Influence of polyproline region and macro domain genetic heterogeneity on HEV persistence in immunocompromised patients

Journal of Infectious Diseases

Volumn 209, Issue 2, 2014, Pages 300-303

  Lhomme, Sebastien ^a   Garrouste, Cyril ^a,b   Kamar, Nassim ^a,b   Saune, Karine ^a   Abravanel, Florence ^a   Mansuy, Jean Michel ^a   Dubois, Martine ^a   Rostaing, Lionel ^a,b   Izopet, Jacques ^a  

^a CHU PURPAN   (France)

^b TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

Chronic infection; Hepatitis E; Macro domain; ORF1; Polyproline region

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENETIC DISTANCE; GENETIC HETEROGENEITY; GENOTYPE; GRAFT RECIPIENT; HEPATITIS E VIRUS; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPROMISED PATIENT; IMMUNOMODULATION; INFECTION; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; ORF2 GENE; PRIORITY JOURNAL; UNINDEXED SEQUENCE; VIRUS GENE;

EID: 84891552668     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit438     Document Type: Article

References (15)

1. Kamar N, Bendall R, Legrand-Abravanel F, et al. Hepatitis E. Lancet 2012; 379:2477-88
2. Ahmad I, Holla RP, Jameel S. Molecular virology of hepatitis E virus. Virus Res 2011; 161:47-58
3. Purdy MA, Lara J, Khudyakov YE. The hepatitis E virus polyproline region is involved in viral adaptation. PLoS One 2012; 7:e35974
4. Pudupakam RS, Huang YW, Opriessnig T, Halbur PG, Pierson FW, Meng XJ. Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: Evidence for attenuation of HVR deletion mutants in vivo. J Virol 2009; 83:384-95
5. Chen Z, Zhou X, Lunney JK, et al. Immunodominant epitopes in nsp2 of porcine reproductive and respiratory syndrome virus are dispensable for replication, but play an important role in modulation of the host immune response. J Gen Virol 2010; 91:1047-57
6. Eriksson KK, Cervantes-Barragan L, Ludewig B, Thiel V. Mouse hepatitis virus liver pathology is dependent on ADP-ribose-1′′-phosphatase, a viral function conserved in the alpha-like supergroup. J Virol 2008; 82:12325-34
7. Kamar N, Selves J, Mansuy JM, et al. Hepatitis E virus and chronic hepatitis in organ-Transplant recipients. N Engl J Med 2008; 358:811-7
8. Legrand-Abravanel F, Kamar N, Sandres-Saune K, et al. Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France. J Infect Dis 2010; 202:835-44
9. Abravanel F, Sandres-Saune K, Lhomme S, Dubois M, Mansuy JM, Izopet J. Genotype 3 diversity and quantification of hepatitis E virus RNA. J Clin Microbiol 2012; 50:897-902
10. Legrand-Abravanel F, Mansuy JM, Dubois M, et al. Hepatitis E virus genotype 3 diversity, France. Emerg Infect Dis 2009; 15:110-4
11. Yang Z, Bielawski JP. Statistical methods for detecting molecular adaptation. Trends Ecol Evol 2000; 15:496-503
12. Lhomme S, Abravanel F, Dubois M, et al. HEV quasispecies and the outcome of acute hepatitis E in solid-organ transplant patients. J Virol 2012; 86:10006-14
13. Farci P, Shimoda A, Coiana A, et al. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science 2000; 288:339-44
14. Putics A, Filipowicz W, Hall J, Gorbalenya AE, Ziebuhr J. ADP-ribose-1′′-monophosphatase: A conserved coronavirus enzyme that is dispensable for viral replication in tissue culture. J Virol 2005; 79:12721-31
15. Perttila J, Spuul P, Ahola T. Early secretory pathway localization and lack of processing for hepatitis E virus replication protein pORF1. J Gen Virol 2013; 94:807-16