Novel inflammatory markers, clinical risk factors and virus type associated with severe respiratory syncytial virus infection

Pediatric Infectious Disease Journal

Volumn 32, Issue 12, 2013, Pages

  Tabarani, Christy M ^a   Bonville, Cynthia A ^a   Suryadevara, Manika ^a   Branigan, Patrick ^b   Wang, Dongliang ^c   Huang, Danning ^c   Rosenberg, Helene F ^d   Domachowske, Joseph B ^a  

^a Upstate Golisano Children's Hospital   (United States)

^b CENTOCOR INC   (United States)

^c SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Hepatocyte growth factor; Illness severity; Innate immunity; Respiratory syncytial virus

Indexed keywords

ALPHA INTERFERON; BIOLOGICAL MARKER; CARBON TETRACHLORIDE; EPIDERMAL GROWTH FACTOR; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; NOVEL INFLAMMATORY MARKER; SCATTER FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE;

ARTICLE; ASSAY; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HEART DISEASE; HUMAN; LONGITUDINAL STUDY; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; PREMATURITY; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT INFECTION; RISK FACTOR; SEVERE RESPIRATORY SYNCYTIAL VIRUS INFECTION; VIRUS INFECTION; VIRUS TYPING; BLOOD; CLASSIFICATION; HUMAN RESPIRATORY SYNCYTIAL VIRUS; IMMUNOLOGY; INFANT; ISOLATION AND PURIFICATION; NEWBORN; NOSE CAVITY; RESPIRATORY SYNCYTIAL VIRUS INFECTION; VIROLOGY;

BIOMARKERS; CHILD, PRESCHOOL; CYTOKINES; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LONGITUDINAL STUDIES; MALE; NASAL CAVITY; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; RISK FACTORS;

EID: 84891743754     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e3182a14407     Document Type: Article

References (42)

1. Hall CB, Weinberg GA, Iwane MK, et al. The burden of respiratory syncyt-ial virus infection in young children. N Engl J Med. 2009;360:588-598.
2. Kristensen K, Hjuler T, Ravan H, et al. Chronic diseases, chromosomal abnormalities, and congenital malformations as risk factors for respiratory syncytial virus hospitalization: a population-based study. Clin Infect Dis. 2012;54:810-817.
3. Zachariah P, Ruttenber M, Simões EA. down syndrome and hospitaliza-tions due to respiratory syncytial virus: a population-based study. J Pediatr. 2012;160:827-31.e1.
4. Holberg CJ, Wright AL, Martinez FD, et al. Risk factor for respiratory syn-cytial virus-associated lower respiratory tract illnesses in the frst year of life. Am J Epidemiol. 1991;133:1135-1151.
5. Glezen W P, Paredes A, Allison JE, et al. Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level. J Pediatr. 1981;98:708-715.
6. Peck AJ, Holman RC, Curns AT, et al. Lower respiratory tract infections among american indian and alaska native children and the general population of u.S. Children. Pediatr Infect Dis J. 2005;24:342-351.
7. Miyairi I, Devincenzo J P. Human genetic factors and respiratory syncytial virus disease severity. Clin Microbiol Rev. 2008;21:686-703.
8. Karron RA, Thumar B, Schappell E, et al. Attenuation of live respiratory syncytial virus vaccines is associated with reductions in levels of nasal cytokines. J Infect Dis. 2013;207:1773-1779.
9. Anderson LJ, Hendry RM, Pierik LT, et al. Multicenter study of strains of respiratory syncytial virus. J Infect Dis. 1991;163:687-692.
10. Mcnamara PS, Flanagan BF, Hart CA, et al. Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis. 2005;191:1225-1232.
11. Garofalo R P, Patti J, Hintz KA, et al. Macrophage infammatory protein-1a (not t helper type 2 cytokines) is associated with severe forms of respiratory syncytial virus bronchiolitis. J Infect Dis. 2001;184:393-399.
12. Harrison AM, Bonville CA, Rosenberg HF, et al. Respiratory syncyti-cal virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation. Am J Respir Crit Care Med. 1999;159: 1918-1924.
13. Hull J, Rowlands K, Lockhart E, et al. Variants of the chemokine receptor CCr5 are associated with severe bronchiolitis caused by respiratory syncy-tial virus. J Infect Dis. 2003;188:904-907.
14. Amanatidou V, Sourvinos G, Apostolakis S, et al. Rantes promoter gene polymorphisms and susceptibility to severe respiratory syncytial virus-induced bronchiolitis. Pediatr Infect Dis J. 2008;27:38-42.
15. Miller AL, Bowlin TL, Lukacs N W. respiratory syncytial virus-induced chemokine production: linking viral replication to chemokine production in vitro and in vivo. J Infect Dis. 2004;189:1419-1430.
16. Smyth RL, Mobbs KJ, O'HEA U, et al. Respiratory syncytial virus bronchi-olitis: disease severity, interleukin-8, and virus genotype. Pediatr Pulmonol. 2002;33:339-346.
17. Alonso Fernández J, Roine I, Vasquez A, et al. Soluble interleukin-2 receptor (sCd25) and interleukin-10 plasma concentrations are associated with severity of primary respiratory syncytial virus (rSV) infection. Eur Cytokine Netw. 2005;16:81-90.
18. Gentile DA, Doyle WJ, Zeevi A, et al. Cytokine gene polymorphisms moderate responses to respiratory syncytial virus in adults. Hum Immunol. 2003;64:93-98.
19. Vieira RA, Diniz EM, Ceccon ME. Correlation between infammatory mediators in the nasopharyngeal secretion and in the serum of children with lower respiratory tract infection caused by respiratory syncytial virus and disease severity. J Bras Pneumol. 2010;36:59-66.
20. Hoebee B, Bont L, Rietveld E, et al. Infuence of promoter variants of inter-leukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. J Infect Dis. 2004;189:239-247.
21. Bonville CA, Bennett NJ, Koehnlein M, et al. Respiratory dysfunction and proinfammatory chemokines in the pneumonia virus of mice (PVM) model of viral bronchiolitis. Virology. 2006;69:53-59.
22. Bonville CA, Rosenberg HF, Domachowske JB. Macrophage infammatory protein-1alpha and ranteS are present in nasal secretions during ongoing upper respiratory tract infection. Pediatr Allergy Immunol. 1999;10:39-44.
23. El Feghaly RE, Mcgann L, Bonville CA, et al. Local production of infam-matory mediators during childhood parainfuenza virus infection. Pediatr Infect Dis J. 2010;29:e26-e31.
24. Rossen RD, Schade AL, Butler WT, et al. The proteins in nasal secretion: a longitudinal study of the ga-globulin, gg-globulin, albumin, siderophilin, and total protein concentrations in nasal washings from adult male volunteers. J Clin Invest. 1966;45:768-776
25. American academy of pediatrics subcommittee on diagnosis and management of bronchiolitis. Diagnosis andmanagement of bronchiolitis. Pediatrics. 2006;18:1774-1793.
26. Hall CB, Walsh EE, Schnabel KC, et al. Occurrence of groups a and B of respiratory syncytial virus over 15 years: associated epidemiologic and clinical characteristics in hospitalized and ambulatory children. J Infect Dis. 1990;162:1283-1290.
27. Walsh EE, Mcconnochie KM, Long CE, et al. Severity of respiratory syn-cytial virus infection is related to virus strain. J Infect Dis. 1997;175:814-820.
28. Kneyber MC, Brandenburg AH, Rothbarth PH, et al. Relationship between clinical severity of respiratory syncytial virus infection and subtype. Arch Dis Child. 1996;75:137-140.
29. Straliotto SM, Roitman B, Lima JB, et al. Respiratory syncytial virus (rSV) bronchiolitis: comparative study of rSV groups a and B infected children. Rev Soc Bras Med Trop. 1994;27:1-4.
30. Hornsleth A, Klug B, Nir M, et al. Severity of respiratory syncytial virus disease related to type and genotype of virus and to cytokine values in naso-pharyngeal secretions. Pediatr Infect Dis J. 1998;17:1114-1121.
31. Hall CB, Douglas RG Jr, Geiman JM. respiratory syncytial virus infections in infants: quantitation and duration of shedding. J Pediatr. 1976;89:11-15.
32. Buckingham SC, Bush AJ, Devincenzo J P. nasal quantity of respiratory syncytical virus correlates with disease severity in hospitalized infants. Pediatr Infect Dis J. 2000;19:113-117.
33. Scagnolari C, Midulla F, Selvaggi C, et al. Evaluation of viral load in infants hospitalized with bronchiolitis caused by respiratory syncytial virus. Med Microbiol Immunol. 2012;201:311-317.
34. El Saleeby CM, Bush AJ, Harrison LM, et al. Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children. J Infect Dis. 2011;204:996-1002.
35. García C, Soriano-Fallas A, Lozano J, et al. Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis. Pediatr Infect Dis J. 2012;31:86-89.
36. Rubin JS, Bottaro D P, Aaronson SA. Hepatocyte growth factor/scatter factor and its receptor, the c-met proto-oncogene product. Biochim Biophys Acta. 1993;1155:357-371.
37. Yanagita K, Matsumoto K, Sekiguchi K, et al. Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury. J Biol Chem. 1993;268:21212-21217.
38. Narasaraju T, Ng HH, Phoon C, et al. Mcp-1 antibody treatment enhances damages and impedes repair of the alveolar epithelium in infuenza pneu-monitis. Am J Respir Cell Mol Biol. 2010;42:732-743.
39. Crosby LM, Waters CM. epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol. 2010;298:l715-l731.
40. Monick MM, Cameron K, Staber J, et al. Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased infamma-tion and delayed apoptosis. J Biol Chem. 2005;280:2147-2158.
41. Eierhoff T, Hrincius ER, Rescher U, et al. The epidermal growth factor receptor (egFr) promotes uptake of infuenza a viruses (iaV) into host cells. PLoS Pathog. 2010;6:e1001099.
42. Moro MR, Bonville CA, Suryadevara M, et al. Clinical features, adenovirus types, and local production of infammatory mediators in adenovirus infections. Pediatr Infect Dis J. 2009;28:376-380.