An update on chronic wounds and the role of biofilms

Journal of Cutaneous Medicine and Surgery

Volumn 17, Issue 6, 2013, Pages 371-376

  Scali, Christina ^a   Kunimoto, Brian ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIADHESION MOLECULE; ANTIBIOFILM AGENT; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CADEXOMER IODINE; DISINFECTANT AGENT; LACTOFERRIN; QUORUM SENSING INHIBITOR; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; AWARENESS; BACTERIAL CLEARANCE; BACTERIAL COLONIZATION; BIOFILM; CHRONIC WOUND; DEBRIDEMENT; DRUG RESEARCH; ENTEROBACTER; FINEGOLDIA; HEMOSTASIS; HUMAN; INFLAMMATION; LEG ULCER; MICROBIOLOGY; NONHUMAN; PEPTONIPHILUS; PRIORITY JOURNAL; PROTEUS; PSEUDOMONAS; QUORUM SENSING; REVIEW; RISK FACTOR; SERRATIA; STAPHYLOCOCCUS; STENOTROPHOMONAS; STREPTOCOCCUS; WOUND HEALING; CHRONIC DISEASE; GROWTH, DEVELOPMENT AND AGING; HEALTH; MORBIDITY; TRENDS; WOUND INFECTION;

BIOFILMS; CHRONIC DISEASE; GLOBAL HEALTH; HUMANS; MORBIDITY; WOUND HEALING; WOUND INFECTION; WORLD HEALTH;

EID: 84891724860     PISSN: 12034754     EISSN: None     Source Type: Journal    
DOI: 10.2310/7750.2013.12129     Document Type: Review

References (60)

1. Fowler E. Chronic wounds: an overview. In: Krasner D, editor. Chronic wound care: a clinical source book for healthcare professionals. King of Prussia (PA): Health Management Publications; 1990. p. 2-8.
2. Brunicardi F. Charles Schwartz's principles of surgery. 8th ed. New York: McGraw-Hill; 2004.
3. Walmsley S. Advances in wound management: executive summary. Clinical reports. London: PJB Publications; 2002.
4. Wicke C, Bachinger A, Coerper S, et al. Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized wound care center. Wound Repair Regen 2009;17:25-33, doi:10.1111/j.1524-475X.2008. 00438.x.
5. Labropoulos N, Wang E, Lanier S, et al. Factors associated with poor healing and recurrence of venous ulceration. Plast Reconstr Surg 2012;129:179-86, doi:10.1097/PRS.0b013e3182362a53.
6. Moffatt CJ, Doherty DC, Smithdale R, et al. Clinical predictors of leg ulcer healing. Br J Dermatol 2010;162:51-8, doi:10.1111/j.1365-2133.2009.09397. x.
7. Zhao G, Hochwalt PC, Usui ML, et al. Delayed wound healing in diabetic (db/db)mice with Pseudomonas aeruginosa biofilm challenge: a model for the study of chronic wounds. Wound Repair Regen 2010;18:467-77, doi:10.1111/j.1524-475X. 2010.00608.x.
8. Schierle C, De la Garza M, Mustoe T, et al. Staphylococcal biofilms impair wound healing by delaying reepithelialization in a murine cutaneous wound model. Wound Repair Regen 2009;17:354-9, doi:10.1111/j.1524-475X.2009.00489.x.
9. Wolcott R, Rhoads D, Dowd S. Biofilms and chronic wound inflammation. J Wound Care 2008;17:333-41.
10. Kane D. Chronic wound healing and chronic wound management. In: Krasner DL, Rodeheaver G, Sibbald G, editors. Chronic wound care: a clinical source book for healthcare professionals. 4th ed. Malvern (PA): HMP Communications; 2007. p. 11-24.
11. Frank C, Bayoumi I, Westendorp C. Approach to infected skin ulcers. Can Fam Physician 2005;51:1352-9.
12. Landis S. Chronic wound infection and antimicrobial use. Adv Skin Wound Care 2008;21:531-40, doi:10.1097/01.ASW.0000323578.87700.a5.
13. Madsen S, Westh H, Danielsen L, et al. Bacterial colonization and healing of venous leg ulcers. APMIS 1996;104:895-9, doi:10.1111/j.1699-0463.1996. tb04955.x.
14. Kingsley A. The wound infection continuum and its application to clinical practice. Ostomy Wound Manage 2003;49 Suppl 7A:S1-7.
15. Halbert A, Stacey M, Rohr J, et al. The effect of bacterial colonization on venous ulcer healing. Aust J Dermatol 1992;33:75-80, doi:10.1111/j.1440-0960. 1992.tb00083.x.
16. Salcido R. What is bioburden? The link to chronic wounds. Adv Skin Wound Care 2007;20:368, doi:10.1097/01.ASW.0000280205.88754.57.
17. Cutting KF, Harding KG. Criteria for identifying wound infection. J Wound Care 1994;3:198-201.
18. Wysocki AB. Evaluating and managing open skin wounds: colonization versus infection. AACN Clin Issues 2002;13:382-97, doi:10.1097/00044067-200208000- 00005.
19. Bowler P, Davies B. The microbiology of acute and chronic wounds. Wounds 1999;11:72-8.
20. Moore K, Hall V, Paull A, et al. Surface bacteriology of venous leg ulcers and healing outcome. J Clin Pathol 2010;63:830-4, doi: 10.1136/jcp.2010.077032.
21. Sheffield P. Tissue oxygen measurements. In: Jefferson CD, Hunt TK, editors. Problem wounds: the role of oxygen. Amsterdam: Elsevier; 1988. p. 17-51.
22. Gjodsbol K, Christensen J, Karlsmark T, et al. Multiple bacterial species reside in chronic wounds: a longitudinal study. Int Wound J 2006;3:225-31, doi:10.1111/j.1742-481X.2006.00159.x.
23. Hansson C, Hoborn J, Moller A, et al. The microbial flora in venous leg ulcers without clinical signs of infection. Acta Dermatol Venereol 1995;75:24-30.
24. Dowd SE, Sun Y, Secor PR, et al. Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing. BMC Microbiol 2008;8:43-58, doi:10.1186/1471-2180-8-43.
25. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 1999;284:1318-22, doi:10.1126/science. 284.5418.1318.
26. Chen L, Wen Y. The role of bacterial biofilm in persistent infections and control strategies. Int J Oral Sci 2011;3:66-73, doi:10.4248/IJOS11022.
27. Davies D, Parsek M, Pearson J, et al. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 1998;280:295-8, doi:10.1126/science.280.5361.295.
28. Kievit TR, Iglewski BH. Bacterial quorum sensing in pathogenic relationships. Infect Immun 2000;68:4839-49, doi:10.1128/IAI.68.9.4839-4849. 2000.
29. Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 2002;15:167-93, doi:10.1128/CMR.15. 2.167-193.2002.
30. Costerton JW, Veeh R, Shirtliff M. The application of biofilm science to the study and control of chronic bacterial infections. J Clin Invest 2003;112:1466-77.
31. Parsek MR, Singh PK. Bacterial biofilms: an emerging link to disease pathogenesis. Annu Rev Microbiol 2003;57:677-701, doi:10.1146/annurev.micro.57. 030502.090720.
32. Ehrlich GD, Ze Hu F, Shen K, et al. Bacterial plurality as a general mechanism driving persistence in chronic infections. Clin Orthop Relat Res 2005;437:20-4, doi:10.1097/00003086-200508000-00005.
33. Thomson C. Biofilms: do they affect wound healing? Int Wound J 2011;8:63-7, doi:10.1111/j.1742-481X.2010.00749.x.
34. Leid J, Wilson C, Shirtliff M, et al. The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from INF-gamma-mediated macrophage killing. J Immunol 2005;175:7512-8.
35. Bjarnsholt T, Kirketerp-Moller K, Jensen P, et al. Why chronic wounds won't heal: a novel hypothesis. Wound Repair Regen 2008;1:2-10, doi:10.1111/j.1524-475X.2007.00283.x.
36. Davis S, Ricotti C, Cazzaniga A, et al. Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo. Wound Repair Regen 2008;16:23-9, doi:10.1111/j.1524-475X.2007.00303.x.
37. Jesaitis A, Franklin M, Berglund D, et al. Compromised host defense on Pseudomonas aeruginosa biofilms: characterization of neutrophil and biofilm interactions. J Immunol 2003;171:4329-39.
38. Stewart PS, Costerton JW. Antibiotic resistance of bacteria in biofilms. Lancet 2001;358:135-8, doi:10.1016/S0140-6736(01)05321-1.
39. James G, Swogger E, Wolcott R, et al. Biofilms in chronic wounds. Wound Repair Regen 2008;16:37-44, doi:10.1111/j.1524-475X.2007.00321.x.
40. Falanga V. The chronic wound: impaired healing and solutions in the context of wound bed preparation. Blood Cells Mol Dis 2004;32:88-94, doi:10.1016/j.bcmd.2003.09.020.
41. Hurlow J, Bowler P. Clinical experience with wound biofilm and management: a case series. Ostomy Wound Manage 2009;55:38-49.
42. Wolcott RD, Rhoads DD. A study of biofilm-based wound management in subjects with critical limb ischemia. J Wound Care 2008;17:145-8.
43. Wolcott RD, Rumbaugh KP, James G, et al. Biofilm maturity studies indicate sharp debridement opens a time-dependent therapeutic window. J Wound Care 2010;19:320-8.
44. Davis SC, Martinez L, Kirsner R. The diabetic foot: the importance of biofilms and wound bed preparation. Curr Diabet Rep 2006;6:439-45, doi:10.1007/s11892-006-0076-x.
45. Wilson JR, Mills JG, Prather ID. A toxicity index of skin and wound cleansers used on in vitro fibroblasts and keratinocytes. Adv Skin Wound Care 2005;18:373-8, doi:10.1097/00129334-200509000-00011.
46. Zaki I, Shall L, Dalziel K. Bacitracin: a significant sensitizer in leg ulcer patients? Contact Dermatitis 1994;31:92-4, doi:10.1111/j.1600-0536.1994. tb01924.x.
47. Fraki JE, Peltonen L, Hopsu-Havu VK. Allergy to various components of topical preparations in stasis dermatitis and leg ulcer. Contact Dermatitis 1979;5:97-100, doi:10.1111/j.1600-0536.1979.tb04806.x.
48. Schultz GS, Sibbald RG, Falanga V. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen 2003;11 Suppl 1:S1-28, doi:10.1046/j.1524-475X.11.s2.1.x.
49. Dalton T, Dowd SE, Wolcott RD, et al. An in vivo polymicrobial biofilm wound infection model to study interspecies interactions. PLoS One 2011;6:e27317, doi:10.1371/journal.pone.0027317.
50. Gurjala AN, Geringer MR, Seth AK. Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing. Wound Repair Regen 2011;19:400-10, doi:10.1111/j.1524-475X.2011.00690. x.
51. Lenselink E, Andriessen A. A cohort study on the efficacy of a polyhexanide-containing biocellulose dressing in the treatment of biofilms in wounds. J Wound Care 2011;20:536-9.
52. Baffoni M, Bessa LJ, Grande R, et al. Laser irradiation effect on Staphylococcus aureus and Pseudomonas aeruginosa biofilms isolated from venous leg ulcer. Int Wound J 2012;9:517-24, doi:10.1111/j.1742-481X.2011.00910.
53. Ngo QD, Vickery K, Deva AK. The effect of topical negative pressure on wound biofilms using an in vitro wound model. Wound Repair Regen 2012;20:83-90, doi:10.1111/j.1524-475X.2011.00747.x.
54. Folsom JP, Baker B, Stewart PS. In vitro efficacy of bismuth thiols against biofilms formed by bacteria isolated from human chronic wounds. J Appl Microbiol 2011;111:989-96, doi:10.1111/j.1365-2672.2011.05110.x.
55. Dean SN, Bishop BM, van Hoek ML. Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus. BMC Microbiol 2011;11:114, doi:10.1186/1471-2180-11-114.
56. Ammons MC, Ward LS, James GA. Anti-biofilm efficacy of a lactoferrin/xylitol wound hydrogel used in combination with silver wound dressings. Int Wound J 2011;8:268-73, doi:10.1111/j.1742-481X.2011.00781.x.
57. Iwase T, Uehara Y, Shinji H, et al. Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization. Nature 2010;465:346-51, doi:10.1038/nature09074.
58. Asad S, Opal S. Bench to bedside review: quorum sensing and the role of cell-to-cell communication during invasive bacterial infection. Crit Care 2008;12:236-47, doi:10.1186/cc7101.
59. Kiedrowski M, Horswill A. New approaches for treating staphylococci biofilm infections. Ann N Y Acad Sci 2011;1241:104-21, doi:10.1111/j.1749-6632. 2011.06281.x.
60. Darouiche RO, Mansouri MD, Gawande PV, et al. Antimicrobial and antibiofilm efficacy of triclosan and DispersinB combination. J Antimicrob Chemother 2009;64:88-93, doi:10.1093/jac/dkp158.