Role for terminal complement activation in amyotrophic lateral sclerosis disease progression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 1, 2014, Pages

  Woodruff, Trent M ^a   Lee, John D ^a   Noakes, Peter G ^a,b  

^a School of Biomedical Sciences   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT FACTOR; COPPER ZINC SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; BRAIN CELL; CELL SURVIVAL; COMPLEMENT ACTIVATION; DISEASE COURSE; LETTER; METABOLIC STRESS; MOTONEURON; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; COMPLEMENT C1Q; COMPLEMENT PATHWAY, CLASSICAL; MOTOR NEURONS; SUPEROXIDE DISMUTASE;

EID: 84891916131     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321248111     Document Type: Letter

References (5)

1. Lobsiger CS, et al. (2013) C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proc Natl Acad Sci USA 110(46): E4385-E4392.
2. Lee JD, et al. (2013) Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis. J Neuroinflammation 10(1):119.
3. Huber-Lang M, et al. (2006) Generation of C5a in the absence of C3: A new complement activation pathway. Nat Med 12(6): 682-687.
4. Pavlovski D, et al. (2012) Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis. FASEB J 26(9): 3680-3690.
5. Woodruff TM, et al. (2008) The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol 181(12): 8727-8734.