Discovery of inhibitors of Shiga toxin type 2 by On-plate generation and screening of a focused compound library

Angewandte Chemie - International Edition

Volumn 53, Issue 6, 2014, Pages 1510-1515

  Dasgupta, Somnath ^a   Kitov, Pavel I ^a   Sadowska, Joanna M ^a   Bundle, David R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

drug discovery; glycoarrays; haemolytic uremic syndrome; inhibitors; Shiga toxins

Indexed keywords

COMPOUND LIBRARIES; DRUG DISCOVERY; GLYCOARRAYS; HAEMOLYTIC UREMIC SYNDROME; HIGH AFFINITY LIGANDS; REACTION CONDITIONS; REACTIVE FUNCTIONALITY; SHIGA TOXIN;

CORROSION INHIBITORS; ESCHERICHIA COLI; ITERATIVE METHODS; TOXIC MATERIALS;

LIGANDS;

ENZYME INHIBITOR; LIGAND; SHIGA TOXIN; VEROTOXIN 2;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GLYCOARRAYS; HAEMOLYTIC UREMIC SYNDROME; INHIBITORS; METABOLISM; MOLECULAR LIBRARY; PROTEIN BINDING;

DRUG DISCOVERY; GLYCOARRAYS; HAEMOLYTIC UREMIC SYNDROME; INHIBITORS; SHIGA TOXINS;

ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; LIGANDS; PROTEIN BINDING; SHIGA TOXIN 2; SMALL MOLECULE LIBRARIES;

EID: 84891947883     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201309436     Document Type: Article

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