Caspase 3 activation and PARP cleavage in lymphocytes from newborn babies of diabetic mothers with unbalanced glycaemic control

Cell Biochemistry and Function

Volumn 32, Issue 1, 2014, Pages 87-95

  Tarquini, F ^a,e   Tiribuzi, R ^b   Crispoltoni, L ^b   Porcellati, S ^b   Del Pino, A M ^b   Orlacchio, A ^b,c,d,e   Coata, G ^a   Arnone, S ^b   Torlone, E ^b,e   Cappuccini, B ^a,e   Di Renzo, G C ^a,e  

^a University Hospital   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e GeBiSa Research Foundation   (Italy)

Author keywords

Caspase 3; Gestational diabetes mellitus; Lymphocytes; PARP

Indexed keywords

CASPASE 3; GLUCOSE; LIPOPOLYSACCHARIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1;

ADAPTIVE IMMUNITY; ADULT; APOPTOSIS; ARTICLE; BIRTH WEIGHT; CELL CULTURE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; FEMALE; FETUS WEIGHT; FOLLOW UP; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE; MATERNAL DIABETES MELLITUS; METABOLIC REGULATION; MIDDLE AGED; NEWBORN; PLACENTA WEIGHT; PRIORITY JOURNAL; PROTEIN CONTENT; UMBILICAL CORD BLOOD; YOUNG ADULT;

CASPASE 3; GESTATIONAL DIABETES MELLITUS; LYMPHOCYTES; PARP;

ADULT; BLOOD GLUCOSE; CASPASE 3; CELL PROLIFERATION; DIABETES, GESTATIONAL; ENZYME ACTIVATION; FEMALE; FETAL BLOOD; HUMANS; INFANT, NEWBORN; LYMPHOCYTES; POLY(ADP-RIBOSE) POLYMERASES; PREGNANCY;

EID: 84891831475     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.2975     Document Type: Article

References (44)

1. Gabbe S. Gestational diabetes mellitus. N Engl J Med 1986; 315: 1025-1026.
2. O'Sullivan IB. Gestational diabetes studies: review and perspectives. In Carbohydrate Metabolism in Pregnancy and Newborn, vol. 4. Sutherlands HW, Stowers JM, Pearson DWM (eds.). Springer: Berlin, Heidelberg, New York, 1989; 278-294.
3. Mauricio D, De Leiva A. Autoimmune gestational diabetes: a clinical entity? Diabetes Metab Res Rev 2002; 17: 422-428.
4. Buchanan TA, Metger BE, Freinkel N, Bergman RN. Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol 1990; 162: 1008-1014.
5. Whitley GS, Cartwright JE. Cellular and molecular regulation of spiral artery remodelling: lessons from the cardiovascular field. Placenta 2010; 31: 465-474.
6. Fetita LS, Sobngwi E, Serradas P, Calvo F, Gautier JF. Consequences of fetal exposure to maternal diabetes in offspring. J Clin Endocrinol Metab 2006; 91: 3718-3724.
7. Chappell JH, Jr, Wang XD, Loeken MR. Diabetes and apoptosis: neural crest cells and neural tube. Apoptosis 2009; 14: 1472-1483.
8. Cindrova-Davies T, Spasic-Boskovic O, Jauniaux E, Charnock-Jones DS, Burton GJ. Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitamins. Am J Pathol 2007; 170: 1511-1520.
9. Sgarbosa F, Barbisan LF, Brasil MA, et al. Changes in apoptosis and Bcl-2 expression in human hyperglycemic, term placental trophoblast. Diabetes Res Clin Pract 2006; 73: 143-149.
10. Weiss U, Cervar M, Puerstner P, et al. Hyperglycaemia in vitro alters the proliferation and mitochondrial activity of the choriocarcinoma cell lines BeWo, JAR and JEG-3 as models for human first-trimester trophoblast. Diabetologia 2001; 44: 209-219.
11. Enari M, Talanian RV, Wong WW, Nagata S. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 1996; 380: 723-726.
12. D'Amelio M, Cavallucci V, Cecconi F. Neuronal caspase-3 signaling: not only cell death. Cell Death Differ 2010; 17(7): 1104-1114.
13. Ulukaya E, Acilan C, Yilmaz Y. Apoptosis: why and how does it occur in biology? Cell Biochem Funct 2011; 29(6): 468-80.
14. Fischer U, Janicke RU, Schulze-Osthoff K. Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death Differ 2003; 10: 76-100.
15. Rosen A, Casciola-Rosen L. Macromolecular substrates for the ICE-like proteases during apoptosis. J Cell Biochem 1997; 64: 50-54.
16. Sidorkina O, Espey MG, Miranda KM, Wink DA, Laval J. Inhibition of poly(ADP-ribose) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species. Free Radic Biol Med 2003; 35: 1431-1438.
17. Ame JC, Spenlehauer C, de Murcia G. The PARP superfamily. Bioessays 2004; 26(8): 882-893.
18. Tewari M, Quan LT, O'Rourke K, et al. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995; 81: 801-809.
19. Boulares AH, Yakovlev AG, Ivanova V, et al. Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 1999; 274(33): 22932-22940.
20. Lee YH, Lee JC, Moon HJ, et al. Differential effect of oxidative stress on the apoptosis of early and late passage human diploid fibroblasts: implication of heat shock protein 60. Cell Biochem Funct 2008; 26(4): 502-508.
21. HAPO Study Cooperative Research Group, Metzger BE, Lowe LP, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008; 358: 1991-2002.
22. Leary J, Pettitt DJ, Jovanovic L. Gestational diabetes guidelines in a HAPO world. Best Pract Res Clin Endocrinol Metab 2010; 24(4): 673-685.
23. Wendland EM, Torloni MR, Falavigna M, et al. Gestational diabetes and pregnancy outcomes-a systematic review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy Study Groups (IADPSG) diagnostic criteria. BMC Pregnancy Childbirth 2012; 12: 23.
24. Metzer BE, Buchanan TA, Coustan DR, et al. Summary and recommendations of the Fifth International Workshop-Conference on gestational diabetes mellitus. Diabetes Care 2007; 30: S251-S260.
25. Bradford MM. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
26. Tiribuzi R, D'Angelo F, Berardi AC, Martino S, Orlacchio A. Knock-down of HEXA and HEXB genes correlate with the absence of the immunostimulatory function of HSC-derived dendritic cells. Cell Biochem Funct 2011. doi:10.1002/cbf.1819.
27. Li ZF, Zhang S, Lv GB, et al. Changes in count and function of splenic lymphocytes from patients with portal hypertension. World J Gastroenterol 2008; 14: 2377-2382.
28. Zhu XL, Chen AF, Lin ZB. Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice. J Ethnopharmacol 2007; 111: 219-226.
29. Yi CH, Yuan J. The Jekyll and Hyde functions of caspases. Dev Cell 2009; 16: 21-34.
30. Chiarugi A. Inhibitors of poly(ADP-ribose) polymerase-1 suppress transcriptional activation in lymphocytes and ameliorate autoimmune encephalomyelitis in rats. Br J Pharmacol 2002; 137: 761-770.
31. Mahmoud F, Abul H, Omu A, Haines D. Lymphocyte sub-populations in gestational diabetes. Am J Reprod Immunol 2005; 53(1): 21-29.
32. Arya AK, Pokharia D, Tripathi K. Relationship between oxidative stress and apoptotic markers in lymphocytes of diabetic patients with chronic non healing wound. Diabetes Res Clin Pract 2011; 94(3): 377-84.
33. Oleszczak B, Szablewski L, Pliszka M. The effect of glucose concentrations in the medium on expression of insulin receptors in human lymphocytes B and T: an in vitro study. J Recept Signal Transduct Res 2012; [in press]
34. Stentz FB, Kitabchi AE. Activated T lymphocytes in Type 2 diabetes: implications from in vitro studies. Curr Drug Targets 2012; 4(6): 493-503.
35. Tiribuzi R, Orlacchio A, Crispoltoni L, et al. Lysosomal β-galactosidase and β-hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer's disease and Type 2 diabetes mellitus. J Alzheimers Dis 2011; 24(4): 785-797.
36. Fanciulli A, Misasi R, Campanelli D, Buttarelli FR, Pontieri FR. Dopaminergic drug-induced modulation of the expression of the dopamine transporter in peripheral blood lymphocytes in Parkinson's disease. Pharmacol Rep 2011; 63(4): 1056-1060.
37. Mochizuki K, Miyauchi R, Misaki Y, Kasezawa N, Tohyama K, Goda T. Associations between leukocyte counts and cardiovascular disease risk factors in apparently healthy Japanese men. J Nutr Sci Vitaminol 2012; 58(3): 181-186.
38. Abrahams VM, Kim YM, Straszewski SL, Romero R, Mor G. Macrophages and apoptotic cell clearance during pregnancy. Am J Reprod Immunol 2004; 51: 275-282.
39. Woo M, Hakem R, Soengas MS, et al. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 1998; 12: 806-819.
40. Woo M, Hakem R, Furlonger C, et al. Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat Immunol 2003; 4: 1016-1022.
41. Comans-Bitter N, de Groot R, van den Beemd R, et al. Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations. J Pediatr 1997; 130: 388-393.
42. O'Gorman MR, Millard DD, Lowder JN, Yogev R. Lymphocyte subpopulations in healthy 1-3-day-old infants. Cytometry 1998; 34: 235-241.
43. Lapolla A, Sanzari MC, Zancanaro F, et al. A study on lymphocyte subpopulation in diabetic mothers at delivery and in their newborn. Diabetes Nutr Metab 1999; 12: 394-399.
44. Sun LQ, Chen YY, Wang X, et al. The protective effect of alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose. Biochem Pharmacol 2012; 84: 961-973.