Pepsin concentrations are elevated in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis after lung transplantation

Journal of Surgical Research

Volumn 185, Issue 2, 2013, Pages

  Davis, Christopher S ^a   Mendez, Bernardino M ^a   Flint, Diana V ^a   Pelletiere, Karen ^a   Lowery, Erin ^a   Ramirez, Luis ^a   Love, Robert B ^a   Kovacs, Elizabeth J ^a   Fisichella, P Marco ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Aspiration; BOS; Bronchiolitis obliterans syndrome; Gastroesophageal reflux disease; GERD; Lung transplantation

Indexed keywords

BARIUM; PEPSIN A;

ACUTE GRAFT REJECTION; ADULT; ALPHA ANTITRYPSIN DEFICIENCY; ARTICLE; BRONCHIOLITIS OBLITERANS; BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CORRELATION ANALYSIS; CYSTIC FIBROSIS; DEMOGRAPHY; DERMATOMYOSITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ESOPHAGUS FUNCTION; ESOPHAGUS MANOMETRY; FEMALE; FIBROSING ALVEOLITIS; FOLLOW UP; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN TISSUE; LOWER ESOPHAGUS SPHINCTER PRESSURE; LUNG FIBROSIS; LUNG FUNCTION TEST; LUNG LAVAGE; LUNG TRANSPLANTATION; LYMPHANGIOLEIOMYOMATOSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PNEUMOCONIOSIS; POLYMYOSITIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULMONARY ASPIRATION; PULMONARY HYPERTENSION; PULMONARY VENO-OCCLUSIVE DISEASE; RHEUMATOID ARTHRITIS; SARCOIDOSIS; SCLERODERMA; STOMACH EMPTYING; TRANSBRONCHIAL BIOPSY; ASPIRATION; ASPIRATION PNEUMONIA; BOS; BRONCHIOLITIS OBLITERANS SYNDROME; CHEMISTRY; GASTROESOPHAGEAL REFLUX; GERD; MANOMETRY; METABOLISM; PH; POSTOPERATIVE COMPLICATION; RISK FACTOR; IDIOPATHIC PULMONARY FIBROSIS; PNEUMONIA, ASPIRATION; POSTOPERATIVE COMPLICATIONS;

ASPIRATION; BOS; BRONCHIOLITIS OBLITERANS SYNDROME; GASTROESOPHAGEAL REFLUX DISEASE; GERD; LUNG TRANSPLANTATION;

BRONCHIOLITIS OBLITERANS; BRONCHOALVEOLAR LAVAGE FLUID; FEMALE; GASTROESOPHAGEAL REFLUX; HUMANS; HYDROGEN-ION CONCENTRATION; IDIOPATHIC PULMONARY FIBROSIS; LUNG TRANSPLANTATION; MALE; MANOMETRY; MIDDLE AGED; PEPSIN A; PNEUMONIA, ASPIRATION; POSTOPERATIVE COMPLICATIONS; RISK FACTORS;

EID: 84891701384     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.06.011     Document Type: Article

References (40)

1. D'Ovidio F, Mura M, Tsang M, et al. Bile acid aspiration and the development of bronchiolitis obliterans after lung transplantation. Thorac Cardiovasc Surg 2005;129: 1144.
2. Hadjiliadis D, Davis RD, Steele MP, et al. Gastroesophageal reflux disease in lung transplant recipients. Clin Transplant 2003;17:363.
3. Cantu E III, Appel JZ III, Hartwig MG, et al. Maxwell Chamberlain Memorial Paper: early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease. Ann Thorac Surg 2004;78: 1142.
4. Davis RD Jr, Lau CL, Eubanks S, et al. Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation. J Thorac Cardiovasc Surg 2003;125:533.
5. Lau CL, Palmer SM, Howell DN, et al. Laparoscopic antireflux surgery in the lung transplant population. Surg Endosc 2002; 16:1674.
6. Fisichella PM, Davis CS, Lundberg PW, et al. The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery 2011;150:598.
7. Hartwig MG, Appel JZ, Li B, et al. Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation. J Thorac Cardiovasc Surg 2006;131:209.
8. Li B, Hartwig MG, Appel JZ, et al. Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants. Am J Transplant 2008;8:1614.
9. Meltzer AJ, Weiss MJ, Veillette GR, et al. Repetitive gastric aspiration leads to augmented indirect allorecognition after lung transplantation in the miniature swine. Transplantation 2008;86:1824.
10. Young LR, Hadjiliadis D, Davis RD, Palmer SM. Lung transplantation exacerbates gastroesophageal reflux disease. Chest 2003;124:1689.
11. Davis CS, Shankaran V, Kovacs EJ, et al. Gastroesophageal reflux disease after lung transplantation: pathophysiology and implications for treatment. Surgery 2010;148:737.
12. Neujahr DC, Mohammed A, Ulukpo O, et al. Surgical correction of gastroesophageal reflux in lung transplant patients is associated with decreased effector CD8 cells in lung lavages: a case series. Chest 2010;138:937.
13. Fisichella PM, Davis CS, Lowery E, et al. Pulmonary immune changes early after laparoscopic antireflux surgery in lung transplant patients with gastroesophageal reflux disease. J Surg Res 2012;177:e65.
14. Basseri B, Conklin JL, Pimentel M, et al. Esophageal motor dysfunction and gastroesophageal reflux are prevalent in lung transplant candidates. Ann Thorac Surg 2010;90:1723.
15. Tobin RW, Pope CE II, Pellegrini CA, et al. Increased prevalence of gastroesophageal reflux disease in patients with idiopathic pulmonary fibrosis. Am J Respir Cri Care Med 1998;158:1804.
16. Sweet MP, Patti MG, Leard LE, et al. Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation. J Thorac Cardiovasc Surg 2007;133: 1078.
17. Salvioli B, Belmonte G, Stanghellini V, et al. Gastro-oesophageal reflux and interstitial lung disease. Dig Liver Dis 2006;38:879.
18. Raghu G, Freudenberger TD, Yang S, et al. High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis. Eur Respir J 2006;27:136.
19. Mays EE, Dubois JJ, Hamilton GB. Pulmonary fibrosis associated with tracheobronchial aspiration: a study of the frequency of hiatal hernia and gastroesophageal reflux in interstitial pulmonary fibrosis of obscure etiology. Chest 1976;69:512.
20. Patti MG, Tedesco P, Golden J, et al. Idiopathic pulmonary fibrosis: how often is it really idiopathic? J Gastrointest Surg 2005;9:1053.
21. Soares RV, Forsythe A, Hogarth K, et al. Interstitial lung disease and gastroesophageal reflux disease: key role of esophageal function tests in the diagnosis and management. Arq Gastroenterol 2011;48:91.
22. Linden PA, Gilbert RJ, Yeap BY, et al. Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation. J Thorac Cardiovasc Surg 2006;131: 438.
23. Stewart S, Fishbein MC, Snell GI, et al. Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection. J Heart Lung Transplant 2007;26:1229.
24. Mendez B, Davis C, Weber C, et al. Gastroesophageal reflux disease in lung transplant patients with cystic fibrosis. Am J Surg 2012;204:e21.
25. Estenne M, Maurer JR, Boehler A, et al. Bronchiolitis obliterans syndrome 2001, an update of the diagnostic criteria. J Heart Lung Transplant 2002;21:297.
26. Sweet MP, Patti MG, Hoopes C, et al. Gastro-oesophageal reflux and aspiration in patients with advanced lung disease. Thorax 2009;64:167.
27. Sweet MP, Herbella FA, Leard L, et al. The prevalence of distal and proximal gastroesophageal reflux in patients awaiting lung transplantation. Ann Surg 2006;244:491.
28. Hoppo T, Jarido V, Pennathur A, et al. Anti-reflux surgery preserves lung function in patients with gastroesophageal reflux disease and end-stage lung disease before and after lung transplantation. Arch Surg 2011;146:1041.
29. Hershcovici T, Jha LK, Johnson T, et al. Systematic review: the relationship between interstitial lung diseases and gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2011;34:1295.
30. Raghu G, Yang ST, Spada C, et al. Sole treatment of acid gastroesophageal reflux in idiopathic pulmonary fibrosis: a case series. Chest 2006;129:794.
31. Scott M, Gelhot AR. Gastroesophageal reflux disease: diagnosis and management. Am Fam Physician 1999;59:1161.
32. Ward C, Forrest IA, Brownlee IA, et al. Pepsin like activity in bronchoalveolar lavage fluid is suggestive of gastric aspiration in lung allografts. Thorax 2005;60:872.
33. D'Ovidio F, Mura M, Ridsdale R, et al. The effect of reflux and bile acid aspiration on the lung allograft and its surfactant and innate immunity molecules SP-A and SP-D. Am J Transplant 2006;6:1930.
34. D'Ovidio F, Mura M, Waddell TK, et al. Bile acids in bronchoalveolar lavage after lung transplantation as a marker of pulmonary aspiration associated with alveolar neutrophilia. J Heart Lung Transplant 2004;23(2 Suppl 1):42S.
35. Fisichella PM, Davis CS, Lowery E, et al. Aspiration, localized pulmonary inflammation, and predictors of early-onset bronchiolitis obliterans syndrome after lung transplantation. J Am Coll Surg Epub 2013 Apr 26; doi: pii: S1072-7515(13) 00226-3. http://dx.doi.org/10.1016/j.jamcollsurg.2013.03.008.
36. Jaoude PA, Knight PR, Ohtake P, et al. Biomarkers in the diagnosis of aspiration syndrome. Expert Rev Mol Diagn 2010;10:309.
37. Blondeau K, Mertens V, Vanaudenaerde BA, et al. Gastro-oesophageal reflux and gastric aspiration in lung transplant patients with or without chronic rejection. Eur Respir J 2008; 31:707.
38. Christie JD, Edwards LB, Aurora P, et al. Registry for the International Society for Heart and Lung Transplantation: twenty-fifth official adult lung and heart/lung transplantation report. J Heart Lung Transplant 2008;27:957.
39. D'Ovidio F, Singer LG, Hadjiliadis D, et al. Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Ann Thorac Surg 2005;80:1254.
40. Bandeira CD, Rubin AS, Cardoso PF, et al. Prevalence of gastroesophageal reflux disease in patients with idiopathic pulmonary fibrosis. J Bras Pneumol 2009;35:1182.