메뉴 건너뛰기




Volumn 757, Issue 1, 2013, Pages 31-35

Comparative genotoxic and cytotoxic effects of the oral antidiabetic drugs sitagliptin, rosiglitazone, and pioglitazone in patients with type-2 diabetes: A cross-sectional, observational pilot study

Author keywords

Cytotoxicity; Genotoxicity; Pioglitazone; Rosiglitazone; Sitagliptin; Type 2 diabetes

Indexed keywords

PIOGLITAZONE; ROSIGLITAZONE; SITAGLIPTIN; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; PYRAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

EID: 84891541369     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2013.04.024     Document Type: Article
Times cited : (20)

References (34)
  • 3
    • 77949285419 scopus 로고    scopus 로고
    • Sitagliptin: a review of its use in the management of type 2 diabetes mellitus
    • Dhillon, S., Sitagliptin: a review of its use in the management of type 2 diabetes mellitus. Drugs 70 (2010), 489–512.
    • (2010) Drugs , vol.70 , pp. 489-512
    • Dhillon, S.1
  • 4
    • 84860375795 scopus 로고    scopus 로고
    • Thiazolidinediones and PPARγ agonists: time for a reassessment
    • Cariou, B., Charbonnel, B., Staels, B., Thiazolidinediones and PPARγ agonists: time for a reassessment. Trends Endocrinol. Metab. 23 (2012), 205–215.
    • (2012) Trends Endocrinol. Metab. , vol.23 , pp. 205-215
    • Cariou, B.1    Charbonnel, B.2    Staels, B.3
  • 5
    • 80051675688 scopus 로고    scopus 로고
    • Thiazolidinediones and type 2 diabetes: from cellular targets to cardiovascular benefit
    • Papaetis, G.S., Orphanidou, D., Panagiotou, T.N., Thiazolidinediones and type 2 diabetes: from cellular targets to cardiovascular benefit. Curr. Drug Targets 12 (2011), 1498–1512.
    • (2011) Curr. Drug Targets , vol.12 , pp. 1498-1512
    • Papaetis, G.S.1    Orphanidou, D.2    Panagiotou, T.N.3
  • 6
    • 59149084957 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonists as insulin sensitizers: from the discovery to recent progress
    • Cho, N., Momose, Y., Peroxisome proliferator-activated receptor gamma agonists as insulin sensitizers: from the discovery to recent progress. Curr. Top. Med. Chem. 8 (2008), 1483–1507.
    • (2008) Curr. Top. Med. Chem. , vol.8 , pp. 1483-1507
    • Cho, N.1    Momose, Y.2
  • 8
    • 70349779185 scopus 로고    scopus 로고
    • Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes
    • Rachek, L.I., Yuzefovych, L.V., Ledoux, S.P., Julie, N.L., Wilson, G.L., Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes. Toxicol. Appl. Pharmacol. 240 (2009), 348–354.
    • (2009) Toxicol. Appl. Pharmacol. , vol.240 , pp. 348-354
    • Rachek, L.I.1    Yuzefovych, L.V.2    Ledoux, S.P.3    Julie, N.L.4    Wilson, G.L.5
  • 10
    • 77953150270 scopus 로고    scopus 로고
    • Role of pioglitazone with metformin or glimepiride on oxidative stress-induced nuclear damage and reproductive toxicity in diabetic rats, Malays
    • Rabbani, S.I., Devi, K., Khanam, S., Role of pioglitazone with metformin or glimepiride on oxidative stress-induced nuclear damage and reproductive toxicity in diabetic rats, Malays. J. Med. Sci. 17 (2010), 3–11.
    • (2010) J. Med. Sci. , vol.17 , pp. 3-11
    • Rabbani, S.I.1    Devi, K.2    Khanam, S.3
  • 11
    • 84865043604 scopus 로고    scopus 로고
    • Evaluation of vitamin B12 effects on DNA damage induced by pioglitazone
    • Alzoubi, K., Khabour, O., Hussain, N., Al-Azzam, S., Mhaidat, N., Evaluation of vitamin B12 effects on DNA damage induced by pioglitazone. Mutat. Res. 748 (2012), 48–51.
    • (2012) Mutat. Res. , vol.748 , pp. 48-51
    • Alzoubi, K.1    Khabour, O.2    Hussain, N.3    Al-Azzam, S.4    Mhaidat, N.5
  • 12
    • 78049445549 scopus 로고    scopus 로고
    • Increased frequency of micronuclei in diabetes mellitus patients using pioglitazone and glimepiride in combination
    • Shaik, N.A., Shaik, J.P., Ali, S., Imran, A., Rao, D.K., Increased frequency of micronuclei in diabetes mellitus patients using pioglitazone and glimepiride in combination. Food Chem. Toxicol. 48 (2010), 3432–3435.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 3432-3435
    • Shaik, N.A.1    Shaik, J.P.2    Ali, S.3    Imran, A.4    Rao, D.K.5
  • 13
    • 80052963329 scopus 로고    scopus 로고
    • Sitagliptin augments protective effects of GLP-1 against advanced glycation end product receptor axis in endothelial cells
    • Ishibashi, Y., Matsui, T., Takeuchi, M., Yamagishi, S., Sitagliptin augments protective effects of GLP-1 against advanced glycation end product receptor axis in endothelial cells. Horm. Metab. Res. 43 (2011), 731–734.
    • (2011) Horm. Metab. Res. , vol.43 , pp. 731-734
    • Ishibashi, Y.1    Matsui, T.2    Takeuchi, M.3    Yamagishi, S.4
  • 14
    • 84866645242 scopus 로고    scopus 로고
    • Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition
    • Rizzo, M.R., Barbieri, M., Marfella, R., Paolisso, G., Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition. Diabetes Care, 2012, 10.2337/dc12-0199.
    • (2012) Diabetes Care
    • Rizzo, M.R.1    Barbieri, M.2    Marfella, R.3    Paolisso, G.4
  • 15
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff, M., Matveyenko, A.V., Gier, B., Elashoff, R., Butler, P.C., Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 141 (2011), 150–156.
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3    Elashoff, R.4    Butler, P.C.5
  • 16
    • 1842334456 scopus 로고    scopus 로고
    • Report of the expert committee on the diagnosis and classification of diabetes mellitus
    • No authors listed, Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20 (1997), 1183–1197.
    • (1997) Diabetes Care , vol.20 , pp. 1183-1197
    • No authors listed1
  • 17
    • 72049115492 scopus 로고    scopus 로고
    • Comparative effects of pioglitazone and rosiglitazone on plasma levels of soluble receptor for advanced glycation end products in type 2 diabetes mellitus patients
    • Oz Gul, O., Tuncel, E., Yilmaz, Y., Ulukaya, E., Gul, C.B., Kiyici, S., Oral, A.Y., Guclu, M., Ersoy, C., Imamoglu, S., Comparative effects of pioglitazone and rosiglitazone on plasma levels of soluble receptor for advanced glycation end products in type 2 diabetes mellitus patients. Metabolism 59 (2010), 64–69.
    • (2010) Metabolism , vol.59 , pp. 64-69
    • Oz Gul, O.1    Tuncel, E.2    Yilmaz, Y.3    Ulukaya, E.4    Gul, C.B.5    Kiyici, S.6    Oral, A.Y.7    Guclu, M.8    Ersoy, C.9    Imamoglu, S.10
  • 18
    • 0023947114 scopus 로고
    • International commission for protection against environmental mutagens and carcinogens. ICPEMC publication no. 14. Considerations for population monitoring using cytogenetic techniques
    • Carrano, A.V., Natarajan, N.T., International commission for protection against environmental mutagens and carcinogens. ICPEMC publication no. 14. Considerations for population monitoring using cytogenetic techniques. Mutat. Res. 204 (1988), 379–406.
    • (1988) Mutat. Res. , vol.204 , pp. 379-406
    • Carrano, A.V.1    Natarajan, N.T.2
  • 19
    • 0003681814 scopus 로고
    • Guide to Short Term Tests for Detecting Mutagenic and Carcinogenic Chemicals
    • World Health Organization Geneva
    • IPCS, Guide to Short Term Tests for Detecting Mutagenic and Carcinogenic Chemicals. 1985, World Health Organization, Geneva.
    • (1985)
    • IPCS1
  • 20
    • 67349143652 scopus 로고    scopus 로고
    • Evaluation of chromosome aberrations, sister chromatid exchange and micronuclei in patients with type-1 diabetes mellitus
    • Cinkilic, N., Kiyici, S., Celikler, S., Vatan, O., Oz Gul, O., Tuncel, E., Bilaloglu, R., Evaluation of chromosome aberrations, sister chromatid exchange and micronuclei in patients with type-1 diabetes mellitus. Mutat. Res. 676 (2009), 1–4.
    • (2009) Mutat. Res. , vol.676 , pp. 1-4
    • Cinkilic, N.1    Kiyici, S.2    Celikler, S.3    Vatan, O.4    Oz Gul, O.5    Tuncel, E.6    Bilaloglu, R.7
  • 21
    • 0037427878 scopus 로고    scopus 로고
    • HUman MicronNucleus project, HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures
    • Fenech, M., Chang, W.P., Kirsch-Volders, M., Holland, N., Bonassi, S., Zeiger, E., HUman MicronNucleus project, HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat. Res. 534 (2003), 65–75.
    • (2003) Mutat. Res. , vol.534 , pp. 65-75
    • Fenech, M.1    Chang, W.P.2    Kirsch-Volders, M.3    Holland, N.4    Bonassi, S.5    Zeiger, E.6
  • 22
    • 0000437062 scopus 로고
    • Average generation time: a new method of analysis and quantitation of cellular proliferation kinetics
    • Ivett, J.L., Tice, R.R., Average generation time: a new method of analysis and quantitation of cellular proliferation kinetics. Environ. Mutagen., 4, 1982, 358.
    • (1982) Environ. Mutagen. , vol.4 , pp. 358
    • Ivett, J.L.1    Tice, R.R.2
  • 23
    • 0024461337 scopus 로고
    • Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody
    • Eastmond, D.A., Tucker, J.D., Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody. Environ. Mol. Mutagen. 13 (1989), 34–43.
    • (1989) Environ. Mol. Mutagen. , vol.13 , pp. 34-43
    • Eastmond, D.A.1    Tucker, J.D.2
  • 25
    • 79953203593 scopus 로고    scopus 로고
    • Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies
    • Loke, Y.K., Kwok, C.S., Singh, S., Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ, 342, 2011, d1309.
    • (2011) BMJ , vol.342 , pp. d1309
    • Loke, Y.K.1    Kwok, C.S.2    Singh, S.3
  • 27
    • 58849143927 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma pathway targeting in carcinogenesis: implications for chemoprevention
    • Ondrey, F., Peroxisome proliferator-activated receptor gamma pathway targeting in carcinogenesis: implications for chemoprevention. Clin. Cancer Res. 15 (2009), 2–8.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2-8
    • Ondrey, F.1
  • 28
    • 3042815666 scopus 로고    scopus 로고
    • Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists
    • Grommes, C., Landreth, G.E., Heneka, M.T., Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists. Lancet Oncol. 5 (2004), 419–429.
    • (2004) Lancet Oncol. , vol.5 , pp. 419-429
    • Grommes, C.1    Landreth, G.E.2    Heneka, M.T.3
  • 29
    • 33846653083 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma: a novel target for cancer therapeutics
    • Han, S., Roman, J., Peroxisome proliferator-activated receptor gamma: a novel target for cancer therapeutics. Anticancer Drugs 18 (2007), 237–244.
    • (2007) Anticancer Drugs , vol.18 , pp. 237-244
    • Han, S.1    Roman, J.2
  • 30
    • 84862684037 scopus 로고    scopus 로고
    • The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case–control study
    • Azoulay, L., Yin, H., Filion, K.B., Assayag, J., Majdan, A., Pollak, M.N., Suissa, S., The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case–control study. BMJ, 344, 2012, e3645.
    • (2012) BMJ , vol.344 , pp. e3645
    • Azoulay, L.1    Yin, H.2    Filion, K.B.3    Assayag, J.4    Majdan, A.5    Pollak, M.N.6    Suissa, S.7
  • 31
    • 49649107776 scopus 로고    scopus 로고
    • Rosiglitazone and risk of cancer: a meta-analysis of randomized clinical trials
    • Monami, M., Lamanna, C., Marchionni, N., Mannucci, E., Rosiglitazone and risk of cancer: a meta-analysis of randomized clinical trials. Diabetes Care 31 (2008), 1455–1460.
    • (2008) Diabetes Care , vol.31 , pp. 1455-1460
    • Monami, M.1    Lamanna, C.2    Marchionni, N.3    Mannucci, E.4
  • 32
    • 84865414136 scopus 로고    scopus 로고
    • Diabetes and cancer research consortium. Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence
    • Johnson, J.A., Carstensen, B., Witte, D., Bowker, S.L., Lipscombe, L., Renehan, A.G., Diabetes and cancer research consortium. Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence. Diabetologia 55 (2012), 1607–1618.
    • (2012) Diabetologia , vol.55 , pp. 1607-1618
    • Johnson, J.A.1    Carstensen, B.2    Witte, D.3    Bowker, S.L.4    Lipscombe, L.5    Renehan, A.G.6
  • 33
    • 84864917469 scopus 로고    scopus 로고
    • Cancer risk in type 2 diabetes mellitus: metabolic links and therapeutic considerations
    • Sun, G., Kashyap, S.R., Cancer risk in type 2 diabetes mellitus: metabolic links and therapeutic considerations. J. Nutr. Metab., 2011, 2011, 708183.
    • (2011) J. Nutr. Metab. , vol.2011 , pp. 708183
    • Sun, G.1    Kashyap, S.R.2
  • 34
    • 81855194761 scopus 로고    scopus 로고
    • Safety of dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized clinical trials
    • Monami, M., Dicembrini, I., Martelli, D., Mannucci, E., Safety of dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized clinical trials. Curr. Med. Res. Opin. 27:Suppl. 3 (2011), 57–64.
    • (2011) Curr. Med. Res. Opin. , vol.27 , pp. 57-64
    • Monami, M.1    Dicembrini, I.2    Martelli, D.3    Mannucci, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.