Intravesical instillation of c-MYC inhibitor KSI-3716 suppresses orthotopic bladder tumor growth

Journal of Urology

Volumn 191, Issue 2, 2014, Pages 510-518

  Jeong, Kyung Chae ^a   Kim, Kyung Tae ^a   Seo, Hye Hyun ^a   Shin, Seung Pil ^a   Ahn, Kyung Ohk ^a   Ji, Min Ju ^a   Park, Weon Seo ^a   Kim, In Hoo ^a   Lee, Sang Jin ^a   Seo, Ho Kyung ^a  

^a National Cancer Center   (South Korea)

Author keywords

administration; drug therapy; gene expression; heterografts; intravesical; urinary bladder neoplasms

Indexed keywords

ANTINEOPLASTIC AGENT; KSI 3716; UNCLASSIFIED DRUG; CYCLIN D2; CYCLIN DEPENDENT KINASE 4; MAX PROTEIN; MYC PROTEIN; PROTEIN INHIBITOR; TELOMERASE REVERSE TRANSCRIPTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER CANCER; CANCER INHIBITION; CELL CYCLE; CELL CYCLE ARREST; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOTOXICITY ASSAY; FEMALE; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; LUMINESCENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TUMOR XENOGRAFT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; COMPLEX FORMATION; CONCENTRATION RESPONSE; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; HISTOPATHOLOGY; IN VIVO STUDY; PROTEIN BINDING; QUANTITATIVE ANALYSIS; TRANSCRIPTION TERMINATION;

5-ETHYNYL-2′-DEOXYURIDINE; ADMINISTRATION; CDK4; CHIP; CHROMATIN IMMUNOPRECIPITATION; CONSENSUS RESPONSE ELEMENT; CRE; CYCLIN-DEPENDENT KINASE 4; DIMETHYL SULFOXIDE; DMSO; DRUG THERAPY; EDU; GENE EXPRESSION; HALF INHIBITORY CONCENTRATION; HETEROGRAFTS; HTERT; HUMAN TELOMERASE REVERSE TRANSCRIPTASE; IC(50); INTRAVESICAL; PARP; PBS; PCR; PEG; PHOSPHATE BUFFERED SALINE; POLY ADENOSINE DIPHOSPHATE RIBOSE POLYMERASE; POLYETHYLENE GLYCOL; POLYMERASE CHAIN REACTION; QRT-PCR; QUANTITATIVE RT-PCR; REVERSE TRANSCRIPTASE-PCR; RT-PCR; URINARY BLADDER NEOPLASMS;

4-QUINOLONES; ADMINISTRATION, INTRAVESICAL; ANILINE COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; MICE, INBRED BALB C; PROTO-ONCOGENE PROTEINS C-MYC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84891904422     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2013.07.019     Document Type: Article

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