Evaluation of Phyllanthus emblica extract on cold pressor induced cardiovascular changes in healthy human subjects

Pharmacognosy Research

Volumn 6, Issue 1, 2014, Pages 29-35

  Fatima, Nishat ^a   Pingali, Usharani ^a   Pilli, Raveendranadh ^a  

^a NIZAM'S INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Augmentation index; cardiovascular disease; cold pressor test; Phyllanthus emblica

Indexed keywords

EMBLICA OFFICINALIS EXTRACT; EMBLICANIN A; EMBLICANIN B; PEDUNCULAGIN; PLACEBO; PUNIGLUCONON; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

ABDOMINAL DISCOMFORT; ADULT; AORTA PRESSURE; ARTERIAL STIFFNESS; ARTICLE; AUGMENTATION INDEX; AUGMENTATION PRESSURE; CARDIOVASCULAR PARAMETERS; COLD PRESSOR TEST; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG INDUCED HEADACHE; EMBLICA OFFICINALIS; HEART MUSCLE PERFUSION; HEART RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; NORMAL HUMAN; PRESSURE; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; YOUNG ADULT;

EID: 84891878245     PISSN: None     EISSN: 09748490     Source Type: Journal    
DOI: 10.4103/0974-8490.122914     Document Type: Article

References (30)

1. McEwen BS, Wingfield JC. The concept of allostasis in biology and biomedicine. Horm Behav 2003;43:2-15.
2. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 1992;267:1244-52.
3. Rozanski A, Blumenthal JA, Kaplan J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation 1999;99:2192-217.
4. Lopacszyski W, Zeisel SH. Antioxidants, programmed cell death and cancer. Nutr Res 2001;21:295-307.
5. Eqbal MD, Abdullah A, Sani AH. Natural antioxidants, lipid profile, lipid peroxidation, antioxidant enzymes of different vegetable oils. Adv J Food Sci Technol 2011;3:308-16.
6. Hallibell V. Antioxidants in Disease Mechanisms and Therapy. Advances in Pharmacology. Vol. 38. Academic Press; 1997. p. 3-17.
7. Udupa KN, Singh RH. Clinical and experimental studies on rasayana drugs and panchakarma therapy. New Delhi: Central Council for Research in Ayurveda and Siddha; 1995.
8. Kenjale RD, Shah RK, Sathaye SS. Anti-stress and anti-oxidant effects of roots of Chlorophytum borivilianum (Santa Pau and Fernandes). Indian J Exp Biol 2007;45:974-9.
9. Bhatia J, Tabassum F, Sharma AK, Bharti S, Golechha M, Joshi S, et al. Emblica officinalis exerts antihypertensive effect in a rat model of DOCA-salt-induced hypertension: Role of (p) eNOS, NO and oxidative stress. Cardiovasc Toxicol 2011;11:272-9.
10. Reddy KS, Rani PU, Naidu MU, Rao TR. A simple cold pressure technique for the evaluation of analgesic drugs in healthy subjects. Indian J Pharmacol 2012;44:571-5.
11. Karamanoglu M, ORourke MF, Avolio AP, Kelly RP. An analysis of the relationship between central aortic and peripheral upper limb pressure waves in man. Eur Heart J 1993;14:160-7.
12. Chen CH, Nevo E, Fetics B, Pak PH, Yin FC, Maughan WL, et al. Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function. Circulation 1997;95:1827-36.
13. Vlachopoulos C, Hirata K, ORourke MF. Effect of caffeine on aortic elastic properties and wave reflection. J Hypertens 2003;21:563-70.
14. Doonan RJ, Scheffler P, Yu A, Egiziano G, Mutter A, Bacon S, et al. Altered arterial stiffness and subendocardial viability ratio in young healthy light smokers after acute exercise. PLoS One 2011;6:e26151.
15. Culić V. Acute risk factors for myocardial infarction. Int J Cardiol 2007;117:260-9.
16. Marchant B, Ranjadayalan K, Stevenson R, Wilkinson P, Timmis AD. Circadian and seasonal factors in the pathogenesis of acute myocardial infarction: The influence of environmental temperature. Br Heart J 1993;69:385-7.
17. Boutouyrie P, Lacolley P, Girerd X, Beck L, Safar M, Laurent S. Sympathetic activation decreases medium-sized arterial compliance in humans. Am J Physiol 1994;267:H1368-76.
18. Mitchell GF. Arterial stiffness and wave reflection: Biomarkers of cardiovascular risk. Artery Res 2009;3:56-64.
19. Rajak S, Banerjee SK, Sood S, Dinda AK, Gupta YK, Gupta SK, et al. Emblica officinalis causes myocardial adaptation and protects against oxidative stress in ischemic-reperfusion injury in rats. Phytother Res 2004;18:54-60.
20. Bhattacharya A, Chatterjee A, Ghosal S, Bhattacharya SK. Antioxidant activity of active tannoid principles of Emblica officinalis (amla). Indian J Exp Biol 1999;37:676-80.
21. McRae AL, Saladin ME, Brady KT, Upadhyaya H, Back SE, Timmerman MA. Stress reactivity: Biological and subjective responses to the cold pressor and trier social stressors. Hum Psychopharmacol 2006;21:377-85.
22. Schwabe L, Haddad L, Schachinger H. HPA axis activation by a socially evaluated cold-pressor test. Psychoneuroendocrinology 2008;33:890-5.
23. Edwards DG, Gauthier AL, Hayman MA, Lang JT, Kenefick RW. Acute effects of cold exposure on central aortic wave reflection. J Appl Physiol 2006;100:1210-4.
24. Brown CM, Sanya EO, Hilz MJ. Effect of cold face stimulation on cerebral blood flow in humans. Brain Res Bull 2003;61:81-6.
25. Patel HM, Mast JL, Sinoway LI, Muller MD. Effect of healthy aging on renal vascular responses to local cooling and apnea. J Appl Physiol 2013;115:90-6.
26. Edwards DG, Roy MS, Prasad RY. Wave reflection augments central systolic and pulse pressures during facial cooling. Am J Physiol Heart Circ Physiol 2008;294:H2535-9.
27. Tapas P, Regmi P, Adhikari P, Roychowdhury P. Cold pressor test as a predictor of hypertension. J Tehran Univ Heart Cent 2009;3:177-80.
28. Mourot L, Bouhaddi M, Regnard J. Effects of the cold pressor test on cardiac autonomic control in normal subjects. Physiol Res 2009;58:83-91.
29. Thangaraj R, Rathakrishnan SA, Pannerselvam M, Jayaraman B. Antioxidant property of Emblica officinalis during experimentally induced restrain stress in rats. J Health Sci 2007;53:496-9.
30. Gopa B, Bhatt J, Hemavathi KG. A comparative clinical study of hypolipidemic efficacy of Amla (Emblica officinalis) with 3-hydroxy-3- methylglutaryl-coenzyme-A reductase inhibitor simvastatin. Indian J Pharmacol 2012;44:238-42.