Pancreatic digestive enzyme blockade in the small intestine prevents insulin resistance in hemorrhagic shock

Shock

Volumn 41, Issue 1, 2014, Pages 55-61

  Delano, Frank A ^a   Schmid Schönbein, Geert W ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

autodigestion; Glucose tolerance; leukocytes; mesentery microvessels; pancreatic enzymes; proteases; Wistar rat

Indexed keywords

DIGESTIVE ENZYME; ENZYME; INSULIN RECEPTOR; MACROGOL; PROTEINASE; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BLOOD VOLUME; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; HEMORRHAGIC SHOCK; HYPERGLYCEMIA; INFLAMMATION; INSULIN RESISTANCE; INTRAVENOUS GLUCOSE TOLERANCE TEST; MESENTERY BLOOD FLOW; MICROCIRCULATION; NONHUMAN; RAT; SHOCK; SMALL INTESTINE; SYSTEMIC CIRCULATION;

ANIMALS; BLOOD GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; INTESTINE, SMALL; MALE; PANCREAS; RATS; RATS, WISTAR; RECEPTOR, INSULIN; SERINE PROTEASES; SERINE PROTEINASE INHIBITORS; SHOCK, HEMORRHAGIC; SPLANCHNIC CIRCULATION; TRANEXAMIC ACID;

EID: 84891613348     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000048     Document Type: Article

References (34)

1. Barroso-Aranda J, Schmid-Schönbein GW, Zweifach BW, Engler RL: Granulocytes and the no-reflow phenomenon in irreversible hemorrhagic shock. Circ Res 63:437-447, 1988.
2. Brierre S, Kumari R, Deboisblanc BP: The endocrine system during sepsis. Am J Med Sci 328:238-247, 2004.
3. Carrithers M, Tandon S, Canosa S, Michaud M, Graesser D, Madri JA: Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice. Am J Pathol 166:185-196, 2005.
4. Chang M, Alsaigh T, Kistler EB, Schmid-Schönbein GW: Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine. PloS one 7:e40087, 2012.
5. Chang M, Kistler EB, Schmid-Schönbein GW: Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall. Shock 37:297-305, 2012.
6. Chaudry IH, Sayeed MM, Baue AE: Insulin resistance and its reversal by in vivo infusion of ATP in hemorrhagic shock. Can J Physiol Pharmacol 54:736-741, 1976.
7. Chen SJ, Wu CC, Yen MH: Alterations of ex vivo vascular reactivity in intraperitoneal sepsis. J Cardiovasc Pharmacol 24:786-793, 1994.
8. Das UN: Insulin: an endogenous cardioprotector. Curr Opin Crit Care 9: 375-383, 2003.
9. DeLano FA, Hoyt DB, Schmid-Schönbein GW: Pancreatic digestive enzyme blockade in the intestine increases survival after experimental shock. Sci Transl Med 5:169ra111, 2013.
10. DeLano FA, Parks DA, Ruedi JM, Babior BM, Schmid-Schönbein GW: Microvascular display of xanthine oxidase and NADPH oxidase in the spontaneously hypertensive rat. Microcirculation 13:551-566, 2006.
11. DeLano FA, Schmid-Schönbein GW: Proteinase activity and receptor cleavage. Mechanism for insulin resistance in the spontaneously hypertensive rat. Hypertension 52:415-423, 2008.
12. DeLano FA, Zhang H, Tran EE, Zhang C, Schmid-Schönbein GW: New hypothesis for insulin resistance in hypertension due to receptor cleavage. Expert Rev Endocrinol Metab 5:149-158, 2010.
13. Fitzal F, DeLano FA, Young C, Rosario HS, Schmid-Schönbein GW: Pancreatic protease inhibition during shock attenuates cell activation and peripheral inflammation. J Vasc Res 39:320-329, 2002.
14. Gorbunov NV, Asher LV, Ayyagari V, Atkins JL: Inflammatory leukocytes and iron turnover in experimental hemorrhagic lung trauma. Exp Mol Pathol 80:11-25, 2006.
15. Granger DN, McCord JM, Parks DA, Hollwarth ME: Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine. Gastroenterology 90:80-84, 1986.
16. Soluble Insulin Receptor Group. Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes. Diabetes 56:2028-2035, 2007.
17. Ji S, Guan R, Frank SJ, Messina JL: Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathway. J Biol Chem 274:13434-13442, 1999.
18. Jiang S, Gavrikova TA, Sharifov OF, Messina JL: Role of tissue macrophages in the development of critical illness diabetes. Shock 37:70-76, 2012.
19. Jiang S, Messina JL: Role of inhibitory kappaB kinase and c-Jun NH2-terminal kinase in the development of hepatic insulin resistance in critical illness diabetes. Am J Physiol Gastrointest Liver Physiol 301:G454-G463, 2011.
20. Kelly E, Shah NS, Morgan NN, Watkins SC, Peitzman AB, Billiar TR: Physiologic and molecular characterization of the role of nitric oxide in hemorrhagic shock: evidence that type II nitric oxide synthase does not regulate vascular decompensation. Shock 7:157-163, 1997.
21. Kistler EB, Hugli TE, Schmid-Schönbein GW: The pancreas as a source of cardiovascular cell activating factors. Microcirculation 7:183-192, 2000.
22. Lang CH, Dobrescu C: In vivo insulin resistance during nonlethal hypermetabolic sepsis. Circ Shock 28:165-178, 1989.
23. Li L, Messina JL: Acute insulin resistance following injury. Trends in endocrinology and metabolism: Trends Endocrinol Metab 20:429-435, 2009.
24. Mendes Ribeiro AC, Brunini TM: L-Arginine transport in disease. Curr Med Chem Cardiovasc Hematol Agents 2: 123-131, 2004.
25. Mitsuoka H, Kistler EB, Schmid-Schönbein GW: Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes. Proc Natl Acad Sci USA 97:1772-1777, 2000.
26. Penn AH, Hugli TE, Schmid-Schönbein GW: Pancreatic enzymes generate cytotoxic mediators in the intestine. Shock 27:296-304, 2007.
27. Ren J, Wu S: A burning issue: do sepsis and systemic inflammatory response syndrome (SIRS) directly contribute to cardiac dysfunction? Front Biosci 11:15-22, 2006.
28. Ryan NT, George BC, Egdahl DH, Egdahl RH: Chronic tissue insulin resistance following hemorrhagic shock. Ann Surg 180:402-407, 1974.
29. Schmid-Schönbein GW: An emerging role of degrading proteinases in hypertension and the metabolic syndrome: autodigestion and receptor cleavage. Curr Hypertens Rep 14:88-96, 2012.
30. Thompson LH, Kim HT, Ma Y, Kokorina NA, Messina JL: Acute, muscle-type specific insulin resistance following injury. Mol Med 14:715-723, 2008.
31. van Meurs M, Wulfert FM, Knol AJ, De Haes A, Houwertjes M, Aarts LP, Molema G: Early organ-specific endothelial activation during hemorrhagic shock and resuscitation. Shock 29:291-299, 2008.
32. Williams VL, Martin RE, Franklin JL, Hardy RW, Messina JL: Injury-induced insulin resistance in adipose tissue. Biochem Biophys Res Commun 421: 442-448, 2012.
33. Xu J, Kim HT, Ma Y, Zhao L, Zhai L, Kokorina N, Wang P, Messina JL: Trauma and hemorrhage-induced acute hepatic insulin resistance: dominant role of tumor necrosis factor-alpha. Endocrinology 149:2369-2382, 2008.
34. Zhai L, Ballinger SW, Messina JL: Role of reactive oxygen species in injuryinduced insulin resistance. Mol Endocrinol 25:492-502, 2011.