Transcriptional profile characterization for the identification of peripheral blood biomarkers in patients with cerebral aneurysms

Journal of Biological Regulators and Homeostatic Agents

Volumn 27, Issue 3, 2013, Pages 729-738

  Sabatino, G ^a   Rigante, Luigi ^a   Minella, D ^b   Novelli, G ^b   Della Pepa, G M ^a   Esposito, G ^a   Albanese, A ^a   Maira, G ^a   Marchese, E ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Apoptosis; Cerebral aneurysm; Cytoskeleton proteins; Metalloproteinase; Microarray; Subarachnoid hemorrhage

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; HEAT SHOCK PROTEIN; MOLECULAR MARKER; RAS PROTEIN; BIOLOGICAL MARKER; MATRIX METALLOPROTEINASE; TRANSCRIPTOME;

ADULT; AGED; ARTERY WALL; ARTICLE; BLOOD; BRAIN ARTERY ANEURYSM; BRAIN ARTERY ANEURYSM RUPTURE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSKELETON; EXTRACELLULAR MATRIX; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; HUMAN; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; WESTERN BLOTTING; GENETICS; INTRACRANIAL ANEURYSM; MIDDLE AGED; PHYSIOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; FEMALE; HUMANS; INTRACRANIAL ANEURYSM; MALE; MATRIX METALLOPROTEINASES; MIDDLE AGED; TRANSCRIPTOME;

EID: 84891589273     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Lai L, Morgan MK. Incidence of subarachnoid haemorrhage: an Australian national hospital morbidity database analysis. J Clin Neurosci. 2012;19(5):733-9. doi: 10.1016/j.jocn.2011.09.001. Epub 2012 Feb 10.
2. Fontanella M, Rainero I, Gallone S, et al. Tumor necrosis factor-alpha gene and cerebral aneurysms. Neurosurgery 2007; 60:668-72.
3. Ruigrok YM, Elias R, Wijmenga C, Rinkel GJ. A comparison of genetic chromosomal loci for intracranial, thoracic aortic, and abdominal aortic aneurysms in search of common genetic risk factors. Cardiovasc Pathol 2008; 17:40-7.
4. Ruigrok YM, Rinkel GJ, vant Slot R, Wolfs M, Tang S, Wijmenga C. Evidence in favour of the contribution of genes involved in the maintenance of the extracellular matrix of the arterial wall to the development of intracranial aneurysms. Hum Mal Gene 2006; 15:2261-8.
5. Ruigrok YM, Rinkel GJ, Wijmenga C. Genetics of intracranial aneurysms. Lancet Neurol 2005; 4:179-89.
6. Ruigrok YM, Rinkel GJ, Wijmenga C, et al. Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort. Cerebrovasc Dis 2009; 28:131-4.
7. Ruigrok YM, Rinkel GJ. From GWAS to the clinic: risk factors for intracranial aneurysms. Genome Med 2010; 2(9):61.
8. Ruigrok YM, Rinkel GJ. Genetics of intracranial aneurysms. Stroke 2008; 39:1049-55.
9. Ruigrok YM, Wijmenga C, Rinkel GJ, van't Slot R, Baas F, Wolfs M, Westerveld A, Roos YB. Genomewide linkage in a large Dutch family with intracranial aneurysms: replication of 2 loci for intracranial aneurysms to chromosome 1p36.11-p36.13 and Xp22.2-p22.32. Stroke 2008; 39:1096-102.
10. Yurt A, Vardar E, Selçuki M, Ertürk AR, Ozbek G, Atçi B. Biomarkers of connective tissue disease in patients with intracranial aneurysms. J Clin Neurosci 2010; 17:1119-21.
11. Pentimalli L, Modesti A, Vignati A, et al. Role of apoptosis in intracranial aneurysm rupture. J Neurosurg 2004; 101:1018-25.
12. Marchese E, Vignati A, Albanese A, et al. Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms. J Biol Regul Homeost Agents 2010; 24:185-95.
13. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162(1):156-9.
14. Scharpf RB, Iacobuzio-Donahue CA, Sneddon JB, Parmigiani G. When should one subtract background fluorescence in 2-color microarrays? Biostatistics 2007; 8(4):695-707.
15. Yang YH, Dudoit S, Luu P, Lin DM, Peng V, Ngai J, Speed TP. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 2002; 15(4):e15.
16. Jayaraman T, Berenstein V. Tumor Necrosis Factor α is a key modulator of inflammation in cerebral aneurysms. Neurosurgery 2005; 57:558-64 discussion 558-64.
17. Kassel NF, Drake CG. Timing of aneurysm surgery. Neurosurgery 1982; 10:514-19.
18. Kontusaari S, Tromp G, Kuivaniemi H, Romanic AM, Prockop DJ. A mutation in the gene for type III procollagen (COL3A1) in family with aortic aneurysms. J Clin Invest 1990; 86:1465-73.
19. Khurama V, Meissner I, Sohni YR, Bamlet WR, McClelland RL, Cunningham JM, Meyer FB. The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture. J Neurosurg 2005; 102:526-31.
20. Khurana VG, Meissner I, Meyer FB. Update on genetic evidence for rupture-prone compared with rupture-resistant intracranial saccular aneurysms. Neurosurg Focus 2004; 15:E7.
21. Akagawa H, Kasuya H, Onda H, et al. Influence of endothelial nitric oxide synthase T-786C single nucleotide polymorphism on aneurysm size. J Neurosurg 2005; 102:68-71.
22. Krischek B, Kasuya H, Akagawa H, Tajima A, Narita A, Onda H, Hori T, Inoue I. Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients. J Neurosurg 2006; 105:717-22.
23. Lopez-Farre A, Rodriguez-Feo JA. Role of nitrix oxide in the control of apoptosis in the microvascularure. Int J Biochem Cell Bio 1998; 10.
24. Kassam A, Horowitz M, Chang YF, Peters D. Altered arterial homeostasis and cerebral aneurysms: a molecular epidemiology study. Neurosurgery 2004; 54:1450-60 discussion 1460-2.
25. Pannu H, Kim DH, Guo D, et al. The role of MMP-2 and MMP-9 polymorphisms in sporadic intracranial aneurysms. J Neurosurg 2006; 105:418-23.