Androgen receptor decreases CMYC and KRAS expression by upregulating let-7a expression in ER-, PR-, AR+ breast cancer

International Journal of Oncology

Volumn 44, Issue 1, 2014, Pages 229-237

  Lyu, Shuhua ^a,b   Yu, Qi ^c   Ying, Guoguang ^a   Wang, Shuling ^a   Wang, Yahong ^a   Zhang, Jing ^a   Niu, Yun ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b NANKAI UNIVERSITY AFFILIATED HOSPITAL   (China)

^c Jinghai Hospital   (China)

Author keywords

Androgen receptor positive; Breast cancer; CMYC; Estrogen receptor negative; KRAS; let 7a; Progesterone receptor negative

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANTISENSE OLIGONUCLEOTIDE; ESTROGEN RECEPTOR; K RAS PROTEIN; LET 7A PROTEIN; MICRORNA; MYC PROTEIN; PROGESTERONE RECEPTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER CELL; CANCER PATIENT; CANCER SURGERY; CANCER TISSUE; CELL GROWTH; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GROWTH INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MIDDLE AGED; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

BREAST NEOPLASMS; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MCF-7 CELLS; MICRORNAS; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; RAS PROTEINS; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; SIGNAL TRANSDUCTION;

EID: 84891932877     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2151     Document Type: Article

References (46)

1. Moe RE and Anderson BO: Androgens and androgen receptors: a clinically neglected sector in breast cancer biology. J Surg Oncol 95: 437-439, 2007.
2. Birrell SN, Hall RE and Tilley WD: Role of the androgen receptor in human breast cancer. J Mammary Gland Biol Neoplasia 3: 95-103, 1998.
3. Somboonporn W and Davis SR: Testosterone effects on the breast: implications for testosterone therapy for women. Endocr Rev 25: 374-388, 2004.
4. Labrie F, Luu-The V, Labrie C, Bélanger A, Simard J, Lin SX and Pelletier G: Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocr Rev 24: 152-182, 2003.
5. Yeh S, Hu YC, Wang PH, Xie C, Xu Q, Tsai MY, Dong Z, Wang RS, Lee TH and Chang C: Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J Exp Med 198: 1899-1908, 2003.
6. Agrawal AK, Jeleń M, Grzebieniak Z, Zukrowski P, Rudnicki J and Nienartowicz E: Androgen receptors as a prognostic and predictive factor in breast cancer. Folia Histochem Cytobiol 46: 269-276, 2008.
7. Niemeier LA, Dabbs DJ, Beriwal S, Striebel JM and Bhargava R: Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. Mod Pathol 232: 205-212, 2010.
8. Lanzino M, Sisci D, Morelli C, Garofalo C, Catalano S, Casaburi I, Capparelli C, Giordano C, Giordano F, Maggiolini M and Andò S: Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells - identification of a novel androgen response element. Nucleic Acids Res 38: 5351-5365, 2010.
9. Gonzalez LO, Corte MD, Vazquez J, Junquera S, Sanchez R, Alvarez AC, Rodriguez JC, Lamelas ML and Vizoso FJ: Androgen receptor expression in breast cancer: relationship with clinicopathological characteristics of the tumors, prognosis, and expression of metalloproteases and their inhibitors. BMC Cancer 8: 149, 2008.
10. Castellano I, Allia E, Accortanzo V, Vandone AM, Chiusa L, Arisio R, Durando A, Donadio M, Bussolati G, Coates AS, Viale G and Sapino A: Androgen receptor expression is a significant prognostic factor in estrogen receptor positive breast cancers. Breast Cancer Res Treat 124: 607-617, 2010.
11. Agoff SN, Swanson PE, Linden H, Hawes SE and Lawton TJ: Androgen receptor expression in estrogen receptor-negative breast cancer. Immunohistochemical, clinical, and prognostic associations. Am J Clin Pathol 120: 725-731, 2003.
12. Nahleh Z: Androgen receptor as a target for the treatment of hormone receptor negative breast cancer: an unchartered territory. Future Oncol 4: 15-21, 2008.
13. Yu Q, Niu Y, Liu N, Zhang JZ, Liu TJ, Zhang RJ, Wang SL, Ding XM and Xiao XQ: Expression of androgen receptor in breast cancer and its significance as a prognostic factor. Ann Oncol 226: 1288-1294, 2011.
14. Collins LC, Cole KS, Marotti JD, Hu R, Schnitt SJ and Tamimi RM: Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the Nurses' Health Study. Mod Pathol 24: 924-931, 2011.
15. Baniahmad A: Nuclear hormone receptor co-repressors. J Steroid Biochem Mol Biol 93: 89-97, 2005.
16. Dehm SM and Tindall DJ: Molecular regulation of androgen action in prostate cancer. J Cell Biochem 99: 333-344, 2006.
17. Nicolás Díaz-Chico B, Germán Rodríguez F, González A, Ramírez R, Bilbao C, Cabrera de León A, Aguirre Jaime A, Chirino R, Navarro D and Díaz-Chico JC: Androgens and androgen receptors in breast cancer. J Steroid Biochem Mol Biol 105: 1-15, 2007.
18. Shi XB, Tepper CG and De Vere White RW: Cancerous miRNAs and their regulation. Cell Cycle 7: 1529-1538, 2008.
19. Shi XB, Xue L, Yang J, Ma AH, Zhao J, Xu M, Tepper CG, Evans CP, Kung HJ and De Vere White RW: An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proc Natl Acad Sci USA 104: 19983-19988, 2007.
20. Takayama K, Tsutsumi S, Katayama S, Okayama T, Horie-Inoue K, Ikeda K, Urano T, Kawazu C, Hasegawa A, Ikeo K, Gojyobori T, Ouchi Y, Hayashizaki Y, Aburatani H and Inoue S: Integration of cap analysis of gene expression and chromatin immunoprecipitation analysis on array reveals genome-wide androgen receptor signaling in prostate cancer cells. Oncogene 30: 619-630, 2011.
21. Jovanovic M and Hengartner MO: miRNAs and apoptosis: RNAs to die for. Oncogene 25: 6176-6187, 2006.
22. Büssing I, Slack FJ and Grosshans H: Let-7 microRNAs in development, stem cells and cancer. Trends Mol Med 14: 400-409, 2008.
23. Schickel R, Boyerinas B, Park SM and Peter ME: MicroRNAs, key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 27: 5959-5974, 2008.
24. Stefani G and Slack FJ: Small non-coding RNAs in animal develop ment. Nat Rev Mol Cell Biol 9: 219-230, 2008.
25. Cho WC: OncomiRs: the discovery and progress of microRNAs in cancers. Mol Cancer 6: 60, 2007.
26. Hall RE, Birrell SN, Tilley WD and Sutherland RL: MDA-MB-453, an androgen-responsive human breast carcinoma cell line with high level androgen receptor expression. Eur J Cancer 30A: 484-490, 1994.
27. Yeap BB, Krueger RG and Leedman PJ: Differential posttranscriptional regulation of androgen receptor gene expression by androgen in prostate and breast cancer cells. Endocrinology 140: 3282-3291, 1999.
28. Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P, Xing L, Hung MC, Bonfiglio T, Hicks DG and Tang P: The expression patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines. Breast Cancer (Auckl) 4: 35-41, 2010.
29. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR, Lao KQ, Livak KJ and Guegler KJ: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33: e179, 2005.
30. Louie MC, Yang HQ, Ma AH, Xu W, Zou JX, Kung HJ and Chen HW: Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex. Proc Natl Acad Sci USA 100: 2226-2230, 2003.
31. Seifer DB, MacLaughlin DT, Penzias AS, Behrman HR, Asmundson L, Donahoe PK, Haning RV Jr and Flynn SD: Gonadotropin-releasing hormone agonist-induced differences in granulosa cell cycle kinetics are associated with alterations in follicular fluid müllerian-inhibiting substance and androgen content. J Clin Endocrinol Metab 76: 711-714, 1993.
32. Harvey JM, Clark GM, Osborne CK and Allred DC: Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J Clin Oncol 17: 1474-1481, 1999.
33. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T and Takahashi T: Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 64: 3753-3756, 2004.
34. Dahiya N, Sherman-Baust CA, Wang TL, Davidson B, Shih IeM, Zhang Y, Wood W III, Becker KG and Morin PJ: MicroRNA expression and identification of putative miRNA targets in ovarian cancer. PLoS One 3: e2436, 2008.
35. O'Hara AJ, Wang L, Dezube BJ, Harrington WJ Jr, Damania B and Dittmer DP: Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcoma. Blood 113: 5938-5941, 2009.
36. Engels BM and Hutvagner G: Principles and effects of microRNA-mediated post-transcriptional gene regulation. Oncogene 25: 6163-6169, 2006.
37. Sampson VB, Rong NH, Han J, Yang Q, Aris V, Soteropoulos P, Petrelli NJ, Dunn SP and Krueger LJ: MicroRNA let-7a downregulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res 67: 9762-9770, 2007.
38. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D and Slack FJ: RAS is regulated by the let-7 microRNA family. Cell 120: 635-647, 2005.
39. He XY, Chen JX, Zhang Z, Li CL, Peng QL and Peng HM: The let-7a microRNA protects from growth of lung carcinomaby suppression of k-Ras and c-Myc in nude mice. J Cancer Res Clin Oncol 136: 1023-1028, 2010.
40. Akao Y, Nakagawa Y and Naoe T: let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull 29: 903-906, 2006.
41. Lee RC, Feinbaum RL, Ambros V and The C: Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854, 1993.
42. Cho WC: OncomiRs: the discovery and progress of microRNAs in cancers. Mol Cancer 6: 60, 2007.
43. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR and Ruvkun G: The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403: 901-906, 2000.
44. Ruby JG, Jan C, Player C, Axtell MJ, Lee W, Nusbaum C, Ge H and Bartel DP: Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell 127: 1193-1207, 2006.
45. Sempere LF, Christensen M, Silahtaroglu A, Bak M, Heath CV, Schwartz G, Wells W, Kauppinen S and Cole CN: Altered microRNA expression confined to specific epithelial cell subpopulations in breast cancer. Cancer Res 67: 11612-11620, 2007.
46. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J and Song E: let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131: 1109-1123, 2007.