메뉴 건너뛰기




Volumn 34, Issue 3, 2015, Pages 332-341

Overexpression of AKIP1 promotes angiogenesis and lymphangiogenesis in human esophageal squamous cell carcinoma

Author keywords

AKIP1; Angiogenesis; Lymphangiogenesis; VEGF C

Indexed keywords

AKIP1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; VASCULOTROPIN C;

EID: 84891771944     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.559     Document Type: Article
Times cited : (54)

References (46)
  • 3
    • 0037145746 scopus 로고    scopus 로고
    • Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970-90
    • Ke L. Mortality and incidence trends from esophagus cancer in selected geographic areas of China circa 1970-90. Intl J cancer 2002; 102: 271-274.
    • (2002) Intl J Cancer , vol.102 , pp. 271-274
    • Ke, L.1
  • 5
    • 0037378595 scopus 로고    scopus 로고
    • Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease
    • Mariette C, Balon JM, Piessen G, Fabre S, Van Seuningen I, Triboulet JP. Pattern of recurrence following complete resection of esophageal carcinoma and factors predictive of recurrent disease. Cancer 2003; 97: 1616-1623.
    • (2003) Cancer , vol.97 , pp. 1616-1623
    • Mariette, C.1    Balon, J.M.2    Piessen, G.3    Fabre, S.4    Van Seuningen, I.5    Triboulet, J.P.6
  • 6
    • 35448938866 scopus 로고    scopus 로고
    • Lymph node metastasis density and growth pattern as independent prognostic factors in advanced esophageal squamous cell carcinoma
    • Ooki A, Yamashita K, Kobayashi N, Katada N, Sakuramoto S, Kikuchi S et al. Lymph node metastasis density and growth pattern as independent prognostic factors in advanced esophageal squamous cell carcinoma. World J Surg 2007; 31: 2184-2191.
    • (2007) World J Surg , vol.31 , pp. 2184-2191
    • Ooki, A.1    Yamashita, K.2    Kobayashi, N.3    Katada, N.4    Sakuramoto, S.5    Kikuchi, S.6
  • 7
    • 33646841502 scopus 로고    scopus 로고
    • Esophageal squamous cell carcinomas with distinct invasive depth show different gene expression profiles associated with lymph node metastasis
    • Sato T, Iizuka N, Hamamoto Y, Yoshino S, Abe T, Takeda S et al. Esophageal squamous cell carcinomas with distinct invasive depth show different gene expression profiles associated with lymph node metastasis. Int J Oncol 2006; 28: 1043-1055.
    • (2006) Int J Oncol , vol.28 , pp. 1043-1055
    • Sato, T.1    Iizuka, N.2    Hamamoto, Y.3    Yoshino, S.4    Abe, T.5    Takeda, S.6
  • 8
    • 0033396574 scopus 로고    scopus 로고
    • Number of lymph node metastases influences survival in patients with thoracic esophageal carcinoma: Therapeutic value of radiation treatment for recurrence
    • Kimura H, Konishi K, Arakawa H, Oonishi I, Kaji M, Maeda K et al. Number of lymph node metastases influences survival in patients with thoracic esophageal carcinoma: therapeutic value of radiation treatment for recurrence. Dis Esophagus 1999; 12: 205-208.
    • (1999) Dis Esophagus , vol.12 , pp. 205-208
    • Kimura, H.1    Konishi, K.2    Arakawa, H.3    Oonishi, I.4    Kaji, M.5    Maeda, K.6
  • 9
    • 0030026897 scopus 로고    scopus 로고
    • A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
    • Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 1996; 15: 290-298.
    • (1996) EMBO J , vol.15 , pp. 290-298
    • Joukov, V.1    Pajusola, K.2    Kaipainen, A.3    Chilov, D.4    Lahtinen, I.5    Kukk, E.6
  • 10
    • 0029962242 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-related protein: A ligand and specific activator of the tyrosine kinase receptor Flt4
    • Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI. Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. Proc Natl Acad Sci USA 1996; 93: 1988-1992.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1988-1992
    • Lee, J.1    Gray, A.2    Yuan, J.3    Luoh, S.M.4    Avraham, H.5    Wood, W.I.6
  • 11
    • 0035122537 scopus 로고    scopus 로고
    • Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
    • Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 2001; 7: 192-198.
    • (2001) Nat Med , vol.7 , pp. 192-198
    • Skobe, M.1    Hawighorst, T.2    Jackson, D.G.3    Prevo, R.4    Janes, L.5    Velasco, P.6
  • 12
    • 17744390184 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
    • Mandriota SJ, Jussila L, Jeltsch M, Compagni A, Baetens D, Prevo R et al. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J 2001; 20: 672-682.
    • (2001) EMBO J , vol.20 , pp. 672-682
    • Mandriota, S.J.1    Jussila, L.2    Jeltsch, M.3    Compagni, A.4    Baetens, D.5    Prevo, R.6
  • 13
    • 33846857321 scopus 로고    scopus 로고
    • VEGF-Cinduced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites
    • Hirakawa S, Brown LF, Kodama S, Paavonen K, Alitalo K, Detmar M. VEGF-Cinduced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood 2007; 109: 1010-1017.
    • (2007) Blood , vol.109 , pp. 1010-1017
    • Hirakawa, S.1    Brown, L.F.2    Kodama, S.3    Paavonen, K.4    Alitalo, K.5    Detmar, M.6
  • 14
    • 0035266283 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
    • Karpanen T, Egeblad M, Karkkainen MJ, Kubo H, Ylä-Herttuala S, Jäättelä M et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res 2001; 61: 1786-1790.
    • (2001) Cancer Res , vol.61 , pp. 1786-1790
    • Karpanen, T.1    Egeblad, M.2    Karkkainen, M.J.3    Kubo, H.4    Ylä-Herttuala, S.5    Jäättelä, M.6
  • 15
    • 44449133602 scopus 로고    scopus 로고
    • Molecular control of lymphatic metastasis
    • Achen MG, Stacker SA. Molecular control of lymphatic metastasis. Ann NY Acad Sci 2008; 1131: 225-234.
    • (2008) Ann NY Acad Sci , vol.1131 , pp. 225-234
    • Achen, M.G.1    Stacker, S.A.2
  • 17
    • 73949133917 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway
    • Chien MH, Ku CC, Johansson G, Chen MW, Hsiao M, Su JL et al. Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis 2009; 30: 2005-2013.
    • (2009) Carcinogenesis , vol.30 , pp. 2005-2013
    • Chien, M.H.1    Ku, C.C.2    Johansson, G.3    Chen, M.W.4    Hsiao, M.5    Su, J.L.6
  • 18
    • 80052759793 scopus 로고    scopus 로고
    • VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway
    • Kumar B, Chile SA, Ray KB, Reddy GE, Addepalli MK, Kumar AS et al. VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway. Angiogenesis 2011; 14: 371-380.
    • (2011) Angiogenesis , vol.14 , pp. 371-380
    • Kumar, B.1    Chile, S.A.2    Ray, K.B.3    Reddy, G.E.4    Addepalli, M.K.5    Kumar, A.S.6
  • 19
    • 0036310244 scopus 로고    scopus 로고
    • Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes
    • Saaristo A, Veikkola T, Enholm B, Hytönen M, Arola J, Pajusola K et al. Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes. FASEB J 2002; 16: 1041-1049.
    • (2002) FASEB J , vol.16 , pp. 1041-1049
    • Saaristo, A.1    Veikkola, T.2    Enholm, B.3    Hytönen, M.4    Arola, J.5    Pajusola, K.6
  • 20
    • 80053343082 scopus 로고    scopus 로고
    • RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axes-induced ERK, p38 and AKT signalling pathways
    • Feng Y, Hu J, Ma J, Feng K, Zhang X, Yang S et al. RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axes-induced ERK, p38 and AKT signalling pathways. Eur J Cancer 2011; 47: 2353-2363.
    • (2011) Eur J Cancer , vol.47 , pp. 2353-2363
    • Feng, Y.1    Hu, J.2    Ma, J.3    Feng, K.4    Zhang, X.5    Yang, S.6
  • 21
    • 33644822574 scopus 로고    scopus 로고
    • The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells
    • Su JL, Yang PC, Shih JY, Yang CY, Wei LH, Hsieh CY et al. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell 2006; 9: 209-223.
    • (2006) Cancer Cell , vol.9 , pp. 209-223
    • Su, J.L.1    Yang, P.C.2    Shih, J.Y.3    Yang, C.Y.4    Wei, L.H.5    Hsieh, C.Y.6
  • 22
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    • He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T et al. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 2002; 94: 819-825.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 819-825
    • He, Y.1    Kozaki, K.2    Karpanen, T.3    Koshikawa, K.4    Yla-Herttuala, S.5    Takahashi, T.6
  • 24
    • 0037414909 scopus 로고    scopus 로고
    • Characterization of a novel human breast cancer associated gene (BCA3) encoding an alternatively spliced proline-rich protein
    • Kitching R, Li H, Wong MJ, Kanaganayakam S, Kahn H, Seth A. Characterization of a novel human breast cancer associated gene (BCA3) encoding an alternatively spliced proline-rich protein. Biochim Biophys Acta 2003; 1625: 116-121.
    • (2003) Biochim Biophys Acta , vol.1625 , pp. 116-121
    • Kitching, R.1    Li, H.2    Wong, M.J.3    Kanaganayakam, S.4    Kahn, H.5    Seth, A.6
  • 25
    • 43149105404 scopus 로고    scopus 로고
    • AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65
    • Gao N, Asamitsu K, Hibi Y, Ueno T, Okamoto T. AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65. J Biol Chem 2008; 283: 7834-7843.
    • (2008) J Biol Chem , vol.283 , pp. 7834-7843
    • Gao, N.1    Asamitsu, K.2    Hibi, Y.3    Ueno, T.4    Okamoto, T.5
  • 26
    • 77956249593 scopus 로고    scopus 로고
    • A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling
    • Gao N, Hibi Y, Cueno M, Asamitsu K, Okamoto T. A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling. J Biol Chem 2010; 285: 28097-28104.
    • (2010) J Biol Chem , vol.285 , pp. 28097-28104
    • Gao, N.1    Hibi, Y.2    Cueno, M.3    Asamitsu, K.4    Okamoto, T.5
  • 27
    • 2942677282 scopus 로고    scopus 로고
    • Crosstalk between angiogenesis and lymphangiogenesis in tumor progression
    • Scavelli C, Vacca A, Di Pietro G, Dammacco F, Ribatti D. Crosstalk between angiogenesis and lymphangiogenesis in tumor progression. Leukemia 2004; 18: 1054-1058.
    • (2004) Leukemia , vol.18 , pp. 1054-1058
    • Scavelli, C.1    Vacca, A.2    Di Pietro, G.3    Dammacco, F.4    Ribatti, D.5
  • 28
    • 84872343720 scopus 로고    scopus 로고
    • Tumor angiogenesis and lymphangiogenesis: Tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms
    • Gomes FG, Nedel F, Alves AM, Nör JE, Tarquinio SB. Tumor angiogenesis and lymphangiogenesis: tumor/endothelial crosstalk and cellular/microenvironmental signaling mechanisms. Life Sci 2013; 92: 101-107.
    • (2013) Life Sci , vol.92 , pp. 101-107
    • Gomes, F.G.1    Nedel, F.2    Alves, A.M.3    Nör, J.E.4    Tarquinio, S.B.5
  • 29
    • 25444525461 scopus 로고    scopus 로고
    • Opinion: Emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis
    • Cao Y. Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat Rev Cancer 2005; 5: 735-743.
    • (2005) Nat Rev Cancer , vol.5 , pp. 735-743
    • Cao, Y.1
  • 30
    • 30744477450 scopus 로고    scopus 로고
    • Lymphangiogenesis in development and human disease
    • Alitalo K, Tammela T, Petrova TV. Lymphangiogenesis in development and human disease. Nature 2005; 438: 946-953.
    • (2005) Nature , vol.438 , pp. 946-953
    • Alitalo, K.1    Tammela, T.2    Petrova, T.V.3
  • 31
    • 33947402251 scopus 로고    scopus 로고
    • Up-regulation of VEGF-C secreted by cancer cells and not VEGF-A correlates with clinical evaluation of lymph node metastasis in esophageal squamous cell carcinoma (ESCC)
    • Krzystek-Korpacka M, Matusiewicz M, Diakowska D, Grabowski K, Blachut K, Banas T. Up-regulation of VEGF-C secreted by cancer cells and not VEGF-A correlates with clinical evaluation of lymph node metastasis in esophageal squamous cell carcinoma (ESCC). Cancer Lett 2007; 249: 171-177.
    • (2007) Cancer Lett , vol.249 , pp. 171-177
    • Krzystek-Korpacka, M.1    Matusiewicz, M.2    Diakowska, D.3    Grabowski, K.4    Blachut, K.5    Banas, T.6
  • 32
    • 77953176817 scopus 로고    scopus 로고
    • The number of lymph node metastases influences survival and International Union Against Cancer tumor-node-metastasis classification for esophageal squamous cell carcinoma
    • Zhang HL, Chen LQ, Liu RL, Shi YT, He M, Meng XL et al. The number of lymph node metastases influences survival and International Union Against Cancer tumor-node-metastasis classification for esophageal squamous cell carcinoma. Dis Esophagus 2010; 23: 53-58.
    • (2010) Dis Esophagus , vol.23 , pp. 53-58
    • Zhang, H.L.1    Chen, L.Q.2    Liu, R.L.3    Shi, Y.T.4    He, M.5    Meng, X.L.6
  • 35
    • 63849273950 scopus 로고    scopus 로고
    • The onset of angiogenesis in a multistep process of esophageal squamous cell carcinoma
    • Kubota Y, Kaneko K, Konishi K, Ito H, Yamamoto T, Katagiri A et al. The onset of angiogenesis in a multistep process of esophageal squamous cell carcinoma. Front Biosci 2009; 14: 3872-3878.
    • (2009) Front Biosci , vol.14 , pp. 3872-3878
    • Kubota, Y.1    Kaneko, K.2    Konishi, K.3    Ito, H.4    Yamamoto, T.5    Katagiri, A.6
  • 36
    • 0031014494 scopus 로고    scopus 로고
    • Tumor vascularity correlates with the prognosis of patients with esophageal squamous cell carcinoma
    • Tanigawa N, Matsumura M, Amaya H, Kitaoka A, Shimomatsuya T, Lu C et al. Tumor vascularity correlates with the prognosis of patients with esophageal squamous cell carcinoma. Cancer 1997; 79: 220-225.
    • (1997) Cancer , vol.79 , pp. 220-225
    • Tanigawa, N.1    Matsumura, M.2    Amaya, H.3    Kitaoka, A.4    Shimomatsuya, T.5    Lu, C.6
  • 37
    • 3242813943 scopus 로고    scopus 로고
    • Angiogenic switch occurs during the precancerous stage of human esophageal squamous cell carcinoma
    • Kitadai Y, Onogawa S, Kuwai T, Matsumura S, Hamada H, Ito M et al. Angiogenic switch occurs during the precancerous stage of human esophageal squamous cell carcinoma. Oncol Rep 2004; 11: 315-319.
    • (2004) Oncol Rep , vol.11 , pp. 315-319
    • Kitadai, Y.1    Onogawa, S.2    Kuwai, T.3    Matsumura, S.4    Hamada, H.5    Ito, M.6
  • 38
    • 0037458645 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway
    • Tsai PW, Shiah SG, Lin MT, Wu CW, Kuo ML. Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway. J Biol Chem 2003; 278: 5750-5759.
    • (2003) J Biol Chem , vol.278 , pp. 5750-5759
    • Tsai, P.W.1    Shiah, S.G.2    Lin, M.T.3    Wu, C.W.4    Kuo, M.L.5
  • 39
    • 84879080436 scopus 로고    scopus 로고
    • Nkx2-8 downregulation promotes angiogenesis and activates NF-kB in esophageal cancer
    • Lin C, Song L, Gong H, Liu A, Lin X, Wu J et al. Nkx2-8 downregulation promotes angiogenesis and activates NF-kB in esophageal cancer. Cancer Res 2013; 73: 3638-3648.
    • (2013) Cancer Res , vol.73 , pp. 3638-3648
    • Lin, C.1    Song, L.2    Gong, H.3    Liu, A.4    Lin, X.5    Wu, J.6
  • 40
    • 84857636386 scopus 로고    scopus 로고
    • Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells
    • Zhang Y, Du XL, Wang CJ, Lin DC, Ruan X, Feng YB et al. Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells. Gastroenterology 2012; 142: 521-530e523.
    • (2012) Gastroenterology , vol.142 , pp. 521-530e523
    • Zhang, Y.1    Du, X.L.2    Wang, C.J.3    Lin, D.C.4    Ruan, X.5    Feng, Y.B.6
  • 41
    • 84878551843 scopus 로고    scopus 로고
    • Acylglycerol kinase augments JAK2/ STAT3 signaling in esophageal squamous cells
    • Chen X, Ying Z, Lin X, Lin H, Wu J, Li M et al. Acylglycerol kinase augments JAK2/ STAT3 signaling in esophageal squamous cells. J Clin Invest 2013; 123: 2576-2589.
    • (2013) J Clin Invest , vol.123 , pp. 2576-2589
    • Chen, X.1    Ying, Z.2    Lin, X.3    Lin, H.4    Wu, J.5    Li, M.6
  • 42
    • 0037449752 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo
    • Andl CD, Mizushima T, Nakagawa H, Oyama K, Harada H, Chruma K et al. Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo. J Biol Chem 2003; 278: 1824-1830.
    • (2003) J Biol Chem , vol.278 , pp. 1824-1830
    • Andl, C.D.1    Mizushima, T.2    Nakagawa, H.3    Oyama, K.4    Harada, H.5    Chruma, K.6
  • 43
    • 30944457987 scopus 로고    scopus 로고
    • Isolation and culture of microvascular endothelial cells from gliomas of different WHO grades
    • Miebach S, Grau S, Hummel V, Rieckmann P, Tonn JC, Goldbrunner RH. Isolation and culture of microvascular endothelial cells from gliomas of different WHO grades. J Neurooncol 2006; 76: 39-48.
    • (2006) J Neurooncol , vol.76 , pp. 39-48
    • Miebach, S.1    Grau, S.2    Hummel, V.3    Rieckmann, P.4    Tonn, J.C.5    Goldbrunner, R.H.6
  • 44
    • 0026543603 scopus 로고
    • Characterization of 21 newly established esophageal cancer cell lines
    • Shimada Y, Imamura M, Wagata T, Yamaguchi N, Tobe T. Characterization of 21 newly established esophageal cancer cell lines. Cancer 1992; 69: 277-284.
    • (1992) Cancer , vol.69 , pp. 277-284
    • Shimada, Y.1    Imamura, M.2    Wagata, T.3    Yamaguchi, N.4    Tobe, T.5
  • 46
    • 50349090038 scopus 로고    scopus 로고
    • Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival
    • Li J, Zhang N, Song LB, Liao WT, Jiang LL, Gong LY et al. Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 2008; 14: 3319-3326.
    • (2008) Clin Cancer Res , vol.14 , pp. 3319-3326
    • Li, J.1    Zhang, N.2    Song, L.B.3    Liao, W.T.4    Jiang, L.L.5    Gong, L.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.