Treatment of agarose-agarose RENCA macrobeads with docetaxel selects for OCT4+ cells with tumor-initiating capability

Cancer Biology and Therapy

Volumn 14, Issue 12, 2013, Pages 1147-1157

  Gazda, Lawrence S ^a   Martis, Prithy C ^a   Laramore, Melissa A ^a   Bautista, Melissa A ^a   Dudley, Atira ^a   Vinerean, Horatiu V ^a,d   Smith, Barry H ^a,b,c  

^a ROGOSIN INSTITUTE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^d FLORIDA INTERNATIONAL UNIVERSITY   (United States)

Author keywords

Encapsulation; Macrobeads; OCT4; RENCA; Tumor initiating cells

Indexed keywords

AGAROSE; DOCETAXEL; OCTAMER TRANSCRIPTION FACTOR 4; PACLITAXEL; ANTINEOPLASTIC AGENT; POU5F1 PROTEIN, HUMAN; SEPHAROSE; TAXOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER RECURRENCE; CANCER STEM CELL; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DAUGHTER CELL; HYPOTHESIS; IN VITRO STUDY; KIDNEY CARCINOMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; DRUG RESISTANCE; HUMAN; KIDNEY TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; KIDNEY NEOPLASMS; MICE, INBRED BALB C; NEOPLASTIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; PACLITAXEL; SEPHAROSE; TAXOIDS;

EID: 84891764928     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.26455     Document Type: Article

References (46)

1. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414:105-11; PMID:11689955; http://dx.doi.org/10. 1038/35102167 (Pubitemid 33041634)
2. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994; 367:645-8; PMID:7509044; http://dx.doi.org/10.1038/367645a0 (Pubitemid 24067706)
3. Bomken S, Fiser K, Heidenreich O, Vormoor J. Understanding the cancer stem cell. Br J Cancer 2010; 103:439-45; PMID:20664590; http://dx.doi.org/10. 1038/sj.bjc.6605821
4. Visvader JE. Cells of origin in cancer. Nature 2011; 469:314-22; PMID:21248838; http://dx.doi.org/10.1038/nature09781
5. Kvinlaug BT, Huntly BJ. Targeting cancer stem cells. Expert Opin Ther Targets 2007; 11:915-27; PMID:17614760; http://dx.doi.org/10.1517/14728222.11.7. 915 (Pubitemid 47061315)
6. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006; 66:9339-44; PMID:16990346; http://dx.doi.org/10.1158/0008-5472.CAN-06-3126 (Pubitemid 44623625)
7. Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 2012; 337:730-5; PMID:22855427; http://dx.doi.org/10.1126/science.1224676
8. Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C. Defining the mode of tumour growth by clonal analysis. Nature 2012; 488:527-30; PMID:22854777; http://dx.doi.org/10.1038/nature11344
9. Chen J, Li Y, Yu TS, McKay RM, Burns DK, Kernie SG, Parada LF. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 2012; 488:522-6; PMID:22854781; http://dx.doi.org/10.1038/nature11287
10. Smith BH, Gazda LS, Conn BL, Jain K, Asina S, Levine DM, Parker TS, Laramore MA, Martis PC, Vinerean HV, et al. Three-dimensional culture of mouse renal carcinoma cells in agarose macrobeads selects for a subpopulation of cells with cancer stem cell or cancer progenitor properties. Cancer Res 2011; 71:716-24; PMID:21266363; http://dx.doi.org/10.1158/0008-5472.CAN-10-2254
11. Smith BH, Gazda LS, Conn BL, Jain K, Asina S, Levine DM, Parker TS, Laramore MA, Martis PC, Vinerean HV, et al. Hydrophilic agarose macrobead cultures select for outgrowth of carcinoma cell populations that can restrict tumor growth. Cancer Res 2011; 71:725-35; PMID:21266362; http://dx.doi.org/10. 1158/0008-5472.CAN-10-2258
12. Zhou S, Li F, Xiao J, Xiong W, Fang Z, Chen W, Niu P. Isolation and identification of cancer stem cells from human osteosarcom by serum-free three-dimensional culture combined with anticancer drugs. J Huazhong Univ Sci Technolog Med Sci 2010; 30:81-4; PMID:20155460; http://dx.doi.org/10.1007/ s11596-010-0114-4
13. Ma L, Lai D, Liu T, Cheng W, Guo L. Cancer stem-like cells can be isolated with drug selection in human ovarian cancer cell line SKOV3. Acta Biochim Biophys Sin (Shanghai) 2010; 42:593-602; PMID:20705681; http://dx.doi.org/10.1093/abbs/gmq067
14. Rosner MH, Vigano MA, Ozato K, Timmons PM, Poirier F, Rigby PW, Staudt LM. A POUdomain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 1990; 345:686-92; PMID:1972777; http://dx.doi.org/10. 1038/345686a0
15. Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998; 95:379-91; PMID:9814708; http://dx.doi.org/10.1016/S0092-8674(00)81769-9 (Pubitemid 28507326)
16. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007; 448:313-7; PMID:17554338; http://dx.doi.org/10.1038/nature05934 (Pubitemid 47080336)
17. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007; 318:1917-20; PMID:18029452; http://dx.doi.org/10.1126/science.1151526
18. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008; 451:141-6; PMID:18157115; http://dx.doi.org/10.1038/ nature06534
19. Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, Pilotti S, Pierotti MA, Daidone MG. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005; 65:5506-11; PMID:15994920; http://dx.doi.org/10.1158/0008-5472.CAN-05- 0626 (Pubitemid 40911148)
20. Chen YC, Hsu HS, Chen YW, Tsai TH, How CK, Wang CY, Hung SC, Chang YL, Tsai ML, Lee YY, et al. Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells. PLoS One 2008; 3:e2637; PMID:18612434; http://dx.doi.org/10.1371/journal.pone.0002637
21. Suvà ML, Riggi N, Stehle JC, Baumer K, Tercier S, Joseph JM, Suvà D, Clément V, Provero P, Cironi L, et al. Identification of cancer stem cells in Ewing's sarcoma. Cancer Res 2009; 69:1776-81; PMID:19208848; http://dx.doi.org/10.1158/0008-5472.CAN-08-2242
22. Hochedlinger K, Yamada Y, Beard C, Jaenisch R. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 2005; 121:465-77; PMID:15882627; http://dx.doi.org/10.1016/j.cell. 2005.02.018 (Pubitemid 40692305)
23. Beltran AS, Rivenbark AG, Richardson BT, Yuan X, Quian H, Hunt JP, Zimmerman E, Graves LM, Blancafort P. Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor. Breast Cancer Res 2011; 13:R94; PMID:21952072; http://dx.doi.org/10.1186/bcr3019
24. Eyler CE, Rich JN. Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol 2008; 26:2839-45; PMID:18539962; http://dx.doi.org/10.1200/JCO.2007.15.1829
25. Schatton T, Frank NY, Frank MH. Identification and targeting of cancer stem cells. Bioessays 2009; 31:1038-49; PMID:19708024; http://dx.doi.org/10. 1002/bies.200900058
26. Moore N, Lyle S. Quiescent, slow-cycling stem cell populations in cancer: a review of the evidence and discussion of significance. J Oncol 2011; 2011; PMID:20936110; http://dx.doi.org/10.1155/2011/396076
27. Morrison R, Schleicher SM, Sun Y, Niermann KJ, Kim S, Spratt DE, Chung CH, Lu B. Targeting the mechanisms of resistance to chemotherapy and radiotherapy with the cancer stem cell hypothesis. J Oncol 2011; 2011:941876; PMID:20981352; http://dx.doi.org/10.1155/2011/941876
28. Linn DE, Yang X, Sun F, Xie Y, Chen H, Jiang R, Chen H, Chumsri S, Burger AM, Qiu Y. A Role for OCT4 in Tumor Initiation of Drug-Resistant Prostate Cancer Cells. Genes Cancer 2010; 1:908-16; PMID:21779471; http://dx.doi.org/10. 1177/1947601910388271
29. Wang XQ, Ongkeko WM, Chen L, Yang ZF, Lu P, Chen KK, Lopez JP, Poon RT, Fan ST. Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4-AKTATP-binding cassette G2 pathway. Hepatology 2010; 52:528-39; PMID:20683952; http://dx.doi.org/10.1002/hep.23692
30. Guo Y, Mantel C, Hromas RA, Broxmeyer HE. Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin. Stem Cells 2008; 26:30-4; PMID:17932422; http://dx.doi.org/10.1634/stemcells.2007-0401
31. Rolf HJ, Niebert S, Niebert M, Gaus L, Schliephake H, Wiese KG. Intercellular transport of Oct4 in mammalian cells: a basic principle to expand a stem cell niche? PLoS One 2012; 7:e32287; PMID:22359678; http://dx.doi.org/10. 1371/journal.pone.0032287
32. Jones DL, Wagers AJ. No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol 2008; 9:11-21; PMID:18097443; http://dx.doi.org/10.1038/nrm2319
33. Borovski T, De Sousa E Melo F, Vermeulen L, Medema JP. Cancer stem cell niche: the place to be. Cancer Res 2011; 71:634-9; PMID:21266356; http://dx.doi.org/10.1158/0008-5472.CAN-10-3220
34. Cabarcas SM, Mathews LA, Farrar WL. The cancer stem cell niche-there goes the neighborhood? Int J Cancer 2011; 129:2315-27; PMID:21792897; http://dx.doi.org/10.1002/ijc.26312
35. Korkaya H, Liu S, Wicha MS. Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest 2011; 121:3804-9; PMID:21965337; http://dx.doi.org/10.1172/JCI57099
36. Boulanger CA, Mack DL, Booth BW, Smith GH. Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo. Proc Natl Acad Sci U S A 2007; 104:3871-6; PMID:17360445; http://dx.doi.org/10.1073/pnas.0611637104 (Pubitemid 47181546)
37. Marusyk A, Polyak K. Tumor heterogeneity: causes and consequences. Biochim Biophys Acta 2010; 1805:105-17; PMID:19931353; http://dx.doi.org/10. 1016/j.bbcan.2009.11.002
38. LaBarge MA. The difficulty of targeting cancer stem cell niches. Clin Cancer Res 2010; 16:3121-9; PMID:20530700; http://dx.doi.org/10.1158/1078-0432. CCR-09-2933
39. Xie T, Spradling AC. A niche maintaining germ line stem cells in the Drosophila ovary. Science 2000; 290:328-30; PMID:11030649; http://dx.doi.org/10. 1126/science.290.5490.328
40. Jin Z, Kirilly D, Weng C, Kawase E, Song X, Smith S, Schwartz J, Xie T. Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell 2008; 2:39-49; PMID:18371420; http://dx.doi.org/10.1016/j.stem.2007.10.021
41. Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 2006; 126:677-89; PMID:16923388; http://dx.doi.org/10.1016/j.cell.2006.06.044
42. Reilly GC, Engler AJ. Intrinsic extracellular matrix properties regulate stem cell differentiation. J Biomech 2010; 43:55-62; PMID:19800626; http://dx.doi.org/10.1016/j.jbiomech.2009.09.009
43. Lee DA, Knight MM, Campbell JJ, Bader DL. Stem cell mechanobiology. J Cell Biochem 2011; 112:1-9; PMID:20626029; http://dx.doi.org/10.1002/jcb.22758
44. Albini A, Sporn MB. The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer 2007; 7:139-47; PMID:17218951; http://dx.doi.org/10.1038/nrc2067 (Pubitemid 46160989)
45. TAXOL® product insert [Internet]. Bristol-Myers Squibb: c2011 [cited 2013 June 26]. Available at: http://packageinserts.bms.com/pi/pi-taxol.pdf
46. TAXOTERE® product insert [Internet]. Sanofi-Aventis US LLC; c2010 April [cited 2013 June 26]. Available at: http://products.sanofi.us/taxotere/ taxotere.html