Role of endothelial cell septin 7 in the endocytosis of Candida albicans

mBio

Volumn 4, Issue 6, 2013, Pages

  Phan, Quynh T ^a   Eng, David K ^a   Mostowy, Serge ^b,c,d,g   Park, Hyunsook ^e   Cossart, Pascale ^b,c,d   Filler, Scott G ^a,f  

^a LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b INSTITUT PASTEUR   (France)

^c INSERM   (France)

^d CEMAGREF   (France)

^e CALIFORNIA STATE UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BACTERIAL PROTEIN; ENDOTHELIAL CELL SEPTIN 7; NERVE CELL ADHESION MOLECULE; UNCLASSIFIED DRUG; ALS3 PROTEIN, CANDIDA ALBICANS; CADHERIN; CDH2 PROTEIN, HUMAN; CELL CYCLE PROTEIN; FUNGAL PROTEIN; LEUKOCYTE ANTIGEN; PROTEIN BINDING; SEPT7 PROTEIN, HUMAN; SEPTIN;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CANDIDA ALBICANS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSKELETON; DEPOLYMERIZATION; ENDOCYTOSIS; ENZYME INHIBITION; GENE SILENCING; HOST PATHOGEN INTERACTION; MICROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; CELL ADHESION; CELL CULTURE; ENDOTHELIUM CELL; FUNGUS HYPHAE; HUMAN; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; PROTEIN MULTIMERIZATION;

ACTINS; ANTIGENS, CD; CADHERINS; CANDIDA ALBICANS; CELL ADHESION; CELL CYCLE PROTEINS; CELLS, CULTURED; ENDOCYTOSIS; ENDOTHELIAL CELLS; FUNGAL PROTEINS; HUMANS; HYPHAE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SEPTINS;

EID: 84891609530     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.00542-13     Document Type: Article

References (35)

1. Horn DL, Neofytos D, Anaissie EJ, Fishman JA, Steinbach WJ, Olyaei AJ, Marr KA, Pfaller MA, Chang CH, Webster KM. 2009. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin. Infect. Dis. 48:1695-1703.
2. Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. 2004. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin. Infect. Dis. 39:309-317.
3. Grubb SE, Murdoch C, Sudbery PE, Saville SP, Lopez-Ribot JL, Thornhill MH. 2008. Candida albicans-endothelial cell interactions: a key step in the pathogenesis of systemic candidiasis. Infect. Immun. 76: 4370-4377.
4. Phan QT, Fratti RA, Prasadarao NV, Edwards JE, Jr, Filler SG. 2005. N-cadherin mediates endocytosis of Candida albicans by endothelial cells. J. Biol. Chem. 280:10455-10461.
5. Phan QT, Myers CL, Fu Y, Sheppard DC, Yeaman MR, Welch WH, Ibrahim AS, Edwards JE, Filler SG. 2007. Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells. PLoS Biol. 5:e64. doi:10.1371/journal.pbio.0050064.
6. Sun JN, Solis NV, Phan QT, Bajwa JS, Kashleva H, Thompson A, Liu Y, Dongari-Bagtzoglou A, Edgerton M, Filler SG. 2010. Host cell invasion and virulence mediated by Candida albicans Ssa1. PLoS Pathog. 6:e1001181. doi:10.1371/journal.ppat.1001181.
7. Liu Y, Filler SG. 2011. Candida albicans Als3, a multifunctional adhesion and invasin. Eukaryot. Cell 10:168-173.
8. Moreno-Ruiz E, Galán-Díez M, Zhu W, Fernández-Ruiz E, d'Enfert C, Filler SG, Cossart P, Veiga E. 2009. Candida albicans internalization by host cells is mediated by a clathrin-dependent mechanism. Cell. Microbiol. 11:1179-1189.
9. Fratti RA, Ghannoum MA, Edwards JE, Jr, Filler SG. 1996. Gamma interferon protects endothelial cells from damage by Candida albicans by inhibiting endothelial cell phagocytosis. Infect. Immun. 64:4714-4718.
10. Hall PA, Russell SE. 2012. Mammalian septins: dynamic heteromers with roles in cellular morphogenesis and compartmentalization. J. Pathol. 226: 287-299.
11. Mostowy S, Cossart P. 2012. Septins: the fourth component of the cytoskeleton. Nat. Rev. Mol. Cell Biol. 13:183-194.
12. Hu Q, Milenkovic L, Jin H, Scott MP, Nachury MV, Spiliotis ET, Nelson WJ. 2010. A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science 329: 436-439.
13. Sharma S, Quintana A, Findlay GM, Mettlen M, Baust B, Jain M, Nilsson R, Rao A, Hogan PG. 2013. An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca entry. Nature 499:238-242.
14. Mostowy S, Janel S, Forestier C, Roduit C, Kasas S, Pizarro-Cerdá J, Cossart P, Lafont F. 2011. A role for septins in the interaction between the Listeria monocytogenes invasion protein InlB and the Met receptor. Biophys. J. 100:1949-1959.
15. Mostowy S, Nam Tham T, Danckaert A, Guadagnini S, Boisson-Dupuis S, Pizarro-Cerdá J, Cossart P. 2009. Septins regulate bacterial entry into host cells. PLoS One 4:e4196. doi:10.1371/journal.pone.0004196.
16. Serrão VH, Alessandro F, Caldas VE, Marçal RL, Pereira HD, Thiemann OH, Garratt RC. 2011. Promiscuous interactions of human septins: the GTP binding domain of SEPT7 forms filaments within the crystal. FEBS Lett. 585:3868-3873.
17. Rotrosen D, Edwards JE, Jr, Gibson TR, Moore JC, Cohen AH, Green I. 1985. Adherence of Candida to cultured vascular endothelial cells: mechanisms of attachment and endothelial cell penetration. J. Infect. Dis. 152:1264-1274.
18. Filler SG, Swerdloff JN, Hobbs C, Luckett PM. 1995. Penetration and damage of endothelial cells by Candida albicans. Infect. Immun. 63: 976-983.
19. Liu Y, Mittal R, Solis NV, Prasadarao NV, Filler SG. 2011. Mechanisms of Candida albicans trafficking to the brain. PLoS Pathog. 7:e1002305. doi:10.1371/journal.ppat.1002305.
20. Sheppard DC, Yeaman MR, Welch WH, Phan QT, Fu Y, Ibrahim AS, Filler SG, Zhang M, Waring AJ, Edwards JE, Jr. 2004. Functional and structural diversity in the Als protein family of Candida albicans. J. Biol. Chem. 279:30840-30849.
21. Hagiwara A, Tanaka Y, Hikawa R, Morone N, Kusumi A, Kimura H, Kinoshita M. 2011. Submembranous septins as relatively stable components of actin-based membrane skeleton. Cytoskeleton 68:512-525.
22. Veiga E, Cossart P. 2006. The role of clathrin-dependent endocytosis in bacterial internalization. Trends Cell Biol. 16:499-504.
23. Mostowy S, Cossart P. 2011. Septins as key regulators of actin based processes in bacterial infection. Biol. Chem. 392:831-835.
24. Mostowy S, Danckaert A, Tham TN, Machu C, Guadagnini S, Pizarro-Cerdá J, Cossart P. 2009. Septin 11 restricts InlB-mediated invasion by Listeria. J. Biol. Chem. 284:11613-11621.
25. Huang YW, Yan M, Collins RF, Diciccio JE, Grinstein S, Trimble WS. 2008. Mammalian septins are required for phagosome formation. Mol. Biol. Cell 19:1717-1726.
26. Mostowy S, Bonazzi M, Hamon MA, Tham TN, Mallet A, Lelek M, Gouin E, Demangel C, Brosch R, Zimmer C, Sartori A, Kinoshita M, Lecuit M, Cossart P. 2010. Entrapment of intracytosolic bacteria by septin cage-like structures. Cell Host Microbe 8:433-444.
27. Zhu W, Phan QT, Boontheung P, Solis NV, Loo JA, Filler SG. 2012. EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection. Proc. Natl. Acad. Sci. U. S. A. 109:14194-14199.
28. Wilson RB, Davis D, Mitchell AP. 1999. Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J. Bacteriol. 181:1868-1874.
29. Park H, Myers CL, Sheppard DC, Phan QT, Sanchez AA, Edwards JE, Jr, Filler SG. 2005. Role of the fungal Ras-protein kinase A pathway in governing epithelial cell interactions during oropharyngeal candidiasis. Cell. Microbiol. 7:499-510.
30. Jaffe EA, Nachman RL, Becker CG, Minick CR. 1973. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52:2745-2756.
31. Phan QT, Belanger PH, Filler SG. 2000. Role of hyphal formation in interactions of Candida albicans with endothelial cells. Infect. Immun. 68:3485-3490.
32. Fonzi WA, Irwin MY. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
33. Murad AM, Lee PR, Broadbent ID, Barelle CJ, Brown AJ. 2000. CIp10, an efficient and convenient integrating vector for Candida albicans. Yeast 16:325-327.
34. Nobile CJ, Andes DR, Nett JE, Smith FJ, Yue F, Phan QT, Edwards JE, Filler SG, Mitchell AP. 2006. Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo. PLoS Pathog. 2:e63. doi:10.1371/journal.ppat.0020063.
35. Li XS, Sun JN, Okamoto-Shibayama K, Edgerton M. 2006. Candida albicans cell wall Ssa proteins bind and facilitate import of salivary histatin 5 required for toxicity. J. Biol. Chem. 281:22453-22463.