Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

Neuropharmacology

Volumn 79, Issue , 2014, Pages 380-388

  Lou, Haiyan ^a   Jing, Xu ^a   Wei, Xinbing ^a   Shi, Huanying ^a   Ren, Dongmei ^b   Zhang, Xiumei ^a  

^a SHANDONG UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

6 OHDA; Naringenin; Nrf2; Oxidative stress; Parkinson's disease

Indexed keywords

NARINGENIN; OXIDOPAMINE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; FLAVANONE DERIVATIVE; NEUROPROTECTIVE AGENT; NFE2L2 PROTEIN, HUMAN; NFE2L2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRIATONIGRAL DEGENERATION; ANIMAL; APOPTOSIS; C57BL MOUSE; CHEMISTRY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DRUG EFFECTS; METABOLISM; OXIDATIVE STRESS; PARKINSONIAN DISORDERS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SUBSTANTIA NIGRA; TOXICITY; TUMOR CELL LINE;

ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; APOPTOSIS; CELL LINE, TUMOR; CORPUS STRIATUM; DOPAMINERGIC NEURONS; FLAVANONES; HUMANS; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; OXIDOPAMINE; PARKINSONIAN DISORDERS; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA;

EID: 84891699279     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.11.026     Document Type: Article

References (26)

1. S.L. Albarracin, B. Stab, Z. Casas, J.J. Sutachan, I. Samudio, J. Gonzalez, L. Gonzalo, F. Capani, L. Morales, and G.E. Barreto Effects of natural antioxidants in neurodegenerative disease Nutr. Neurosci. 15 2012 1 9
2. M.J. Calkins, D.A. Johnson, J.A. Townsend, M.R. Vargas, J.A. Dowell, T.P. Williamson, A.D. Kraft, J.M. Lee, J. Li, and J.A. Johnson The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease Antioxid. Redox Signal. 11 2009 497 508
3. P.C. Chen, M.R. Vargas, A.K. Pani, R.J. Smeyne, D.A. Johnson, Y.W. Kan, and J.A. Johnson Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte Proc. Natl. Acad. Sci. U. S. A. 106 2009 2933 2938
4. A. Cuadrado, P. Moreno-Murciano, and J. Pedraza-Chaverri The transcription factor Nrf2 as a new therapeutic target in Parkinson's disease Expert Opin. Ther. Targets 13 2009 319 329
5. H.E. de Vries, M. Witte, D. Hondius, A.J. Rozemuller, B. Drukarch, J. Hoozemans, and J. van Horssen Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic. Biol. Med. 45 2008 1375 1383
6. Y. Du, N.F. Villeneuve, X.J. Wang, Z. Sun, W. Chen, J. Li, H. Lou, P.K. Wong, and D.D. Zhang Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response Environ. Health Perspect. 116 2008 1154 1161
7. X. Gao, A. Cassidy, M.A. Schwarzschild, E.B. Rimm, and A. Ascherio Habitual intake of dietary flavonoids and risk of Parkinson disease Neurology 78 2012 1138 1145
8. K. Gopinath, and G. Sudhandiran Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway Neuroscience 27 2012 34 43
9. H.J. Heo, D.O. Kim, S.C. Shin, M.J. Kim, B.G. Kim, and D.H. Shin Effect of antioxidant flavanone, naringenin, from Citrus junoson neuroprotection J. Agric. Food Chem. 52 2004 1520 1525
10. O. Hwang Role of oxidative stress in Parkinson's disease Exp. Neurobiol. 22 2013 11 17
11. A. Jazwa, A.I. Rojo, N.G. Innamorato, M. Hesse, J. Fernández-Ruiz, and A. Cuadrado Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism Antioxid. Redox Signal. 14 2011 2347 2360
12. N.A. Kaidery, R. Banerjee, L. Yang, N.A. Smirnova, D.M. Hushpulian, K.T. Liby, C.R. Williams, M. Yamamoto, T.W. Kensler, R.R. Ratan, M.B. Sporn, M.F. Beal, I.G. Gazaryan, and B. Thomas Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease Antioxid. Redox Signal. 18 2013 139 157
13. H. Klintworth, K. Newhouse, T. Li, W.S. Choi, R. Faigle, and Z. Xia Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis Toxicol. Sci. 97 2007 149 162 (Pubitemid 47072164)
14. J.K. Prasain, S.H. Carlson, and J.M. Wyss Flavonoids and age-related disease: risk, benefits and critical windows Maturitas 66 2010 163 171
15. I. Rahman, A. Kode, and S. Biswas Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method Nat. Protoc. 1 2007 3159 3165
16. C.P. Ramsey, C.A. Glass, M.B. Montgomery, K.A. Lindl, G.P. Ritson, L.A. Chia, R.L. Hamilton, C.T. Chu, and K.L. Jordan-Sciutto Expression of Nrf2 in neurodegenerative diseases J. Neuropathol. Exp. Neurol. 66 2007 75 85 (Pubitemid 46066791)
17. J.M. Savitt, V.L. Dawson, and T.M. Dawson Diagnosis and treatment of Parkinson disease: molecules to medicine J. Clin. Invest. 116 2006 1744 1754 (Pubitemid 44033293)
18. A.P. Signore, Z. Weng, T. Hastings, A.D. Van Laar, Q. Liang, Y.J. Lee, and J. Chen Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death J. Neurochem. 96 2006 428 443
19. G.P. Sykiotis, and D. Bohmann Stress-activated cap'n'collar transcription factors in aging and human disease Sci. Signal. 3 2010 re3
20. J.C. Tobón-Velasco, G. Vázquez-Victorio, M. Macías-Silva, E. Cuevas, S.F. Ali, P.D. Maldonado, M.E. González-Trujano, A. Cuadrado, J. Pedraza-Chaverrí, and A. Santamaría S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades Free Radic. Biol. Med. 53 2012 1024 1040
21. J.C. Tobón-Velasco, J.H. Limón-Pacheco, M. Orozco-Ibarra, M. Macías-Silva, G. Vázquez-Victorio, E. Cuevas, S.F. Ali, A. Cuadrado, J. Pedraza-Chaverrí, and A. Santamaría 6-OHDA-induced apoptosis and mitochondrial dysfunction are mediated by early modulation of intracellular signals and interaction of Nrf2 and NF-κB factors Toxicology 304 2013 109 119
22. M. von Otter, S. Landgren, S. Nilsson, D. Celojevic, P. Bergström, A. Hakansson, H. Nissbrandt, M. Drozdzik, M. Bialecka, M. Kurzawski, K. Blennow, M. Nilsson, O. Hammarsten, and H. Zetterberg Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease BMC Med. Genet. 11 2010 36
23. L. Yang, N.Y. Calingasan, B. Thomas, R.K. Chaturvedi, M. Kiaei, E.J. Wille, K.T. Liby, C. Williams, D. Royce, R. Risingsong, E.S. Musiek, J.D. Morrow, M. Sporn, and M.F. Beal Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription PLoS One 4 2009 e5757
24. K.A. Youdim, M.S. Dobbie, G. Kuhnle, A.R. Proteggente, N.J. Abbott, and C. Rice-Evans Interaction between flavonoids and the blood-brain barrier: in vitro studies J. Neurochem. 85 2003 180 192 (Pubitemid 36389708)
25. V. Zbarsky, K.P. Datla, S. Parkar, D.K. Rai, O.I. Aruoma, and D.T. Dexter Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease Free Radic. Res. 39 2005 1119 1125 (Pubitemid 41358566)
26. K.Y. Zhu, Q. Fu, K.W. Leung, Z.C. Wong, R.C. Choi, and K.W. Tsim The establishment of a sensitive method in determining different neurotransmitters simultaneously in rat brains by using liquid chromatography-electrospray tandem mass spectrometry J. Chromatogr. B 879 2011 737 742