IRF4 links antigen affinity to CD8 + T-cell metabolism

Immunology and Cell Biology

Volumn 92, Issue 1, 2014, Pages 6-7

  Finlay, David ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERFERON REGULATORY FACTOR 4; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTOME;

ANTIGEN BINDING; BACTERIAL INFECTION; BINDING AFFINITY; CD8+ T LYMPHOCYTE; CELL METABOLISM; EFFECTOR CELL; FATTY ACID OXIDATION; GENE EXPRESSION REGULATION; GLYCOLYSIS; HUMAN; LISTERIOSIS; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; MEMORY T LYMPHOCYTE; MITOCHONDRIAL RESPIRATION; NOTE; PHENOTYPE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; VIRUS INFECTION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HUMANS; INTERFERON REGULATORY FACTORS; ORTHOMYXOVIRIDAE INFECTIONS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS;

EID: 84891831374     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2013.72     Document Type: Note

References (8)

1. Man K, Miasari M, Shi W, Xin A, Henstridge DC, Preston S et al. The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat Immunol 2013; 14: 1155-1165.
2. Zehn D, Lee SY, Bevan MJ. Complete but curtailed T-cell response to very low-affinity antigen. Nature 2009; 458: 211-214.
3. Finlay DK, Rosenzweig E, Sinclair LV, Feijoo-Carnero C, Hukelmann JL, Rolf J et al. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J Exp Med 2012; 209: 2441-2453.
4. Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 2009; 460: 103-107.
5. Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Hocker L et al. The transcription factor interferon regulatory factor 4 is required for the generation of protective effector CD8+ T cells. Proc Natl Acad Sci USA 2013; 110: 15019-15024.
6. Nayar R, Enos M, Prince A, Shin H, Hemmers S, Jiang JK et al. TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Proc Natl Acad Sci USA 2012; 109: E2794-E2802.
7. Cao Y, Li H, Sun Y, Chen X, Liu H, Gao X et al. Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression. Eur J Immunol 2010; 40: 3198-3209.
8. Chang CH, Curtis JD, Maggi LB Jr., Faubert B, Villarino AV, O'Sullivan D et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 2013; 153: 1239-1251.