & Kovarik, A. (2003). Epigenetic switch from posttranscriptional to transcriptional silencing is correlated with promoter hypermethylation. Plant Physiology 133, 1240-50.
47. Frischmuth, T., Engel, M. & Jeske, H. (1997). Beet curly top virus DI DNA-mediated resistance is linked to its size. Molecular Breeding 3, 213-217.
48. Frischmuth, T. & Stanley, J. (1991). African cassava mosaic virus DI DNA interferes with the replication of both genomic components. Virology 183, 539-544.
49. Frischmuth, T. & Stanley, J. (1994). Beet curly top virus symptom amelioration in Nicotiana benthamiana transformed with a naturally occurring viral subgenomic DNA. Virology 200, 826-830.
50. Frischmuth, T. & Stanley, J. (1998). Recombination between viral DNA and the transgenic coat protein gene of African cassava mosaic geminivirus. Journal of General Virology 79, 1265-1271.
51. Fuentes, A., Ramos, P. L., Fiallo, E., Callard, D., Sanchez, Y., Peral, R., Rodriguez, R. & Pujol, M. (2006). Intron-hairpin RNA derived from replication associated protein C1 gene confers immunity to Tomato yellow leaf curl virus infection in transgenic tomato plants. Transgenic Research 15, 291-304.
52. Garcia-Andres, S., Tomas, D. M., Navas-Castillo, J. & Moriones, E. (2009). Resistancedriven selection of begomoviruses associated with the tomato yellow leaf curl disease. Virus Research 146, 66-72.
53. Ghanima, M., Kontsedalova, S. & Czosnek, A. H. (2007). Tissue-specific gene silencing by RNA interference in the whitefly Bemisia tabaci (Gennadius). Insect Biochemistry and Molecular Biology 37, 732-738.
54. Gharsallah Chouchane, S., Gorsane, F., Nakhla, M. K., Salus, M., Martin, C. T., Maxwell, D.P., Marrakchi, M. & Fakhfakh, H. (2008). Evaluation of two gene-silencing constructs for resistance to tomato yellow leaf curl viruses in Nicotiana benthamiana plants. Acta Virologica 52, 143-9.
55. Gonsalves, D., Ferreira, S., Manshardt, R., Fitch, M., & Slightom, J. (1998). Transgenic virus resistant papaya: New hope for control of papaya ringspot virus in Hawaii. APSnet Feature, American Pythopathological Society, www.apsnet.org/education/feature/papaya
56. Hamilton, W. D. O., Bisaro, D. M. & Buck, K. W. (1982). Identification of novel DNA forms in Tomato golden mosaic virus infected tissue. Evidence for a two component genome. Nucleic Acids Research 19, 4901-4912.
57. Hamilton, W. D. O., Bisaro, D. M., Coutts, R. H. A. & Buck, K. W. (1983). Demonstration of the bipartite nature of the genome of a single-stranded DNA plant virus by infection with the cloned DNA components. Nucleic Acids Research 11, 7387-7396.
58. Hanley-Bowdoin, L., Elmer, J. S. & Rogers, S. G. (1990). Expression of functional replication protein from Tomato golden mosaic virus in transgenic tobacco plants. Proceedings of the National Academy of Sciences, USA 87, 1446-1450.
59. Hanley-Bowdoin, L., Settlage, S. B., Orozco, B. M., Nagar, S. & Robertson, D. (1999). Geminviruses: models for plant DNA replication, transcription, and cell cycle regulation. Critical Reviews in Plant Sciences 18, 71-106.
60. Hanson, S. F. & Maxwell, D. P. (1999). Trans-dominant inhibition of geminiviral DNA replication by Bean golden mosaic geminivirus rep gene mutants. Phytopathology 89, 480-486.
61. Haseloff, J. & Gerlach, W. L. (1988). Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 334, 585-591.
62. Herr, A. J., Jensen, M. B., Dalmay, T. & Baulcombe, D. C. (2005). RNA polymerase IV directs silencing of endogenous DNA. Science 308, 118-120.
63. Hong, H., Saunders, K., Hartley, M. R. & Stanley, J. (1996). Resistance to geminivirus infection by virus-induced expression of dianthin in transgenic plants. Virology 220, 119-127.
64. Hong, J. & Stanley, J. (1996). Virus resistance in Nicotiana benthamiana conferred by African cassava mosaic virus replication-associated protein (AC1) transgene. Molecular Plant-Microbe Interactions 4, 219-225.
65. Hoppe-Seyler, F., Crnkovic-Mertens, I., Tomai, E. & Butz, K. (2004). Peptide aptamers:specific inhibitors of protein function. Current Molecular Medicine 4, 529-38.
66. Hou, Y. M., Sanders, R., Ursin, V. M. & Gilbertson, R. L. (2000). Transgenic plants expressing geminivirus movement proteins: abnormal phenotypes and delayed infection by Tomato mottle virus in transgenic tomatoes expressing the Bean dwarf mosaic virus BV1 or BC1 proteins. Molecular Plant-Microbe Interactions 13, 297-308.
67. Hussain, M., Mansoor, S., Iram, S., Zafar, Y. & Briddon, R. W. (2007). The Hypersensitive Response to Tomato leaf curl New Delhi virus Nuclear Shuttle Protein Is Inhibited by Transcriptional Activator Protein. Mol Plant Microbe Interact 20, 1581-1588.
68. Huttner, E., Tucker, W., Vermeulen, A., Ignart, F., Sawyer, B. & Birch, R. (2001). Ribozyme genes protecting transgenic melon plants against potyviruses. Current Issues in Molecular Biology 3, 27-34.
69. Kawasaki, H. & Taira, K. (2004). Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature 431, 211-217.
70. Khvorova, A., Reynolds, A. & Jayasena, S. D. (2003). Functional siRNAs and miRNAs exhibit strand bias. Cell 115, 209-216.
71. Kim, V. N. (2005). MicroRNA biogenesis: coordinated cropping and dicing. Nature Review of Molecular Cell Biology 6, 376-385.
72. Koshino-Kimura, Y., Takenaka, K., Domoto, F., Aoyama, Y. & Sera, T. (2008). Generation of plants resistant to tomato yellow leaf curl virus by using artificial zinc-finger proteins. Nucleic Acids Symposium Series (Oxford) 52, 189-90.
73. Koshino-Kimura, Y., Takenaka, K., Domoto, F., Ohashi, M., Miyazaki, T., Aoyama, Y. & Sera, T. (2009). Construction of plants resistant to TYLCV by using artificial zinc-finger proteins. Nucleic Acids Symposium Series (Oxford) 53, 281-282.
74. Krek, A., Grun, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M. & Rajewsky, N. (2005). Combinatorial microRNA target predictions. Nature Genetics 37, 495-500.
75. Kunik, T., Salomon, R., Zamir, D., Navot, N., Zeidan, M., Michelson, I., Gafni, Y. & Czosnek, H. (1994). Transgenic tomato plants expressing the Tomato yellow leaf curl virus capsid protein are resistant to the virus. Biotechnology 12, 500-504.
76. Lecoq, H. (1998). Control of plant virus diseases by cross protection. In: A. Hadidi, R.K.Khetarpal and H. Koganezawa (eds) Plant Virus Disease Control, pp. 33-40. APS Press, St. Paul, MN, USA.
77. Lee, R. C., Feinbaum, R. L. & Ambros, V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843-854.
78. Lee, Y., Kim, M., Han, J., Yeom, K. H., Lee, S., Baek, S. H. & Kim, V. N. (2004). MicroRNA genes are transcribed by RNA polymerase II. EMBO Journal 23, 4051-60.
79. Lefeuvre, P., Lett, J. M., Reynaud, B. & Martin, D. P. (2007a). Avoidance of protein fold disruption in natural virus recombinants. PLoS Pathogens 3, e181.
80. Lefeuvre, P., Martin, D. P., Hoareau, M., Naze, F., Delatte, H., Thierry, M., Varsani, A., Becker, N., Reynaud, B. & Lett, J. M. (2007b). Begomovirus 'melting pot' in the southwest Indian Ocean islands: molecular diversity and evolution through recombination. Journal of General Virology 88, 3458-68.
81. Lehmann, P. (2002). Structure and evolution of plant disease resistance genes. Journal of Applied Genetics 43, 403-414.
82. Leung, A. K. & Sharp, P. A. (2007). microRNAs: a safeguard against turmoil? Cell 130, 581-5.
83. Levy, A., Dafny-Yelin, M. & Tzfira, T. (2008). Attacking the defenders: plant viruses fight back. Trends in Microbiology 16, 194-7.
84. Lindbo, J. A., Silva-Rosales, L., Proebsting, W. M. & Dougherty, W. G. (1993). lnduction of a highly specific antiviral state in transgenic plants: implications for regulation of gene expression and virus resistance. Plant Cell 5, 1749-1759.
85. Llave, C., Xie, Z., Kasschau, K. D. & Carrington, J. C. (2002). Cleavage of Scarecrowlike mRNA targets directed by a class of Arabidopsis miRNA. Science 297, 2053-2056.
86. Lopez-Ochoa, L. & Hanley-Bowdoin, L. (2007). Use of peptide aptamers for broad-based geminivirus disease resistance, in: Conference abstract, American Society of Plant Biologists (ASPB) Plant Biology and Botany Joint Congress, Chicago, USA, 2007, www.botonyconference.org.
87. Lopez-Ochoa, L., Ramirez-Prado, J. & Hanley-Bowdoin, L. (2006). Peptide aptamers that bind to a geminivirus replication protein interfere with viral replication in plant cells. Journal of Virology 80, 5841-53.
88. Lucioli, A., Noris, E., Brunetti, A., Tavazza, R., Ruzza, V., Castillo, A. G., Bejarano, E. R., Accotto, G. P. & Tavazza, M. (2003). Tomato yellow leaf curl Sardinia virus Repderived resistance to homologous and heterologous geminiviruses occurs by different mechanisms and is overcome if virus-mediated transgene silencing is activated. Journal of Virology 77, 6785-6798.
89. Mansoor, S., Amin, I., Hussain, M., Zafar, Y. & Briddon, R. W. (2006). Engineering novel traits in plants through RNA interference. Trends in Plant Science 11, 559-565.
90. Mansoor, S., Amin, I., Iram, S., Hussain, M., Zafar, Y., Malik, K. A. & Briddon, R. W. (2003). The breakdown of resistance in cotton to cotton leaf curl disease in Pakistan. New Disease Reports 52, 784.
91. Martin, D. P. & Rybicki, E. P. (2001). Sequence diversity and virulence in Zea mays of Maize streak virus isolates. Virology 288, 247-255.
92. Martin, D. P., van der Walt, E., Posada, D. & Rybicki, E. P. (2005). The evolutionary value of recombination is constrained by genome modularity. PLoS Genetics 1, e51.
93. Mattick, J. S. & Makunin, I. V. (2005). Small regulatory RNAs in mammals. Human Molecular Genetics 14 Spec No 1, R121-32.
94. Michelson, I., Zeidan, M., Zamir, D. & Czosnek, H. (1997). Localization of Tomato yellow leaf curl virus (TYLCV) in susceptible and tolerant nearly isogenic tomato lines. Acta Horticulture 447, 407-414.
95. Mubin, M., Amin, I., Amrao, L., Briddon, R. W. & Mansoor, S. (2010). The hypersensitive response induced by the V2 protein of a monopartite begomovirus is countered by the C2 protein. Molecular Plant Pathology 11, 245-254.
96. Mubin, M., Mansoor, S., Hussain, M. & Zafar, Y. (2007). Silencing of the AV2 gene by antisense RNA protects transgenic plants against a bipartite begomovirus. Virology Journal 4, 10.
97. Mur, L. A. J., Kenton, P., Lloyd, A. J., Ougham, H. & Prats, E. (2008). The hypersensitive response; the centenary is upon us but how much do we know? Journal of Experimental Botany 59, 501-520.
98. Narayanan, S., Surendranath, K., Bora, N., Surolia, A. & Karande, A. A. (2005). Ribosome inactivating proteins and apoptosis. FEBS Letters 579, 1324-1331.
99. Negi, S., Imanishi, M., Matsumoto, M. & Sugiura, Y. (2008). New redesigned zinc-finger proteins: design strategy and its application. Chemistry - A European Journal 14, 3236-3249.
100. Noris, E., Accotto, G. P., Tavazza, R., Brunetti, A., Crespi, S. & Tavazza, M. (1996). Resistance to tomato yellow leaf curl geminivirus in Nicotiana benthamiana plants transformed with a truncated viral C1 gene. Virology 224, 130-138.
101. Orozco, B. M. & Hanley-Bowdoin, L. (1998). Conserved sequence and structural motifs contribute to the DNA binding and cleavage activities of a geminivirus replication protein. Journal of Biological Chemistry 273, 24448-24456.
102. Orozco, B. M., Kong, L.-J., Batts, L. A., Elledge, S. & Hanley-Bowdoin, L. (2000). The multifunctional character of a geminivirus replication protein is reflected by its complex oligomerization properties. Journal of Biological Chemistry 275, 6114-6122.
103. Owor, B., Legg, J. P., Okao-Okuja, G., Obonyo, R., Kyamanywa, S. & Ogenga-Latigo, M.W. (2004). Field studies of cross protection with cassava mosaic geminiviruses in Uganda. Journal of Plant Pathology 152, 243-249.
104. Padidam, M., Sawyer, S. & Fauquet, C. M. (1999). Possible emergence of new geminiviruses by frequent recombination. Virology 265, 218-225.
105. Patil, B. L. & Dasgupta, I. (2006). Defective interfering DNAs of plant viruses. Critical Reviews in Plant Sciences 25, 47-64.
106. Patil, B. L. & Fauquet, C. M. (2009). Cassava mosaic geminiviruses: actual knowledge and perspectives. Molecular Plant Pathology 10, 685-701.
107. Polston, J. E. & Hiebert, E. (2001). Engineered ressitance to tomato geminiviruses. Pages 19-22 In: Proceedings of the Florida Tomato Institute. Naples, FL. P. Gilreath, ed. PRO-518, University of Florida, Gainesville.
108. Pooggin, M. & Hohn, T. (2004). Fighting geminiviruses by RNAi and vice versa. Plant Molecular Biology 55, 149-152.
109. Pooggin, M., Shivaprasad, P. V., Veluthambi, K. & Hohn, T. (2003). RNAi targeting of DNA virus in plants. Nature Biotechnology 21, 131-132.
110. Prasanna, H. C. & Rai, M. (2007). Detection and frequency of recombination in tomatoinfecting begomoviruses of South and Southeast Asia. Virology Journal 4, 111.
111. Praveen, S., Kushwaha, C. M., Mishra, A. K., Singh, V., Jain, R. K. & Varma, A. (2005). Engineering tomato for resistance to tomato leaf curl disease using viral Rep gene sequences. Plant Cell, Tissue and Organ Culture 83, 311.
112. Ramesh, S. V., Mishra, A. K. & Praveen, S. (2007). Hairpin RNA-mediated strategies for silencing of tomato leaf curl virus AC1 and AC4 genes for effective resistance in plants. Oligonucleotides 17, 251-7.
113. Ratcliff, F. G., MacFarlane, S. A. & Baulcombe, D. C. (1999). Gene silencing without DNA:RNA-mediated cross-protection between viruses. Plant Cell 11, 1207-1215.
114. Rosell, R. C., Torres-Jerez, I. & Brown, J. K. (1999). Tracing the geminivirus-whitefly transmission pathway by polymerase chain reaction in whitefly extracts, saliva, hemolymph, and honeydew. Phytopathology 89, 239-246.
115. Ruby, J. G., Jan, C. H. & Bartel, D. P. (2007). Intronic microRNA precursors that bypass Drosha processing. Nature 448, 83-6.
116. Rudolph, C., Schreier, P. H. & Uhrig, J. F. (2003). Peptide-mediated broad-spectrum plant resistance to tospoviruses. Proceedings of the National Academy of Sciences USA 100, 4429-4434.
117. Safarnejad, M., Fischer, R. & Commandeur, U. (2009). Recombinant-antibody-mediated resistance against Tomato yellow leaf curl virus in Nicotiana benthamiana. Archives of Virology 154, 457-467.
118. Safarnejad, M. R., Fischer, R. & Commandeur, U. (2008). Generation and characterization of functional recombinant antibody fragments against tomato yellow leaf curl virus replication-associated protein. Communications in Agricultural and Applied Biological Sciences 73, 311-321.
119. Salstrom, J., & Pratt, D. (1971). Role of coliphage M13 gene 5 in singlestranded DNA production. Journal of Molecular Biology 61, 489-501.
120. Sanford, J. C. & Johnson, S. A. (1985). The concept of parasite-derived resistance: deriving resistance genes from the parasites own genome. Journal of Theoretical Biology 115, 395-405.
121. Sangaré, A., Deng, D., Fauquet, C. M. & Beachy, R. N. (1999). Resistance to African cassava mosaic virus conferred by a mutant of the putative NTP-binding domain of the Rep Gene (AC1) in Nicotiana benthamiana. Molecular Breeding 5, 95-102.
122. Saunders, K., Briddon, R. W. & Stanley, J. (2008). Replication promiscuity of DNA-β satellites associated with monopartite begomoviruses; deletion mutagenesis of the Ageratum yellow vein virus DNA-β satellite localizes sequences involved in replication. Journal of General Virology 89, 3165-72.
123. Saunders, K. & Stanley, J. (1995). Complementation of African cassava mosaic virus AC2 gene function in a mixed bipartite geminivirus infection. Journal of General Virology 76, 2287-2292.
124. Schwarz, D. S., Hutvagner, G., Du, T., Xu, Z., Aronin, N. & Zamore, P. D. (2003). Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199-208.
125. Seal, S. E., Jeger, M. J., Van den Bosch, F., Maramorosch, K., Shatkin, A. J. & Thresh, J. M. (2006a). Begomovirus evolution and disease management. Advances in Virus Research, 67, 297-316.
126. Seal, S. E., van den Bosch, F. & Jeger, M. J. (2006b). Factors influencing begomovirus evolution and their increasing global significance: implications for sustainable control. Critical Reviews in Plant Sciences 25, 23-46.
127. Sera, T. (2005). Inhibition of virus DNA replication by artificial zinc finger proteins. Journal of Virology 79, 2614-2619.
128. Settlage, S. B., See, R. G. & Hanley-Bowdoin, L. (2005). Geminivirus C3 protein: replication enhancement and protein interactions. Journal of Virology 79, 9885-9895.
129. Sharma, P. & Ikegami, M. (2008). RNA-silencing suppressors of geminiviruses. Journal of General Plant Pathology 74, 189-202.
130. Shepherd, D. N., Mangwende, T., Martin, D. P., Bezuidenhout, M., Kloppers, F. J., Carolissen, C. H., Monjane, A. L., Rybicki, E. P. & Thomson, J. A. (2007a). Maize streak virus-resistant transgenic maize: a first for Africa. Plant Biotechnology Journal 5, 759-67.
131. Shepherd, D. N., Mangwende, T., Martin, D. P., Bezuidenhout, M., Thomson, J. A. & Rybicki, E. P. (2007b). Inhibition of maize streak virus (MSV) replication by transient and transgenic expression of MSV replication-associated protein mutants. Journal of General Virology 88, 325-36.
132. Shepherd, D. N., Martin, D. P., McGivern, D. R., Boulton, M. I., Thomson, J. A. & Rybicki, E. P. (2005). A three-nucleotide mutation altering the Maize streak virus Rep pRBRinteraction motif reduces symptom severity in maize and partially reverts at high frequency without restoring pRBR-Rep binding. Journal of General Virology 86, 803-13.
133. Shepherd, D. N., Martin, D. P. & Thomson, J. A. (2009). Transgenic strategies for developing crops resistant to geminiviruses. Plant Science 176, 1-11.
134. Shivaprasad, P. V., Thillaichidambaram, P., Balaji, V. & Veluthambi, K. (2006). Expression of full-length and truncated Rep genes from Mungbean yellow mosaic virus-Vigna inhibits viral replication in transgenic tobacco. Virus Genes 33, 365-74.
135. Sinisterra, X. H., Polston, J. E., Abouzid, A. M. & Hiebert, E. (1999). Tobacco plants transformed with a modified coat protein of tomato mottle begomovirus show resistance to virus infection. Phytopathology 89, 701-706.
136. Smith, N. A., S.P., S., Wang, M.-B., Stoutjesdijk, P. A., Green, A. G. & Waterhouse, P. M. (2000). Total silencing by intron-spliced hairpin RNAs. Nature 407, 319-320.
137. Soosaar, J. L. M., Burch-Smith, T. M. & Dinesh-Kumar, S. P. (2005). Mechanisms of plant resistance to viruses. Nat Reviews Microbiology 3, 789-798.
138. Stanley, J., Bisaro, D. M., Briddon, R. W., Brown, J. K., Fauquet, C. M., Harrison, B. D., Rybicki, E. P. & Stenger, D. C. (2005). Geminiviridae. In Virus Taxonomy, VIIIth Report of the ICTV, pp. 301-326. Edited by C. M. Fauquet, M. A. Mayo, J. Maniloff, U. Desselberger & L. A. Ball. London: Elsevier/Academic Press.
139. Stanley, J., Frischmuth, T. & Ellwood, S. (1990). Defective viral DNA ameliorates symptoms of geminivirus infection in transgenic plants. Proceedings of the National Academy of Sciences, USA 87, 6291-6295.
140. Stanley, J. & Townsend, R. (1985). Characterization of DNA forms associated with cassava latent virus infection. Nucleic Acids Research 13, 2189-2205.
141. Stenger, D. C. (1994). Strain-specific mobilization and amplification of a transgenic defective-interfering DNA of the geminivirus Beet curly top virus. Virology 203, 397-402.
142. Sunter, G. & Bisaro, D. M. (1992). Transactivation of geminivirus AR1 and BR1 gene expression by the viral AL2 gene product occurs at the level of transcription. Plant Cell 4, 1321-1331.
143. Sunter, G., Stenger, D. C. & Bisaro, D. M. (1994). Heterologous complementation by geminivirus AL2 and AL3 genes. Virology 203, 203-210.
144. Takenaka, K., Koshino-Kimura, Y., Aoyama, Y. & Sera, T. (2007). Inhibition of tomato yellow leaf curl virus replication by artificial zinc-finger proteins. Nucleic Acids Symposium Series, 429-30.
145. Tamarzizt, B.H., Chouchane, S. G., Lengliz, R., Maxwell, D. P., Marrakchi, M., Fakhfakh, H. & Gorsane, F. (2009). Use of Tomato yellow leaf curl virus (TYLCV) truncated Rep gene sequence to engineer TYLCV resistance in tomato plants. Acta Virologica 53, 99-104.
146. Tang, G., Reinhart, B. J., Bartel, D. P. & Zamore, P. D. (2003). A biochemical framework for RNA silencing in plants. Genes & Development 17, 49-63.
147. Tenllado, F., Llave, C. & Diaz-Ruiz, J. R. (2004). RNA interference as a new biotechnological tool for the control of virus diseases in plants. Virus Res 102, 85-96.
148. Thresh, J. M. & Otim-Nape, G. W. (1994). Strategies for controlling African cassava mosaic geminivirus. In: Advances in Disease Vector Research, pp. 215-236. Edited by K. F. Harris. New York: Springer Verlag.
149. Uhlenbeck, O. (1987). A small catalytic oligoribinucleotide. Nature 328, 596-600.
150. Usharani, K. S., Surendranath, B., Haq, Q. M. R. & Malathi, V. G. (2004). Yellow mosaic virus infecting soybean in northern India is distinct from the species infecting soybean in southern and western India. Current Science 86, 845-850.
151. Ushasri, C., Sunil, K. M. & Deb, J. K. (2007). Intervention of geminiviral replication in yeast by ribozyme mediated downregulation of its Rep protein. FEBS letters 581, 2675.
152. Vanderschuren, H., Akbergenov, R., Pooggin, M. M., Hohn, T., Gruissem, W. & Zhang, P. (2007a). Transgenic cassava resistance to African cassava mosaic virus is enhanced by viral DNA-A bidirectional promoter-derived siRNAs. Plant Molecular Biology 64, 549-57.
153. Vanderschuren, H., Alder, A., Zhang, P. & Gruissem, W. (2009). Dose-dependent RNAimediated geminivirus resistance in the tropical root crop cassava. Plant Molecular Biology 70, 265-72.
154. Vanderschuren, H., Stupak, M., Fütterer, J., Gruissem, W. & Zhang, P. (2007b). Engineering resistance to geminiviruses - review and perspectives. Plant Biotechnology Journal 5, 207-220.
155. Vanitharani, R., Chellappan, P. & Fauquet, C. M. (2003). Short interfering RNA-mediated interference of gene expression and viral DNA accumulation in cultured plant cells. Proceedings of the National Academy of Sciences USA 100, 9632-9636.
156. Vanitharani, R., Chellappan, P., Pita, J. S. & Fauquet, C. M. (2004). Differential roles of AC2 and AC4 of cassava geminiviruses in mediating synergism and suppression of posttranscriptional gene silencing. Journal of Virology 78, 9487-9498.
157. Varma, A. & Malathi, V. G. (2003). Emerging geminivirus problems: A serious threat to crop production. Annals of Applied Biology 142, 145-164.
158. Varsani, A., Shepherd, D. N., Monjane, A. L., Owor, B. E., Erdmann, J. B., Rybicki, E. P., Peterschmitt, M., Briddon, R. W., Markham, P. G., Oluwafemi, S., Windram, O. P., Lefeuvre, P., Lett, J. M. & Martin, D. P. (2008). Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen. Journal of General Virology 89, 2063-74.
159. Vazquez, F., Vaucheret, H., Rajagopalan, R., Lepers, C., Gasciolli, V., Mallory, A. C., Hilbert, J. L., Bartel, D. P. & Crete, P. (2004). Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs. Molecular Cell 16, 69-79.
160. Voinnet, O. (2001). RNA silencing as a plant immune system against viruses. Trends in Genetics 17, 449-459.
161. Voinnet, O. (2005a). Induction and suppression of RNA silencing: insights from viral infections. Nature Reviews Genetics 6, 206-20.
162. Voinnet, O. (2005b). Induction and suppression of RNA silencing: insights from viral infections. Nature Genetics 6, 206-221.
163. von Arnim, A. & Stanley, J. (1992). Inhibition of African cassava mosaic virus systemic infection by a movement protein from the related geminivirus tomato golden mosaic virus. Virology 187, 555-564.
164. Wright, E. A., Heckel, T., Groenendijk, J., Davies, J. W. & Boulton, M. I. (1997). Splicing features in maize streak virus virion- and complementary-sense gene expression. Plant Journal 12, 1285-1297.
165. Wu, Q., Huang, L. & hang, Y. (2009). The structure and function of catalytic RNAs. Science in China Series C: Life Sciences 52, 232-244.
166. Xie, Z., Johansen, L. K., Gustafson, A. M., Kasschau, K. D., Lellis, A. D., Zilberman, D., Jacobsen, S. E. & Carrington, J. C. (2004). Genetic and functional diversification of small RNA pathways in plants. PLoS Biology 2, e104
167. Yang, X., Yie, Y., Zhu, F., Liu, Y., Kang, L., Wang, X. & Tien, P. (1997). Ribozymemediated high resistance against potato spindle tuber viroid in transgenic potatoes. Proceedings of the National Academy of Sciences USA 94, 4861-4865.
168. Zamir, D., Ekstein-Michelson, I., Zakay, Y., Navot, N., Zeidan, M., Sarfatti, M., Eshed, Y., Harel, E., Pleban, T., van-Oss, H., Kedar, N., Rabinowitch, H. D. & Czosnek, H. (1994). Mapping and introgression of a Tomato yellow leaf curl virus tolerance gene, TY-1. Theoretical and Applied Genetics 88, 141-146.
169. Zhang, P., Fütterer, J., Frey, P., Potrykus, I., Puonti-Kaerlas, J. & Gruissem, W. (2003). Engineering virus-induced ACMV resistance by mimicking a hypersensitive reaction in transgenic cassava plants. In: Plant Biotechnology 2002 and Beyond (Vasil, I.K., ed.),pp. 143-146. Norwell and Dordrecht: Kluwer Academic.
170. Zhang, P., Vanderschuren, H., Futterer, J. & Gruissem, W. (2005). Resistance to cassava mosaic disease in transgenic cassava expressing antisense RNAs targeting virus replication genes. Plant Biotechnology Journal 3, 385-397.
171. Zilberman, D., Cao, X., Johansen, L. K., Xie, Z., Carrington, J. C. & Jacobsen, S. E. (2004). Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by inverted repeats. Current Biology 14, 1214-20.
172. Zrachya, A., Kumar, P. P., Ramakrishnan, U., Levy, Y., Loyter, A., Arazi, T., Lapidot, M. & Gafni, Y. (2007). Production of siRNA targeted against TYLCV coat protein transcripts leads to silencing of its expression and resistance to the virus. Transgenic Research 16, 385-398.