Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes

Diabetes

Volumn 62, Issue 11, 2013, Pages 3747-3750

  Vaittinen, Maija ^a   Kaminska, Dorota ^a   Käkelä, Pirjo ^b   Eskelinen, Matti ^b   Kolehmainen, Marjukka ^a   Pihlajamäki, Jussi ^a,b   Uusitupa, Matti ^a,b   Pulkkinen, Leena ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; CALCINEURIN; CALCINEURIN LIKE PHOSPHOESTERASE DOMAIN CONTAINING 1; PHOSPHATASE; UNCLASSIFIED DRUG; CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN 1, HUMAN; GLUCOSE; INSULIN; SMALL INTERFERING RNA; CALCINEURIN LIKE PHOSPHOESTERASE DOMAIN CONTAINING PROTEIN 1, HUMAN;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN EXPRESSION; WEIGHT REDUCTION; BIOSYNTHESIS; CELL CULTURE; GENE SILENCING; GENETICS; METABOLISM; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; CONTROLLED CLINICAL TRIAL;

ADIPOCYTES; ADIPOSE TISSUE; ADULT; AGED; CALCINEURIN; CELL DIFFERENTIATION; CELLS, CULTURED; DOWN-REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HUMANS; INSULIN; MIDDLE AGED; RNA, SMALL INTERFERING; WEIGHT LOSS;

EID: 84891667094     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0830     Document Type: Article

References (12)

1. Lindström J, Peltonen M, Eriksson JG, et al.; Finnish Diabetes Prevention Study (DPS). Improved lifestyle and decreased diabetes risk over 13 years: long-term follow-up of the randomised Finnish Diabetes Prevention Study (DPS). Diabetologia 2013;56:284-293
2. Kolehmainen M, Salopuro T, Schwab US, et al. Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN study. Int J Obes (Lond) 2008;32:292-303
3. Vaittinen M, Kolehmainen M, Schwab U, Uusitupa M, Pulkkinen L. Microfibrillar-associated protein 5 is linked with markers of obesityrelated extracellular matrix remodeling and inflammation. Nutr Diabetes 2011;1:e15
4. Wabitsch M, Brenner RE, Melzner I, et al. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes Relat Metab Disord 2001;25:8-15
5. Kaminska D, Kuulasmaa T, Venesmaa S, et al. Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism. Diabetes 2012;61:2807-2813
6. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408
7. Hauner H. Secretory factors from human adipose tissue and their functional role. Proc Nutr Soc 2005;64:163-169
8. Mack I, BelAiba RS, Djordjevic T, Görlach A, Hauner H, Bader BL. Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFalpha exposure. Am J Physiol Endocrinol Metab 2009;297:E735- E748
9. Hajer GR, van Haeften TW, Visseren FL. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 2008;29:2959-2971
10. Ziemke F, Mantzoros CS. Adiponectin in insulin resistance: lessons from translational research. Am J Clin Nutr 2010;91:258S-261S
11. Chen MB, McAinch AJ, Macaulay SL, et al. Impaired activation of AMPkinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics. J Clin Endocrinol Metab 2005;90: 3665-3672
12. Rabe K, Lehrke M, Parhofer KG, Broedl UC. Adipokines and insulin resistance. Mol Med 2008;14:741-751