Oncothermia: A new paradigm and promising method in cancer therapies

Acupuncture and Electro-Therapeutics Research

Volumn 38, Issue 3-4, 2013, Pages 161-197

  Hegyi, Gabriella ^a   Szasz, Oliver ^b   Szasz, Andras ^b  

^a UNIVERSITY OF PÉCS   (Hungary)

^b Saint Stephan's University   (Hungary)

Author keywords

Cancer therapy; Cell membrane; Hyperthermia; Modulated radiofrequency; Oncothermia

Indexed keywords

ACUPUNCTURE; ANIMAL; ARTICLE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HYPERTHERMIC THERAPY; IMMUNOLOGY; MOUSE; MULTIMODALITY CANCER THERAPY; NEOPLASM; RADIOFREQUENCY RADIATION; TUMOR CELL LINE;

ACUPUNCTURE THERAPY; ANIMALS; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPERTHERMIA, INDUCED; MICE; NEOPLASMS; RADIO WAVES;

EID: 84891922882     PISSN: 03601293     EISSN: None     Source Type: Journal    
DOI: 10.3727/036012913X13831832269243     Document Type: Article

References (132)

1. Seegenschmiedt MH, Vemon CCA: Historical perspective on hyperthermia in oncology. Seegenschmiedt MH, Fessenden P, Vemon CC : Thermoradiotherapy and thermochemotherapy Vol 1, Springer Verlag Berlin Heidelberg . 1995
2. Szasz A, Szasz N, Szasz O: Hyperthermie in der Onkologie mit einem historischen uberblick, Deutsche Zeitschrift fur Onkologie. 35:140-154. 2000 (Pubitemid 37356140)
3. Medieval literature - 1. Medieval Turkish Surgical manuscript from Charaf ed-Din, 1465 (Paris, Bibliotheque Nationale), 2. Armamentarium chirurgicum of Johann Schultes, Amsterdam 1672 (Paris, Bibliotheque de Faculte Medicine), cited by: Seegenschmiedt MH, Vemon CC:A Historical Perspective on Hyperthermia in Oncology, In: Seegenschmiedt MH, Fessenden P, Vemon CC (eds): Thermoradiotherapy and thermochemotherapy Vol 1. Springer/Verlag Berlin Heidelberg. 1995
4. Seegenschmiedt MH, Vemon CC A historical perspective on hyperthermia in oncology, In: Seegenschmiedt MH., Fessenden P., Vemon CC. (Eds.) Thermo-radiotherapy and Thermochemiotherapy. Springer. Berlin Heidelberg. 1:3-46.1996
5. Szasz A Physical background and technical realization of hyperthermia, in: Locoregional Radiofrequency-Perfusional- and Wholebody- Hyperthermia in Cancer Treatment: New clinical aspects, Eds Baronzio GF, Hager ED), Springer Science Eurekah.com. Ch.3. PP. 27-59.2006
6. Szasz A, Szasz O, Szasz N Electrohyperthermia: a new paradigm in cancer therapy, Wissenschaft & Forschung, Deutsche Zeitschrift für Onkologie. 33:91-99. 2001 (Pubitemid 38173273)
7. Szasz A, Vincze Gy Dose concept of oncological hyperthermia: heat-equation considering the cell destruction, Journal of Cancer Research and Therapeutics. 2:17-181.2007
8. Oliveira RS, Bevilacqua FRG, Chammas R: Hyperthermia increases the metastatic potential of murine melanoma. Braz J Med Biol Res. 30:941-945. 1997
9. Erdmann B, Lang J, Seebass M Optimization of temperature distributions for regional hyperthermia based on a nonlinear heat transfer model. Annals of NY AS, 85836-46 1998
10. Szasz A, Szasz N, Szasz O Oncothermia - Principles and Practices Springer. 2010
11. An docs G et al. Strong synergy of beat and modulated electromagnetic field in tumor cell killing, Study of HT29 xenograft tumors in a nude mice model. Radiology and Oncology, Strahlentherapic und Onkologie.185:120-126.2009
12. Manno AA, Iliev IG, Schwalke MA, Gonzalez E, Marter KC, Flanagan CA Association between cell membrane potential and breast cancer. Tumour Biol. 15.82-89.1994
13. Cure JC Ont he electrical charateristics of cacer. II> International Congress of Electrochemical Treatment of Cancer. Jupiter. Florida.1995
14. Revici E: Research in Pathophysiology as Basis Guided Chemotherapy, with Special Application to Cancer. Princeton, NJ > D. Van Nostrand Compani.1961
15. Seeger PG, Wolz S Succesful biological contol of cancer. Neuwieder Verlagsgesellschaft Gmbh. 1991
16. Cure JC. :Cancer an electrical phenomenon. Resonant 1.1991
17. Foster KR, Schepps JL Dielectric properties of tumor and normal tissues at radio through microwave frequencies J. Microwave Power 16:107-1191981
18. Camazine S, Deneubourg JL, Franks NR et al Self-organization in biological systems Princeton Studies in Complexity. Princeton Univ. Press. Princeton, Oxford,2003
19. Bak P, Tang C, Wicserteld K Self-organized criticality Phys Rev. A. 38 364-373.1988.
20. Raff Mr Social controls on cell survival and death. Nature 356(6368) 397-400.1992
21. Loewenstein WR, Kanno Y Intercellular Communications and Tissue Growth, I. Cancerous Growth. The Journal of Cell Biology 33; 225-234,1967
22. Loeweastern WR The touchstone of life, Molecular information, cell communication and the foundations of the life. Oxford University Press. Oxford, New York, pp 298-304,1999
23. Barnes F, Kwon Y A theoretical Study of the Effects of RF Fields in the vicinity of membranes. Bioelectromagnetics 26: 118-124.2005
24. Groves JT, Boxer SG, McConnell HM Electric field-induced critical demixing in lipid bilayer membranes. Proc. Natl. Acad. Sci. USA 95:935-938.1998
25. de Pomerai DI et al Growth and maturation of the nematode Caenorhabditis elegans following exposure to weak microwave fields. Enzyme and Microbial Technology 30:73-79.2002
26. Szasz A, Vincze Gy, Szasz O, Szasz N: An energy analysis of extracellular hyperthermia. Magneto- and electro-biology 22:103-115.2003
27. Renner H Klinikum Nord, Nuernberg, Cases of Prof.Dr.Renner's Office. 2008
28. Weaver JC, Astumian RD The response of living cells to very week electric fields: The thermal noise limit. Science 247:459-462.1990
29. Kaune WT Thermal noises limit on the sensitivity of cellular membranes to power frequency electric and magnetic fields. Bioelectromagnetics 23:622-628.2002
30. Vincze Gy, Szász A, Szasz N On the thermal noise limit of cellular membranes. Bioelectromagnetics.26:28-35. 2005 (Pubitemid 40053360)
31. Szasz A, Szendro P, Vincze Gy Pink-noise behaviour of biosystems. Eur.Biophvsics J. 30:227-231.2001
32. Szendrö P, Vincze G, Szász A Bio-response to white noise excitation. Electro- and Magnetobiologv 20:215-229.2001
33. Kotnik T, Miklavcic D Theoretical evaluation of the distributed power dissipation in biological cells exposed to electric field. Bioelectromagnetics. 21:385-394.2000
34. Weinbaurn S, Jiji LM A new simplified bioheat equation for the effect of blood-flow on local average tissue temperature. J. Biomech. Ene 107:131-139.1985
35. Szász A: Hyperthermia a modality in the wings, Journal of Cancer Research and Therapeutics. 3:56-66.2007
36. Watson B W Reappraisal: The treatment of tumors with direct electric current. Med. Sci. Res. 19.103-105.1991
37. Xin Y-L Organization and spread electrochemical therapy ECT in China, Eur J Surg S-574:25-30,1994, and
38. Xin Y-L Advances in the treatment of malignant tumors by electrochemical therapy (ECT). Eur. J Surg S-574 31-36.1994
39. Xin Y-L, Xue F-Z, Ge B-S et al. Electrochemical treatment of lung cancer, Bioelectromagnetics, 18.8-13. 1997
40. The first international conference on the topic was in Beijing, China October 20-22,1992 (200 Chinese and 30 foreign participants, one-hundred-thirty-six papers were presented), from that time in every second year regularly held, special international organization (IABC) organized with the center in USA
41. Holt JAG. Microwaves are not hyperthermia.The Radiographer.35.151-162. 1988
42. McCaig CD, Rajnicek AM, Song B, Zhao M. Controlling cell behaviour electrically: Current views and future potential Phvsiol Rev. 85.943-978.2005
43. Szasz N. Electric field regulation of chondrocyte proliferation, biosynthesis and cellular signalling PhD theses, MIT, Cambridge, USA
44. Scholz B, Anderson R: On electrical impedance scanning - principles and simulations. Erectromedica 68:35-44, 2000
45. Sersa I, Beravs K, Dodd NJF et al.: Electric current density imaging of mice tumors. MRM 37:404-409.1997
46. Scott GC, Joy MLG, Armstrong RL, Henkelman RM. Electromagnetic considerations for RF current density imaging IEEE Trans Med Imaging 14 515-524, 1995
47. Mikac U, Dernsar F, Beravs K, Sersa I. Magnetic Resonance Imaging of alternating electric currents Magnetic Resonance Imaging 19.845-856.2001
48. Johns L.D: Nonthermal effects of therapeutic ultrasound: The frequency resonance hypothes Journal of Athletic Training 37(31:293-299.2002
49. Szent-Györgyi A Introduction to a submolecular biology. Academic Press. New York and London. 1960
50. Schwan HP: Nonthermal cellular effects of electromagnetic fields: AC-field induced ponderomotoric forces. Br. J. Cancer 45:220.1982
51. Pekar R, Korpan NN: Krebs - Die medizinische und die biologische Tragödie. Vienna, Munich Berne,2002
52. Ling X-Y: Advances in the treatment of malignant tumors by Electrochemical Therapy ECT Eur.J.Surgery. Suppl. 574:S31-36.1994
53. Xin Y, Xue F.Ge B et al. Electrochemical treatment of lung cancer Bioelectromagnetics 18(1) 8-13 2001 (Pubitemid 127472932)
54. Quan K Analysis of the clinical effectiveness of 144 cases of soft tissue and superficial maligniant tumors treated with electrochemical therapy The European Journal of Sureerv Suppl. 574:S45-49. Scandinavian University Press.1994
55. IABC Public Symposium and Professional Seminar, Palm Beach, FL, USA, November 6-8, 2008
56. Andocs G, Szasz O, Renner H, Patonay L, Balogh L, Fonyad L, Jakab Cs, Szasz A: Synergy of temperature-dependent and field-dependent effects at HT29 xenograft study in nude mice. Electromagnetic Biology and Medicine. 2008
57. Andocs G, Renner H, Balogh L, Fonyad L, Jakab Cs, Szasz A: Strong synergy of heat and modulated electromagnetic field in tumor cell killing, Study of HT29 xenograft tumors in a nude mice model, Radiology and Oncology [Strahlentheraoie und Onkologie]. 185:120-126.2009
58. Brunner G Klinik Hornheide, Munster Univ., Germany, Hyperthermia Symposium, Cologne.2006
59. Andocs G, Meggyeshazy n experimental oncothermia in nude mice xenograft tumor models It International Oncothermia Symposium. Cologne. November 22-23.2010
60. Andocs G, Szasz O, Szasz A Oncothermia treatment of cancer: From the laboratory to clinic. Electromagn. Biol. Med. 28(21:148-165.2009
61. Oliveira-Filho RS, Bevilacqua RG, Chammas R: Hyperthermia increases the metastatic potential of murine melanoma, Brazilian Journal of Medical and Biological Research. 30:941-945.1997
62. Brunner G.:Zellulare hyperthermie-effecte in vitro in einem progressionsmodell des plattenepithelkarzinoms. Hyperhermia Seminar. Cologne. Germany Sept 22-23.2006
63. Brunner G, Erkell L: Cellular and molecular effects of electrohyperthermia in a cell model of skin cancer progression. 10th International Congress on Hyperthermic Oncology.ICHO'2008. 9-12 April. Munich. 2008
64. Andocs G Forum hyperthermia, (Forum Medizine), Front page, 1/10/2008
65. Andocs G, Kampinga HH Private communication. Unpublished results made at Department of Radiation and Stress Cell Biology, Faculty of Medical Sciences, University of Groningen (2008).
66. Szasz O, Andocs G, Szasz A Thermally induced effects in oncothermia treatment, Symposium on Biophysical Aspects of Cancer, Electromagnetic mechanisms, (in memoriam H. Froelich), Prague, 1-3. July, 2008, submitted to Electrom. Bio. Med. (2008)
67. Bremnes RM, Veve R, Hirsch FR, Franklin WA The E-cadherin cell-cell adhesion complex and lung cancer invasion, metastasis, and prognosis, Lung Cancer 36:115-124,2002 (Pubitemid 34302891)
68. Andocs G, Szasz O, Szasz A. Oncothermia treatment of cancer: From the laboratory to clinic, symposium on biophysical aspects of cancer, electromagnetic mechanisms, (in memoriam H. Froelich), Prague, 1-3. July, 2008, Electrom. Bio. Med. 2008
69. Gijnvan ME, Snel F, Cleutjens JPM, Smits JFM, Blankesteijn WM. Overexpression of components of the frizzled-dishevelled cascade results in apoptotic cell death, mediated by b-catenin. Exp. Cell Res. 265:46-53.2001
70. Surveillance, Epidemiology, and End Results (SEER), National Cancer Institute. www.sccr.cancer.gov. April, 2000
71. EUROCARE-3, European Cancer Database, www.eurocare org/profiles/index. html
72. Szasz A, Dani A, et al: Retrospective analysis of 1180 oncological patients treated by electrohyperthermia in Hungary, DEGRO 11. Jahreskongress der Deutschen Gesellschaft für Radioonkologie. 26-29 Mai 2005. Kongresszentrum. Karlsruhe. 2005
73. Szasz A, Dani A, Varkonyi A Az elektro-hipertermia eredményei nagyszámú beteg retrospektív kiérté kelésének tükrében Magyarországon, Magyar Klinikai Onkológiai Tàrsasàg III Kongresszusa. 2004. November 17-20. Hilton Budapest Hotel WestEnd. 2004
74. Sahinbas H, Baier JE, Groenemeyer DHW, Boecher E, Szasz A: Retrospective clinical study for advanced brain-gliomas by adjuvant oncothermia (electro-hyperthermia) treatment, ICHS Conference. 2006
75. Hager ED, Dziambor H, App EM, Popa C, Popa O, Hertlein M The treatment of patients with high-grade malignant gliomas with RF-hyperthermia. Proc ASCO 2003; 22:118, #47, Proc Am Soc Clin Oncol 22.2003
76. Hager ED, Dziambor H, Hohmann D, Gallenbeck D, Stephan M, Popa C et al: Deep hyperthermia with radiofrequencies in patients with liver metastases from colorectal cancer. Anticancer Res. 19(4C):3403-3408. 1999 (Pubitemid 30000195)
77. Hager ED, Süße B, Popa C, Schrittwieser G, Heise A, Kleef R Complex therapy of the not in sano respectable carcinoma of the pancreas - a pilot study. J Cancer Res Clin Oncol. 120 (Suppl.):R47.P 1.04.15.1994
78. Hager ED, Dziambor H, Hoehmann D Survival and quality of life patients with advanced pancreatic cancer. Proc ASCO 2002; 21:136b, No.2357; Proc Am Soc Clin Oncol 21. 2002
79. Dani A, Varkonyi A, Nyiro I, Osvath M Clinical experience of electro-hyperthermia for advanced pancreatic tumors. ESHO Conference. Munich. June. 2003
80. Dani A: Electro-hyperthermia for advanced pancreas tumors, Deutscher Kongress für Radioonkologie. Strahlenbiologie und Medizinische Physik, Erfurt 10-13 June 2004
81. Dani A, Varkonyi A, Magyar T, Szasz A: Clinical study for advanced pancreas cancer treated by oncothermia. Forum Hyperthermia, Forum Medizine. 2:13-19.2008
82. Hager ED, Krautgartner I, Popa C, Höhmann D, Dziambor H Deep Hyperthermia with short waves of patients with advanced stage lung cancer. Hyperthermia in clinical practice. XXII Meeting of the International Clinical Hyperthermia Society. 1999
83. Dani A et al. Treatment of non-small-cell lung cancer by electro-hyperthermia. Strahlenbiologie und Medizinische Physik Deutscher Kongress für Radioonkologie (DEGRO) Erfurt 10-13 June 2004.2004
84. Aydin H Radiotherapy for liver-metastases and therapy-resistant bone-metastases. Hyperthermia Seminaries. 24-25. October 2003. Cologne. 2003
85. Bogovic J, Douwes F, Muravjov G, Istomin Jet al Posttreatment histology and microcirculation status of osteogenic sarcoma after a neoadjuvant chemo- and radiotherapy in combination with local electromagnetic hyperthermia. Onkologie. 24:55-58.2001
86. Unschuld, Paul Ulrich: Medicine in China: A History of Ideas. University of California Press. 1985
87. Longo F "Traditional chinese medicine in oncology", in "Proceedings of the 56th S.C.I.V.A.C. National Congress": Rimini. June 1/3. PP. 230 - 232. 2007
88. Szasz A, Hegyi G, Andocs G, Szasz O: Oncothermia combination with traditional Chinese medicine: network approach. First International Oncothermia Symposium. 22-23 November. Cologne. Germany, 2010
89. Yun-Mo Li et al: Extracts from the roots of lindera strychifolia induces apoptosis in lung cancer cells and prolongs survival of tumor-bearing Mice. The American Journal of Chinese Medicine. 31(6):857-869. 2003
90. Saw CL-L, Qing Wu, Ah-Ng Tony Kong Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 anti-oxidative stress/anti-inflammatory pathways. Chinese Medicine 5:37. 2010
91. Ernst E, Pittler MH, Wider B, Boddy K "Acupuncture: its evidence-base is changing". Am J Chin Med. 35(1):21-25.2007
92. Szasz A, Hegyi,G: Electromagnetic considerations of meridian network (A network approach). International Council of Medical Acupuncture and Related Techniques, (ICMART). XIII World Congress. Oct. 10-12. Budapest. 2008
93. Haken H: Self-organization and information. Phys. Script. 35(3):247-254.1987
94. Deering W, West BJ: Fractal physiology. IEEE Engineering in Medicine and Biology 11(2):40-46. 1992
95. Brown JH, West GB eds Scaling in Biology. Oxford University Press. Oxford. 2000
96. Szendrô P, Vincze G, Szász A Pink-noise behaviour of biosystems. Eur.Biophvsics J. 30:227-231.2001
97. Vincze G, Szasz A, Liboff A New theoretical treatment of inon resonance phenomena. Bioelectromagnetics. 29:380-386.2008
98. Szász A, Vincze Gy, Andocs G, Szasz O Do Field-Free Electromagnetic Potentials Play a Role in Biology? Electromagnetic Biology and Medicine. 28:135-147. 2009
99. Hegyi G, Ji'an L, Bingsheng H, Andocs G, Szasz O, Szasz A Oncothermia combination with traditional Chinese medicine: Proposal on Chinese herbal medicine approach. First International Oncothermia Symposium. 22-23 November. 2011, Cologne. Germany, 2010
100. Yamaguchi N, Takahashi T, Sakuma M, Sugita T, Ichikawa K., Sakaihara S, Kanda T et al: Acupuncture regulates leukocyte, and lymphocyte subpopulations in human peripheral blood: A, quantitative and qualitative discussion. Evid Based Complement, Alternat Med 4:447-453. 2007
101. Petti F, Bangrazi A, Liguori A, Reale G, Ippoliti F: Effects of acupuncture, on immune response related to opioid-like peptides. J Tradit Chin Med 18:55-63. 1998 (Pubitemid 128682138)
102. Karst M, Scheinichen D, Rueckert T, Wagner T, Wiese B., Piepenbrock S, Fink M: Effect of acupuncture on the neutrophil, respiratory burst: a placebo-controlled single-blinded study. Complement Ther Med 11:4-10.2003
103. Lu W, Matulonis UA, Doherty-Gilman A, Lee H, Dean-Clower E, Rosulek A, Gibson C et al Acupuncture for chemotherapyinduced, neutropenia in patients with gynecologic malignancies:, A pilot randomized, sham-controlled clinical trial. J Ahem. Complement Med 15:745-753. 2009
104. Karst M, Scheinichen D, Rueckert T, Wagner T, Wiese B, Fink M: Acupuncture has no immediate treatment effect on the neutrophil, respiratory burst: a randomized single-blinded twoperiod, crossover study. Brain Behav Immun 16:813-6. 2002 (Pubitemid 36027071)
105. Wu B, Zhou RX, Zhou MS: Effect of acupuncture on interleukin-, 2 level and NK cell immunoactivity of peripheral blood of malignant, tumor patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 14:537-539. 1994
106. Liu X, Sun L, Xiao J, Yin S, Liu C, Li Q, Li H et al: Effect of acupuncture, and pointinjection treatment on immunologic function, in rheumatoid arthritis. J Tradit Chin Med 13:174-178. 1993
107. Petti FB, Liguori A, Ippoliti F: Study on cytokines IL-2, IL-6, IL-10, in patients of chronic allergic rhinitis treated with acupuncture. J Tradit Chin Med 22:104-111.2002
108. Yu P, Bai H, Chen L, Zhang W, Xia Y, Wu G: Clinical study on therapeutic, effect of acupuncture on Behcet's disease. J Tradit Chin, Med 23:271-273.2003
109. Wozniak PR, Stachowiak GP, Pieta-Dolinska AK, Oszukowski PJ: Anti-phlogistic and immunocompetent effects of acupuncture, treatment in women suffering from chronic pelvic inflammatory, diseases. Am J Chin Med 31:315-320. 2003 (Pubitemid 41758852)
110. Akimoto T, Nakahori C, Aizawa K, Kimura F, Fukubayashi T, Kono, I: Acupuncture and responses of immunologic and endocrine, markers during competition. Med Sci Snorts Exerc 35:1296-302. 2003 (Pubitemid 36936146)
111. Kho HG, Van Egmond J, Eijk RJ, Kapteyns WM: Lack of influence of acupuncture and transcutaneous stimulation on the immunoglobulin, levels and leucocyte counts following upperabdominal, surgery. Eur J Anaesthesiol 8:39-45. 1991
112. Zhang BR, Li S, Yuan PY, Zhang XB, Cheng LX, Zhou HH, Zhou CY et al: Effects of injection of Huangqi injectio into Zusanli (ST 36), on immune function in the patient of schizophrenia. Zhongguo. Zhen Jiu 26:625-628.2006
113. Zhao R, Ma C, Tan L, Zhao X, Zhuang D:The effect of acupuncture, on the function of macrophages in rats of immunodepression. Zhen Ci Yan Jiu 19:66-68. 1994
114. Scognamillo-Szabo MV, Bechara GH, Ferreira SH, Cunha FQ: Effect of various acupuncture treatment protocols upon sepsis, in Wistar rats. Ann. N Y. Acad. Sci. 1026:251-256.2004
115. Okumura M, Toriizuka K, Iijima K, Haruyama K, Ishino S, Cyong JC. Effects of acupuncture on peripheral T lymphocyte subpopulation, and amounts of cerebral catecholamines in mice. Acupunct. and Electrotherapies 24:127-139. 1999
116. Sato T, Yu Y, Guo SY, Kasahara T, Hisamitsu T Acupuncture stimulation, enhances splenic natural killer cell cytotoxicity in rats. Jpn J Phvsiol 46:131-136. 1996 (Pubitemid 26229273)
117. Ye F, Liu D, Wang S, Xu L: Effects of electro-acupuncture on T cell, subpopulations, NK activity, humoral immunity and leukocyte, count in patients undergoing chemotherapy. J Tradit Chin Med 27:19-21.2007
118. Aoki E, Kasahara T, Hagiwara H, Sunaga M, Hisamitsu N, Hisamitsu T: Electroacupuncture and moxibustion influence, the lipopolysaccharide-induced TNF-alpha production by macrophages. In Vivo 19:495-500. 2005 (Pubitemid 40568126)
119. Fang JQ, Aoki E, Yu Y, Sohma T, Kasahara T, Hisamitsu T: Inhibitory effect of electroacupuncture on murine collagen arthritis and, its possible mechanisms. In Vivo 13:311-318. 1999 (Pubitemid 29515581)
120. Kavoussi B, Ross BE: The neuroimmune basis of anti-inflammatory, acupuncture. Integr Cancer Ther 6:251 -257.2007
121. Yu Y, Kasahara T, Sato T, Asano K, Yu G, Fang J, Guo S et al: Role, of endogenous interferon-gamma on the enhancement of, splenic NK cell activity by electroacupuncture stimulation in, mice. J Neuroimmunol 90:176-186. 1998 (Pubitemid 28511482)
122. Yu Y, Kasahara T, Sato T, Guo SY, Liu Y, Asano K, Hisamitsu T: Enhancement of splenic interferon-gamma, interleukin-2, and, NK cytotoxicity by S36 acupoint acupuncture in F344 rats. Jnn J Phvsiol 47:173178. 1997
123. Hahm ET, Lee JJ, Lee WK, Bae HS, Min BI, Cho YW: Electroacupuncture, enhancement of natural killer cell activity suppressed by, anterior hypothalamic lesions in rats. Neuroimmunomodulation 11:268-272. 2004
124. Choi GS, Oha SD, Han JB, Bae HS, Cho YW, Yun YS, Lee WK et al: Modulation of natural killer cell activity affected by electroacupuncture, through lateral hypothalamic area in rats. Neurosci Lett 329:1-4. 2002
125. Kim CK, Choi GS, Oh SD, Han JB, Kim SK, Ahn HJ, Bae H et al: Electroacupuncture upregulates natural killer cell activity: identification, of genes altering their expressions in electroacupuncture, induced up-regulation of natural killer cell activity. J Neuroimmuno 168:144-153.2005
126. Park MB, Ko E, Ahn C, Choi H, Rho S, Shin MK, Hong MC et al: Suppression of IgE production and modulation of Th1/Th2, cell response by electroacupuncture in DNP-KLH immunized mice. J Neuroimmunol 151:40-44.2004
127. Zhang Y, Wu GC, He QZ, Cao XD: Effect of morphine and electroacupuncture, (EA) on apoptosis of thymocytes. Acupunct. Electrother Res 25:17-26. 2000 (Pubitemid 30333697)
128. Cheng XD, Wu GC, He QZ, Cao XD Effect of electroacupuncture, on the activities of tyrosine protein kinase in subcellular fractions, of activated T lymphocytes from the traumatized rats. Acupunct Electrother Res 23:161- 170 1998
129. McMaster University Explores Evidence based Chinese medicine, http://www.integrativeonc.org/mcmaster-universitv-explores-evidence-based- chinese-medicine
130. Jin-Ling Tang, Bao-Yan Liu, Kan-Wen Ma Traditional chinese medicine, The Lancet. 373:1938-1940.2008
131. Normile D: The new face of traditional chinese medicine. Science, 299, www.sciencemag.org. 2003
132. .Hegyi G, Han Bingsheng, Li Jian, Andocs G, Szasz O, Szasz A.: Oncothermia combination with Traditional Chinese Medicine, http://www.io- svmposium.com/oncothermia/2010/noster/P24-Herbs.pdf and lecture. 2010