Wnt5b promotes the cell motility essential for metastasis of oral squamous cell carcinoma through active Cdc42 and RhoA

International Journal of Oncology

Volumn 44, Issue 1, 2014, Pages 59-68

  Takeshita, Akinori ^a   Iwai, Soichi ^a   Morita, Yoshihiro ^a   Niki Yonekawa, Atsuko ^a   Hamada, Masakazu ^a   Yura, Yoshiaki ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Cell invasion and migration; Oral squamous cell carcinoma; Rho family; Wnt signal; Wnt5b

Indexed keywords

BETA CATENIN; CALVASCULIN; CYCLIN D1; GREEN FLUORESCENT PROTEIN; GUANOSINE TRIPHOSPHATASE; KALININ; LAMININ 5GAMMA2; MATRILYSIN; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; PROTEIN CDC42; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WNT11 PROTEIN; WNT5A PROTEIN; WNT5B PROTEIN;

ACTIN FILAMENT; ARTICLE; CANCER CELL CULTURE; CELL CONTACT; CELL INVASION; CELL INVASION ASSAY; CELL MIGRATION; CELL MIGRATION ASSAY; CELL MOTILITY; CELL PROLIFERATION ASSAY; CELL STIMULATION; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; FILOPODIUM; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; JAPANESE; LYMPH NODE METASTASIS; METASTASIS; METASTASIS POTENTIAL; MOUTH SQUAMOUS CELL CARCINOMA; ONCOGENE C MYC; PHASE CONTRAST MICROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; WNT SIGNALING PATHWAY;

BETA CATENIN; CARCINOMA, SQUAMOUS CELL; CDC42 GTP-BINDING PROTEIN; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; LYMPHATIC METASTASIS; MOUTH NEOPLASMS; RHOA GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; WNT PROTEINS;

EID: 84891935015     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2172     Document Type: Article

References (39)

1. Rousseau A and Badoual C: Head and neck: squamous cell carcinoma: an overview. Atlas Genet Cytogenet Oncol Haematol 16: 145-155, 2012.
2. Howell GM and Grandis JR: Molecular mediators of metastasis in head and neck squamous cell carcinoma. Head Neck 27: 710-717, 2005.
3. Sahai E: Illuminating the metastatic process. Nat Rev Cancer 7: 737-749, 2007.
4. Veeman MT, Axelrod JD and Moon RT: A second canon: functions and mechanisms of β-catenin-independent Wnt signaling. Dev Cell 5: 367-377, 2003.
5. Nelson WJ and Nusse R: Convergence of Wnt, β-catenin, and cadherin pathways. Science 303: 1483-1487, 2004.
6. 2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet 16: 279-283, 2000.
7. Miller JR: The Wnts. Genome Biol 3(1) reviews3001.1-3001.15, 2001.
8. Kikuchi A and Yamamoto H: Tumor formation due to abnormalities in the β-catenin-independent pathway of Wnt signaling. Cancer Sci 99: 202-208, 2008.
9. Kikuchi A: Wnt signaling; its abnormalities and diseases. Seikagaku 81: 780-792, 2009.
10. Polakis P: The many ways of Wnt in cancer. Curr Opin Genet Dev 17: 45-51, 2007.
11. Kikuch A: Tumor formation by genetic mutations in the components of the Wnt signaling pathway. Cancer Sci 94: 225-229, 2003.
12. Takahashi K, Kanazawa H, Akiyama Y, Tazaki S, Takahara M, Muto T, Tanzawa H and Sato K: Establishment and characterization of a cell line (SAS) from poorly differentiated human squamous cell carcinoma of the tongue. J Jpn Stomatol Soc 38: 20-28, 1989.
13. Morita Y, Hata K, Nakanishi M, Nishisho T, Yura Y and Yoneda T: Cyclooxygenase-2 promotes tumor lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. Int J Oncol 41: 885-892, 2012.
14. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R and Ben-Ze'ev A: The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 96: 5522-5527, 1999.
15. Tetsu O and McCormick F: β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398: 422-426, 1999.
16. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, Da Costa LT, Morin PJ, Vogelstein B and Kinzler KW: Identification of c-myc as a target of the APC pathway. Science 281: 1509-1512, 1998.
17. Takahashi M, Tsunoda T, Seiki M, Nakamura Y and Furukawa Y: Identification of membrane-type matrix metalloproteinase-1 as a target of the β-catenin/Tcf4 complex in human colorectal cancers. Oncogene 21: 5861-5867, 2002.
18. Brabletz T, Jung A, Dag S, Hlubek F and Kirchner T: β-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 155: 1033-1038, 1999.
19. Hlubek F, Jung A, Kotzor N, Kirchner T and Brabletz T: Expression of the invasion factor laminin γ2 in colorectal carcinomas is regulated by β-catenin. Cancer Res 61: 8089-8093, 2001.
20. Mann B, Gelos M, Siedow A, Hanski ML, Gratchev A, Ilyas M, Bodmer WF, Moyer MP, Riecken EO, Buhr HJ and Hanski C: Target genes of beta-catenin-T cell factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci USA 96: 1603-1608, 1999.
21. Hiendlmeyer E, Regus S, Wassermann S, Hlubek F, Haynl A, Dimmler A, Koch C, Knoll C, van Beest M, Reuning U, Brabletz T, Kirchner T and Jung A: β-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors, Cancer Res 64: 1209-1214, 2004.
22. Stein U, Arlt F, Walther W, Smith J, Waldman T, Harris ED, Mertins SD, Heizmann CW, Allard D, Birchmeier W, Schlag PM and Shoemaker RH: The metastasis-associated gene S100A4 is a novel target of beta-catenin/T-cell factor signaling in colon cancer. Gastroenterology 131: 1486-1500, 2006.
23. Katoh M: WNT/PCP signaling pathway and human cancer (Review). Oncol Rep 14: 1583-1588, 2005.
24. Sahai E and Marshall CJ: Rho-GTPases and cancer. Nat Rev Cancer 2: 133-142, 2002.
25. Price LS and Collard JG: Regulation of the cytoskeleton by Rho-family GTPases: implications for tumour cell invasion. Cancer Biol 11: 167-173, 2001.
26. Vega FM and Ridley AJ: Rho GTPases in cancer cell biology. FEBS Lett 582: 2093-2101, 2008.
27. Iwai S, Yonekawa A, Harada C, Hamada M, Katagiri W, Nakazawa M and Yura Y: Involvement of the Wnt-β-catenin pathway in invasion and migration of oral squamous carcinoma cells. Int J Oncol 37: 1095-1103, 2010.
28. Kremenevskaja N, von Wasielewski R, Rao AS, Schöfl C, Andersson T and Brabant G: Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene 24: 2144-2154, 2005.
29. Dejmek J, Dejmek A, Säfholm A, Sjölander A and Andersson T: Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis. Cancer Res 65: 9142-9146, 2005.
30. Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M and Trent JM: Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 1: 279-288, 2002.
31. Kurayoshi M, Oue N, Yamamoto H, Kishida M, Inoue A, Asahara T, Yasui W and Kikuchi A: Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res 66: 10439-10448, 2006.
32. Kanazawa A, Tsukada S, Kamiyama M, Yanagimoto T, Nakajima M and Maeda S: Wnt5b partially inhibits canonical Wnt/β-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Biochem Biophys Res Commun 330: 505-510, 2005.
33. van Tienen F, Laeremans H, van der Kallen C and Smeets H: Wnt5b stimulates adipogenesis by activating PPARγ, and inhibiting the β-catenin dependent Wnt signaling pathway together with Wnt5a. Biochem Biophys Res Commun 387: 207-211, 2009.
34. Deraz EM, Kudo Y, Yoshida M, Obayashi M, Tsunematsu T, Tani H, Siriwardena SBSM, Kiekhaee MR, Qi G, Iizuka S, Ogawa I, Campisi G, Muzio LL, Abiko Y, Kikuchi A and Takata T: MMP-10/stromelysin-2 promotes invasion of head and neck cancer. PLoS One 6: 1-14, 2011.
35. Weaver AM: Invadopodia: specialized cell structures for cancer invasion. Clin Exp Metastasis 23: 97-105, 2006.
36. Friedl P and Wolf K: Plasticity of cell migration: a multiscale tuning model. J Cell Biol 188: 11-19, 2010.
37. Sahai E: Mechanisms of cancer cell invasion. Curr Opin Genet Dev 15: 87-96, 2005.
38. Rørth P: Collective cell migration. Annu Rev Cell Dev Biol 25: 407-429, 2009.
39. Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K and Sahai E: Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol 9: 1392-1400, 2007.