Influence of high altitude on cerebrovascular and ventilatory responsiveness to CO2

Journal of Physiology

Volumn 588, Issue 3, 2010, Pages 539-549

  Fan, Jui Lin ^a   Burgess, Keith R ^b   Basnyat, Riche ^c,d   Thomas, Kate N ^a   Peebles, Karen C ^a   Lucas, Samuel J E ^a,e   Lucas, Rebekah A I ^a,e   Donnelly, Joseph ^a   Cotter, James D ^e   Ainslie, Philip N ^f  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF SYDNEY   (Australia)

^c NEPAL INTERNATIONAL CLINIC   (Nepal)

^d Himalayan Rescue Association   (Nepal)

^e UNIVERSITY OF OTAGO   (New Zealand)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CARBON DIOXIDE; OXYGEN;

ACID BASE BALANCE; ADULT; ALTITUDE ACCLIMATIZATION; ARTERIAL GAS; ARTICLE; BICARBONATE BLOOD LEVEL; BLOOD FLOW VELOCITY; BLOOD OXYGEN TENSION; BLOOD VESSEL TONE; BRAIN BLOOD FLOW; BRAIN CIRCULATION; CHEMORECEPTOR REFLEX; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERCAPNIA; HYPEROXIA; HYPOCAPNIA; LUNG VENTILATION; MALE; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN; PH; PRIORITY JOURNAL; REBREATHING; SEA LEVEL; ALTITUDE; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; END TIDAL CARBON DIOXIDE TENSION; END TIDAL OXYGEN TENSION; RESPIRATORY TRACT PARAMETERS;

ACID-BASE EQUILIBRIUM; ADULT; ALTITUDE; BLOOD FLOW VELOCITY; CARBON DIOXIDE; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOCAPNIA; MALE; PULMONARY VENTILATION;

EID: 75649109272     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2009.184051     Document Type: Article

References (38)

1. Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 1982, 57:769-774.
2. Ainslie PN, Barach A, Murrell C, Hamlin M, Hellemans J, Ogoh S. Alterations in cerebral autoregulation and cerebral blood flow velocity during acute hypoxia: rest and exercise. Am J Physiol Heart Circ Physiol 2007, 292:H976-983.
3. Ainslie PN, Burgess KR. Cardiorespiratory and cerebrovascular responses to hyperoxic and hypoxic rebreathing: effects of acclimatization to high altitude. Respir Physiol Neurobiol 2008, 161:201-209.
4. Ainslie PN, Duffin J. Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol 2009, 296:R1473-1495.
5. Ainslie PN, Ogoh S, Burgess K, Celi L, McGrattan K, Peebles K, Murrell C, Subedi P, Burgess KR. Differential effects of acute hypoxia and high altitude on cerebral blood flow velocity and dynamic cerebral autoregulation: alterations with hyperoxia. J Appl Physiol 2008, 104:490-498.
6. Blaber AP, Hartley T, Pretorius PJ. Effect of acute exposure to 3660 m altitude on orthostatic responses and tolerance. J Appl Physiol 2003, 95:591-601.
7. Burgess K, Fan JL, Peebles KC, Thomas K, Lucas S, Lucas RA, Dawson A, Swart M, Shepherd K, Ainslie P. Exacerbation of obstructive sleep apnea by oral indomethacin. Chest 2010
8. Chapman RW, Santiago TV, Edelman NH. Effects of graded reduction of brain blood flow on chemical control of breathing. J Appl Physiol 1979, 47:1289-1294.
9. Claassen JA, Zhang R, Fu Q, Witkowski S, Levine BD. Transcranial Doppler estimation of cerebral blood flow and cerebrovascular conductance during modified rebreathing. J Appl Physiol 2007, 102:870-877.
10. Cunningham DJ, Hey EN, Patrick JM, Lloyd BB. The effect of noradrenaline infusion on the relation between pulmonary ventilation and the alveolar PO2 and PCO2 in man. Ann N Y Acad Sci 1963, 109:756-771.
11. Dempsey JA, Forster HV, DoPico GA. Ventilatory acclimatization to moderate hypoxemia in man. The role of spinal fluid (H+). J Clin Invest 1974, 53:1091-1100.
12. Duffin J, Mohan RM, Vasiliou P, Stephenson R, Mahamed S. A model of the chemoreflex control of breathing in humans: model parameters measurement. Respir Physiol 2000, 120:13-26.
13. Forster HV, Dempsey JA, Chosy LW. Incomplete compensation of CSF [H+] in man during acclimatization to high altitude (4,300 m). J Appl Physiol 1975, 38:1067-1072.
14. Gardner WN. The pattern of breathing following step changes of alveolar partial pressures of carbon dioxide and oxygen in man. J Physiol 1980, 300:55-73.
15. Hornbein TF, Townes BD, Schoene RB, Sutton JR, Houston CS. The cost to the central nervous system of climbing to extremely high altitude. N Engl J Med 1989, 321:1714-1719.
16. Jansen GF, Krins A, Basnyat B. Cerebral vasomotor reactivity at high altitude in humans. J Appl Physiol 1999, 86:681-686.
17. Lindegaard KF, Lundar T, Wiberg J, Sjoberg D, Aaslid R, Nornes H. Variations in middle cerebral artery blood flow investigated with noninvasive transcranial blood velocity measurements. Stroke 1987, 18:1025-1030.
18. Mahamed S, Cunningham DA, Duffin J. Changes in respiratory control after three hours of isocapnic hypoxia in humans. J Physiol 2003, 547:271-281.
19. Mahamed S, Duffin J. Repeated hypoxic exposures change respiratory chemoreflex control in humans. J Physiol 2001, 534:595-603.
20. Mathew L, Gopinath PM, Purkayastha SS, Sen Gupta J, Nayar HS. Chemoreceptor sensitivity in adaptation to high altitude. Aviat Space Environ Med 1983, 54:121-126.
21. Milledge JS, Sorensen SC. Cerebral arteriovenous oxygen difference in man native to high altitude. J Appl Physiol 1972, 32:687-689.
22. Mohan R, Duffin J. The effect of hypoxia on the ventilatory response to carbon dioxide in man. Respir Physiol 1997, 108:101-115.
23. Mohan RM, Amara CE, Cunningham DA, Duffin J. Measuring central-chemoreflex sensitivity in man: rebreathing and steady-state methods compared. Respir Physiol 1999, 115:23-33.
24. Moller K, Paulson OB, Hornbein TF, Colier WN, Paulson AS, Roach RC, Holm S, Knudsen GM. Unchanged cerebral blood flow and oxidative metabolism after acclimatization to high altitude. J Cereb Blood Flow Metab 2002, 22:118-126.
25. Peebles K, Celi L, McGrattan K, Murrell C, Thomas K, Ainslie PN. Human cerebrovascular and ventilatory CO2 reactivity to end-tidal, arterial and internal jugular vein PCO2. J Physiol 2007, 584:347-357.
26. Reichmuth KJ, Dopp JM, Barczi SR, Skatrud JB, Wojdyla P, Hayes D, Morgan BJ. Impaired vascular regulation in patients with obstructive sleep apnea: Effects of CPAP treatment. Am J Respir Crit Care Med 2010
27. Roy SB, Guleria JS, Khanna PK, Talwar JR, Manchanda SC, Pande JN, Kaushik VS, Subba PS, Wood JE. Immediate circulatory response to high altitude hypoxia in man. Nature 1968, 217:1177-1178.
28. Sahn SA, Zwillich CW, Dick N, McCullough RE, Lakshminarayan S, Weil JV. Variability of ventilatory responses to hypoxia and hypercapnia. J Appl Physiol 1977, 43:1019-1025.
29. Schoene RB, Roach RC, Hackett PH, Sutton JR, Cymerman A, Houston CS. Operation Everest II: ventilatory adaptation during gradual decompression to extreme altitude. Med Sci Sports Exerc 1990, 22:804-810.
30. Secher NH, Seifert T, Van Lieshout JJ. Cerebral blood flow and metabolism during exercise: implications for fatigue. J Appl Physiol 2008, 104:306-314.
31. Severinghaus JW, Mitchell RA, Richardson BW, Singer MM. Respiratory control at high altitude suggesting active transport regulation of Csf Ph. J Appl Physiol 1963, 18:1155-1166.
32. Somogyi RB, Preiss D, Vesely A, Fisher JA, Duffin J. Changes in respiratory control after 5 days at altitude. Respir Physiol Neurobiol 2005, 145:41-52.
33. Vovk A, Cunningham DA, Kowalchuk JM, Paterson DH, Duffin J. Cerebral blood flow responses to changes in oxygen and carbon dioxide in humans. Can J Physiol Pharmacol 2002, 80:819-827.
34. Weiskopf RB, Gabel RA, Fencl V. Alkaline shift in lumbar and intracranial CSF in man after 5 days at high altitude. J Appl Physiol 1976, 41:93-97.
35. Wilson MH, Newman S, Imray CH. The cerebral effects of ascent to high altitudes. Lancet Neurol 2009, 8:175-191.
36. Xie A, Skatrud JB, Barczi SR, Reichmuth K, Morgan BJ, Mont S, Dempsey JA. Influence of cerebral blood flow on breathing stability. J Appl Physiol 2009, 106:850-856.
37. Xie A, Skatrud JB, Khayat R, Dempsey JA, Morgan B, Russell D. Cerebrovascular response to carbon dioxide in patients with congestive heart failure. Am J Respir Crit Care Med 2005, 172:371-378.
38. Xie A, Skatrud JB, Morgan B, Chenuel B, Khayat R, Reichmuth K, Lin J, Dempsey JA. Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans. J Physiol 2006, 577:319-329.