Awake Nonhuman Primate Brain PET Imaging with Minimal Head Restraint: Evaluation of GABAA-Benzodiazepine Binding with 11C- Flumazenil in awake and anesthetized animals

Journal of Nuclear Medicine

Volumn 54, Issue 11, 2013, Pages 1962-1968

  Sandiego, Christine M ^a,b   Jin, Xiao ^a,b   Mulnix, Tim ^b   Fowles, Krista ^b   Labaree, David ^b   Ropchan, Jim ^b   Huang, Yiyun ^b   Cosgrove, Kelly ^b,c   Castner, Stacy A ^c   Williams, Graham V ^c   Wells, Lisa ^d   Rabiner, Eugenii A ^d,e   Carson, Richard E ^a,b  

^a Yale University   (United States)

^b YALE UNIVERSITY   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Imanova Ltd   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Conscious; Cortisol; Flumazenil; GABA shift; Isoflurane; Monkey; PET

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; FLUMAZENIL C 11; HYDROCORTISONE; 4 AMINOBUTYRIC ACID; BENZODIAZEPINE DERIVATIVE; CARBON; DIAGNOSTIC AGENT; FLUMAZENIL; ISOFLURANE;

AMYGDALOID NUCLEUS; ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; BINDING KINETICS; BODY EQUILIBRIUM; CEREBELLUM; CINGULATE GYRUS; FEMALE; FRONTAL CORTEX; HEAD MOVEMENT; IMAGE QUALITY; IMMOBILIZATION; INSULA; MALE; NEUROIMAGING; NONHUMAN; OCCIPITAL CORTEX; PONS; POSITRON EMISSION TOMOGRAPHY; PRIMATE; PRIORITY JOURNAL; RHESUS MONKEY; TEMPORAL CORTEX; THALAMUS; WAKEFULNESS; ANIMAL; BRAIN; CONSCIOUS; EQUIPMENT; EXERCISE; GABA SHIFT; HAPLORHINI; HEAD; METABOLISM; METHODOLOGY; PET; SCINTISCANNING; DEVICES; DIAGNOSTIC USE; PROCEDURES;

CONSCIOUS; CORTISOL; FLUMAZENIL; GABA SHIFT; ISOFLURANE; MONKEY; PET;

ANESTHESIA; ANIMALS; BENZODIAZEPINES; BRAIN; CARBON RADIOISOTOPES; FEMALE; FLUMAZENIL; GAMMA-AMINOBUTYRIC ACID; HEAD; MACACA MULATTA; MALE; POSITRON-EMISSION TOMOGRAPHY; RESTRAINT, PHYSICAL; WAKEFULNESS;

EID: 84891686846     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.122077     Document Type: Article

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