Effect of single nucleotide polymorphisms of the prostacyclin receptor gene on platelet activation in Japanese healthy subjects and patients with cerebral infarction

Journal of Clinical Neuroscience

Volumn 20, Issue 6, 2013, Pages 851-856

  Shimizu, Mie ^a   Yoshimura, Shinichi ^a   Takizawa, Shunya ^a   Kohara, Saori ^a   Inoko, Hidetoshi ^a   Takagi, Shigeharu ^a  

^a TOKAI UNIVERSITY   (Japan)

Author keywords

Cerebral infarction; Platelet activation; Prostacyclin receptor gene; Single nucleotide polymorphism

Indexed keywords

ADENINE; CYTOSINE; PROSTACYCLIN RECEPTOR; (4 BENZYLPIPERAZIN 1 YL)ACETIC ACID (3 ALLYL 2 HYDROXYBENZYLIDENE)HYDRAZINE; (4-BENZYLPIPERAZIN-1-YL)ACETIC ACID (3-ALLYL-2-HYDROXYBENZYLIDENE)HYDRAZINE; HYDRAZONE DERIVATIVE; PADGEM PROTEIN; PIPERAZINE DERIVATIVE; PROSTAGLANDIN RECEPTOR; PTGIR PROTEIN, HUMAN; SELP PROTEIN, HUMAN;

ADULT; ARTICLE; BRAIN INFARCTION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROSTACYCLIN RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; GENETIC PREDISPOSITION; GENETICS; JAPAN; METABOLISM; MIDDLE AGED;

ADULT; CEREBRAL INFARCTION; FEMALE; FLOW CYTOMETRY; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYDRAZONES; JAPAN; MALE; MIDDLE AGED; P-SELECTIN; PIPERAZINES; PLATELET ACTIVATION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, PROSTAGLANDIN;

EID: 84891881898     PISSN: 09675868     EISSN: 15322653     Source Type: Journal    
DOI: 10.1016/j.jocn.2012.06.011     Document Type: Article

References (28)

1. Jennings LK. Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis. Thromb Haemost 2009;102:248-57.
2. Langer HF, Gawaz M. Platelet-vessel wall interactions in atherosclerotic disease. Thromb Haemost 2008;99:480-6.
3. Matarin M, Brown WM, Dena H, et al. Candidate gene polymorphisms for ischemic stroke. Stroke 2009;40:3436-42.
4. Yamada Y, Kato K, Oguri M, et al. Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population. J Med Genet 2008;45:216-21.
5. Marenberg ME, Risch N, Berkman LF, et al. Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 1994;330:1041-6.
6. Peters A, Schneider A, Greven S, et al. AIRGENE study group. Air pollution and inflammatory response in myocardial infarction survivors: gene-environment interactions in a high-risk group. Inhal Toxicol 2007;19:161-75.
7. Turin TC, Kita Y, Rumana N, et al. Morning surge in circadian periodicity of ischaemic stroke is independent of conventional risk factor status: findings from the Takashima Stroke Registry 1990-2003. Eur J Neurol 2009;16:843-51.
8. Ilveskoski E, Perola M, Lehtimäki T, et al. Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: an autopsy study. Circulation 1999;100:608-13.
9. Granér M, Kahri J, Varpula M, et al. Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease. Nutr Metab Cardiovasc Dis 2008;18:271-7.
10. Weiss EJ, Bray PF, Tayback M, et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med 1996;334:1090-4.
11. Grove EL, Ørntoft TF, Lassen JF, et al. The platelet polymorphism PlA2 is a genetic risk factor for myocardial infarction. J Intern Med 2004;255:637-44.
12. Carter AM, Catto AJ, Bamford JM, et al. Platelet GP IIIa P1A and GP Ib variable number tandem repeat polymorphisms and markers of platelet activation in acute stroke. Arterioscler Thromb Vasc Biol 1998;18:1124-31.
13. Fetalvero KM, Martin KA, Hwa J. Cardioprotective prostacyclin signaling in vascular smooth muscle. Prostaglandins Other Lipid Mediat 2007;82:109-18.
14. Michelson AD. Flow cytometry: a clinical test of platelet function. Blood 1996;87:4925-36.
15. Michelson AD. Evaluation of platelet function by flow cytometry. Pathophysiol Haemost Thromb 2006;35:67-82.
16. Shimizu M, Kohara S, Yamamoto M, et al. Significant relationship between platelet activation and intra-media thickness of the carotid artery in patients with ischemic cerebrovascular disease. Thromb Res 2006;117:647-52.
17. Ogawa Y, Tanaka I, Inoue M, et al. Structural organization and chromosomal assignment of the human prostacyclin receptor gene. Genomics 1995;27:142-8.
18. Stitham J, Stojanovic A, Hwa J. Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism. J Biol Chem 2002;277:15439-44.
19. Murata T, Ushikubi F, Matsuoka T, et al. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 1997;388:678-82.
20. Xiao CY, Hara A, Yuhki K, et al. Roles of prostaglandin I2 and thromboxane A2 in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors. Circulation 2001;104:2210-5.
21. Cheng Y, Austin SC, Rocca B, et al. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 2002;296:539-41.
22. Francois H, Athirakul K, Howell D, et al. Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metab 2005;2:201-7.
23. Ginsberg MH, Frelinger AL, Lam SC, et al. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Blood 1990;76:2017-23.
24. Merten M, Thiagarajan P. P-selectin in arterial thrombosis. Z Kardiol 2004;93:855-63.
25. Stitham J, Arehart EJ, Gleim SR, et al. Human prostacyclin receptor structure and function from naturally-occurring and synthetic mutations. Prostaglandins Other Lipid Mediat 2007;82:95-108.
26. Patrignani P, Di Febbo C, Tacconelli S, et al. Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study. Pharmacogenet Genomics 2008;18:611-20.
27. Fontana P, Gandrille S, Remones V, et al. Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers. Thromb Haemost 2006;96:356-60.
28. Nakayama T, Soma M, Saito S, et al. Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction. Am Heart J 2002;143:797-801.