Antineuronal antibodies and infectious pathogens in severe acute pediatric encephalitis

Journal of Child Neurology

Volumn 29, Issue 1, 2014, Pages 11-16

  Lin, Jainn Jim ^a,b,c   Lin, Kuang Lin ^a,c   Chiu, Cheng Hsun ^b,c   Hsia, Shao Hsuan ^b,c   Wang, Huei Shyong ^a,c   Chou, I Jun ^a,c   Lin, Yun Tong ^c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c CHANG GUNG CHILDREN S HOSPITAL   (Taiwan)

Author keywords

antineuronal antibody; immune mediated inflammation; severe acute encephalitis

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR ANTIBODY; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID RECPTOR ANTIBODY; ANTIBODY; ANTICONVULSIVE AGENT; AUTOANTIBODY; CONTACTIN ASSOCIATED PROTEIN 2 ANTIBODY; GLUTAMATE DECARBOXYLASE ANTIBODY; GRANULOCYTE ANTIBODY; LEUCINE RICH GLIOMA INACTIVATED 1 PROTEIN ANTIBODY; N METHYL DEXTRO ASPARTIC ACID RECEPTOR ANTIBODY; NEURONAL ANTIBODY; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL COMPLEX ANTIBODY;

ACUTE DISEASE; ADOLESCENT; ARTICLE; BACTERIUM CULTURE; BRAIN HERNIA; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENCEPHALITIS; ENTEROVIRUS; ENTEROVIRUS INFECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPSY; FEMALE; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMUNOASSAY; INFANT; INFLUENZA A; INFLUENZA B; INTENSIVE CARE UNIT; INTRACRANIAL PRESSURE; LEUKOCYTE COUNT; MALE; MYCOPLASMA PNEUMONIA; MYCOPLASMA PNEUMONIAE; OUTCOME ASSESSMENT; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; SEPSIS; THERAPY RESISTANT EPILEPSY; VIRUS CULTURE;

ANTINEURONAL ANTIBODY; IMMUNE-MEDIATED INFLAMMATION; SEVERE ACUTE ENCEPHALITIS;

ADOLESCENT; AUTOANTIBODIES; AUTONOMIC NERVOUS SYSTEM DISEASES; CHILD; CHILD, PRESCHOOL; ENCEPHALITIS; EPILEPSY; FEMALE; GLASGOW COMA SCALE; GLUTAMATE DECARBOXYLASE; HUMANS; INFANT; INFANT, NEWBORN; INFLUENZA A VIRUS; MAGNETIC RESONANCE IMAGING; MALE; MYCOPLASMA PNEUMONIAE; POTASSIUM CHANNELS, VOLTAGE-GATED; RETROSPECTIVE STUDIES; TOMOGRAPHY SCANNERS, X-RAY COMPUTED;

EID: 84891776492     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073812461944     Document Type: Article

References (23)

1. Willoughby RE Principles and Practice of Pediatric Infectious Diseases. Long SS Pickering LK Prober CG, ed. Philadelphia, PA: Elsevier Science ; 2003: 291-292.
2. Graus F, Saiz A, Dalmau J. Antibodies and neuronal autoimmune disorders of the CNS. J Neurol. 2010 ; 257: 509-517
3. Vincent A, Irani SR, Lang B. The growing recognition of immunotherapy-responsive seizure disorders with auto-antibodies to specific neuronal proteins. Curr Opin Neurol. 2010 ; 23: 144-150
4. Vincent A, Bien CG, Irani SR, Waters P. Auto-antibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol. 2011 ; 10: 759-772
5. Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology. 2011 ; 77: 179-189
6. Lin JJ, Lin KL, Wang HS, Hsia SH, Wu CT. Analysis of status epilepticus related presumed encephalitis in children. Eur J Paediatr Neurol. 2008 ; 12: 32-37
7. Lin JJ, Lin KL, Wang HS, Hsia SH, Wu CT.. Effect of topiramate, in combination with lidocaine, and phenobarbital, in acute encephalitis with refractory repetitive partial seizures. Brain Dev. 2009 ; 31: 605-611
8. Lin JJ, Lin KL, Hsia SH, Wu CT, Chou IJ, Wang HS. Analysis of status epilepticus with Mycoplasma pneumoniae encephalitis. Pediatr Neurol. 2010 ; 43: 41-45
9. Fiser DH. Assessing the outcome of pediatric intensive care. J Pediatr. 1992 ; 121: 68-74
10. Wandinger KP, Saschenbrecker S, Stoecker W, Dalmau J. Anti-NMDA-receptor encephalitis: a severe, multi-stage, treatable disorder presenting with psychosis. J Neuroimmunol. 2011 ; 231: 86-91
11. Granerod J, Tam CC, Crowcroft NS, Davies NW, Borchert M, Thomas SL. Challenge of the unknown. A systematic review of acute encephalitis in non-outbreak situations. Neurology. 2010 ; 75: 924-932
12. Gable MS, Gavali S, Radner A, et al. Anti-NMDA receptor encephalitis: report of ten cases and comparison with viral encephalitis. Eur J Clin Microbiol Infect Dis. 2009 ; 28: 1421-1429
13. Gable MS, Sheriff H, Dalmau J, Tilley DH, Glaser CA. The frequency of autoimmune N-methyl-d-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis. 2012 ; 54: 899-904
14. Granerod J, Ambrose HE, Davies NWS, et al. Causes of encephalitis and differences in their clinical presentations in England: a multi-centre, population-based prospective study. Lancet Infect Dis. 2010 ; 10: 835-844
15. van Baalen A, Häusler M, Boor R, et al. Febrile infection-related epilepsy syndrome (FIRES): a non-encephalitic encephalopathy in childhood. Epilepsia. 2010 ; 51: 1323-1328
16. Malter MP, Helmstaedter C, Urbach H, Vincent A, Bien CG. Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. Ann Neurol. 2010 ; 67: 470-478
17. Haberlandt E, Bast T, Ebner A, et al. Limbic encephalitis in children and adolescents. Arch Dis Child. 2011 ; 96: 186-191
18. Korff CM, Parvex P, Cimasoni L, et al. Encephalitis associated with glutamic acid decarboxylase autoantibodies in a child: a treatable condition?. Arch Neurol. 2011 ; 68: 1065-1068
19. Takanashi J, Takahashi Y, Imamura A, et al. Late delirious behavior with 2009 H1N1 influenza: mild autoimmune-mediated encephalitis?. Pediatrics. 2012 ; 129: e1068 - e1071
20. Mata S, Muscas GC, Naldi I, et al. Non-para-neoplastic limbic encephalitis associated with anti-glutamic acid decarboxylase antibodies. J Neuroimmunol. 2008 ; 199: 155-159
21. Blanc F, Ruppert E, Kleitz C, et al. Acute limbic encephalitis and glutamic acid decarboxylase antibodies: a reality?. J Neurol Sci. 2009 ; 287: 69-71
22. Cianci V, Labate A, Lanza P, et al. Non-para-neoplastic limbic encephalitis characterized by mesio-temporal seizures and extra-temporal lesions: a case report. Seizure. 2010 ; 19: 446-449
23. Najjar S, Pearlman D, Najjar A, Ghiasian V, Zagzag D, Devinsky O. Extra-limbic autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: an under-diagnosed entity?. Epilepsy Behav. 2011 ; 21: 306-313