Locked-in syndrome after basilary artery thrombosis by mucormycosis masquerading as meningoencephalitis in a lymphoma patient

ecancermedicalscience

Volumn 7, Issue 1, 2013, Pages

  Maffini, Fausto ^a   Cocorocchio, Emilia ^a   Pruneri, Giancarlo ^a   Bonomo, Guido ^a   Peccatori, Fedro ^a   Chiapparini, Laura ^a   Di Vincenzo, Silvia ^a   Martinelli, Giovanni ^a   Viale, Giuseppe ^a,b  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Cutaneous lymphomas; Infectious disease; Mucorales fungi; Mycosis; Oncology; Stroke; Thrombosis

Indexed keywords

ACICLOVIR; AMIKACIN; AMPHOTERICIN B LIPID COMPLEX; CEFTAZIDIME; CEFTRIAXONE; CHLORAMBUCIL; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DESMOPRESSIN; DOXORUBICIN; FLUCONAZOLE; FLUDARABINE; FOSCARNET; GADOLINIUM; GENTAMICIN; MEROPENEM; METHYLPREDNISOLONE; PREDNISONE; RITUXIMAB; STEROID; T LYMPHOCYTE RECEPTOR; TEICOPLANIN; VINCRISTINE;

ADULT; AREFLEXIA; ARTERY THROMBOSIS; ARTICLE; AUTOPSY; BABINSKI REFLEX; BASILAR ARTERY; BASILARY ARTERY THROMBOSIS; CANCER COMBINATION CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER PATIENT; CANCER STAGING; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; COMA; CYTOLOGY; DECEREBRATION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ERYTHEMA; FEMALE; GRANULOCYTE; HISTOLOGY; HUMAN; HUMAN TISSUE; HYDRATION; HYPERCHLOREMIA; HYPERNATREMIA; LEUKOCYTE COUNT; LOCKED IN SYNDROME; LUMBAR PUNCTURE; MENINGOENCEPHALITIS; MESENCEPHALON; MUCOR; MUCORMYCOSIS; NEUROIMAGING; NEUTROPENIA; NEUTROPHIL COUNT; NONHODGKIN LYMPHOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCYTOPENIA; PARESIS; POLYMERASE CHAIN REACTION; POLYURIA; PONS; PUNCH BIOPSY; PYREXIA IDIOPATHICA; SEPSIS; SKIN DEFECT; SKIN EDEMA; SKIN INFECTION; SKIN PAIN; SLURRED SPEECH; SUBCUTANEOUS T CELL LYMPHOMA; THALAMUS; THROMBOCYTOPENIA; TONGUE SWELLING; VASOPRESSIN RELEASE;

EID: 84891959476     PISSN: None     EISSN: 17546605     Source Type: Journal    
DOI: 10.3332/ecancer.2013.382     Document Type: Article

References (25)

1. Bauer G, Gerstenbrand F and Rumpl E (1979) Varieties of the lockedin syndrome J Neurol 221 77-91 DOI: 10.1007/BF00313105 PMID: 92545
2. Fujimoto Y, Ohnishi YI, Wakayama A and Yoshimine T (2012) Transient total mesencephalic locked-in syndrome after bilateral ptosis due to basilar artery thrombosis J Stroke Cerebrovascular Dis 21(8) 909e7-8
3. Yager PH, Singhal AB and Nogueira RG (2012) Case 31-2012: an 18-year-old man with blurred vision, dysarthria, and ataxia N Engl J Med 367 1450-60 DOI: 10.1056/NEJMcpc1208150 PMID: 23050529
4. Hibbett DS, Binder M, Bischoff JF, et al (2007) A higher-level phylogenetic classification of the Fungi Mycol Res 111 509-47 DOI: 10.1016/j.mycres.2007.03.004 PMID: 17572334
5. Bitar D, Van Cauteren D, Lanternier F, et al (2009) Increasing incidence of zygomycosis (mucormycosis), France, 1997-2006 Emerg Infect Dis 15 1395-401 DOI: 10.3201/eid1509.090334 PMID: 19788806 PMCID: 2819884
6. Husain, Alexander BD, Munoz P, et al (2003) Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-aspergillus mycelial fungi Clin Infect Dis 37 221-9 DOI: 10.1086/375822 PMID: 12856215
7. Kontoyiannis DP and Lewis RE (2009) Agents of mucormycosis and entomophthoramycosis Principles and Practice of Infectious Diseases 7th edn, ed GL Mandell, JE Bennett, R Dolin (Philadelphia, PA: Churchill Livingstone/Elsevier)
8. Roden MM, Zaoutis TE, Buchanan WL, et al (2005) Epidemiology and outcome of zygomycosis: a review of 929 reported cases Clin Infect Dis 41 634-53 DOI: 10.1086/432579 PMID: 16080086
9. Inamasu J, Uchida K, Mayanagi K, Suga S and Kawase T (2000) Basilar artery occlusion due to mucormycotic emboli, preceded by acute hydrocephalus Clin Neurol Neurosurg 102(1) 18-22 DOI: 10.1016/S0303-8467(99)00065-7 PMID: 10717397
10. Tuder RM (1985) Myocardial infarct in disseminated mucormycosis: case report with special emphasis on the pathogenic mechanisms Mycopathologia 89 81 DOI: 10.1007/BF00431474 PMID: 3990762
11. Kitabayashi A, Hirokawa M, Yamaguchi A, Takatsu H, Miura AB (1998) Invasive pulmonary mucormycosis with rupture of the thoracic aorta Am J Hematol 58 326 DOI: 10.1002/(SICI)1096-8652(199808)58:4<326::AID-AJH13>3.0.CO;2-5 PMID: 9692398
12. Dizbay M, Adisen E, Kustimur S, et al (2009) Fungemia and cutaneous zygomycosis due to mucor circinelloides in an intensive care unit patient: case report and review of literature Jpn J Infect Dis 62 146 PMID: 19305057
13. Francesconi A, Kasai M, Harrington SM, et al (2008) Automated and manual methods of DNA extraction for Aspergillus Fumigatus and Rhizopus orza analyzed by quantitative real-time PCR J Clin Microbiol 46 1978 DOI: 10.1128/JCM.02246-07 PMID: 18353931 PMCID: 2446852
14. Hata DJ, Buckalter SP, Pritt BS, Roberts GD, Wengenack NL (2008) Real-time PCR method for detection of zygomycetes J Clin Microbiol 46 2353 DOI: 10.1128/JCM.02331-07 PMID: 18480229 PMCID: 2446880
15. Chamilos G, Lewis RE, Kontoyiannis DP (2008) Delaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis Clin Infect Dis 47 503-9 DOI: 10.1086/590004 PMID: 18611163
16. Ruping MJ, Heinz WJ, Kindo AJ, et al (2010) Forty-one recent cases of invasive zygomycosis from a global clinical registry J Antimicrob Chemother 65 296-302 DOI: 10.1093/jac/dkp430
17. Singh N, Aguado JM, Bonatti H, et al (2009) Zygomycosis in solid organ transplant recipients: a prospective, matched case-control study to assess risks for disease and outcome J Infect Dis 200 1002-11 DOI: 10.1086/605445 PMID: 19659439
18. Gleissner B, Schilling A, Anagnostopolous I, Siehl I and Thiel E (2004) Improved outcome of zygomycosis in patients with hematological diseases? Leuk Lymphoma 45 1351-60 DOI: 10.1080/10428190310001653691 PMID: 15359632
19. Cornely OA, Vehreschild JJ and Ruping MJ (2009) Current experience in treating invasive zygomycosis with posaconazole Clin Microbiol Infect 15 (suppl 5) 77-81 DOI: 10.1111/j.1469-0691.2009.02985.x PMID: 19754763
20. Dannaoui E, Meis JF, Loebenberg D, Verweij PE (2003) Activity of posaconazole in treatment of experimental disseminated zygomycosis Antimicrob Agents Chemother 47 3647-50 DOI: 10.1128/AAC.47.11.3647-3650.2003 PMID: 14576138 PMCID: 253802
21. Sun QN, Najvar LK, Bocanegra R, Loebenberg D and Graybill JR (2002) In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model Antimicrob Agents Chemother 46 2310-2 DOI: 10.1128/AAC.46.7.2310-2312.2002 PMID: 12069997 PMCID: 127310
22. Denning DW (2003) Echinocandin antifungal drugs Lancet 362 1142-51 DOI: 10.1016/S0140-6736(03)14472-8 PMID: 14550704
23. Ibrahim AS, Bowman JC, Avanessian V, Brown K, Spellberg B, Edwards JE Jr, et al (2005) Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase,lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis Antimicrob Agents Chemother 49 721-7 DOI: 10.1128/AAC.49.2.721-727.2005 PMID: 15673756 PMCID: 547300
24. Spellberg B, Ibrahim AS, Chin-Hong PV, Kontoyiannis DP, Morris MI, Perfect JR, Fredricks D and Brass EP (2012) The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial J Antimicrob Chemother 67 (3) 715-22 DOI: 10.1093/jac/dkr375 PMCID: 3383100
25. Best LA, Singh N, Ben-Ami R, et al (2009) In vitro interactions of tacrolimus with posaconazole or caspofungin against zygomycetes 47th Annual Meeting of the Infectious Diseases Society of America (Oct. 29-Nov. 1) (Philadelphia, PA) (abstr M-1046)