Follicle number, not assessments of the ovarian stroma, represents the best ultrasonographic marker of polycystic ovary syndrome

Fertility and Sterility

Volumn 101, Issue 1, 2014, Pages

  Christ, Jacob P ^a   Willis, Amy D ^a   Brooks, Eric D ^a   Vanden Brink, Heidi ^a   Jarrett, Brittany Y ^a   Pierson, Roger A ^b   Chizen, Donna R ^b   Lujan, Marla E ^a  

^a 216 Savage Hall ^*  (United States)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

follicle; hyperandrogenism; Polycystic ovary syndrome; stroma; ultrasound

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE MARKER; FEMALE; HUMAN; HYPERANDROGENISM; MAJOR CLINICAL STUDY; OLIGOMENORRHEA; OVARY FOLLICLE; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TRANSVAGINAL ECHOGRAPHY; YOUNG ADULT;

EID: 84891561226     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2013.10.001     Document Type: Article

References (46)

1. I.F. Stein, and M.L. Leventhal Amenorrhea associated with bilateral polycystic ovaries Am J Obstet Gynecol 29 1935 181 191
2. D.A. Zawadzki Diagnostic criteria for polycystic ovary syndrome: towards a rational approach A. Dunaif, J.R. Givens, F.P. Haseltine, G.R. Merriam, Polycystic ovary syndrome 1992 Blackwell Scientific Boston 377 384
3. Group REA-SPCW Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome Fertil Steril 81 2004 19 25
4. Group REA-SPCW Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) Humanit Rep 19 2004 41 47
5. R. Azziz, E. Carmina, D. Dewailly, E. Diamanti-Kandarakis, H.F. Escobar-Morreale, and W. Futterwiet et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report Fertil Steril 91 2009 456 488
6. M. Swanson, E.E. Sauerbrei, and P.L. Cooperberg Medical implications of ultrasonically detected polycystic ovaries J Clin Ultrasound 9 1981 219 222 (Pubitemid 11111100)
7. J. Adams, S. Franks, D.W. Polson, H.D. Mason, N. Abdulwahid, and M. Tucker et al. Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone Lancet 2 1985 8469 8470
8. K. Takahashi, T. Ozaki, M. Okada, A. Uchida, and M. Kitao Relationship between ultrasonography and histopathological changes in polycystic ovarian syndrome Hum Reprod 9 1994 2255 2258
9. W.U. Atiomo, S. Pearson, S. Shaw, A. Prencice, and P. Dubbins Ultrasound criteria in the diagnosis of polycystic ovary syndrome (PCOS) Ultrasound Med Biol 26 2000 977 980
10. A. Erdem, M. Erdem, K. Biberoglu, O. Hayit, M. Arslan, and R. Gursoy Age-related changes in ovarian volume, antral follicle counts and basal FSH in women with normal reproductive health J Reprod Med 47 2002 835 839
11. M. Erdem, A. Erdem, K. Biberoglu, and M. Arslan Age-related changes in ovarian volume, antral follicle counts and basal follicle stimulating hormone levels: comparison between fertile and infertile women Gynecol Endocrinol 17 2003 199 205 (Pubitemid 36760720)
12. A. Ersen, H. Onal, D. Yildirim, and E. Adal Ovarian and uterine ultrasonography and relation to puberty in healthy girls between 6 and 16 years in the Turkish population: a cross-sectional study J Pediatr Endocrinol Metab 25 2012 447 451
13. M. Razzaghy-Azar, F. Ghasemi, F. Hallaji, A. Ghasemi, and M. Ghasemi Sonographic measurement of uterus and ovaries in premenarcheal healthy girls between 6 and 13 years old: correlation with age and pubertal status J Clin Ultrasound 39 2011 64 73
14. C.A. Bastos, K. Oppermann, S.C. Fuchs, G.B. Donato, and P.M. Spritzer Determinants of ovarian volume in pre-, menopausal transition, and post-menopausal women: a population-based study Maturitas 53 2006 405 412
15. R. Frajndlich, and P.M. Spritzer Association between ovarian volume and serum insulin levels in ovulatory patients with idiopathic hirsutism Fertil Steril 83 2005 1561 1564 (Pubitemid 40615843)
16. I.J. Duijkers, and C. Klipping Polycystic ovaries, as defined by the 2003 Rotterdam consensus criteria, are found to be very common in young healthy women Gynecol Endocrinol 26 2010 152 160
17. E.B. Johnstone, M.P. Rosen, R. Neril, D. Trevithick, B. Sternfeld, and R. Murphy et al. The polycystic ovary post-Rotterdam: a common, age-dependent finding in ovulatory women without metabolic significance J Clin Endocrinol Metab 95 2010 4965 4972
18. S.L. Kristensen, C.H. Ramlau-Hansen, E. Ernst, S.F. Olsen, J.P. Bonde, and A. Vested et al. A very large proportion of young Danish women have polycystic ovaries: is a revision of the Rotterdam criteria needed? Hum Reprod 25 2010 3117 3122
19. M.E. Lujan, D.R. Chizen, A.K. Peppin, A. Dhir, and R.A. Pierson Assessment of ultrasonographic features of polycystic ovaries is associated with modest levels of inter-observer agreement J Ovarian Res 2 2009 6
20. M.E. Lujan, D.R. Chizen, A.K. Peppin, S. Kriegler, D.A. Leswick, and T.G. Blotski et al. Improving inter-observer variability in the evaluation of ultrasonographic features of polycystic ovaries Reprod Biol Endocrinol 6 2008 30 41
21. M.E. Lujan, E.D. Brooks, A.L. Kepley, D.R. Chizen, R.A. Pierson, and A.K. Peppin Grid analysis improves reliability in follicle counts made by ultrasonography in women with polycystic ovary syndrome Ultrasound Med Biol 36 2010 712 718
22. M.E. Lujan, B.Y. Jarrett, E.D. Brooks, J.K. Reines, A.K. Peppin, and N. Muhn et al. Updated ultrasound criteria for polycystic ovary syndrome: reliable thresholds for elevated follicle population and ovarian volume Hum Reprod 28 2013 1361 1368
23. D. Dewailly, H. Gronier, E. Poncelet, G. Robin, M. Leroy, and P. Pigny et al. Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries Hum Reprod 26 2011 3123 3129
24. M.C. Allemand, I.S. Tummon, J.L. Phy, S.C. Foong, D.A. Dumesic, and D.R. Session Diagnosis of polycystic ovaries by three-dimensional transvaginal ultrasound Fertil Steril 85 2006 214 219 (Pubitemid 43063448)
25. A.M. Fulghesu, M. Ciampelli, C. Belosi, R. Apa, V. Pavone, and A. Lanzone A new ultrasound criterion for the diagnosis of polycystic ovary syndrome: the ovarian stroma/total area ratio Fertil Steril 76 2001 326 331 (Pubitemid 32703821)
26. W.M. Buckett, R. Bouzayen, K.L. Watkin, T. Tulandi, and S.L. Tan Ovarian stromal echogenicity in women with normal and polycystic ovaries Hum Reprod 14 1999 618 621 (Pubitemid 29131235)
27. M. Lujan, T.G. Bloski, D.R. Chizen, D.C. Lehotay, and R.A. Pierson Digit ratios do not serve as anatomical evidence of prenatal androgen exposure in clinical phenotypes of polycystic ovary syndrome Hum Reprod 25 2010 204 211
28. American Institute of Ultrasound in M AIUM practice guideline for the performance of pelvic ultrasound examinations J Ultrasound Med 29 2010 166 172
29. L. Scoutt, J. Wax, H.L. Cohen, L. Diacon, J.C. Fox, and P. Fulgham et al. AIUM Practice guideline for the performance of a focused reproductive endocrinology and infertility scan J Ultrasound Med 31 2012 1865 1874
30. J. Neter, W. Wasserman, and M.H. Kutner Applied linear statistical models: regression, analysis of variance, and experimental designs 3rd ed. 1990 Irwin Homewood, IL
31. T.D. Pache, J.W. Wladimiroff, W.C. Hop, and B.C. Fauser How to discriminate between normal and polycystic ovaries: transvaginal US study Radiology 183 1992 421 423
32. R. Fox Transvaginal ultrasound appearances of the ovary in normal women and hirsute women with oligomenorrhoea Aust N Z J Obstet Gynaecol 39 1999 63 68 (Pubitemid 29108188)
33. S. Jonard, Y. Robert, C. Cortet-Rudelli, P. Pigny, C. Decanter, and D. Dewailly Ultrasound examination of polycystic ovaries: is it worth counting the follicles? Hum Reprod 18 2003 598 603 (Pubitemid 36329332)
34. S. Jonard, Y. Robert, and D. Dewailly Revisiting the ovarian volume as a diagnostic criterion for polycystic ovaries Hum Reprod 20 2005 2893 2898 (Pubitemid 41487648)
35. Y. Chen, L. Li, X. Chen, Q. Zha ng, W. Wang, and Y. Li et al. Ovarian volume and follicle number in the diagnosis of polycystic ovary syndrome in Chinese women Ultrasound Obstet Gynecol 32 2008 700 703
36. H.C. Yeh, W. Futterweit, and J.C. Thornton Polycystic ovarian disease: US features in 104 patients Radiology 163 1987 111 116 (Pubitemid 17043012)
37. N. Köşüş, A. Köşüş, N.Ö. Turhan, and Z. Kamalak Do threshold values of ovarian volume and follicle number for diagnosing polycystic ovarian syndrome in Turkish women differ from western countries? Eur J Obstet Gynecol Reprod Biol 154 2011 177 181
38. E.J.P. Van Santbrink, W.C. Hop, and B.C.J.M. Fause Classification of normogonadotropic infertility: polycystic ovaries diagnosed by ultrasound versus endocrine characteristics of polycystic ovary syndrome Fertil Steril 67 1997 452 458 (Pubitemid 27085957)
39. A.M. Fulghesu, S. Angioni, E. Frau, C. Belosi, R. Apa, and R. Mioni et al. Ultrasound in polycystic ovary syndrome - the measuring of ovarian stroma and relationship with circulating androgens: results of a multicentric study Hum Reprod 22 2007 2501 2508 (Pubitemid 47289066)
40. C. Battaglia, B. Battaglia, E. Morotti, R. Paradisi, I. Zanetti, and M.C. Meriggiola et al. Two- and three-dimensional sonographic and color Doppler techniques for diagnosis of polycystic ovary syndrome. The stromal/ovarian volume ratio as a new diagnostic criterion J Ultrasound Med 31 2012 1015 1024
41. D. Dewailly, Y. Robert, I. Hellin, Y. Ardsens, P. Thomas-Desrousseaux, and L. Lemaitre et al. Ovarian stromal hypertrophy in hyperandrogenic women Clin Endocrinol 41 1994 557 562 (Pubitemid 24336855)
42. C. Belosi, L. Selvaggi, R. Apa, M. Guido, D. Romualdi, and A.M. Fulghesu et al. Is the PCOS diagnosis solved by ESHRE/ASRM 2003 consensus or could it include ultrasound examination of the ovarian stroma? Hum Reprod 21 2006 3108 3115 (Pubitemid 44811611)
43. E. Diamanti-Kandarakis, and D. Panidis Unravelling the phenotypic map of polycystic ovary syndrome (PCOS): a prospective study of 634 women with PCOS Clin Endocrinol 67 2007 735 742 (Pubitemid 47620439)
44. T.L. Loucks, E.O. Talbott, K.P. McHugh, M. Keelan, S.L. Berga, and D.S. Guzick Do polycystic-appearing ovaries affect the risk of cardiovascular disease among women with polycystic ovary syndrome? Fertil Steril 74 2000 547 552
45. E. Guastella, R.A. Longo, and E. Carmina Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes Fertil Steril 94 2010 2197 2201
46. L. Moran, and H. Teede Metabolic features of the reproductive phenotypes of polycystic ovary syndrome Hum Reprod Update 15 2009 477 488