Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation

Nucleic Acids Research

Volumn 42, Issue 1, 2014, Pages 224-234

  Choi, Jinmi ^a   Jang, Hyonchol ^a,b   Kim, Hyunsoo ^a   Lee, Jong Hyuk ^a   Kim, Seong Tae ^c   Cho, Eun Jung ^d   Youn, Hong Duk ^a,e  

^a Seoul National University College of Medicine   (South Korea)

^b National Cancer Center   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

^d Sungkyunkwan University   (South Korea)

^e Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEMETHYLASE; HISTONE METHYLTRANSFERASE; LYSINE; MYOCYTE ENHANCER FACTOR 2; PROTEIN G9A; PROTEIN LSD1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CHROMATIN; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE TARGETING; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN METHYLATION; PROTEIN PROTEIN INTERACTION; SKELETAL MUSCLE; TRANSCRIPTION REGULATION; UPREGULATION; C2C12 CELL LINE; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DEMETHYLATION; ELECTROSPRAY MASS SPECTROMETRY; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LYSINE METHYLATION; METHYLATION; MYOBLAST; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION;

EID: 84891765885     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt873     Document Type: Article

References (39)

1. Schreiber, S.L. and Bernstein, B.E. (2002) Signaling network model of chromatin. Cell, 111, 771-778
2. Shinkai, Y. and Tachibana, M. (2011) H3K9 methyltransferase G9a and the related molecule GLP. Genes Dev., 25, 781-788
3. Tachibana, M., Sugimoto, K., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Kato, H. et al. (2002) G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev., 16, 1779-1791
4. Shi, Y., Do, J.T., Desponts, C., Hahm, H.S., Scholer, H.R. and Ding, S. (2008) A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell, 2, 525-528
5. Stancheva, I. (2011) Revisiting heterochromatin in embryonic stem cells. PLoS Genet., 7, e1002093
6. Youn, H.D., Sun, L., Prywes, R. and Liu, J.O. (1999) Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Science, 286, 790-793
7. Arnold, M.A., Kim, Y., Czubryt, M.P., Phan, D., McAnally, J., Qi, X., Shelton, J.M., Richardson, J.A., Bassel-Duby, R. and Olson, E.N. (2007) MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev. Cell, 12, 377-389
8. Potthoff, M.J. and Olson, E.N. (2007) MEF2: A central regulator of diverse developmental programs. Development, 134, 4131-4140
9. McKinsey, T.A., Zhang, C.L. and Olson, E.N. (2002) MEF2: A calcium-dependent regulator of cell division, differentiation and death. Trends Biochem. Sci., 27, 40-47
10. Elgar, S.J., Han, J. and Taylor, M.V. (2008) mef2 activity levels differentially affect gene expression during Drosophila muscle development. Proc. Natl Acad. Sci. USA, 105, 918-923
11. Sandmann, T., Jensen, L.J., Jakobsen, J.S., Karzynski, M.M., Eichenlaub, M.P., Bork, P. and Furlong, E.E. (2006) A temporal map of transcription factor activity: Mef2 directly regulates target genes at all stages of muscle development. Dev. Cell, 10, 797-807
12. Jang, H., Choi, D.E., Kim, H., Cho, E.J. and Youn, H.D. (2007) Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1. J. Biol. Chem., 282, 11172-11179
13. Zhang, C.L., McKinsey, T.A., Chang, S., Antos, C.L., Hill, J.A. and Olson, E.N. (2002) Class II histone deacetylases act as signalresponsive repressors of cardiac hypertrophy. Cell, 110, 479-488
14. Youn, H.D. and Liu, J.O. (2000) Cabin1 represses MEF2- dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2. Immunity, 13, 85-94
15. Backs, J., Worst, B.C., Lehmann, L.H., Patrick, D.M., Jebessa, Z., Kreusser, M.M., Sun, Q., Chen, L., Heft, C., Katus, H.A. et al. (2011) Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4. J. Cell Biol., 195, 403-415
16. Kim, M.S., Fielitz, J., McAnally, J., Shelton, J.M., Lemon, D.D., McKinsey, T.A., Richardson, J.A., Bassel-Duby, R. and Olson, E.N. (2008) Protein kinase D1 stimulates MEF2 activity in skeletal muscle and enhances muscle performance. Mol. Cell. Biol., 28, 3600-3609
17. Choi, J., Jang, H., Kim, H., Kim, S.T., Cho, E.J. and Youn, H.D. (2010) Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem. Biophys. Res. Commun., 401, 327-332
18. Guasconi, V. and Puri, P.L. (2009) Chromatin: The interface between extrinsic cues and the epigenetic regulation of muscle regeneration. Trends Cell Biol, 19, 286-294
19. Yang, J.H., Choi, J.H., Jang, H., Park, J.Y., Han, J.W., Youn, H.D. and Cho, E.J. (2011) Histone chaperones cooperate to mediate Mef2-Targeted transcriptional regulation during skeletal myogenesis. Biochem. Biophys. Res. Commun., 407, 541-547
20. Yang, S.H., Galanis, A. and Sharrocks, A.D. (1999) Targeting of p38 mitogen-Activated protein kinases to MEF2 transcription factors. Mol. Cell. Biol., 19, 4028-4038
21. Barsyte-Lovejoy, D., Galanis, A., Clancy, A. and Sharrocks, A.D. (2004) ERK5 is targeted to myocyte enhancer factor 2A (MEF2A) through a MAPK docking motif. Biochem. J., 381, 693-699
22. Ma, K., Chan, J.K., Zhu, G. and Wu, Z. (2005) Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation. Mol. Cell. Biol., 25, 3575-3582
23. Angelelli, C., Magli, A., Ferrari, D., Ganassi, M., Matafora, V., Parise, F., Razzini, G., Bachi, A., Ferrari, S. and Molinari, S. (2008) Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells. Nucleic Acids Res., 36, 915-928
24. Gregoire, S., Xiao, L., Nie, J., Zhang, X., Xu, M., Li, J., Wong, J., Seto, E. and Yang, X.J. (2007) Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol. Cell. Biol., 27, 1280-1295
25. Paris, J., Virtanen, C., Lu, Z. and Takahashi, M. (2004) Identification of MEF2-regulated genes during muscle differentiation. Physiol. Genomics, 20, 143-151
26. Blais, A., Tsikitis, M., Acosta-Alvear, D., Sharan, R., Kluger, Y. and Dynlacht, B.D. (2005) An initial blueprint for myogenic differentiation. Genes Dev., 19, 553-569
27. Flavell, S.W., Kim, T.K., Gray, J.M., Harmin, D.A., Hemberg, M., Hong, E.J., Markenscoff-Papadimitriou, E., Bear, D.M. and Greenberg, M.E. (2008) Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron, 60, 1022-1038
28. Jang, H., Kim, T.W., Yoon, S., Choi, S.Y., Kang, T.W., Kim, S.Y., Kwon, Y.W., Cho, E.J. and Youn, H.D. (2012) O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network. Cell Stem Cell, 11, 62-74
29. Nishio, H. and Walsh, M.J. (2004) CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription. Proc. Natl Acad. Sci. USA, 101, 11257-11262
30. Pless, O., Kowenz-Leutz, E., Knoblich, M., Lausen, J., Beyermann, M., Walsh, M.J. and Leutz, A. (2008) G9a-mediated lysine methylation alters the function of CCAAT/enhancerbinding protein-beta. J. Biol. Chem., 283, 26357-26363
31. Wang, J., Hevi, S., Kurash, J.K., Lei, H., Gay, F., Bajko, J., Su, H., Sun, W., Chang, H., Xu, G. et al. (2009) The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat. Genet., 41, 125-129
32. Yang, J.H., Song, Y., Seol, J.H., Park, J.Y., Yang, Y.J., Han, J.W., Youn, H.D. and Cho, E.J. (2011) Myogenic transcriptional activation of MyoD mediated by replication-independent histone deposition. Proc. Natl Acad. Sci. USA, 108, 85-90
33. Kubicek, S., O'Sullivan, R.J., August, E.M., Hickey, E.R., Zhang, Q., Teodoro, M.L., Rea, S., Mechtler, K., Kowalski, J.A., Homon, C.A. et al. (2007) Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol. Cell, 25, 473-481
34. Sebastian, S., Faralli, H., Yao, Z., Rakopoulos, P., Palii, C., Cao, Y., Singh, K., Liu, Q.C., Chu, A., Aziz, A. et al. (2013) Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation. Genes Dev., 27, 1247-1259
35. Cripps, R.M., Lovato, T.L. and Olson, E.N. (2004) Positive autoregulation of the Myocyte enhancer factor-2 myogenic control gene during somatic muscle development in Drosophila. Dev. Biol., 267, 536-547
36. Jang, H., Choi, S.Y., Cho, E.J. and Youn, H.D. (2009) Cabin1 restrains p53 activity on chromatin. Nat. Struct. Mol. Biol., 16, 910-915
37. Azmi, S., Ozog, A. and Taneja, R. (2004) Sharp-1/DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors. J. Biol. Chem., 279, 52643-52652
38. Ling, B.M., Gopinadhan, S., Kok, W.K., Shankar, S.R., Gopal, P., Bharathy, N., Wang, Y. and Taneja, R. (2012) G9a mediates Sharp- 1-dependent inhibition of skeletal muscle differentiation. Mol. Biol. Cell, 23, 4778-4785
39. Ling, B.M., Bharathy, N., Chung, T.K., Kok, W.K., Li, S., Tan, Y.H., Rao, V.K., Gopinadhan, S., Sartorelli, V., Walsh, M.J. et al. (2012) Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation. Proc. Natl Acad. Sci. USA, 109, 841-846