Activation of the mitochondrial caspase pathway and subsequent calpain activation in monkey RPE cells cultured under zinc depletion

Eye (Basingstoke)

Volumn 28, Issue 1, 2014, Pages 85-92

  Nakajima, E ^a,b   Hammond, K B ^a,b   Shearer, T R ^b   Azuma, M ^a,b  

^a Senju Laboratory of Ocular Sciences Senju Pharmaceutical Co Ltd   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

AMD; calpain; caspase; monkey; non human primate; zinc depletion

Indexed keywords

CALNEXIN; CALPAIN; CALPAIN 1; CALPAIN 2; CASPASE; CASPASE 12; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CYTOKERATIN 18; DEATH RECEPTOR; MITOCHONDRIAL ENZYME; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; THAPSIGARGIN; VIMENTIN; ZINC; [1 [(1 BENZYL 3 CYCLOPROPYLAMINO 2,3 DIOXOPROPYL)CARBAMOYL] 3 METHYLBUTYL]CARBAMIC ACID 2 (2 METHOXYETHOXY)ETHYL ESTER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; CYTOSOL; DRUG INHIBITION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVE SITE; IMMUNOBLOTTING; NONHUMAN; PIGMENT EPITHELIUM; PRIMARY CULTURE; PROTEIN DEGRADATION; RETINA MACULA AGE RELATED DEGENERATION; RHESUS MONKEY; SIGNAL TRANSDUCTION; ZINC DEFICIENCY;

ANIMALS; APOPTOSIS; CALPAIN; CARBAMATES; CASPASE INHIBITORS; CASPASES; CELLS, CULTURED; CHELATING AGENTS; ENZYME ACTIVATION; ETHYLENEDIAMINES; MACACA MULATTA; MICROSCOPY, PHASE-CONTRAST; MITOCHONDRIA; OLIGOPEPTIDES; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; TIME FACTORS; ZINC;

EID: 84891953726     PISSN: 0950222X     EISSN: 14765454     Source Type: Journal    
DOI: 10.1038/eye.2013.239     Document Type: Article

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