Cerebral hemodynamic and ventilatory responses to hypoxia, hypercapnia, and hypocapnia during 5 days at 4,350 m

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 1, 2014, Pages 52-60

  Rupp, Thomas ^a   Esteve, François ^b   Bouzat, Pierre ^b   Lundby, Carsten ^c   Perrey, Stéphane ^d   Levy, Patrick ^a   Robach, Paul ^a,e   Verges, Samuel ^a  

^a University Grenoble Alpes   (France)

^b GRENOBLE INSTITUT DES NEUROSCIENCES   (France)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY OF MONTPELLIER   (France)

^e Ecole Nationale de Ski et d'Alpinisme   (France)

Author keywords

altitude illness; carbon dioxide; cerebral hemodynamic; near infrared spectroscopy; oxygenation

Indexed keywords

CARBON DIOXIDE; DEOXYHEMOGLOBIN; HEMOGLOBIN;

ADULT; ALTITUDE; ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; AMBIENT AIR; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; CARDIOPULMONARY FUNCTION; CLINICAL ARTICLE; DEOXYGENATION; HEART RATE; HEMODYNAMICS; HEMOGLOBIN DETERMINATION; HUMAN; HYPERCAPNIA; HYPOCAPNIA; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; NEAR INFRARED SPECTROSCOPY; OXYGENATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; SEA LEVEL; SPIN LABELING; TISSUE OXYGENATION; TRANSCRANIAL DOPPLER;

EID: 84891832656     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.167     Document Type: Article

References (44)

1. Hornbein TF. The high-altitude brain. J Exp Biol 2001; 204: 3129-3132.
2. Moller K, Paulson OB, Hornbein TF, Colier WN, Paulson AS, Roach RC et al. Unchanged cerebral blood flow and oxidative metabolism after acclimatization to high altitude. J Cereb Blood Flow Metab 2002; 22: 118-126.
3. Severinghaus JW, Chiodi H, Eger 2nd EI, Brandstater B, Hornbein TF. Cerebral blood flow in man at high altitude. Role of cerebrospinal fluid pH in normalization of flow in chronic hypocapnia. Circ Res 1966; 19: 274-282.
4. Jensen JB, Wright AD, Lassen NA, Harvey TC, Winterborn MH, Raichle ME et al. Cerebral blood flow in acute mountain sickness. J Appl Physiol 1990; 69: 430-433.
5. Ainslie PN, Ogoh S. Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance. Exp Physiol 2009; 95: 251-262.
6. Smielewski P, Kirkpatrick P, Minhas P, Pickard JD, Czosnyka M. Can cerebrovascular reactivity be measured with near-infrared spectroscopy? Stroke 1995; 26: 2285-2292.
7. Perrey S. Non-invasive NIR spectroscopy of human brain function during exercise. Methods 2008; 45: 289-299.
8. Ainslie PN, Barach A, Murrell C, Hamlin M, Hellemans J, Ogoh S. Alterations in cerebral autoregulation and cerebral blood flow velocity during acute hypoxia: rest and exercise. Am J Physiol Heart Circ Physiol 2007; 292: H976-H983.
9. Kolb JC, Ainslie PN, Ide K, Poulin MJ. Protocol to measure acute cerebrovascular and ventilatory responses to isocapnic hypoxia in humans. Respir Physiol Neurobiol 2004; 141: 191-199.
10. Peltonen JE, Kowalchuk JM, Paterson DH, DeLorey DS, duManoir GR, Petrella RJ et al. Cerebral and muscle tissue oxygenation in acute hypoxic ventilatory response test. Respir Physiol Neurobiol 2007; 155: 71-81.
11. Jensen JB, Sperling B, Severinghaus JW, Lassen NA. Augmented hypoxic cerebral vasodilation in men during 5 days at 3, 810 m altitude. J Appl Physiol 1996; 80: 1214-1218.
12. Poulin MJ, Fatemian M, Tansley JG, O'Connor DF, Robbins PA. Changes in cerebral blood flow during and after 48 h of both isocapnic and poikilocapnic hypoxia in humans. Exp Physiol 2002; 87: 633-642.
13. Ainslie PN, Burgess K, Subedi P, Burgess KR. Alterations in cerebral dynamics at high altitude following partial acclimatization in humans: wakefulness and sleep. J Appl Physiol 2007; 102: 658-664.
14. Ainslie PN, Burgess KR. Cardiorespiratory and cerebrovascular responses to hyperoxic and hypoxic rebreathing: effects of acclimatization to high altitude. Respir Physiol Neurobiol 2008; 161: 201-209.
15. Jansen GF, Krins A, Basnyat B. Cerebral vasomotor reactivity at high altitude in humans. J Appl Physiol 1999; 86: 681-686.
16. Lucas SJ, Burgess KR, Thomas KN, Donnelly J, Peebles KC, Lucas RA et al. Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m. J Physiol 2011; 589: 741-753.
17. Fan JL, Burgess KR, Basnyat R, Thomas KN, Peebles KC, Lucas SJ et al. Influence of high altitude on cerebrovascular and ventilatory responsiveness to CO2. J Physiol 2010; 588: 539-549.
18. Blaber AP, Hartley T, Pretorius PJ. Effect of acute exposure to 3660 m altitude on orthostatic responses and tolerance. J Appl Physiol 2003; 95: 591-601.
19. Terborg C, Gora F, Weiller C, Rother J. Reduced vasomotor reactivity in cerebral microangiopathy: a study with near-infrared spectroscopy and transcranial Doppler sonography. Stroke 2000; 31: 924-929.
20. Imray CH, Myers SD, Pattinson KT, Bradwell AR, Chan CW, Harris S et al. Effect of exercise on cerebral perfusion in humans at high altitude. J Appl Physiol 2005; 99: 699-706.
21. Salvaggio A, Insalaco G, Marrone O, Romano S, Braghiroli A, Lanfranchi P et al. Effects of high-altitude periodic breathing on sleep and arterial oxyhaemoglobin saturation. Eur Respir J 1998; 12: 408-413.
22. Ainslie PN, Poulin MJ. Ventilatory, cerebrovascular, and cardiovascular interactions in acute hypoxia: regulation by carbon dioxide. J Appl Physiol 2004; 97: 149-159.
23. Villien M, Bouzat P, Rupp T, Robach P, Lamalle L, Tropres I et al. Changes in cerebral blood flow and vasoreactivity to CO(2) measured by Arterial Spin Labeling after 6 days at 4, 350 m. Neuroimage 2013; 72: 272-279.
24. Teppema LJ, Dahan A. The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis. Physiol Rev 2010; 90: 675-754.
25. Martin PJ, Evans DH, Naylor AR. Measurement of blood flow velocity in the basal cerebral circulation: advantages of transcranial color-coded sonography over conventional transcranial Doppler. J Clin Ultrasound 1995; 23: 21-26.
26. Duncan A, Meek JH, Clemence M, Elwell CE, Fallon P, Tyszczuk L et al. Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy. Pediatr Res 1996; 39: 889-894.
27. Roach RC, Bartsch P, Hackett PH, Oelz O. The lake louise acute mountain sickness scoring system. In: Sutton JR, Coates J, HC S (eds). Hypoxia and Molecular Medicine. Queen City Printers: Burlington, VT, 1993, pp 272-274.
28. Sampson JB, Cymerman A, Burse RL, Maher JT, Rock PB. Procedures for the measurement of acute mountain sickness. Aviat Space Environ Med 1983; 54: 1063-1073.
29. Sato M, Severinghaus JW, Powell FL, Xu FD, Spellman Jr. MJ. Augmented hypoxic ventilatory response in men at altitude. J Appl Physiol 1992; 73: 101-107.
30. Kolb JC, Ainslie PN, Ide K, Poulin MJ. Effects of five consecutive nocturnal hypoxic exposures on the cerebrovascular responses to acute hypoxia and hypercapnia in humans. J Appl Physiol 2004; 96: 1745-1754.
31. Winslow RM. The role of hemoglobin oxygen affinity in oxygen transport at high altitude. Respir Physiol Neurobiol 2007; 158: 121-127.
32. Brugniaux JV, Hodges AN, Hanly PJ, Poulin MJ. Cerebrovascular responses to altitude. Respir Physiol Neurobiol 2007; 158: 212-223.
33. Smith ZM, Krizay E, Guo J, Shin DD, Scadeng M, Dubowitz DJ. Sustained high-altitude hypoxia increases cerebral oxygen metabolism. J Appl Physiol 2013; 114: 11-18.
34. Dempsey JA, Forster HV, Gledhill N, doPico GA. Effects of moderate hypoxemia and hypocapnia on CSF [H] and ventilation in man. J Appl Physiol 1975; 38: 665-674.
35. Forster HV, Dempsey JA, Chosy LW. Incomplete compensation of CSF [H] in man during acclimatization to high altitude (48300 M). J Appl Physiol 1975; 38: 1067-1072.
36. Ainslie PN, Lucas SJ, Fan JL, Thomas KN, Cotter JD, Tzeng YC et al. Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans. J Appl Physiol 2012; 113: 1058-1067.
37. Ainslie PN, Tzeng YC. On the regulation of the blood supply to the brain: old age concepts and new age ideas. J Appl Physiol 2010; 108: 1447-1449.
38. Smielewski P, Czosnyka M, Pickard JD, Kirkpatrick P. Clinical evaluation of near-infrared spectroscopy for testing cerebrovascular reactivity in patients with carotid artery disease. Stroke 1997; 28: 331-338.
39. Ide K, Eliasziw M, Poulin MJ. Relationship between middle cerebral artery blood velocity and end-tidal PCO2 in the hypocapnic-hypercapnic range in humans. J Appl Physiol 2003; 95: 129-137.
40. Moller K. Every breath you take: acclimatisation at altitude. J Physiol 2010; 588: 1811-1812.
41. Pagani M, Salmaso D, Sidiras G, Jonsson C, Jacobsson H, Larsson SA et al. Impact of acute hypobaric hypoxia on blood flow distribution in brain. Acta Physiol 2011; 202: 203-209.
42. Poulin MJ, Robbins PA. Indexes of flow and cross-sectional area of the middle cerebral artery using doppler ultrasound during hypoxia and hypercapnia in humans. Stroke 1996; 27: 2244-2250.
43. Wilson MH, Edsell ME, Davagnanam I, Hirani SP, Martin DS, Levett DZ et al. Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia-an ultrasound and MRI study. J Cereb Blood Flow Metab 2011; 31: 2019-2029.
44. McMahon CJ, McDermott P, Horsfall D, Selvarajah JR, King AT, Vail A. The reproducibility of transcranial Doppler middle cerebral artery velocity measurements: implications for clinical practice. Br J Neurosurg 2007; 21: 21-27.