Strong synergy of heat and modulated electromagnetic field in tumor cell killing;Ausgeprägte Synergie zwischen Hyperthermie und moduliertem elektromagnetischem Feld bei der Abtötung von Tumorzellen

Strahlentherapie und Onkologie

Volumn 185, Issue 2, 2009, Pages 120-126

  Andocs, Gabor ^a,b   Renner, Helmut ^c,e   Balogh, Lajos ^a   Fonyad, Laszlo ^d   Jakab, Csaba ^b   Szasz, Andras ^b  

^a National Research Institute for Radiobiology and Radiohygiene Budapest   (Hungary)

^b SZENT ISTVÁN UNIVERSITY   (Hungary)

^c KLINIKUM NÜRNBERG   (Germany)

^d SEMMELWEIS UNIVERSITY   (Hungary)

^e NONE   (Switzerland)

Author keywords

Bioelectromagnetics; Hyperthermia; Modulated electric field; Tumor treatment

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARCINOMA CELL; COLORECTAL CARCINOMA; CONTROLLED STUDY; ELECTROMAGNETIC FIELD; FEMALE; HISTOPATHOLOGY; HYPERTHERMIC THERAPY; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; TEMPERATURE DEPENDENCE; TUMOR VOLUME;

EID: 61349131963     PISSN: 01797158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00066-009-1903-1     Document Type: Article

References (46)

1. R.O. Becker D.G. Murray 1967 A method for producing cellular redifferentiation by means of very small electrical currents Trans N Y Acad Sci Ser II 29 606 15
2. Becker RO, Selden G. The body electric. New York: Quill, Morrow, 1985.
3. M. Bini A. Ignesti L. Millanta 1985 An unbalanced electric applicator for RF hyperthermia IEEE Trans Biomed Eng 32 638 41
4. Brunner G. Elektrohyperthermie von Hautkrebbszellen: neue Ergebnisse zu potentiellen molekularen Wirkunngsmechanismen. Hyperthermie-Symposium, Köln, 19.-20. Oktober 2007.
5. Brunner G, Erkell L. Cellular and molecular effects of electrohyperthermia in a cell model of skin cancer progression. 10th International Congress on Hyperthermic Oncology, ICHO 2008, Munich, April 9-12, 2008.
6. V. Cherepenin A. Karpov A. Korjenevsky 2002 Preliminary static EIT images of the thorax in health and disease Physiol Meas 23 33 41
7. A. Chiabrera M. Hisenkamp A.A. Pilla 1979 Cytofluorometry of electro-magnetically controlled cell dedifferentiation J Histochem Cytochem 27 375 81
8. C.D. Cone M. Tongier 1971 Control of somatic cell mitosis by simulated changes in transmembrane potential level Oncogenesis 25 168 82
9. DeVita VT, Hellman SJr, Rosenberg SA. Cancer: principles and practice of oncology, 7th edn. Philadelphia: Lippincott, Williams & Wilkins, 2004:771-5, 1110-1, 1312, 2569-70.
10. D. Fatehi J. van der Zee A. Notenboom 2007 Comparison of intratumor and intraluminal temperatures during locoregional deep hyperthermia of pelvic tumors Strahlenther Onkol 183 479 86
11. H.J. Feldmann M. Molls P. Vaupel 1999 Blood flow and oxygenation status of human tumors - clinical investigations Strahlenther Onkol 175 479 86
12. G. Fiorentini A. Szasz 2006 Hyperthermia today: electric energy, a new opportunity in cancer treatment J Cancer Res Ther 2 41 6
13. R. Goldman S. Pollack 1996 Electric fields and proliferation in a chronic wound model Bioelectromagnetics 17 450 7
14. Grimnes S, Martinsen OG. Bioimpedance and bioelectricity basis. New York: Academic Press, 2000.
15. W. Harms R. Krempien C. Grehn 2006 Electromagnetically navigated brachytherapy as a new treatment option for peripheral pulmonary tumors Strahlenther Onkol 182 108 11
16. D.B. Harrington R.O. Becker 1973 Electrical stimulation of RNA and protein synthesis in the frog erythrocyte Exp Cell Res 76 95 8
17. D. Holder 2002 Biomedical applications of electrical impedance tomography [Editorial] Physiol Meas 23 3
18. J.A.G. Holt 1988 Microwaves are not hyperthermia Radiographer 35 151 62
19. E.D. Kirson V. Dbaly F. Tovarys 2007 Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors PNAS 104 10152 7
20. E.D. Kirson Z. Gurvich R. Schneiderman 2004 Disruption of cancer cell replication by alternating electric fields Cancer Res 64 3288 95
21. Kufe DW, Bast RC, Hait W, et al., eds. Cancer medicine. Holland-Frei - Cancer medicine 7. American Association for Cancer Research. Hamilton, Ontario: BC Decker, 2006.
22. J. Lövey B. Bereczky R. Gilly 2008 Recombinant human erythropoietin alpha improves the efficacy of radiotherapy of a human tumor xenograft, affecting tumor cells and microvessels Strahlenther Onkol 184 1 7
23. C.D. McCaig A.M. Rajnicek B. Song 2005 Controlling cell behaviour electrically: current views and future potential Physiol Rev 85 943 78
24. V. Milani M. Pazos R.D. Issels 2008 Radiochemotherapy in combination with regional hyperthermia in preirradiated patients with recurrent rectal cancer Strahlenther Onkol 184 163 8
25. O.S. Nielsen M. Horsman J. Overgaard 2001 A future for hyperthermia in cancer treatment? Eur J Cancer 37 1587 9
26. Overgaard J. Effect of local hyperthermia alone and in combination with radiation on solid tumors. In: Streffer C, van Beuningen D, Dietzel F, et al., eds. Cancer therapy by hyperthermia and radiation. Baltimore-München: Urban & Schwarzenberg, 1978:49-61.
27. Perez CA, Brady LW, Halperin EC, et al. Principles and practice of radiation oncology, 4th edn. Philadelphia: Lippincott, Williams & Wilkins, 2004:699-735.
28. W. Rhomberg J. Hammer F. Sedlmayer 2007 Irradiation with and without razoxane in the treatment of incompletely resected or inoperable recurrent rectal cancer Strahlenther Onkol 183 380 4
29. P.J. Riu J. Rosell R. Bragos 1999 Electrical bioimpedance methods Ann N Y Acad Sci 873 17 24
30. C. Rödel R. Sauer 2007 Integration of novel agents into combined-modality treatment of rectal cancer patients Strahlenther Onkol 183 227 35
31. S. Salinari A. Bertuzzi G. Mingrone 2002 New bioimpedance model accurately predicts lower limb muscle volume: validation by magnetic resonance imaging Am J Physiol Endocrinol Metab 282 E960 6
32. B. Scholtz R. Anderson 2000 On electrical impedance scanning - principles and simulations Electromedica 68 35 44
33. M.H. Seegenschmiedt C.C. Vernon 1995
34. H.J. Smit A. Vonk Noordegraaf R.J. Roeleveld 2002 Epoprostenol-induced pulmonary vasodilatation in patients with pulmonary hypertension measured by electrical impedance tomography Physiol Meas 23 237 43
35. N. Szasz 2003
36. A. Szasz 2006 Hyperthermia: a modality in the wings J Cancer Res Ther 2 171 81
37. A. Szasz 2006
38. A. Szasz O. Szasz N. Szasz 2001 Electrohyperthermia: a new paradigm in cancer therapy Dtsch Z Onkol 33 91 9
39. A. Szasz G. Vincze 2006 Dose concept of oncological hyperthermia: heat-equation considering the cell destruction J Cancer Res Ther 2 171 81
40. A. Szasz G. Vincze O. Szasz 2003 An energy analysis of extracellular hyperthermia Electro-Magneto-biol Med 22 103 15
41. P. Szendro G. Vincze A. Szasz 2001 Bio-response to white noise excitation Electro- Magneto-biol Med 20 215 29
42. P. Szendro G. Vincze A. Szasz 2001 Pink-noise behaviour of biosystems Eur Biophys J 30 227 31
43. W. Tilly J. Gellermann R. Graf 2005 Regional hyperthermia in conjunction with definitive radiotherapy against recurrent or locally advanced prostate cancer T3 pN0 M0 Strahlenther Onkol 181 35 41
44. J. Van der Zee 2002 Heating the patient: a promising approach? Ann Oncol 13 1173 84
45. G. Vincze A. Szasz N. Szasz 2005 On the thermal noise limit of cellular membranes Bioelectromagnetics 26 28 35
46. B.W. Watson 1991 Reappraisal: the treatment of tumours with direct electric current Med Sci Res 19 103 5