Ultrasound in polycystic ovary syndrome - The measuring of ovarian stroma and relationship with circulating androgens: Results of a multicentric study

Human Reproduction

Volumn 22, Issue 9, 2007, Pages 2501-2508

  Fulghesu, A M ^a   Angioni, S ^a   Frau, E ^a   Belosi, C ^b   Apa, R ^b   Mioni, R ^c   Xamin, N ^c   Capobianco, G P ^d   Dessole, S ^d   Fruzzetti, F ^e   Lazzarini, V ^e   Minerba, L ^a   Melis, G B ^a   Lanzone, A ^f  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d UNIVERSITY OF SASSARI   (Italy)

^e UNIVERSITY OF PISA   (Italy)

^f OASI RESEARCH INSTITUTE IRCCS   (Italy)

Author keywords

Androgen; Ovarian stroma; PCOS; S A ratio

Indexed keywords

ANDROGEN; ANDROSTENEDIONE; ESTRADIOL; FOLLITROPIN; HYDROXYPROGESTERONE; LUTEINIZING HORMONE; PRASTERONE SULFATE; PROGESTERONE; PROLACTIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADOLESCENT; ADULT; AMENORRHEA; ANDROGEN BLOOD LEVEL; ANDROSTENEDIONE BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN TISSUE; HYPERANDROGENISM; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; MULTICENTER STUDY; OLIGOMENORRHEA; OVARY; OVARY POLYCYSTIC DISEASE; PROGESTERONE BLOOD LEVEL; STATISTICAL ANALYSIS; STROMA; TESTOSTERONE BLOOD LEVEL; TRANSVAGINAL ECHOGRAPHY;

EID: 34548099659     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dem202     Document Type: Article

References (24)

1. Adams J, Franks S, Polson DW, Mason HD, Abdulwheid M, Tucker M, Morris DV, Price J, Jacobs HS. Multifollicular ovaries: Clinical and endocrine features and response to pulsatile gonadotropin releasing hormone. Lancet 1985;2:1375-1378.
2. Ajossa S, Guerriero S, Paoletti AM, Orrú M, Floris S, Mannias M, Mellis GB. Uterine perfusion and hormonal pattern in patients with polycystic ovary syndrome. Journal of Assisted Reproduction Genetics 18, 436-440.
3. Ardaens Y, Robert Y, Lemaitre I., Fossati P, Dewailly D. Polycystic ovarian disease: Contribution of vaginal endosonography and reassessment of ultrasonic diagnosis. Fertil Steril 1991;55:1062-1068.
4. Balen AH, Laven JSE, Tan SL, Dewailly D. Ultrasound assessment of the polycystic ovary: International consensus definitions. Hum Reprod Update 2003;9:505-514.
5. Belosi C, Selvaggi L, Guido M, Romualdi D, Fulghesu AM, Lanzone A. Is the PCOS diagnosis solved by ESHRE/ASRM 2003 consensus or could it include ultrasound examination of the ovarian stroma? Hum Reprod 2006;21:3108-3115.
6. Ciampelli M, Leoni F, Cucinelli F, Mancuso S, Panunzi S, De Gaetano A, Lanzone A. Assessment of insulin sensitivity from measurements in the fasting state and during oral glucose tolerance test in polycystic ovary syndrome and menopausal patients. J Clin Endocrinol Metab 2005; 90:1398-1406.
7. Dewailly D, Robert Y, Helin I, Ardaens Y, Thomas Desrousseaux P, Laemetre L, Fossati P. Ovarian stromal hypertrophy in hyperandrogenic women. J Clin Endocrinol Metab 1994;41:557-562.
8. Ferriman D, Gallway J. Clinical assessment of body hair growth in woman. J Clin Endocrinol Metab 1961;21:1440-1447.
9. Fulghesu AM, Ciampelli M, Belosi C, Apa R, Pavone V, Lanzone A. A new ultrasound criterion for the diagnosis of polycystic ovary sindrome: The ovarian stroma/total area ratio. Fertil Steril 2001;76 326-331.
10. Hanley JA, Mc Neil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 1983;14:839-843.
11. Kyei Mensah A, Maconochie N. Zaidi J, Pittrof R, Campbell S, Tan SL. Trans-vaginal three dimension ultrasound: Reproducibility of ovarian and endometrial volume measurements. Fertil Steril 1996;66 718-722.
12. Kyei-Mensah A. Zaidi J, Campbell S. Utrasound diagnosis of polycystic ovary syndrome. Baillieres Clin Endocrinol Metab 1996;10 249-262.
13. Kyei-Mensah AA, Lin Tan S, Zaidi J, Jacobs HS. Relationship of ovarian stromal volume to serum androgen concentrations in patients with polycystic ovary syndrome. Hum Reprod 1998;13:1437-1441.
14. Nardo LG, Buckett WM, White D, Digesu AG, Franks S, Khullar V. Three-dimensional assessment of ultrasound features in women with clomiphene citrate-resistant polycystic ovarian syndrome (PCOS): Ovarian stromal volume does not correlate with biochemical. indices. Hum Reprod 2002;17:1052-1055.
15. New MI, Lorentzen F. Lerner AJ, Kohn B, Oberfield SE, Pollack MS, Dupont B, Stoner E, Levy DJ, Pang S, Levine LS. Genotyping steroid 21-hydroxylase deficiency: Hormonal reference data. J Clin Endocrinol Metab 1983;57:320-326.
16. Pache T, Wladimiroff J, Hop WC, Fauser BC. How to dicriminate between normal and polycystic ovaries: trans-vaginal US study. Radiology 1992;183:421-423.
17. Puzigaca Z, Prelevic GM, Stretenovic Z, Balint Peric M. Ovarian enlargement as a possible marker of androgen activity in polycystic ovary syndrome. Gynecol Endocrinol 1991 Sep;5:167-174.
18. Reyes AC, Proust Richard C, Catteu- Jonard S, Dewailly D. Rotterdam consensus in adolescent girls: Which investigations and how to interpret them to make the diagnosis of PCOS? Gynecol Obstet Fertil 2006; 34:341-346.
19. Stein IF, Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol 1935;29:181-191.
20. The Rotterdam ESHRE/ASRM Sponsored PCOS Consensus Workshop Group. Revised 2003 Consensus on diagnostic criteria and long-term health rish related to polycistic ovary syndrome. Fertil Steril 2004;81 19-25.
21. Van Santbrink EJ, Hop WC, Fauser BC. Classification of normogonadotropic infertility: Polycystic ovaries diagnosed by ultrasound versus endocrine characteristics of polycystic ovary syndrome. Fertil Steril 1997;67:452-458.
22. Venturoli S, Porcu E, Fabbri R, Pluchinotta V, Ruggeri S, Macrelli S, Paradisi R, Flamigni C. Longitudinal change of sonographic ovarian aspects and endocrine parameters in irregular cycle of adolescents. Ped Research 1995;38:974-980.
23. Yoo RY, Sirlin CB, Gottschalk M, Chang RJ. Ovarian imaging by magnetic resonance in obese adolescent girls with polycystic ovary syndrome: A pilot study. Fertil Steril 2005:84:985-995.
24. Zweig MH, Campbell G. Receiver operating characteristic (ROC) plots: A fundamental evaluation tool in clinical medicine. Clin Chem 1993;39:561-577.