Towards a practical and affordable oral papaya-based vaccine: A crucial tool for taeniasis cysticercosis control programs

Bioprocess Sciences and Technology

Volumn , Issue , 2011, Pages 323-338

  Sciutto, E ^a   Hernandez M ^a   Diaz Orea A ^b   Cervantes, J ^a   Rosas Salgado, G ^c   Morales, J ^a   Villalobos, N ^d   Aluja, A ^d   Blancas, A ^a   Aquino, R ^a   Fuentes, O ^d   Jimenez H ^e   Trejo Moreno, C ^c   Mendez Martinez M ^c   Manoutcharian, K ^a   Gevorkian, G ^a   Herrera Estrella, L ^e   Cabrera Ponce, J L ^e   Larralde, C ^a   Fragoso, G ^a   Huerta, M ^d   more..

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^d BENEMÉRITA UNIVERSIDAD AUTÓNOMA DE PUEBLA   (Mexico)

^e DEPARTAMENTO DE INGENIERÍA GENÉTICA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84892012981     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (52)

1. Cripps, A. W., Kyd, J. M. & Foxwell, A. R. 2001. Vaccines and mucosal immunization. Vaccine, 19, 2513-2515.
2. Walmsley, A. M. & Arntzen, C. J. 2003. Plant cell factories and mucosal vaccines. Current Opinion in Biotechnology, 14, 145-150.
3. Hooper, D. C. 2009. Plant vaccines: an immunological perspective. Current Topics in Microbiology and Immunology, 332, 1-11.
4. Tacket, C.O., & Mason, H. S. 1999. A review or oral vaccination with transgenic vegetables. Microbes and Infection, 1, 777-783.
5. Strober, W., Kelsall, B. & March, T. 1998. Oral Tolerance. Journal of Clinical Immunology, 18, 1-30
6. Kong, Q., Richter, L., Yang, Y. F., Arntzen, C.J., Mason, H. S. & Thanavala, Y. 2001. Oral immunization with hepatitis B surface antigen expressed in transgenic plants. Proceedings of the National Academy of Sciences of the United States of America, 98, 11539-11544.
7. Streatfield, S. J. 2006. Mucosal immunization using recombinant plant-based oral vaccines. Methods, 38, 150-157.
8. Wen, S. X., Teel, L. D., Judge, N. A., & O'Brien, A.D. 2006. Plant-based oral vaccine to protect against systemic intoxication by Shiga toxin type 2. Proceedings of the National Academy of Sciences of the United States of America, 103, 7082-7087.
9. Weiner, H. L. 1994. Oral Tolerance. Proceedings of the National Academy of Sciences of the United States of America, 91, 10762-10765.
10. Fleury, A., Escobar, A., Fragoso, G., Sciutto, E. & Larralde, C. 2010. Clinical heterogeneity of human neurocysticercosis results from complex interactions among parasite, host and environmental factors. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104, 243-250.
11. Willingham, A. L., De, N. V., Doanh, N. Q., Cong le, D., Dung, T. V., Dorny, P., Cam, P. D. & Dalsgaard, A. 2003. Current status of cysticercosis in Vietnam. The Southeast Asian Journal of Tropical Medicine and Public Health, 34, 35-50.
12. Cruz, I., Cruz, M. E., Teran, W., Schantz, P. M., Tsang, V. & Barry, M. 1994. Human subcutaneous Taenia solium cysticercosis in an Andean population with neurocysticercosis. American Journal of Tropical Medicine and Hygiene, 51, 405-407.
13. Sciutto, E., Fragoso, G., Fleury, A., Laclette, J. P., Sotelo, J., Aluja, A., Vargas, L. & Larralde, C. 2000. Taenia solium disease in humans and pigs: an ancient parasitosis disease rooted in developing countries and emerging as a major health problem of global dimensions. Microbes and Infection, 2, 1875-1890.
14. Schantz, P. M., Wilkins, P. P. & Tsang, V. C. W. 1998. Immigrants, imaging and immunoblots: the emergence of neurocysticercosis as a major public health problem. In: Emerging Infections 2 (edited by Scheld, Craig & Hughes). Pp. 213-242. ASM Press, US: Washington, DC.
15. Villarán, M. V., Montano, S. M., Gonzalvez, G., Moyano, L. M., Chero, J. C., Rodriguez, S., Gonzalez, A. E., Pan, W., Tsang, V. C., Gilman, R. H., Garcia, H. H. & Cysticercosis Working Group in Peru. 2009. Epilepsy and neurocysticercosis: an incidence study in a Peruvian rural population. Neuroepidemiology, 33, 25-31.
16. Villagran, U. J. & Olvera, J. E. 1988. Cisticercosis humana. Estudio clínico y patológico de 481 casos de autopsia. Patología, 26, 149-156.
17. Rabiela, M. T., Lombardo Rivera, L. & Flores Barroeta, F. 1972. Cisticercosis cerebral. Análisis de 68 casos de autopsia. Patología, 10, 27-37
18. Fleury, A., Gomez, T., Alvarez, I., Meza, D., Huerta, M., Chavarria, A., Carrillo Mezo, R. A., Lloyd, C., Dessein, A., Preux, P. M., Dumas, M., Larralde, C., Sciutto, E. & Fragoso, G. 2003. High prevalence of calcified silent neurocysticercosis in a rural village of Mexico. Neuroepidemiology, 22, 139-145.
19. Fleury, A., Morales, J., Bobes, R. J., Dumas, M., Yánez, O., Pina, J., Carrillo-Mezo, R., Martinez, J. J., Fragoso, G., Dessein, A., Larralde, C. & Sciutto, E. 2006. An epidemiological study of familial neurocysticercosis in an endemic Mexican community. Transactions Royal Society of Tropical Medicine and Hygiene, 100, 551-558.
20. Dumas, M. & Preux, P. M. 2008. [Epilepsy in tropical areas]. Bulletin de l'Academie Nationale de Médecine, 192, 949-960.
21. Plancarte, A., Flisser, A., Gauci, C. G. & Lightowlers, M. W. 1999. Vaccination against Taenia solium cysticercosis in pigs using native and recombinant oncosphere antigens. International Journal of Parasitology, 29, 643-647.
22. Huerta, M., de Aluja, A. S., Fragoso, G., Toledo, A., Villalobos, N., Hernandez, M., Gevorkian, G., Acero, G., Diaz, A., Alvarez, I., Avila, R., Beltran, C., Garcia, G., Martinez, J. J., Larralde, C. & Sciutto, E. 2001. Synthetic peptide vaccine against Taenia solium pig cysticercosis: successful vaccination in a controlled field trial in rural Mexico. Vaccine, 20, 262-266.
23. Flisser, A., Gauci, C. G., Zoli, A., Martinez-Ocaña, J., Garza-Rodriguez, A., Dominguez-Alpizar, J. L., Maravilla, P., Rodriguez-Canul, R., Avila, G., Aguilar-Vega, L., Kyngdon, C., Geerts, S. & Lightowlers, M. W. 2004. Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens. Infection and Immunity, 72, 5292-5297.
24. Manoutcharian, K., Diaz-Orea, A., Gevorkian, G., Fragoso, G., Acero, G., Gonzalez, E., De Aluja, A., Villalobos, N., Gomez-Conde, E. & Sciutto, E. 2004. Recombinant bacteriophage-based multiepitope vaccine against Taenia solium pig cysticercosis. Veterinary Immunology and Immunopathology, 99, 11-24.
25. Morales, J., Martinez, J. J., Manoutcharian, K., Hernández, M., Fleury, A., Gevorkian, G., Acero, G., Blancas, A., Toledo, A., Cervantes, J., Maza, V., Quet, F., Bonnabau, H., de Aluja, A. S., Fragoso, G., Larralde, C., Sciutto, E. 2008. Inexpensive anti-cysticercosis vaccine: S3Pvac expressed in heat inactivated M13 filamentous phage proves effective against naturally acquired Taenia solium porcine cysticercosis. Vaccine, 26, 2899-2905.
26. Assana, E., Kyngdon, C.T., Gauci, C.G., Geerts, S., Dorny, P., De Deken, R., Anderson, G.A., Zoli, A.P. & Lightowlers, M. W. 2010. Elimination of Taenia solium transmission to pigs in a field trial of the TSOL18 vaccine in Cameroon. International Journal of Parasitology, 40, 515-519.
27. Patarroyo, M. E., Cifuentes, G., Bermúdez, A. & Patarroyo, M. A. 2008. Strategies for developing multi-epitope, subunit-based, chemically synthesized anti-malarial vaccines. Journal of Cellular and Molecular Medicine, 12, 1915-1935.
28. Cervantes-Torres, J. 2010. Vacunación contra la cisticercosis murina: caracterización inmunogénicas inducida por el péptido KETc1 sintético y recombinante utilizando diferentes sistemas de expresión Tesis. Facultad de Química, UNAM.
29. Manoutcharian, K., Rosas, G., Hernandez, M., Fragoso, G., Aluja, A., Villalobos, N., Rodarte, L. F. & Sciutto, E. 1996. Cysticercosis: identification and cloning of protective recombinant antigens. Journal of Parasitology, 82, 250-254.
30. Rosas, G., Cruz-Revilla, C., Fragoso, G., López-Casillas, F., Pérez, A., Bonilla, M. A., Rosales, R. & Sciutto, E. 1998. Taenia crassiceps cysticercosis: humoral immune response and protection elicited by DNA immunization. Journal of Parasitology, 84, 516-523.
31. Toledo, A., Larralde, C., Fragoso, G., Gevorkian, G., Manoutcharian, K., Hernandez, M., Acero, G., Rosas, G., Lopez-Casillas, F., Garfias, C. K., Vazquez, R., Terrazas, I. & Sciutto, E. 1999. Towards a Taenia solium cysticercosis vaccine: an epitope shared by Taenia crassiceps and Taenia solium protects mice against experimental cysticercosis. Infection and Immunity, 67, 2522-2530.
32. Toledo, A., Fragoso, G., Rosas, G., Hernandez, M., Gevorkian, G., Lopez-Casillas, F., Hernandez, B., Acero, G., Huerta, M., Larralde, C. & Sciutto, E. 2001. Two epitopes shared by Taenia crassiceps and Taenia solium confer protection against murine T. crassiceps cysticercosis along with a prominent T1 response. Infection and Immunity, 69, 1766-1773.
33. Manoutcharian, K., Terrazas, L. I., Gevorkian, G., Acero, G., Petrossian, P., Rodriguez, M. & Govezensky, T. 1999. Phage-displayed T-cell epitope grafted into immunoglobulin heavy-chain complementarity-determining regions: an effective vaccine design tested in murine cysticercosis. Infection and Immunity, 67, 4764-4770.
34. Rassy, D., Bobes, R. J., Rosas, G., Anaya, V. H., Brehm, K., Hernández, B., Cervantes, J., Pedraza, S., Morales, Villalobos, N., de Aluja, A., Laclette, J. P., Nunes, C., Biondi, G., Fragoso, G., Hernández, M. & Sciutto, E. 2010. Characterization of S3Pvac anti-cysticercosis vaccine components: implications for the development of an anti-cestodiasis vaccine. PLoS One, (submitted).
35. Sciutto, E., Morales, J., Martínez, J. J., Toledo, A., Villalobos, M. N., Cruz-Revilla, C., Meneses, G., Hernández, M., Díaz, A., Rodarte, L. F., Acero, G., Gevorkian, G., Manoutcharian, K., Paniagua, J., Fragoso, G., Fleury, A., Larralde, R., De Aluja, A. S. & Larralde, C. 2007. Further evaluation of the synthetic peptide vaccine S3Pvac against Taenia solium cysticercosis in pigs in an endemic town of Mexico. Parasitology, 134, 129-133.
36. Cabrera-Ponce, J. L., Vegas, J. A. & Herrera-Estrella, L. 1995. Herbicide resistant transgenic papaya plants produced by and efficient particle bombardments transformation methods. Plant Cell Reports, 15, 1-7.
37. Cabrera-Ponce, J. L., López, L., Assad-García, C., Medina-Arevalo, N., Bailey, A. & Herrera-Estrella, L. 1997. An efficient particle bombardment system for the genetic transformation of asparagus (Asparagus officinalis L.). Plant Cell Reports, 16, 255-260.
38. Berger, J. & Asenjom, C. F. 1940. Anthelmintic activity of crystalline papain. Science, 91, 387-388.
39. Okeniyi, J. A., Ogunlesi, T. A., Oyelami, O. A. & Adeyemi, L. A. 2007. Effectiveness of dried Carica papaya seeds against human intestinal parasitosis: a pilot study. Journal of Medicinal Food, 10, 194-196.
40. Stepek, G., Behnke, J. M., Buttle., D. J. & Duce, L. R. 2004. Natural plant cisteine proteinases as anthelmintics? Trends in Parasitoogyl, 20, 322-327.
41. Ming, R., Hou, S., Feng, Y., Yu, Q., Dionne-Laporte, A., Saw, H. J., Senin, P., Wang, W. et al., 2008. The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus). Nature, 452, 991-996.
42. Zhang, G. L., Zhou, Z., Guo, A. P., Shen, W. T. & Li, X. Y. 2003. An initial study of transgenic Carica papaya used as a kind of vaccine for anti-tuberculosis. Acta Botanica Yunnanica, 2, 223-229.
43. Christou, P., Ford, T. L. & Kofron, M. 1992. The development of a variety independent gene-transfer method for rice. Trends in Biotechnology, 10, 239-246.
44. Sanford, J. C., De Vit, M. J., Rusell, J. A., Smith, F. D., Harpending, P. R., Roy, M. K. & Jonhson, S. A. 1991. An improvement helium-drive bioballistic device. Techniques, 3, 3-16.
45. Tomes, D. T., Ross, M. C. & Songstad, D. D. 1995. Direct DNA transfer into intact plant cells via microprojectile bombardment. In: Plant Cell Tissue and Organ Culture: Fundamental Methods (edited by O. L. Gamborg & C. G. Phillips). Pp. 197-213. Springer-Verlag, Germany: Berlin, Heidelberg.
46. Hernández, M., Cabrera-Ponce, J. L., Fragoso, G., López-Casillas, F., Guevara-García, A., Rosas, G., León-Ramírez, C., Juárez, P., Sánchez-García, G., Cervantes, J., Acero, G., Toledo, A., Cruz, C., Bojalil, R., Herrera-Estrella, L. & Sciutto, E. 2007. A new highly effective anticysticercosis vaccine expressed in transgenic papaya. Vaccine, 25, 4252-4260.
47. Lowry, O. H., Rosebrough, N. J., Farr, S. L. & Randall, R. J. 1951. The folin phenol protein quantification method of protein, Journal Biological Chemistry. 193, 265-275.
48. Molina, A. & Veramendi, J. 2005. Induction of neutralizing antibodies by a tobacco chloroplast-derived vaccine based on a B cell epitope from canine parvovirus. Virology, 342, 266-275.
49. Hernández, M., Cervantes, J., Cabrera Ponce, J. L., Herrera Estrella, L., Rosas, G., Villarreal, M. L., Fragoso, G. & Sciutto, E. 2009. Development of an oral anticysticercosis vaccine delivered in genetically modified embryogenic callus of papaya. Transgenic Plant Journal, 3, In-Press.
50. Kapusta, J., Pniewski, T., Wojciechowicz, J., Bociag, P. & Piucienniczak, A. 2010. Nanogram doses of alum-adjuvanted HBs antigen induce humoral immune response in mice when orally administered. Archivum Immunologiae et Therapice Experimentalis, 58, 143-151.
51. Kostrzak, A., Cervantes Gonzalez, M., Guetard, D., Nagaraju, D. B., Wain-Hobson, S., Tepfer, D., Pniewski, T. & Sala, M. 2009. Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells. Vaccine, 27, 4798-4807.
52. Mossmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55-63.