Synthesis of the dopamine D2/D3 receptor agonist (+)-PHNO via supercritical fluid chromatography: Preliminary PET imaging study with [3-11C]-(+)PHNO

Tetrahedron Letters

Volumn 55, Issue 3, 2014, Pages 682-685

  Shoup, Timothy M ^a,b   McCauley, John P ^c   Lee, David F ^a   Chen, Rui ^c   Normandin, Marc D ^a,b   Bonab, Ali A ^a,b   El Fakhri, Georges ^a,b   Vasdev, Neil ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c WATERS CORPORATION   (United States)

Author keywords

Brown fat; Carbon 11; PHNO

Indexed keywords

4(CARBON 11)PROPYL 3,4,4A ,5,6,10B HEXAHYDRO 2 NAPHTHO(1,2 B )(1,4)OXAZIN; CARBON 11; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; DEBENZYLATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; ISOTOPE LABELING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SUPERCRITICAL FLUID CHROMATOGRAPHY;

EID: 84891830081     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2013.11.113     Document Type: Article

References (19)

1. J.H. Jones, P.S. Anderson, J.J. Baldwin, B.V. Clineschmidt, D.E. McClure, G.F. Lundell, W.C. Randall, G.E. Martin, and M. Williams J. Med. Chem. 27 1984 1607 1613
2. D.J. Brown, S.K. Luthra, F. Brady, C. Prenant, D. Dijkstra, H. Wikstrom, and D. Brooks Proceedings of the XIIth International Symposium on Radiopharmaceutical Chemistry, Uppsala, Sweden 1997 Wiley Chichester, UK pp 565-566
3. A.A. Wilson, P. McCormick, S. Kapur, M. Willeit, A. Garcia, D. Hussey, S. Houle, P. Seeman, and N. Ginovart J. Med. Chem. 48 2005 4153 4160
4. M. Laruelle Neuromethods 71 2012 163 203
5. M. Skinbjerg, D.R. Sibley, J.A. Javitch, and A. Abi-Dargam Biochem. Pharmacol. 83 2012 193 198
6. C. Plisson, M. Huiban, S. Pampols-Maso, G. Singleton, S.P. Hill, and J. Passchier Appl. Radiat. Isot. 70 2012 380 387
7. S. Oya, S.K. Joseph, P. Carberry, C.R. Divgi, and A.O. Koren J. Labelled Compd. Radiopharm. 56 2013 S466
8. C. Rami-Mark, J. Ungersoeck, D. Haeusler, L. Nics, C. Philippe, M. Mitterhauser, M. Willeit, R. Lanzenberger, G. Karanikas, and W. Wadsak Appl. Radiat. Isot. 82 2013 75 80
9. B. Långström, G. Antoni, P. Gullberg, C. Halldin, and K. Någren et al. Appl. Radiat. Isot. 37 1986 1141 1145
10. S.F. Garcia-Arguello, R. Fortt, R. Colin, J. Steel, D. Brickute, M. Glaser, D.R. Turton, E.G. Robins, E. Arstad, and S.K. Luthra Appl. Radiat. Isot. 73 2013 79 83
11. A. Egerton, E. Hirani, R. Ahmad, D.R. Turton, D. Brickute, L. Rosso, O.D. Howes, S.K. Luthra, and P.M Grasby Synapse 64 2010 301 312
12. R. Perrone, F. Berard, G. Bettoni, and V. Tortorella Farmaco Sci. 40 1985 422 428
13. A. Delgado, J.M. Garcia, D. Mauleon, C. Minguillon, J.R. Subirats, M. Feliz, F. Lopez, and D. Velasco Can. J. Chem. 66 1988 517 527
14. C. O'Brien Chem. Rev. 64 1964 81 90
15. E. Nisoli, C. Tonello, M. Memo, and M.O. Carruba JPET 263 1992 823 829
16. D.C. Borcherding, E.R. Hugo, G. Idelman, A. De Silva, N.W. Richtand, J. Loftus, and N. Ben-Jonathan PLoS One 6 2011 1 10
17. W.W. Blessing, A. Zilm, and Y. Ootsuka Neuroscience 141 2006 2067 2073
18. R.S. McIntyre, D.A. Mancini, and B. Vincenzo J. Clin. Psychiatry 62 2001 23 29
19. M.R. Mirbolooki, C. Constantinescu, M.-L. Pan, and J. Mukherjee J. Nucl. Med. 53 2012 407