5-Aminolevulinic acid protects against cisplatin-induced Nephrotoxicity without compromising the anticancer efficiency of cisplatin in rats in vitro and in vivo

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Terada, Yoshio ^a   Inoue, Keiji ^a   Matsumoto, Tatsuki ^a   Ishihara, Masayuki ^a   Hamada, Kazu ^a   Shimamura, Yoshiko ^a   Ogata, Koji ^a   Inoue, Kosuke ^a   Taniguchi, Yoshinori ^a   Horino, Taro ^a   Karashima, Takashi ^a   Tamura, Kenji ^a   Fukuhara, Hideo ^a   Fujimoto, Shimpei ^a   Tsuda, Masayuki ^a   Shuin, Taro ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE 5 ALPHA; AMINOLEVULINIC ACID; CASPASE 3; CISPLATIN; CYTOCHROME C OXIDASE; HEME OXYGENASE 1; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL STRUCTURE; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; KIDNEY CARCINOMA; KIDNEY TUBULE CELL; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN TISSUE LEVEL; RAT; RENAL PROTECTION; TISSUE LEVEL; UPREGULATION;

ACUTE KIDNEY INJURY; AMINOLEVULINIC ACID; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA; CASPASE 3; CELL LINE; CISPLATIN; ELECTRON TRANSPORT COMPLEX IV; GENE EXPRESSION; HEME OXYGENASE-1; ION CHANNELS; IRON; KIDNEY TUBULES; MALE; MITOCHONDRIAL PROTEINS; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; NEOPLASM TRANSPLANTATION; OXIDATIVE PHOSPHORYLATION COUPLING FACTORS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SKIN; TISSUE CULTURE TECHNIQUES; TRANSCRIPTION FACTORS; TUMOR BURDEN; URINARY BLADDER NEOPLASMS;

EID: 84891939132     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080850     Document Type: Article

References (33)

1. Boulikas T, Vougiouka M (2003) Cisplatin and platinum drugs at the molecular level. (Review). Oncol Rep 10:1663-1682.
2. Arany I, Safirstein RL (2003) Cisplatin nephrotoxicity. Semin Nephrol 23:460-464. (Pubitemid 37176691)
3. Park MS, De Leon M, Devarajan P (2002) Cisplatin induces apoptosis in LLCPK1 cells via activation of mitochondrial pathways. J Am Soc Nephrol 13:858-865. (Pubitemid 34274081)
4. Kaushal GP, Kaushal V, Hong X, Shah SV (2001) Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells. Kidney Int 60:1726-1736. (Pubitemid 32999977)
5. Zhou H, Miyaji T, Kato A, Fujigaki Y, Sano K, et al. (1999) Attenuation of cisplatin-induced acute renal failure is associated with less apoptotic cell death. J Lab Clin Med 134:649-658.
6. Kuwana H, Terada Y, Kobayashi T, Okado T, Penninger JM, et al. (2008) The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int 73:430-445. (Pubitemid 351186288)
7. Terada Y, Inoshita S, Kuwana H, Kobayashi T, Okado T, et al. (2007) Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury. Biochem Biophys Res Commun 364:1043-1049. (Pubitemid 350087906)
8. Hall AM, Rhodes GJ, Sandoval RM, Corridon PR, Molitoris BA (2013) In vivo multiphoton imaging of mitochondrial structure and function during acute kidney injury. Kidney Int 83:72-83.
9. Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, et al. (2013) Sestrin2 and BNIP3 (Bcl-2/adenovirus E1B 19kDa-interacting protein3) regulate autophagy and mitophagy in renal tubular cells in acute kidney injury. Am J Physiol Renal Physiol 305:F495-509.
10. Kobuchi H, Moriya K, Ogino T, Fujita H, Inoue K, et al. (2012) Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation. PloS one 7:e50082.
11. Wallin A, Zhang G, Jones TW, Jaken S, Stevens JL (1992) Mechanism of the nephrogenic repair response. Studies on proliferation and vimentin expression after 35S-1, 2-dichlorovinyl-L-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells. Lab Invest 66:474-484.
12. Inoue K, Kuwana H, Shimamura Y, Ogata K, Taniguchi Y, et al. (2010) Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin Exp Nephrol 14:112-122.
13. Ishizuka M, Abe F, Sano Y, Takahashi K, Inoue K, et al. (2011) Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy. Int Immunopharmacol 11:358-365.
14. Terada Y, Tanaka H, Okado T, Shimamura H, Inoshita S, et al. (2003) Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. J Am Soc Nephrol 14:1223-1233. (Pubitemid 36514664)
15. Tanaka H, Terada Y, Kobayashi T, Okado T, Inoshita S, et al. (2004) Expression and function of Ets-1 during experimental acute renal failure in rats. J Am Soc Nephrol 15:3083-3092. (Pubitemid 39578840)
16. Kobayashi T, Terada Y, Kuwana H, Tanaka H, Okado T, et al. (2008) Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury. Kidney Int 73:1240-1250. (Pubitemid 351693161)
17. Terada Y, Tomita K, Homma MK, Nonoguchi H, Yang T, et al. (1994) Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells. J Biol Chem 269:31296-31301. (Pubitemid 24377631)
18. Tanabe K, Tamura Y, Lanaspa MA, Miyazaki M, Suzuki N, et al. (2012) Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy. Am J Physiol Renal Physiol 303:F1264-1274.
19. Lebwohl D, Canetta R (1998) Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. Eur J Cancer 34:1522-1534. (Pubitemid 28446332)
20. Ries F, Klastersky J (1986) Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity. Am J Kidney Dis 8:368-379. (Pubitemid 17235084)
21. Safirstein R, Winston J, Goldstein M, Moel D, Dikman S, et al. (1986) Cisplatin nephrotoxicity. Am J Kidney Dis 8:356-367. (Pubitemid 17235083)
22. Brady HR, Kone BC, Stromski ME, Zeidel ML, Giebisch G, et al. (1990) Mitochondrial injury: an early event in cisplatin toxicity to renal proximal tubules. Am J Physiol 258:F1181-1187. (Pubitemid 20185251)
23. Lau AH (1999) Apoptosis induced by cisplatin nephrotoxic injury. Kidney Int 56:1295-1298. (Pubitemid 29451234)
24. Ogura S-I, Maruyama K, Hagiya Y, Sugiyama Y, Tsuchiya K, et al. (2011) The effect of 5-aminolevulinic acid on cytochrome c oxidase activity in mouse liver. BMC Res Notes 4:66.
25. Agarwal A, Nick HS (2000) Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression. J Am Soc Nephrol 11:965-973. (Pubitemid 30241733)
26. Nath KA, Balla G, Vercellotti GM, Balla J, Jacob HS, et al. (1992) Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat. J Clin Invest 90:267-270.
27. Nath KA (2006) Heme oxygenase-1: a provenance for cytoprotective pathways in the kidney and other tissues. Kidney Int 70:432-443. (Pubitemid 44141569)
28. Abraham NG, Kappas A (2008) Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 60:79-127. (Pubitemid 351439218)
29. Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, et al. (1999) Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol 1:152-157. (Pubitemid 129656019)
30. Shiraishi F, Curtis LM, Truong L, Poss K, Visner GA, et al. (2000) Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. Am J Physiol Renal Physiol 278:F726-736. (Pubitemid 30351074)
31. Salahudeen AA, Jenkins JK, Huang H, Ndebele K, Salahudeen AK (2001) Overexpression of heme oxygenase protects renal tubular cells against cold storage injury: studies using hemin induction and HO-1 gene transfer. Transplantation 72:1498-1504. (Pubitemid 33095507)
32. Daemen MA, Van't Veer C, Denecker G, Heemskerk VH, Wolfs TG, et al. (1999) Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest 104:541-549.
33. Hagiya Y, Adachi T, Ogura S, An R, Tamura A, et al. (2008) Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy. J Exp Ther Oncol 7:153-167.